Noc2 - PFAM28P - GREMLIN Contacts

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Noc2 - Noc2p family

PFAM:	PF03715	Sequences: SILETVLKGTYLAYVRNSKFTNPHTLPGINFMKNSAVELYGLDPAVSYQHAFVYIRQLAIHLRNAITTKTKESYKAVYNWQYVHSLDFWSRVLSAHCSESPLRPLIYPLVQVILGAIRLIPTARYFPLRFHCIRSLLRLSRSTGTFIPLAPLLLEVLESAEFNKKPKKSTLKPLDFSVILKAPKSYLKTRVYQDGVVEQVVELLLEYLALWSKSIAFPELALPVVVQLKRFLKKCKNAKFRKQLKQLVEKLEENAKFIEEKRAKVDFAPKDRAAVEAFLKDLKWEKTPLGKYVVSW	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	296 (294)
Sequences:	596 (401)
Seq/√Len:	23.4
META:	0.206

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
113_I	132_C	4.865	1.00
41_G	96_H	4.503	1.00
208_L	251_L	4.197	1.00
21_T	84_H	4.056	1.00
7_L	47_S	3.736	1.00
93_L	139_L	3.639	1.00
176_F	195_G	3.468	1.00
287_T	290_G	3.328	1.00
137_L	207_Y	3.148	1.00
12_L	16_R	2.943	1.00
12_L	54_Y	2.756	0.99
62_L	115_G	2.727	0.99
121_P	129_R	2.681	0.99
129_R	155_E	2.622	0.99
60_I	64_N	2.617	0.99
228_L	244_L	2.536	0.99
51_A	55_I	2.511	0.98
48_Y	52_F	2.509	0.98
90_S	135_S	2.506	0.98
10_T	36_A	2.439	0.98
37_V	92_V	2.380	0.98
72_E	270_K	2.303	0.97
83_V	180_L	2.099	0.95
282_L	287_T	2.094	0.95
151_P	183_P	2.068	0.95
93_L	106_I	1.947	0.93
207_Y	211_W	1.895	0.92
90_S	113_I	1.881	0.92
153_L	228_L	1.880	0.92
248_V	251_L	1.870	0.91
56_R	108_P	1.861	0.91
208_L	224_V	1.839	0.91
52_F	56_R	1.828	0.90
56_R	63_R	1.817	0.90
117_I	152_L	1.789	0.89
252_E	256_K	1.779	0.89
134_R	199_Q	1.768	0.89
48_Y	59_A	1.758	0.89
52_F	108_P	1.702	0.87
285_E	294_V	1.678	0.86
232_L	248_V	1.676	0.86
212_S	258_I	1.668	0.86
157_L	200_V	1.657	0.85
57_Q	65_A	1.641	0.85
40_Y	50_H	1.608	0.84
254_N	258_I	1.596	0.83
216_A	255_A	1.592	0.83
48_Y	108_P	1.568	0.82
141_R	229_K	1.558	0.82
56_R	60_I	1.550	0.81
125_Y	128_L	1.549	0.81
31_F	122_T	1.537	0.81
133_I	153_L	1.529	0.80
52_F	63_R	1.525	0.80
162_F	197_V	1.520	0.80
284_W	290_G	1.517	0.80
254_N	257_F	1.507	0.79
10_T	229_K	1.490	0.79
15_V	60_I	1.467	0.77
42_L	47_S	1.466	0.77
84_H	87_D	1.464	0.77
84_H	93_L	1.460	0.77
62_L	82_Y	1.450	0.77
85_S	124_R	1.446	0.76
8_K	54_Y	1.444	0.76
83_V	173_P	1.442	0.76
31_F	38_E	1.438	0.76
88_F	100_S	1.434	0.76
92_V	229_K	1.429	0.76
82_Y	274_A	1.426	0.75
289_L	292_Y	1.413	0.75
193_Q	278_F	1.403	0.74
150_A	154_L	1.402	0.74
75_K	175_D	1.379	0.73
33_K	87_D	1.379	0.73
216_A	247_L	1.368	0.72
215_I	278_F	1.357	0.72
36_A	40_Y	1.344	0.71
247_L	251_L	1.327	0.70
71_K	235_C	1.320	0.69
140_S	211_W	1.306	0.69
146_F	155_E	1.304	0.68
19_K	81_Q	1.301	0.68
170_T	173_P	1.301	0.68
106_I	145_T	1.296	0.68
189_T	269_P	1.292	0.68
130_F	176_F	1.288	0.68
232_L	235_C	1.288	0.68
27_P	253_E	1.262	0.66
221_A	255_A	1.262	0.66
22_N	181_K	1.254	0.65
65_A	69_K	1.254	0.65
199_Q	202_E	1.247	0.65
35_S	38_E	1.237	0.64
41_G	66_I	1.228	0.64
196_V	266_D	1.216	0.63
48_Y	105_L	1.214	0.63
174_L	182_A	1.213	0.63
14_Y	94_S	1.204	0.62
207_Y	220_L	1.200	0.62
113_I	180_L	1.200	0.62
101_P	104_P	1.194	0.61
18_S	85_S	1.193	0.61
111_Q	115_G	1.191	0.61
217_F	251_L	1.189	0.61
290_G	293_V	1.188	0.61
162_F	240_F	1.185	0.61
286_K	291_K	1.172	0.60
104_P	181_K	1.166	0.60
30_N	33_K	1.149	0.58
10_T	70_T	1.148	0.58
9_G	36_A	1.143	0.58
279_L	282_L	1.120	0.56
209_A	287_T	1.119	0.56
150_A	204_L	1.114	0.56
59_A	108_P	1.113	0.56
77_V	93_L	1.112	0.56
99_E	293_V	1.109	0.56
78_Y	121_P	1.106	0.55
128_L	155_E	1.101	0.55
274_A	277_A	1.101	0.55
251_L	261_K	1.099	0.55
74_Y	120_I	1.099	0.55
77_V	147_I	1.098	0.55
150_A	162_F	1.095	0.55
38_E	42_L	1.093	0.55
47_S	128_L	1.087	0.54
208_L	221_A	1.079	0.54
40_Y	47_S	1.078	0.54
37_V	242_K	1.066	0.53
48_Y	55_I	1.066	0.53
34_N	269_P	1.066	0.53
131_H	180_L	1.062	0.52
18_S	268_A	1.058	0.52
34_N	39_L	1.051	0.52
270_K	274_A	1.051	0.52
5_T	13_A	1.049	0.52
122_T	128_L	1.045	0.51
63_R	233_K	1.032	0.50
146_F	149_L	1.032	0.50
137_L	210_L	1.019	0.49
147_I	190_R	1.016	0.49
243_Q	252_E	1.015	0.49
48_Y	56_R	0.991	0.47
81_Q	119_L	0.988	0.47
14_Y	31_F	0.983	0.47
208_L	289_L	0.981	0.47
251_L	254_N	0.979	0.47
147_I	163_N	0.972	0.46
216_A	257_F	0.972	0.46
257_F	287_T	0.961	0.45
13_A	28_G	0.961	0.45
262_R	269_P	0.956	0.45
93_L	115_G	0.956	0.45
277_A	280_K	0.955	0.45
47_S	104_P	0.954	0.45
54_Y	61_H	0.953	0.45
236_K	242_K	0.952	0.45
37_V	41_G	0.951	0.45
93_L	271_D	0.947	0.44
61_H	65_A	0.943	0.44
85_S	138_R	0.941	0.44
182_A	192_Y	0.939	0.44
195_G	229_K	0.935	0.44
232_L	253_E	0.930	0.43
78_Y	128_L	0.930	0.43
49_Q	54_Y	0.928	0.43
73_S	83_V	0.923	0.43
117_I	133_I	0.920	0.43
133_I	215_I	0.918	0.42
149_L	197_V	0.912	0.42
279_L	286_K	0.911	0.42
153_L	204_L	0.909	0.42
80_W	119_L	0.909	0.42
109_L	112_V	0.908	0.42
22_N	25_T	0.906	0.42
105_L	108_P	0.904	0.41
213_K	279_L	0.904	0.41
215_I	258_I	0.903	0.41
12_L	67_T	0.902	0.41
207_Y	250_K	0.893	0.41
261_K	264_K	0.891	0.41
225_V	255_A	0.889	0.40
106_I	112_V	0.888	0.40
176_F	229_K	0.886	0.40
9_G	35_S	0.882	0.40
31_F	91_R	0.880	0.40
83_V	132_C	0.877	0.40
18_S	231_F	0.875	0.39
274_A	292_Y	0.872	0.39
90_S	139_L	0.872	0.39
22_N	75_K	0.870	0.39
17_N	20_F	0.870	0.39
61_H	81_Q	0.869	0.39
184_K	193_Q	0.868	0.39
50_H	53_V	0.865	0.39
116_A	128_L	0.859	0.38
136_L	147_I	0.858	0.38
124_R	181_K	0.855	0.38
186_Y	189_T	0.851	0.38
196_V	223_P	0.850	0.38
283_K	286_K	0.846	0.38
281_D	284_W	0.846	0.38
17_N	31_F	0.836	0.37
48_Y	63_R	0.835	0.37
188_K	210_L	0.834	0.37
36_A	253_E	0.833	0.37
42_L	243_Q	0.832	0.37
87_D	135_S	0.831	0.37
68_T	196_V	0.829	0.36
176_F	237_N	0.822	0.36
230_R	261_K	0.819	0.36
77_V	233_K	0.814	0.35
218_P	230_R	0.814	0.35
280_K	283_K	0.812	0.35
6_V	214_S	0.811	0.35
266_D	283_K	0.808	0.35
23_P	42_L	0.806	0.35
55_I	107_Y	0.805	0.35
12_L	53_V	0.805	0.35
27_P	47_S	0.802	0.35
78_Y	119_L	0.800	0.35
56_R	59_A	0.799	0.35
175_D	230_R	0.795	0.34
146_F	266_D	0.794	0.34
221_A	251_L	0.794	0.34
195_G	199_Q	0.791	0.34
125_Y	295_S	0.791	0.34
215_I	265_V	0.790	0.34
271_D	274_A	0.788	0.34
151_P	181_K	0.787	0.34
167_K	275_V	0.781	0.33
15_V	226_V	0.780	0.33
166_P	264_K	0.780	0.33
6_V	158_E	0.770	0.33
172_K	200_V	0.763	0.32
42_L	266_D	0.759	0.32
55_I	223_P	0.756	0.32
34_N	189_T	0.756	0.32
75_K	132_C	0.754	0.32
200_V	204_L	0.751	0.32
257_F	271_D	0.750	0.31
43_D	57_Q	0.750	0.31
68_T	82_Y	0.749	0.31
189_T	235_C	0.747	0.31
261_K	282_L	0.746	0.31
51_A	271_D	0.745	0.31
151_P	210_L	0.744	0.31
122_T	129_R	0.741	0.31
82_Y	154_L	0.738	0.31
35_S	46_V	0.738	0.31
155_E	198_E	0.737	0.31
144_G	253_E	0.736	0.31
209_A	254_N	0.736	0.31
150_A	245_K	0.735	0.31
152_L	201_V	0.733	0.30
151_P	185_S	0.733	0.30
156_V	159_S	0.724	0.30
70_T	265_V	0.722	0.30
212_S	254_N	0.720	0.30
229_K	239_K	0.720	0.30
20_F	54_Y	0.715	0.29
40_Y	60_I	0.715	0.29
8_K	108_P	0.713	0.29
26_L	47_S	0.706	0.29
72_E	128_L	0.706	0.29
160_A	203_L	0.706	0.29
83_V	112_V	0.705	0.29
50_H	112_V	0.704	0.29
258_I	265_V	0.703	0.29
11_Y	81_Q	0.702	0.29
7_L	29_I	0.701	0.29
284_W	294_V	0.700	0.29
256_K	260_E	0.697	0.28
78_Y	81_Q	0.697	0.28
174_L	273_A	0.697	0.28
249_E	252_E	0.697	0.28
12_L	15_V	0.697	0.28
276_E	289_L	0.695	0.28
276_E	279_L	0.695	0.28
36_A	88_F	0.693	0.28
90_S	222_L	0.689	0.28
164_K	247_L	0.688	0.28
30_N	35_S	0.686	0.28
118_R	161_E	0.685	0.28
102_L	262_R	0.685	0.28
86_L	183_P	0.683	0.28
21_T	219_E	0.681	0.27
222_L	230_R	0.681	0.27
261_K	271_D	0.679	0.27
23_P	131_H	0.672	0.27
60_I	79_N	0.672	0.27
219_E	262_R	0.670	0.27
235_C	238_A	0.667	0.27
218_P	262_R	0.666	0.27
61_H	250_K	0.665	0.27
66_I	168_K	0.663	0.26
116_A	200_V	0.663	0.26
126_F	156_V	0.661	0.26
55_I	145_T	0.659	0.26
24_H	27_P	0.659	0.26
284_W	287_T	0.657	0.26
209_A	212_S	0.655	0.26
26_L	181_K	0.654	0.26
108_P	233_K	0.647	0.26
22_N	39_L	0.646	0.26
25_T	66_I	0.644	0.25
144_G	260_E	0.643	0.25
169_S	179_I	0.641	0.25
55_I	63_R	0.640	0.25
55_I	146_F	0.640	0.25
264_K	291_K	0.638	0.25
119_L	220_L	0.637	0.25
35_S	206_E	0.636	0.25
81_Q	129_R	0.634	0.25
25_T	167_K	0.632	0.25
27_P	40_Y	0.631	0.25
125_Y	184_K	0.631	0.25
222_L	291_K	0.631	0.25
2_I	35_S	0.628	0.25
74_Y	123_A	0.622	0.24
149_L	207_Y	0.620	0.24
20_F	24_H	0.619	0.24
144_G	164_K	0.619	0.24
106_I	110_V	0.618	0.24
44_P	96_H	0.617	0.24
35_S	96_H	0.616	0.24
24_H	180_L	0.614	0.24
82_Y	187_L	0.612	0.24
134_R	195_G	0.612	0.24
9_G	95_A	0.611	0.24
61_H	120_I	0.611	0.24
75_K	177_S	0.611	0.24
55_I	77_V	0.611	0.24
77_V	115_G	0.610	0.24
11_Y	57_Q	0.605	0.23
104_P	261_K	0.605	0.23
43_D	151_P	0.602	0.23
284_W	293_V	0.602	0.23
170_T	286_K	0.600	0.23
188_K	230_R	0.600	0.23
110_V	181_K	0.599	0.23
273_A	283_K	0.598	0.23
253_E	278_F	0.595	0.23
58_L	82_Y	0.594	0.23
144_G	165_K	0.593	0.23
95_A	236_K	0.589	0.23
87_D	138_R	0.589	0.23
126_F	159_S	0.589	0.23
272_R	285_E	0.588	0.23
35_S	41_G	0.588	0.23
187_L	210_L	0.586	0.22
8_K	15_V	0.583	0.22
40_Y	209_A	0.580	0.22
127_P	148_P	0.579	0.22
90_S	122_T	0.578	0.22
254_N	289_L	0.578	0.22
171_L	191_V	0.578	0.22
129_R	138_R	0.577	0.22
131_H	238_A	0.575	0.22
52_F	105_L	0.574	0.22
46_V	54_Y	0.571	0.22
171_L	186_Y	0.569	0.22
31_F	35_S	0.568	0.22
48_Y	107_Y	0.568	0.22
272_R	276_E	0.568	0.22
24_H	34_N	0.567	0.22
105_L	111_Q	0.566	0.22
38_E	63_R	0.565	0.21
18_S	223_P	0.565	0.21
43_D	140_S	0.563	0.21
147_I	156_V	0.563	0.21
188_K	212_S	0.562	0.21
183_P	199_Q	0.561	0.21
156_V	215_I	0.560	0.21
33_K	84_H	0.559	0.21
92_V	281_D	0.558	0.21
4_E	46_V	0.558	0.21
61_H	82_Y	0.555	0.21
267_F	275_V	0.555	0.21
64_N	276_E	0.555	0.21
26_L	178_V	0.554	0.21
18_S	73_S	0.554	0.21
282_L	290_G	0.552	0.21
176_F	247_L	0.549	0.21
122_T	194_D	0.547	0.21
98_S	173_P	0.547	0.21
139_L	270_K	0.546	0.21
289_L	293_V	0.546	0.21
21_T	29_I	0.545	0.21
162_F	249_E	0.545	0.21
29_I	242_K	0.544	0.20
47_S	98_S	0.544	0.20
83_V	244_L	0.544	0.20
197_V	210_L	0.544	0.20
101_P	154_L	0.543	0.20
82_Y	234_K	0.542	0.20
8_K	50_H	0.542	0.20
7_L	19_K	0.540	0.20
62_L	192_Y	0.539	0.20
77_V	84_H	0.539	0.20
137_L	257_F	0.536	0.20
245_K	292_Y	0.536	0.20
24_H	31_F	0.536	0.20
23_P	178_V	0.536	0.20
231_F	240_F	0.535	0.20
25_T	98_S	0.533	0.20
21_T	26_L	0.532	0.20
79_N	215_I	0.531	0.20
86_L	152_L	0.530	0.20
215_I	218_P	0.529	0.20
121_P	164_K	0.528	0.20
65_A	271_D	0.528	0.20
82_Y	115_G	0.527	0.20
55_I	109_L	0.526	0.20
285_E	290_G	0.523	0.20
109_L	247_L	0.523	0.20
229_K	246_Q	0.521	0.19
25_T	79_N	0.521	0.19
112_V	245_K	0.519	0.19
216_A	274_A	0.517	0.19
181_K	220_L	0.517	0.19
6_V	278_F	0.517	0.19
56_R	131_H	0.516	0.19
236_K	270_K	0.514	0.19
266_D	278_F	0.512	0.19
39_L	266_D	0.511	0.19
19_K	43_D	0.510	0.19
202_E	211_W	0.510	0.19
156_V	196_V	0.510	0.19
52_F	107_Y	0.510	0.19
116_A	132_C	0.509	0.19
276_E	290_G	0.508	0.19
57_Q	81_Q	0.508	0.19
235_C	241_R	0.506	0.19
222_L	229_K	0.504	0.19
125_Y	267_F	0.503	0.19
129_R	156_V	0.503	0.19
140_S	147_I	0.502	0.19
168_K	247_L	0.501	0.19
94_S	228_L	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rxxA	1	0.7095	54.5	0.96	Contact Map
2igpA	1	0.3682	35.5	0.965	Contact Map
1wa5C	1	0.8885	16.3	0.97	Contact Map
2ve7A	1	0.7365	13.8	0.971	Contact Map
2bptA	1	0.902	11.7	0.972	Contact Map
3a6pA	1	0.8885	10.2	0.973	Contact Map
4gofA	2	0.1655	9	0.973	Contact Map
2kzsA	1	0.2264	8	0.974	Contact Map
1j1jA	4	0.2568	7.8	0.974	Contact Map
2vj4A	1	0.3986	7.1	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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