GREMLIN Database
MHYT - Bacterial signalling protein N terminal repeat
PFAM: PF03707 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 59 (54)
Sequences: 42325 (27682)
Seq/√Len: 3767.1
META: 0.871

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_D27_L3.0651.00
34_I38_A2.7551.00
40_G44_W2.3231.00
7_M11_G2.0271.00
23_Y28_V1.8501.00
33_L37_V1.6071.00
5_W9_Y1.5811.00
13_A16_R1.5601.00
2_L5_W1.5581.00
22_S25_P1.5081.00
2_L32_L1.4671.00
4_I12_M1.3991.00
26_G30_L1.3961.00
2_L6_A1.3931.00
20_P23_Y1.3741.00
6_A10_T1.3591.00
51_D54_R1.3501.00
32_L36_I1.3411.00
26_G29_A1.3061.00
25_P29_A1.2691.00
10_T13_A1.2441.00
9_Y28_V1.2331.00
48_R51_D1.2191.00
25_P28_V1.2131.00
27_L30_L1.1841.00
24_D28_V1.1641.00
44_W48_R1.1331.00
47_F50_R1.0701.00
42_A45_L1.0341.00
39_S43_L1.0341.00
8_H12_M1.0111.00
48_R54_R1.0081.00
50_R54_R0.9931.00
9_Y31_S0.9551.00
44_W47_F0.9421.00
27_L31_S0.9241.00
1_G36_I0.9241.00
23_Y29_A0.9021.00
23_Y27_L0.8601.00
49_L52_R0.8441.00
38_A41_L0.8401.00
5_W32_L0.8351.00
50_R53_R0.8271.00
4_I8_H0.8141.00
39_S42_A0.8121.00
1_G7_M0.8061.00
5_W13_A0.8041.00
35_A39_S0.7931.00
37_V41_L0.7571.00
7_M17_L0.7531.00
16_R20_P0.7361.00
49_L54_R0.7311.00
11_G14_A0.7191.00
23_Y26_G0.6991.00
38_A46_A0.6861.00
41_L44_W0.6731.00
47_F52_R0.6511.00
35_A45_L0.6361.00
41_L45_L0.6331.00
32_L43_L0.6241.00
34_I46_A0.6141.00
22_S26_G0.6121.00
46_A51_D0.6101.00
48_R52_R0.6091.00
4_I7_M0.6081.00
4_I42_A0.5951.00
49_L53_R0.5891.00
28_V31_S0.5861.00
6_A13_A0.5781.00
36_I39_S0.5571.00
3_G15_M0.5571.00
9_Y12_M0.5551.00
36_I40_G0.5451.00
3_G7_M0.5451.00
3_G6_A0.5421.00
4_I39_S0.5341.00
7_M15_M0.5221.00
35_A43_L0.5141.00
25_P30_L0.5101.00
23_Y31_S0.5081.00
39_S44_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.7288 8.1 0.808 Contact Map
4ev6A 3 0.7627 6.1 0.819 Contact Map
3ig5A 1 1 3.2 0.842 Contact Map
4p02B 1 0.8475 2.8 0.846 Contact Map
3o7qA 1 0.8814 2.1 0.857 Contact Map
1fftA 1 0.9831 1.8 0.861 Contact Map
2l2tA 2 0.678 1.8 0.862 Contact Map
2lx0A 1 0.5424 1.5 0.869 Contact Map
2kluA 1 0.678 1.4 0.871 Contact Map
3d79A 1 0.322 1.2 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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