GREMLIN Database
Noc2 - Noc2p family
PFAM: PF03715 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 296 (294)
Sequences: 596 (401)
Seq/√Len: 23.4
META: 0.206

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_I132_C4.8651.00
41_G96_H4.5031.00
208_L251_L4.1971.00
21_T84_H4.0561.00
7_L47_S3.7361.00
93_L139_L3.6391.00
176_F195_G3.4681.00
287_T290_G3.3281.00
137_L207_Y3.1481.00
12_L16_R2.9431.00
12_L54_Y2.7560.99
62_L115_G2.7270.99
121_P129_R2.6810.99
129_R155_E2.6220.99
60_I64_N2.6170.99
228_L244_L2.5360.99
51_A55_I2.5110.98
48_Y52_F2.5090.98
90_S135_S2.5060.98
10_T36_A2.4390.98
37_V92_V2.3800.98
72_E270_K2.3030.97
83_V180_L2.0990.95
282_L287_T2.0940.95
151_P183_P2.0680.95
93_L106_I1.9470.93
207_Y211_W1.8950.92
90_S113_I1.8810.92
153_L228_L1.8800.92
248_V251_L1.8700.91
56_R108_P1.8610.91
208_L224_V1.8390.91
52_F56_R1.8280.90
56_R63_R1.8170.90
117_I152_L1.7890.89
252_E256_K1.7790.89
134_R199_Q1.7680.89
48_Y59_A1.7580.89
52_F108_P1.7020.87
285_E294_V1.6780.86
232_L248_V1.6760.86
212_S258_I1.6680.86
157_L200_V1.6570.85
57_Q65_A1.6410.85
40_Y50_H1.6080.84
254_N258_I1.5960.83
216_A255_A1.5920.83
48_Y108_P1.5680.82
141_R229_K1.5580.82
56_R60_I1.5500.81
125_Y128_L1.5490.81
31_F122_T1.5370.81
133_I153_L1.5290.80
52_F63_R1.5250.80
162_F197_V1.5200.80
284_W290_G1.5170.80
254_N257_F1.5070.79
10_T229_K1.4900.79
15_V60_I1.4670.77
42_L47_S1.4660.77
84_H87_D1.4640.77
84_H93_L1.4600.77
62_L82_Y1.4500.77
85_S124_R1.4460.76
8_K54_Y1.4440.76
83_V173_P1.4420.76
31_F38_E1.4380.76
88_F100_S1.4340.76
92_V229_K1.4290.76
82_Y274_A1.4260.75
289_L292_Y1.4130.75
193_Q278_F1.4030.74
150_A154_L1.4020.74
75_K175_D1.3790.73
33_K87_D1.3790.73
216_A247_L1.3680.72
215_I278_F1.3570.72
36_A40_Y1.3440.71
247_L251_L1.3270.70
71_K235_C1.3200.69
140_S211_W1.3060.69
146_F155_E1.3040.68
19_K81_Q1.3010.68
170_T173_P1.3010.68
106_I145_T1.2960.68
189_T269_P1.2920.68
130_F176_F1.2880.68
232_L235_C1.2880.68
27_P253_E1.2620.66
221_A255_A1.2620.66
22_N181_K1.2540.65
65_A69_K1.2540.65
199_Q202_E1.2470.65
35_S38_E1.2370.64
41_G66_I1.2280.64
196_V266_D1.2160.63
48_Y105_L1.2140.63
174_L182_A1.2130.63
14_Y94_S1.2040.62
207_Y220_L1.2000.62
113_I180_L1.2000.62
101_P104_P1.1940.61
18_S85_S1.1930.61
111_Q115_G1.1910.61
217_F251_L1.1890.61
290_G293_V1.1880.61
162_F240_F1.1850.61
286_K291_K1.1720.60
104_P181_K1.1660.60
30_N33_K1.1490.58
10_T70_T1.1480.58
9_G36_A1.1430.58
279_L282_L1.1200.56
209_A287_T1.1190.56
150_A204_L1.1140.56
59_A108_P1.1130.56
77_V93_L1.1120.56
99_E293_V1.1090.56
78_Y121_P1.1060.55
128_L155_E1.1010.55
274_A277_A1.1010.55
251_L261_K1.0990.55
74_Y120_I1.0990.55
77_V147_I1.0980.55
150_A162_F1.0950.55
38_E42_L1.0930.55
47_S128_L1.0870.54
208_L221_A1.0790.54
40_Y47_S1.0780.54
37_V242_K1.0660.53
48_Y55_I1.0660.53
34_N269_P1.0660.53
131_H180_L1.0620.52
18_S268_A1.0580.52
34_N39_L1.0510.52
270_K274_A1.0510.52
5_T13_A1.0490.52
122_T128_L1.0450.51
63_R233_K1.0320.50
146_F149_L1.0320.50
137_L210_L1.0190.49
147_I190_R1.0160.49
243_Q252_E1.0150.49
48_Y56_R0.9910.47
81_Q119_L0.9880.47
14_Y31_F0.9830.47
208_L289_L0.9810.47
251_L254_N0.9790.47
147_I163_N0.9720.46
216_A257_F0.9720.46
257_F287_T0.9610.45
13_A28_G0.9610.45
262_R269_P0.9560.45
93_L115_G0.9560.45
277_A280_K0.9550.45
47_S104_P0.9540.45
54_Y61_H0.9530.45
236_K242_K0.9520.45
37_V41_G0.9510.45
93_L271_D0.9470.44
61_H65_A0.9430.44
85_S138_R0.9410.44
182_A192_Y0.9390.44
195_G229_K0.9350.44
232_L253_E0.9300.43
78_Y128_L0.9300.43
49_Q54_Y0.9280.43
73_S83_V0.9230.43
117_I133_I0.9200.43
133_I215_I0.9180.42
149_L197_V0.9120.42
279_L286_K0.9110.42
153_L204_L0.9090.42
80_W119_L0.9090.42
109_L112_V0.9080.42
22_N25_T0.9060.42
105_L108_P0.9040.41
213_K279_L0.9040.41
215_I258_I0.9030.41
12_L67_T0.9020.41
207_Y250_K0.8930.41
261_K264_K0.8910.41
225_V255_A0.8890.40
106_I112_V0.8880.40
176_F229_K0.8860.40
9_G35_S0.8820.40
31_F91_R0.8800.40
83_V132_C0.8770.40
18_S231_F0.8750.39
274_A292_Y0.8720.39
90_S139_L0.8720.39
22_N75_K0.8700.39
17_N20_F0.8700.39
61_H81_Q0.8690.39
184_K193_Q0.8680.39
50_H53_V0.8650.39
116_A128_L0.8590.38
136_L147_I0.8580.38
124_R181_K0.8550.38
186_Y189_T0.8510.38
196_V223_P0.8500.38
283_K286_K0.8460.38
281_D284_W0.8460.38
17_N31_F0.8360.37
48_Y63_R0.8350.37
188_K210_L0.8340.37
36_A253_E0.8330.37
42_L243_Q0.8320.37
87_D135_S0.8310.37
68_T196_V0.8290.36
176_F237_N0.8220.36
230_R261_K0.8190.36
77_V233_K0.8140.35
218_P230_R0.8140.35
280_K283_K0.8120.35
6_V214_S0.8110.35
266_D283_K0.8080.35
23_P42_L0.8060.35
55_I107_Y0.8050.35
12_L53_V0.8050.35
27_P47_S0.8020.35
78_Y119_L0.8000.35
56_R59_A0.7990.35
175_D230_R0.7950.34
146_F266_D0.7940.34
221_A251_L0.7940.34
195_G199_Q0.7910.34
125_Y295_S0.7910.34
215_I265_V0.7900.34
271_D274_A0.7880.34
151_P181_K0.7870.34
167_K275_V0.7810.33
15_V226_V0.7800.33
166_P264_K0.7800.33
6_V158_E0.7700.33
172_K200_V0.7630.32
42_L266_D0.7590.32
55_I223_P0.7560.32
34_N189_T0.7560.32
75_K132_C0.7540.32
200_V204_L0.7510.32
257_F271_D0.7500.31
43_D57_Q0.7500.31
68_T82_Y0.7490.31
189_T235_C0.7470.31
261_K282_L0.7460.31
51_A271_D0.7450.31
151_P210_L0.7440.31
122_T129_R0.7410.31
82_Y154_L0.7380.31
35_S46_V0.7380.31
155_E198_E0.7370.31
144_G253_E0.7360.31
209_A254_N0.7360.31
150_A245_K0.7350.31
152_L201_V0.7330.30
151_P185_S0.7330.30
156_V159_S0.7240.30
70_T265_V0.7220.30
212_S254_N0.7200.30
229_K239_K0.7200.30
20_F54_Y0.7150.29
40_Y60_I0.7150.29
8_K108_P0.7130.29
26_L47_S0.7060.29
72_E128_L0.7060.29
160_A203_L0.7060.29
83_V112_V0.7050.29
50_H112_V0.7040.29
258_I265_V0.7030.29
11_Y81_Q0.7020.29
7_L29_I0.7010.29
284_W294_V0.7000.29
256_K260_E0.6970.28
78_Y81_Q0.6970.28
174_L273_A0.6970.28
249_E252_E0.6970.28
12_L15_V0.6970.28
276_E289_L0.6950.28
276_E279_L0.6950.28
36_A88_F0.6930.28
90_S222_L0.6890.28
164_K247_L0.6880.28
30_N35_S0.6860.28
118_R161_E0.6850.28
102_L262_R0.6850.28
86_L183_P0.6830.28
21_T219_E0.6810.27
222_L230_R0.6810.27
261_K271_D0.6790.27
23_P131_H0.6720.27
60_I79_N0.6720.27
219_E262_R0.6700.27
235_C238_A0.6670.27
218_P262_R0.6660.27
61_H250_K0.6650.27
66_I168_K0.6630.26
116_A200_V0.6630.26
126_F156_V0.6610.26
55_I145_T0.6590.26
24_H27_P0.6590.26
284_W287_T0.6570.26
209_A212_S0.6550.26
26_L181_K0.6540.26
108_P233_K0.6470.26
22_N39_L0.6460.26
25_T66_I0.6440.25
144_G260_E0.6430.25
169_S179_I0.6410.25
55_I63_R0.6400.25
55_I146_F0.6400.25
264_K291_K0.6380.25
119_L220_L0.6370.25
35_S206_E0.6360.25
81_Q129_R0.6340.25
25_T167_K0.6320.25
27_P40_Y0.6310.25
125_Y184_K0.6310.25
222_L291_K0.6310.25
2_I35_S0.6280.25
74_Y123_A0.6220.24
149_L207_Y0.6200.24
20_F24_H0.6190.24
144_G164_K0.6190.24
106_I110_V0.6180.24
44_P96_H0.6170.24
35_S96_H0.6160.24
24_H180_L0.6140.24
82_Y187_L0.6120.24
134_R195_G0.6120.24
9_G95_A0.6110.24
61_H120_I0.6110.24
75_K177_S0.6110.24
55_I77_V0.6110.24
77_V115_G0.6100.24
11_Y57_Q0.6050.23
104_P261_K0.6050.23
43_D151_P0.6020.23
284_W293_V0.6020.23
170_T286_K0.6000.23
188_K230_R0.6000.23
110_V181_K0.5990.23
273_A283_K0.5980.23
253_E278_F0.5950.23
58_L82_Y0.5940.23
144_G165_K0.5930.23
95_A236_K0.5890.23
87_D138_R0.5890.23
126_F159_S0.5890.23
272_R285_E0.5880.23
35_S41_G0.5880.23
187_L210_L0.5860.22
8_K15_V0.5830.22
40_Y209_A0.5800.22
127_P148_P0.5790.22
90_S122_T0.5780.22
254_N289_L0.5780.22
171_L191_V0.5780.22
129_R138_R0.5770.22
131_H238_A0.5750.22
52_F105_L0.5740.22
46_V54_Y0.5710.22
171_L186_Y0.5690.22
31_F35_S0.5680.22
48_Y107_Y0.5680.22
272_R276_E0.5680.22
24_H34_N0.5670.22
105_L111_Q0.5660.22
38_E63_R0.5650.21
18_S223_P0.5650.21
43_D140_S0.5630.21
147_I156_V0.5630.21
188_K212_S0.5620.21
183_P199_Q0.5610.21
156_V215_I0.5600.21
33_K84_H0.5590.21
92_V281_D0.5580.21
4_E46_V0.5580.21
61_H82_Y0.5550.21
267_F275_V0.5550.21
64_N276_E0.5550.21
26_L178_V0.5540.21
18_S73_S0.5540.21
282_L290_G0.5520.21
176_F247_L0.5490.21
122_T194_D0.5470.21
98_S173_P0.5470.21
139_L270_K0.5460.21
289_L293_V0.5460.21
21_T29_I0.5450.21
162_F249_E0.5450.21
29_I242_K0.5440.20
47_S98_S0.5440.20
83_V244_L0.5440.20
197_V210_L0.5440.20
101_P154_L0.5430.20
82_Y234_K0.5420.20
8_K50_H0.5420.20
7_L19_K0.5400.20
62_L192_Y0.5390.20
77_V84_H0.5390.20
137_L257_F0.5360.20
245_K292_Y0.5360.20
24_H31_F0.5360.20
23_P178_V0.5360.20
231_F240_F0.5350.20
25_T98_S0.5330.20
21_T26_L0.5320.20
79_N215_I0.5310.20
86_L152_L0.5300.20
215_I218_P0.5290.20
121_P164_K0.5280.20
65_A271_D0.5280.20
82_Y115_G0.5270.20
55_I109_L0.5260.20
285_E290_G0.5230.20
109_L247_L0.5230.20
229_K246_Q0.5210.19
25_T79_N0.5210.19
112_V245_K0.5190.19
216_A274_A0.5170.19
181_K220_L0.5170.19
6_V278_F0.5170.19
56_R131_H0.5160.19
236_K270_K0.5140.19
266_D278_F0.5120.19
39_L266_D0.5110.19
19_K43_D0.5100.19
202_E211_W0.5100.19
156_V196_V0.5100.19
52_F107_Y0.5100.19
116_A132_C0.5090.19
276_E290_G0.5080.19
57_Q81_Q0.5080.19
235_C241_R0.5060.19
222_L229_K0.5040.19
125_Y267_F0.5030.19
129_R156_V0.5030.19
140_S147_I0.5020.19
168_K247_L0.5010.19
94_S228_L0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rxxA 1 0.7095 54.5 0.96 Contact Map
2igpA 1 0.3682 35.5 0.965 Contact Map
1wa5C 1 0.8885 16.3 0.97 Contact Map
2ve7A 1 0.7365 13.8 0.971 Contact Map
2bptA 1 0.902 11.7 0.972 Contact Map
3a6pA 1 0.8885 10.2 0.973 Contact Map
4gofA 2 0.1655 9 0.973 Contact Map
2kzsA 1 0.2264 8 0.974 Contact Map
1j1jA 4 0.2568 7.8 0.974 Contact Map
2vj4A 1 0.3986 7.1 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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