LPG_synthase_TM - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

LPG_synthase_TM - Lysylphosphatidylglycerol synthase TM region

PFAM:	PF03706	Sequences: ILLGLALGAALLALLLRGVDLAEVLAALRSANPGWLLLALLLTLLSYLLRALRWRLLLRALGVRLSFRRLFRAYLAGYFANNVLPGRVGGEAVRAYLLARREGVPAAAALASVVVERLLDLLALLLLALLGLLLLPGLLGLGLALLLLLALALALLALLALLLLLLLRRRLRRLARLLRRLLRLLRRLRRGLAALARLLLLRSPRRLLLALLLSLLIWLLYALALYLLLRALGLPVSLAAALLVLLLAALAGALPPTPGGLGVREAALVALLALFGVPAAAALAAALLYRLITLLLPLLLG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	301 (295)
Sequences:	90037 (73639)
Seq/√Len:	4287.4
META:	0.911

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
265_E	290_R	3.421	1.00
66_S	69_R	3.051	1.00
55_R	59_R	3.017	1.00
69_R	102_E	2.913	1.00
278_P	281_A	2.862	1.00
25_L	29_R	2.840	1.00
226_Y	230_R	2.578	1.00
20_D	23_E	2.522	1.00
237_S	240_A	2.509	1.00
266_A	270_A	2.487	1.00
32_N	35_W	2.449	1.00
10_A	14_L	2.419	1.00
52_L	55_R	2.335	1.00
105_P	108_A	2.288	1.00
35_W	227_L	2.287	1.00
71_F	75_L	2.256	1.00
42_L	227_L	2.223	1.00
80_A	93_V	2.171	1.00
56_L	209_L	2.150	1.00
205_R	209_L	2.144	1.00
68_R	72_R	2.130	1.00
264_R	290_R	2.124	1.00
13_A	17_R	2.086	1.00
34_G	38_L	2.054	1.00
162_L	166_L	2.039	1.00
65_L	70_L	2.021	1.00
48_L	67_F	2.007	1.00
270_A	273_A	1.976	1.00
53_R	214_S	1.936	1.00
203_S	206_R	1.929	1.00
91_E	117_R	1.928	1.00
167_L	170_R	1.919	1.00
229_L	285_A	1.877	1.00
23_E	26_A	1.841	1.00
99_A	106_A	1.836	1.00
51_A	71_F	1.829	1.00
73_A	97_L	1.824	1.00
270_A	274_L	1.820	1.00
168_R	171_L	1.802	1.00
77_G	94_R	1.773	1.00
49_L	213_L	1.767	1.00
9_A	13_A	1.766	1.00
69_R	72_R	1.757	1.00
52_L	213_L	1.748	1.00
268_L	286_A	1.747	1.00
55_R	70_L	1.723	1.00
148_L	152_A	1.666	1.00
229_L	241_A	1.654	1.00
206_R	209_L	1.638	1.00
265_E	286_A	1.633	1.00
49_L	220_L	1.617	1.00
165_L	168_R	1.615	1.00
173_R	176_R	1.614	1.00
39_A	228_L	1.612	1.00
163_L	167_L	1.608	1.00
173_R	177_L	1.607	1.00
54_W	112_S	1.602	1.00
11_L	15_L	1.531	1.00
67_F	71_F	1.522	1.00
59_R	64_R	1.512	1.00
21_L	25_L	1.503	1.00
257_T	263_V	1.498	1.00
269_V	273_A	1.498	1.00
167_L	171_L	1.489	1.00
91_E	94_R	1.476	1.00
42_L	220_L	1.449	1.00
94_R	116_E	1.449	1.00
184_L	187_R	1.433	1.00
282_A	286_A	1.424	1.00
55_R	67_F	1.414	1.00
53_R	116_E	1.402	1.00
177_L	181_L	1.393	1.00
185_L	191_G	1.365	1.00
35_W	38_L	1.363	1.00
33_P	37_L	1.359	1.00
161_L	165_L	1.351	1.00
148_L	151_L	1.346	1.00
244_V	248_A	1.343	1.00
82_N	298_L	1.333	1.00
146_L	150_A	1.327	1.00
277_V	282_A	1.325	1.00
236_V	240_A	1.319	1.00
52_L	67_F	1.313	1.00
26_A	29_R	1.311	1.00
38_L	227_L	1.309	1.00
56_L	213_L	1.307	1.00
251_A	267_A	1.304	1.00
35_W	230_R	1.303	1.00
147_L	151_L	1.297	1.00
81_N	90_G	1.297	1.00
248_A	252_G	1.287	1.00
286_A	290_R	1.284	1.00
10_A	13_A	1.273	1.00
169_R	172_R	1.265	1.00
229_L	234_L	1.261	1.00
176_R	179_R	1.255	1.00
22_A	25_L	1.255	1.00
177_L	180_R	1.255	1.00
4_G	8_G	1.253	1.00
170_R	173_R	1.250	1.00
261_L	290_R	1.249	1.00
69_R	73_A	1.239	1.00
172_R	176_R	1.234	1.00
57_L	210_A	1.233	1.00
95_A	99_A	1.233	1.00
58_L	70_L	1.226	1.00
56_L	206_R	1.223	1.00
147_L	150_A	1.223	1.00
106_A	110_L	1.219	1.00
49_L	216_L	1.209	1.00
230_R	235_P	1.202	1.00
164_L	167_L	1.201	1.00
23_E	27_A	1.200	1.00
63_V	104_V	1.198	1.00
171_L	175_A	1.196	1.00
104_V	109_A	1.186	1.00
166_L	169_R	1.179	1.00
92_A	96_Y	1.172	1.00
179_R	182_L	1.168	1.00
176_R	180_R	1.154	1.00
279_A	283_L	1.142	1.00
146_L	149_L	1.141	1.00
145_L	149_L	1.139	1.00
182_L	185_L	1.138	1.00
35_W	39_A	1.136	1.00
245_L	249_A	1.134	1.00
145_L	148_L	1.132	1.00
8_G	12_L	1.129	1.00
129_L	133_L	1.120	1.00
226_Y	241_A	1.119	1.00
212_L	216_L	1.117	1.00
269_V	283_L	1.117	1.00
133_L	136_P	1.107	1.00
131_G	135_L	1.102	1.00
135_L	138_L	1.100	1.00
162_L	165_L	1.094	1.00
164_L	168_R	1.083	1.00
149_L	153_L	1.082	1.00
21_L	24_V	1.076	1.00
26_A	30_S	1.073	1.00
174_L	177_L	1.072	1.00
95_A	110_L	1.068	1.00
224_A	289_Y	1.065	1.00
169_R	173_R	1.064	1.00
25_L	28_L	1.062	1.00
27_A	30_S	1.058	1.00
55_R	64_R	1.055	1.00
51_A	67_F	1.055	1.00
151_L	155_L	1.053	1.00
150_A	154_A	1.045	1.00
152_A	156_L	1.045	1.00
41_L	45_L	1.044	1.00
51_A	70_L	1.043	1.00
191_G	194_A	1.042	1.00
150_A	153_L	1.036	1.00
43_T	47_Y	1.031	1.00
160_A	164_L	1.027	1.00
95_A	113_V	1.024	1.00
225_L	289_Y	1.022	1.00
69_R	101_R	1.018	1.00
117_R	120_D	1.013	1.00
96_Y	99_A	1.010	1.00
225_L	285_A	1.009	1.00
244_V	271_L	1.006	1.00
181_L	184_L	1.005	1.00
93_V	97_L	1.002	1.00
180_R	183_R	0.991	1.00
183_R	186_R	0.989	1.00
287_L	290_R	0.982	1.00
149_L	152_A	0.981	1.00
130_L	134_L	0.981	1.00
171_L	174_L	0.965	1.00
228_L	231_A	0.965	1.00
225_L	268_L	0.960	1.00
182_L	186_R	0.960	1.00
37_L	41_L	0.960	1.00
229_L	236_V	0.956	1.00
209_L	213_L	0.952	1.00
269_V	279_A	0.947	1.00
232_L	288_L	0.945	1.00
187_R	190_R	0.943	1.00
93_V	96_Y	0.943	1.00
263_V	266_A	0.943	1.00
43_T	224_A	0.942	1.00
163_L	166_L	0.930	1.00
31_A	231_A	0.928	1.00
106_A	109_A	0.927	1.00
273_A	279_A	0.920	1.00
54_W	94_R	0.919	1.00
22_A	26_A	0.911	1.00
73_A	98_L	0.911	1.00
206_R	210_A	0.911	1.00
96_Y	100_R	0.907	1.00
179_R	183_R	0.904	1.00
281_A	284_A	0.901	1.00
185_L	189_R	0.898	1.00
158_L	162_L	0.897	1.00
96_Y	106_A	0.897	1.00
178_L	184_L	0.897	1.00
34_G	37_L	0.894	1.00
255_P	263_V	0.890	1.00
119_L	210_A	0.887	1.00
188_L	191_G	0.886	1.00
208_L	212_L	0.885	1.00
168_R	172_R	0.875	1.00
35_W	231_A	0.874	1.00
45_L	220_L	0.871	1.00
178_L	182_L	0.868	1.00
11_L	14_L	0.864	1.00
123_A	127_L	0.863	1.00
187_R	192_L	0.859	1.00
138_L	141_L	0.857	1.00
123_A	126_L	0.856	1.00
6_A	10_A	0.855	1.00
269_V	282_A	0.853	1.00
72_R	76_A	0.849	1.00
267_A	270_A	0.844	1.00
181_L	185_L	0.843	1.00
188_L	194_A	0.835	1.00
172_R	175_A	0.835	1.00
187_R	191_G	0.834	1.00
159_L	163_L	0.831	1.00
79_F	83_V	0.830	1.00
256_P	263_V	0.826	1.00
76_A	97_L	0.821	1.00
27_A	281_A	0.820	1.00
48_L	71_F	0.815	1.00
251_A	256_P	0.811	1.00
154_A	158_L	0.808	1.00
135_L	139_L	0.805	1.00
234_L	281_A	0.805	1.00
190_R	193_A	0.804	1.00
43_T	46_S	0.801	1.00
180_R	184_L	0.797	1.00
31_A	36_L	0.794	1.00
153_L	157_A	0.790	1.00
124_L	128_A	0.789	1.00
49_L	217_I	0.789	1.00
31_A	35_W	0.789	1.00
53_R	217_I	0.788	1.00
170_R	174_L	0.787	1.00
120_D	218_W	0.785	1.00
19_V	24_V	0.784	1.00
95_A	109_A	0.783	1.00
5_L	9_A	0.780	1.00
60_A	206_R	0.779	1.00
63_V	108_A	0.778	1.00
166_L	170_R	0.772	1.00
245_L	248_A	0.771	1.00
75_L	79_F	0.769	1.00
40_L	292_I	0.769	1.00
92_A	95_A	0.766	1.00
264_R	286_A	0.764	1.00
37_L	40_L	0.763	1.00
49_L	52_L	0.760	1.00
56_L	59_R	0.755	1.00
207_L	210_A	0.754	1.00
213_L	216_L	0.753	1.00
266_A	269_V	0.752	1.00
204_P	208_L	0.747	1.00
164_L	170_R	0.746	1.00
53_R	120_D	0.743	1.00
258_P	290_R	0.740	1.00
204_P	207_L	0.740	1.00
94_R	99_A	0.739	1.00
250_L	255_P	0.738	1.00
190_R	194_A	0.736	1.00
209_L	212_L	0.734	1.00
14_L	18_G	0.724	1.00
59_R	206_R	0.724	1.00
260_G	264_R	0.723	1.00
31_A	288_L	0.722	1.00
167_L	173_R	0.720	1.00
186_R	190_R	0.719	1.00
99_A	109_A	0.716	1.00
228_L	288_L	0.715	1.00
109_A	113_V	0.714	1.00
177_L	182_L	0.713	1.00
66_S	70_L	0.711	1.00
120_D	124_L	0.706	1.00
97_L	100_R	0.705	1.00
31_A	232_L	0.703	1.00
63_V	105_P	0.702	1.00
72_R	75_L	0.702	1.00
32_N	233_G	0.701	1.00
234_L	285_A	0.699	1.00
16_L	21_L	0.699	1.00
123_A	215_L	0.697	1.00
248_A	268_L	0.696	1.00
76_A	80_A	0.695	1.00
217_I	221_Y	0.695	1.00
151_L	154_A	0.693	1.00
73_A	77_G	0.687	1.00
228_L	285_A	0.687	1.00
50_R	217_I	0.683	1.00
296_L	299_L	0.682	1.00
175_A	179_R	0.681	1.00
50_R	53_R	0.681	1.00
23_E	280_A	0.680	1.00
222_A	242_L	0.679	1.00
56_L	60_A	0.676	1.00
50_R	120_D	0.676	1.00
284_A	287_L	0.675	1.00
116_E	120_D	0.672	1.00
256_P	260_G	0.672	1.00
242_L	246_L	0.671	1.00
126_L	211_L	0.671	1.00
9_A	12_L	0.667	1.00
244_V	251_A	0.662	1.00
174_L	178_L	0.661	1.00
223_L	226_Y	0.659	1.00
119_L	123_A	0.657	1.00
161_L	164_L	0.657	1.00
186_R	189_R	0.656	1.00
236_V	241_A	0.654	1.00
54_W	58_L	0.653	1.00
132_L	136_P	0.648	1.00
285_A	289_Y	0.648	1.00
265_E	287_L	0.647	1.00
219_L	223_L	0.647	1.00
264_R	289_Y	0.647	1.00
283_L	286_A	0.643	1.00
73_A	102_E	0.642	1.00
168_R	173_R	0.641	1.00
33_P	38_L	0.635	1.00
183_R	187_R	0.635	1.00
75_L	300_L	0.633	1.00
165_L	169_R	0.633	1.00
238_L	242_L	0.632	1.00
57_L	112_S	0.632	1.00
42_L	224_A	0.629	1.00
280_A	284_A	0.628	1.00
39_A	231_A	0.625	1.00
14_L	17_R	0.625	1.00
94_R	97_L	0.625	1.00
246_L	250_L	0.624	1.00
27_A	284_A	0.623	1.00
41_L	44_L	0.618	1.00
268_L	285_A	0.618	1.00
214_S	217_I	0.617	1.00
90_G	94_R	0.613	1.00
87_R	91_E	0.613	1.00
235_P	239_A	0.612	1.00
198_L	201_L	0.611	1.00
51_A	55_R	0.610	1.00
220_L	223_L	0.608	1.00
188_L	192_L	0.607	1.00
264_R	268_L	0.607	1.00
175_A	178_L	0.607	1.00
125_L	129_L	0.606	1.00
272_L	277_V	0.604	1.00
20_D	24_V	0.603	1.00
79_F	85_P	0.603	1.00
226_Y	238_L	0.603	1.00
107_A	111_A	0.603	1.00
185_L	188_L	0.603	1.00
38_L	41_L	0.602	1.00
51_A	74_Y	0.600	1.00
173_R	179_R	0.599	1.00
74_Y	78_Y	0.597	1.00
38_L	42_L	0.596	1.00
175_A	180_R	0.596	1.00
174_L	182_L	0.595	1.00
255_P	258_P	0.590	1.00
157_A	160_A	0.589	1.00
269_V	286_A	0.589	1.00
173_R	178_L	0.589	1.00
248_A	251_A	0.588	1.00
184_L	188_L	0.588	1.00
238_L	241_A	0.588	1.00
159_L	162_L	0.585	1.00
180_R	185_L	0.585	1.00
80_A	84_L	0.585	1.00
227_L	230_R	0.583	1.00
200_L	204_P	0.581	1.00
276_G	282_A	0.579	1.00
154_A	157_A	0.579	1.00
156_L	160_A	0.575	1.00
121_L	124_L	0.573	1.00
168_R	174_L	0.571	1.00
167_L	175_A	0.568	1.00
117_R	121_L	0.567	1.00
27_A	31_A	0.566	1.00
289_Y	293_T	0.566	1.00
84_L	89_G	0.566	1.00
155_L	159_L	0.566	1.00
235_P	238_L	0.565	1.00
198_L	202_R	0.565	1.00
40_L	44_L	0.565	1.00
16_L	19_V	0.563	1.00
252_G	263_V	0.563	1.00
84_L	92_A	0.562	1.00
116_E	214_S	0.562	1.00
137_G	140_G	0.560	1.00
281_A	285_A	0.557	1.00
169_R	175_A	0.556	1.00
187_R	194_A	0.554	1.00
178_L	181_L	0.553	1.00
47_Y	75_L	0.552	1.00
246_L	249_A	0.551	1.00
166_L	171_L	0.550	1.00
223_L	227_L	0.549	1.00
32_N	231_A	0.547	1.00
216_L	220_L	0.547	1.00
168_R	175_A	0.546	1.00
221_Y	225_L	0.546	1.00
271_L	274_L	0.546	1.00
215_L	219_L	0.544	1.00
52_L	56_L	0.544	1.00
43_T	221_Y	0.542	1.00
50_R	116_E	0.542	1.00
95_A	106_A	0.542	1.00
17_R	21_L	0.541	1.00
66_S	102_E	0.541	1.00
53_R	57_L	0.540	1.00
224_A	292_I	0.539	1.00
45_L	48_L	0.538	1.00
8_G	13_A	0.535	1.00
259_G	294_L	0.533	1.00
131_G	134_L	0.532	1.00
50_R	54_W	0.527	1.00
268_L	272_L	0.527	1.00
265_E	268_L	0.523	1.00
239_A	242_L	0.522	1.00
203_S	209_L	0.522	1.00
220_L	224_A	0.520	1.00
131_G	246_L	0.520	1.00
145_L	152_A	0.519	1.00
7_L	11_L	0.519	1.00
4_G	15_L	0.518	1.00
189_R	192_L	0.516	1.00
171_L	179_R	0.516	1.00
219_L	222_A	0.516	1.00
47_Y	50_R	0.516	1.00
150_A	157_A	0.515	1.00
126_L	130_L	0.514	1.00
42_L	223_L	0.512	1.00
46_S	220_L	0.505	1.00
289_Y	292_I	0.505	1.00
176_R	181_L	0.505	1.00
262_G	265_E	0.501	1.00
218_W	222_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ytpC	1	0.2957	4	0.946	Contact Map
3wu2Z	1	0.1628	3.9	0.946	Contact Map
3j01B	1	0.3787	3.4	0.947	Contact Map
2qksA	4	0.3223	3.3	0.947	Contact Map
3w9iA	3	0.5116	2.8	0.949	Contact Map
2h88C	2	0.2957	2.8	0.95	Contact Map
4k0jA	3	0.4684	2.7	0.95	Contact Map
3ne5A	3	0.515	2.6	0.95	Contact Map
4ysxC	1	0.3389	2.5	0.951	Contact Map
4gx0A	3	0.3023	2.4	0.951	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.009 seconds.