GREMLIN Database
YjgP_YjgQ - Predicted permease YjgP/YjgQ family
PFAM: PF03739 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 354 (353)
Sequences: 49994 (35940)
Seq/√Len: 1912.9
META: 0.884

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_E168_G4.7901.00
205_G222_F4.6011.00
187_E204_D4.5121.00
188_S203_E4.2551.00
173_D182_R3.7341.00
158_S167_R3.4561.00
273_H338_W3.3841.00
72_L98_V3.3011.00
165_T188_S3.1931.00
259_K269_R2.9851.00
192_D201_V2.8851.00
74_R78_D2.7061.00
182_R207_I2.7011.00
123_K126_E2.6871.00
190_R203_E2.6591.00
5_R9_G2.6411.00
201_V224_E2.6341.00
201_V226_D2.5341.00
11_F67_A2.4551.00
175_D179_G2.3271.00
95_L290_A2.3171.00
4_L101_L2.2961.00
199_R226_D2.2191.00
252_R272_L2.2151.00
102_A286_A2.1841.00
182_R209_E2.1351.00
111_L115_Y2.1321.00
326_G336_A2.1171.00
274_K323_E2.0941.00
152_R173_D2.0891.00
93_R96_R2.0611.00
67_A71_T2.0521.00
203_E224_E2.0501.00
160_D163_G1.9941.00
279_P282_C1.9901.00
119_W123_K1.9741.00
160_D167_R1.9601.00
271_E275_R1.9231.00
209_E218_R1.8621.00
271_E274_K1.8611.00
42_G46_E1.8461.00
298_R301_R1.8461.00
206_T221_R1.8411.00
15_L56_L1.8311.00
189_A202_L1.8271.00
167_R188_S1.8251.00
10_P71_T1.7911.00
40_P43_V1.7761.00
265_A269_R1.7661.00
6_E74_R1.7181.00
204_D223_D1.7141.00
247_S250_E1.6961.00
192_D197_D1.6821.00
43_V46_E1.6811.00
165_T190_R1.6731.00
190_R201_V1.6661.00
92_W96_R1.6661.00
45_L49_L1.6611.00
277_A338_W1.6531.00
107_L111_L1.6011.00
15_L63_A1.5571.00
166_L189_A1.5521.00
84_M94_L1.5441.00
84_M89_I1.5381.00
184_I207_I1.5371.00
103_L107_L1.5081.00
60_L109_S1.5041.00
64_V282_C1.5031.00
19_L52_L1.4941.00
64_V105_L1.4891.00
298_R303_L1.4831.00
349_L353_R1.4781.00
46_E50_L1.4771.00
169_V189_A1.4751.00
207_I220_T1.4751.00
323_E327_E1.4741.00
142_P158_S1.4731.00
106_S283_L1.4711.00
112_L116_V1.4521.00
79_S82_T1.4491.00
57_Y113_S1.4491.00
297_R302_G1.4471.00
1_R5_R1.4421.00
298_R302_G1.4401.00
126_E130_E1.4351.00
156_V166_L1.4221.00
110_F114_E1.4111.00
284_V348_G1.4101.00
186_A202_L1.4081.00
208_Y217_Y1.4081.00
168_G187_E1.4041.00
41_L45_L1.3861.00
338_W341_N1.3851.00
96_R100_I1.3831.00
281_A315_Y1.3711.00
68_V286_A1.3641.00
297_R301_R1.3601.00
34_L44_V1.3581.00
346_L350_Y1.3571.00
49_L53_P1.3511.00
191_L233_P1.3401.00
342_L346_L1.3321.00
284_V344_F1.3231.00
331_L336_A1.2951.00
209_E220_T1.2861.00
252_R256_R1.2821.00
207_I225_Y1.2821.00
266_R269_R1.2801.00
122_R126_E1.2711.00
47_Y124_A1.2681.00
50_L123_K1.2641.00
26_D30_L1.2351.00
248_L272_L1.2271.00
125_R128_L1.2201.00
63_A67_A1.2141.00
98_V286_A1.2131.00
83_A87_S1.2081.00
248_L275_R1.2061.00
232_T235_D1.2051.00
188_S204_D1.1811.00
173_D176_R1.1701.00
199_R228_P1.1651.00
119_W122_R1.1621.00
50_L120_A1.1621.00
332_P335_L1.1621.00
103_L283_L1.1501.00
272_L276_L1.1461.00
273_H334_L1.1391.00
125_R245_E1.1361.00
246_M250_E1.1321.00
6_E9_G1.1301.00
284_V345_L1.1241.00
46_E123_K1.1231.00
169_V202_L1.1221.00
69_L308_G1.1181.00
7_F71_T1.1151.00
8_L12_L1.1141.00
6_E75_L1.1091.00
211_D214_G1.1041.00
104_L107_L1.0901.00
269_R273_H1.0901.00
241_K250_E1.0881.00
194_D197_D1.0871.00
54_S58_L1.0861.00
26_D48_L1.0831.00
322_G336_A1.0801.00
342_L345_L1.0741.00
315_Y341_N1.0721.00
259_K265_A1.0601.00
256_R259_K1.0551.00
116_V119_W1.0481.00
76_A81_L1.0381.00
128_L132_R1.0351.00
51_L124_A1.0311.00
83_A86_A1.0251.00
103_L106_S1.0241.00
192_D199_R1.0211.00
160_D164_G1.0191.00
109_S282_C1.0161.00
117_V120_A1.0141.00
152_R171_I1.0051.00
100_I104_L1.0021.00
64_V286_A0.9971.00
166_L169_V0.9971.00
75_L84_M0.9941.00
3_I75_L0.9931.00
14_V66_L0.9871.00
334_L342_L0.9861.00
204_D221_R0.9841.00
246_M254_Y0.9811.00
124_A128_L0.9791.00
248_L276_L0.9791.00
173_D181_V0.9701.00
297_R304_G0.9701.00
316_Y320_S0.9681.00
65_L289_A0.9651.00
7_F98_V0.9621.00
111_L116_V0.9611.00
277_A341_N0.9591.00
320_S324_A0.9581.00
116_V120_A0.9571.00
18_L59_L0.9571.00
256_R260_S0.9561.00
254_Y258_L0.9551.00
206_T219_I0.9531.00
62_L312_G0.9521.00
160_D165_T0.9491.00
57_Y117_V0.9441.00
332_P336_A0.9431.00
297_R303_L0.9371.00
81_L294_L0.9371.00
255_I272_L0.9351.00
252_R255_I0.9321.00
211_D216_E0.9311.00
170_F183_V0.9301.00
336_A340_P0.9291.00
30_L34_L0.9291.00
43_V127_L0.9251.00
115_Y118_P0.9251.00
42_G45_L0.9231.00
104_L108_L0.9231.00
339_L343_L0.9201.00
159_V166_L0.9191.00
255_I265_A0.9161.00
255_I269_R0.9141.00
314_L344_F0.9121.00
43_V131_I0.9091.00
11_F60_L0.9061.00
258_L261_S0.9061.00
19_L59_L0.9061.00
115_Y249_W0.9041.00
76_A293_G0.9031.00
270_V337_A0.8961.00
322_G339_L0.8941.00
262_G265_A0.8941.00
108_L112_L0.8931.00
107_L110_F0.8931.00
46_E127_L0.8911.00
106_S282_C0.8881.00
255_I259_K0.8861.00
170_F185_T0.8841.00
322_G325_L0.8831.00
184_I225_Y0.8791.00
114_E248_L0.8781.00
276_L279_P0.8741.00
53_P57_Y0.8731.00
145_F155_Y0.8701.00
222_F225_Y0.8701.00
273_H276_L0.8701.00
11_F105_L0.8701.00
288_L348_G0.8691.00
2_Y6_E0.8621.00
270_V326_G0.8591.00
85_R91_L0.8561.00
115_Y119_W0.8551.00
322_G340_P0.8541.00
312_G316_Y0.8541.00
7_F101_L0.8531.00
255_I258_L0.8511.00
320_S323_E0.8491.00
191_L200_W0.8481.00
53_P56_L0.8471.00
23_L48_L0.8451.00
220_T225_Y0.8421.00
184_I205_G0.8391.00
26_D29_E0.8361.00
72_L290_A0.8361.00
130_E134_K0.8351.00
106_S110_F0.8341.00
300_G304_G0.8321.00
64_V101_L0.8291.00
310_L314_L0.8281.00
210_F217_Y0.8261.00
128_L131_I0.8251.00
266_R329_G0.8251.00
114_E275_R0.8251.00
99_L102_A0.8231.00
127_L131_I0.8211.00
293_G296_S0.8201.00
7_F64_V0.8201.00
114_E276_L0.8191.00
345_L348_G0.8141.00
68_V289_A0.8131.00
97_P100_I0.8121.00
125_R129_A0.8061.00
345_L349_L0.8061.00
10_P14_V0.8041.00
274_K319_L0.8041.00
105_L282_C0.8031.00
124_A127_L0.8011.00
19_L56_L0.8001.00
30_L48_L0.7981.00
102_A106_S0.7971.00
335_L342_L0.7961.00
318_L322_G0.7961.00
259_K262_G0.7951.00
316_Y319_L0.7951.00
171_I202_L0.7941.00
25_F29_E0.7911.00
168_G185_T0.7911.00
22_L55_I0.7891.00
71_T75_L0.7891.00
56_L60_L0.7861.00
273_H277_A0.7861.00
280_L341_N0.7831.00
254_Y257_R0.7801.00
2_Y84_M0.7791.00
147_R153_V0.7771.00
180_L209_E0.7761.00
13_L17_V0.7721.00
287_L348_G0.7701.00
60_L63_A0.7691.00
314_L318_L0.7691.00
211_D218_R0.7691.00
298_R304_G0.7651.00
324_A328_S0.7641.00
253_R257_R0.7631.00
100_I103_L0.7601.00
319_L323_E0.7601.00
301_R304_G0.7581.00
9_G13_L0.7581.00
51_L54_S0.7581.00
95_L99_L0.7561.00
258_L262_G0.7551.00
175_D181_V0.7531.00
14_V18_L0.7491.00
46_E49_L0.7481.00
202_L205_G0.7461.00
292_L296_S0.7461.00
64_V68_V0.7451.00
260_S263_L0.7401.00
54_S121_N0.7401.00
120_A123_K0.7381.00
205_G223_D0.7381.00
317_L321_L0.7371.00
12_L16_L0.7341.00
299_G302_G0.7331.00
270_V327_E0.7321.00
89_I93_R0.7311.00
108_L111_L0.7291.00
22_L59_L0.7291.00
92_W352_L0.7261.00
10_P67_A0.7251.00
192_D198_G0.7221.00
207_I222_F0.7181.00
254_Y268_Y0.7151.00
185_T206_T0.7121.00
257_R261_S0.7121.00
14_V17_V0.7121.00
16_L20_F0.7111.00
248_L252_R0.7101.00
51_L55_I0.7101.00
258_L263_L0.7081.00
192_D226_D0.7061.00
23_L52_L0.7061.00
333_P337_A0.7041.00
159_V164_G0.7041.00
257_R260_S0.7041.00
344_F348_G0.7041.00
331_L335_L0.7031.00
213_G216_E0.6971.00
7_F68_V0.6951.00
337_A341_N0.6951.00
315_Y344_F0.6921.00
350_Y353_R0.6901.00
187_E205_G0.6861.00
174_F180_L0.6851.00
106_S279_P0.6851.00
47_Y51_L0.6831.00
81_L94_L0.6821.00
185_T208_Y0.6801.00
29_E32_D0.6791.00
90_S93_R0.6751.00
39_L43_V0.6751.00
70_L74_R0.6741.00
95_L352_L0.6741.00
329_G336_A0.6721.00
60_L105_L0.6711.00
56_L112_L0.6701.00
336_A339_L0.6701.00
117_V121_N0.6691.00
143_G155_Y0.6681.00
114_E249_W0.6671.00
4_L7_F0.6661.00
191_L198_G0.6641.00
127_L130_E0.6621.00
4_L8_L0.6621.00
241_K245_E0.6601.00
281_A341_N0.6581.00
255_I262_G0.6561.00
291_P348_G0.6551.00
260_S264_D0.6551.00
7_F11_F0.6541.00
300_G303_L0.6541.00
315_Y319_L0.6501.00
211_D215_P0.6481.00
14_V70_L0.6481.00
140_I145_F0.6481.00
287_L291_P0.6481.00
311_L344_F0.6471.00
25_F28_L0.6461.00
18_L63_A0.6441.00
32_D36_G0.6411.00
26_D51_L0.6401.00
335_L339_L0.6401.00
81_L84_M0.6401.00
6_E71_T0.6391.00
231_L236_L0.6371.00
337_A340_P0.6341.00
7_F67_A0.6331.00
184_I202_L0.6321.00
299_G303_L0.6311.00
141_K144_V0.6301.00
65_L312_G0.6301.00
270_V274_K0.6291.00
271_E327_E0.6281.00
167_R187_E0.6281.00
248_L251_L0.6281.00
15_L19_L0.6271.00
87_S91_L0.6271.00
54_S57_Y0.6251.00
177_D180_L0.6241.00
318_L340_P0.6231.00
75_L81_L0.6231.00
9_G12_L0.6211.00
86_A89_I0.6191.00
20_F24_L0.6171.00
154_I171_I0.6161.00
171_I184_I0.6121.00
297_R300_G0.6111.00
11_F101_L0.6101.00
2_Y5_R0.6091.00
223_D226_D0.6041.00
111_L114_E0.6041.00
147_R150_D0.6031.00
306_G310_L0.6011.00
341_N345_L0.5971.00
172_Y180_L0.5961.00
129_A133_G0.5941.00
335_L338_W0.5921.00
109_S112_L0.5911.00
14_V67_A0.5891.00
91_L294_L0.5891.00
59_L63_A0.5881.00
22_L26_D0.5881.00
326_G329_G0.5871.00
249_W253_R0.5861.00
288_L311_L0.5851.00
319_L322_G0.5851.00
265_A268_Y0.5841.00
39_L131_I0.5821.00
164_G190_R0.5811.00
96_R107_L0.5811.00
31_L35_V0.5811.00
331_L339_L0.5801.00
277_A337_A0.5791.00
261_S264_D0.5791.00
296_S299_G0.5771.00
114_E247_S0.5771.00
66_L70_L0.5761.00
325_L330_V0.5761.00
253_R256_R0.5741.00
285_L312_G0.5741.00
303_L306_G0.5731.00
121_N125_R0.5711.00
162_D165_T0.5711.00
30_L33_D0.5691.00
172_Y183_V0.5691.00
4_L104_L0.5681.00
100_I107_L0.5671.00
22_L48_L0.5651.00
3_I84_M0.5641.00
2_Y75_L0.5641.00
299_G304_G0.5631.00
176_R181_V0.5631.00
309_I312_G0.5611.00
123_K127_L0.5591.00
164_G188_S0.5581.00
205_G225_Y0.5571.00
282_C286_A0.5571.00
145_F172_Y0.5561.00
170_F174_F0.5541.00
268_Y272_L0.5541.00
295_R304_G0.5531.00
200_W233_P0.5531.00
112_L117_V0.5521.00
99_L103_L0.5511.00
193_S197_D0.5491.00
110_F276_L0.5491.00
156_V159_V0.5451.00
212_P215_P0.5451.00
339_L346_L0.5451.00
146_L149_G0.5441.00
64_V67_A0.5431.00
326_G337_A0.5421.00
53_P120_A0.5401.00
82_T85_R0.5401.00
65_L285_L0.5391.00
244_E271_E0.5391.00
91_L290_A0.5381.00
343_L346_L0.5371.00
26_D55_I0.5371.00
161_P164_G0.5361.00
55_I58_L0.5361.00
29_E33_D0.5361.00
343_L347_L0.5351.00
333_P336_A0.5351.00
76_A294_L0.5341.00
71_T98_V0.5301.00
110_F279_P0.5301.00
319_L337_A0.5301.00
339_L342_L0.5291.00
216_E219_I0.5291.00
317_L320_S0.5291.00
281_A285_L0.5261.00
280_L338_W0.5251.00
32_D35_V0.5251.00
102_A283_L0.5241.00
144_V147_R0.5221.00
23_L26_D0.5221.00
132_R135_K0.5211.00
142_P145_F0.5201.00
96_R99_L0.5181.00
18_L62_L0.5171.00
106_S280_L0.5171.00
4_L100_I0.5161.00
173_D178_G0.5151.00
72_L94_L0.5151.00
143_G157_E0.5151.00
280_L284_V0.5131.00
243_P268_Y0.5131.00
197_D228_P0.5111.00
334_L338_W0.5111.00
334_L337_A0.5101.00
284_V341_N0.5101.00
7_F72_L0.5091.00
285_L288_L0.5091.00
27_L31_L0.5091.00
173_D184_I0.5081.00
145_F148_D0.5071.00
284_V315_Y0.5061.00
11_F64_V0.5061.00
44_V48_L0.5061.00
347_L350_Y0.5061.00
291_P294_L0.5041.00
19_L55_I0.5041.00
186_A205_G0.5041.00
153_V174_F0.5031.00
234_E237_R0.5021.00
53_P59_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m6bA 1 0.2458 4.8 0.96 Contact Map
4a18M 1 0.0932 4.2 0.961 Contact Map
4httA 1 0.2316 3.4 0.962 Contact Map
4us3A 1 0.2768 3.2 0.963 Contact Map
1oedC 1 0.2316 3 0.963 Contact Map
1oedE 1 0.2345 3 0.963 Contact Map
4cadC 1 0.1497 2.5 0.965 Contact Map
1oedB 1 0.2316 2.5 0.965 Contact Map
2llyA 1 0.2373 2.5 0.965 Contact Map
2kncA 1 0.1525 2.4 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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