GREMLIN Database
TerC - Integral membrane protein TerC family
PFAM: PF03741 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 181 (177)
Sequences: 41258 (19693)
Seq/√Len: 1480.2
META: 0.874

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_Q32_R3.6281.00
31_H35_F3.4821.00
40_G111_E3.1901.00
72_W76_K3.0041.00
151_F155_G2.7341.00
46_I136_I2.7211.00
74_A172_L2.5071.00
104_F108_V2.4021.00
133_F137_T2.2841.00
3_L125_A2.2811.00
31_H151_F2.1991.00
91_E95_A2.1761.00
75_T79_H2.1411.00
7_E11_S2.1311.00
33_A103_L2.1091.00
39_L43_V2.0491.00
155_G159_R1.9421.00
76_K80_E1.9331.00
27_P30_Q1.9211.00
50_L54_W1.8581.00
87_P90_R1.7911.00
42_L140_V1.7851.00
44_L115_L1.7741.00
78_I165_Y1.7721.00
28_E32_R1.7371.00
35_F39_L1.6911.00
6_L128_I1.6761.00
25_L33_A1.6471.00
32_R103_L1.6471.00
108_V112_L1.6411.00
51_A54_W1.6081.00
26_P29_Q1.5961.00
176_V180_A1.5731.00
23_S158_D1.5451.00
92_E96_L1.5111.00
50_L132_P1.5011.00
15_A19_A1.4681.00
32_R36_W1.4671.00
43_V47_L1.4441.00
87_P91_E1.4331.00
177_K181_E1.4301.00
67_G179_I1.4021.00
46_I50_L1.3961.00
99_T102_S1.3801.00
54_W58_L1.3791.00
54_W57_Q1.3681.00
4_Y141_F1.3461.00
101_A106_V1.3421.00
44_L111_E1.3391.00
53_A126_V1.3291.00
47_L51_A1.3261.00
55_L62_I1.3211.00
25_L106_V1.3191.00
63_L181_E1.3171.00
76_K79_H1.3171.00
72_W75_T1.3141.00
140_V144_L1.2921.00
155_G158_D1.2871.00
42_L143_I1.2851.00
150_A154_A1.2821.00
5_L9_V1.2801.00
25_L102_S1.2791.00
71_L175_G1.2701.00
4_Y8_I1.2521.00
89_E93_R1.2371.00
86_N89_E1.2321.00
53_A57_Q1.2281.00
162_Y165_Y1.2201.00
33_A110_I1.2021.00
137_T141_F1.1751.00
132_P136_I1.1541.00
98_V105_A1.1421.00
88_L93_R1.1351.00
40_G44_L1.1311.00
173_F177_K1.1221.00
105_A109_Q1.1161.00
108_V111_E1.0651.00
93_R100_A1.0641.00
8_I12_I1.0611.00
36_W40_G1.0541.00
82_E88_L1.0401.00
69_F73_T1.0371.00
32_R35_F1.0321.00
79_H162_Y1.0301.00
173_F176_V1.0281.00
27_P31_H1.0001.00
64_L68_L0.9911.00
88_L92_E0.9801.00
15_A18_I0.9781.00
148_S152_L0.9561.00
152_L155_G0.9431.00
74_A168_L0.9351.00
36_W107_L0.9331.00
28_E31_H0.9301.00
56_L63_L0.9181.00
139_N142_A0.9121.00
49_I53_A0.9111.00
105_A108_V0.9111.00
101_A105_A0.9101.00
33_A107_L0.9091.00
102_S105_A0.9081.00
145_G149_L0.9051.00
48_L115_L0.9051.00
24_K86_N0.9031.00
133_F136_I0.8961.00
23_S30_Q0.8941.00
112_L116_V0.8911.00
86_N90_R0.8841.00
125_A135_V0.8791.00
93_R96_L0.8751.00
60_D63_L0.8751.00
68_L72_W0.8721.00
149_L152_L0.8721.00
161_P165_Y0.8711.00
35_F151_F0.8701.00
22_F33_A0.8551.00
92_E95_A0.8531.00
136_I140_V0.8521.00
98_V101_A0.8521.00
49_I139_N0.8511.00
69_F119_L0.8481.00
60_D64_L0.8451.00
91_E94_R0.8441.00
157_L163_L0.8381.00
90_R95_A0.8351.00
104_F107_L0.8341.00
156_L159_R0.8331.00
127_G174_I0.8321.00
168_L172_L0.8311.00
144_L148_S0.8301.00
53_A56_L0.8271.00
41_A45_R0.8271.00
45_R114_D0.8261.00
49_I135_V0.8251.00
8_I15_A0.8161.00
52_G126_V0.8141.00
139_N143_I0.8141.00
44_L47_L0.8111.00
81_K165_Y0.8101.00
89_E92_E0.8101.00
19_A157_L0.8101.00
50_L53_A0.8091.00
156_L160_F0.8021.00
77_E168_L0.8011.00
88_L95_A0.7981.00
126_V129_T0.7981.00
19_A154_A0.7981.00
64_L179_I0.7941.00
47_L50_L0.7901.00
44_L118_S0.7881.00
165_Y169_A0.7861.00
19_A23_S0.7851.00
129_T133_F0.7841.00
61_W64_L0.7841.00
21_I109_Q0.7801.00
87_P92_E0.7771.00
69_F72_W0.7771.00
157_L164_K0.7691.00
21_I113_A0.7671.00
74_A175_G0.7651.00
2_T6_L0.7631.00
87_P93_R0.7601.00
88_L91_E0.7591.00
38_I42_L0.7581.00
3_L134_I0.7541.00
88_L112_L0.7511.00
90_R93_R0.7491.00
104_F111_E0.7401.00
170_F174_I0.7401.00
36_W39_L0.7231.00
2_T7_E0.7211.00
129_T135_V0.7151.00
92_E98_V0.7141.00
57_Q130_D0.7141.00
38_I147_R0.7111.00
3_L135_V0.7101.00
156_L163_L0.7031.00
97_P100_A0.7011.00
50_L136_I0.6981.00
34_L151_F0.6971.00
56_L126_V0.6911.00
79_H82_E0.6911.00
60_D181_E0.6871.00
89_E109_Q0.6861.00
109_Q113_A0.6851.00
29_Q33_A0.6841.00
62_I66_G0.6751.00
95_A98_V0.6701.00
87_P94_R0.6691.00
8_I149_L0.6681.00
169_A173_F0.6641.00
26_P102_S0.6641.00
12_I15_A0.6631.00
56_L59_F0.6621.00
93_R98_V0.6611.00
22_F34_L0.6601.00
8_I148_S0.6581.00
102_S106_V0.6541.00
152_L156_L0.6501.00
71_L75_T0.6481.00
89_E96_L0.6471.00
88_L96_L0.6471.00
89_E98_V0.6401.00
160_F163_L0.6371.00
18_I22_F0.6341.00
25_L29_Q0.6331.00
4_Y137_T0.6281.00
30_Q154_A0.6261.00
20_L23_S0.6231.00
142_A147_R0.6231.00
42_L147_R0.6191.00
125_A128_I0.6171.00
96_L100_A0.6161.00
86_N93_R0.6141.00
114_D120_D0.6121.00
39_L42_L0.6111.00
21_I106_V0.6101.00
17_V117_F0.6091.00
94_R97_P0.6021.00
2_T5_L0.5991.00
30_Q34_L0.5971.00
153_L156_L0.5961.00
49_I52_G0.5951.00
93_R99_T0.5931.00
78_I168_L0.5911.00
58_L61_W0.5901.00
130_D133_F0.5871.00
92_E97_P0.5801.00
86_N112_L0.5801.00
96_L102_S0.5761.00
35_F147_R0.5761.00
89_E95_A0.5711.00
114_D143_I0.5711.00
61_W65_V0.5701.00
158_D161_P0.5681.00
129_T134_I0.5671.00
40_G107_L0.5641.00
98_V102_S0.5641.00
143_I147_R0.5611.00
31_H34_L0.5581.00
169_A172_L0.5581.00
151_F154_A0.5581.00
89_E94_R0.5581.00
100_A104_F0.5521.00
107_L111_E0.5501.00
8_I42_L0.5501.00
86_N91_E0.5471.00
3_L129_T0.5471.00
71_L179_I0.5381.00
44_L48_L0.5271.00
29_Q103_L0.5261.00
30_Q158_D0.5231.00
88_L98_V0.5231.00
24_K80_E0.5201.00
48_L51_A0.5191.00
57_Q60_D0.5181.00
33_A106_V0.5151.00
51_A55_L0.5121.00
113_A116_V0.5101.00
114_D118_S0.5101.00
82_E90_R0.5071.00
161_P164_K0.5061.00
81_K164_K0.5051.00
18_I21_I0.5031.00
55_L59_F0.5031.00
131_D134_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.5359 43.7 0.893 Contact Map
4w6vA 1 0.4807 43.5 0.893 Contact Map
3o7qA 1 0.989 40.8 0.895 Contact Map
2gfpA 2 0.9779 40.5 0.895 Contact Map
4xnjA 1 1 29.9 0.902 Contact Map
1pw4A 1 0.5304 29.3 0.903 Contact Map
2wswA 3 0.4586 23 0.908 Contact Map
3wdoA 1 0.9834 22.4 0.908 Contact Map
4m64A 1 0.989 17.3 0.913 Contact Map
4ikvA 1 0.4807 16.7 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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