GREMLIN Database
LPG_synthase_TM - Lysylphosphatidylglycerol synthase TM region
PFAM: PF03706 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 301 (295)
Sequences: 90037 (73639)
Seq/√Len: 4287.4
META: 0.911

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
265_E290_R3.4211.00
66_S69_R3.0511.00
55_R59_R3.0171.00
69_R102_E2.9131.00
278_P281_A2.8621.00
25_L29_R2.8401.00
226_Y230_R2.5781.00
20_D23_E2.5221.00
237_S240_A2.5091.00
266_A270_A2.4871.00
32_N35_W2.4491.00
10_A14_L2.4191.00
52_L55_R2.3351.00
105_P108_A2.2881.00
35_W227_L2.2871.00
71_F75_L2.2561.00
42_L227_L2.2231.00
80_A93_V2.1711.00
56_L209_L2.1501.00
205_R209_L2.1441.00
68_R72_R2.1301.00
264_R290_R2.1241.00
13_A17_R2.0861.00
34_G38_L2.0541.00
162_L166_L2.0391.00
65_L70_L2.0211.00
48_L67_F2.0071.00
270_A273_A1.9761.00
53_R214_S1.9361.00
203_S206_R1.9291.00
91_E117_R1.9281.00
167_L170_R1.9191.00
229_L285_A1.8771.00
23_E26_A1.8411.00
99_A106_A1.8361.00
51_A71_F1.8291.00
73_A97_L1.8241.00
270_A274_L1.8201.00
168_R171_L1.8021.00
77_G94_R1.7731.00
49_L213_L1.7671.00
9_A13_A1.7661.00
69_R72_R1.7571.00
52_L213_L1.7481.00
268_L286_A1.7471.00
55_R70_L1.7231.00
148_L152_A1.6661.00
229_L241_A1.6541.00
206_R209_L1.6381.00
265_E286_A1.6331.00
49_L220_L1.6171.00
165_L168_R1.6151.00
173_R176_R1.6141.00
39_A228_L1.6121.00
163_L167_L1.6081.00
173_R177_L1.6071.00
54_W112_S1.6021.00
11_L15_L1.5311.00
67_F71_F1.5221.00
59_R64_R1.5121.00
21_L25_L1.5031.00
257_T263_V1.4981.00
269_V273_A1.4981.00
167_L171_L1.4891.00
91_E94_R1.4761.00
42_L220_L1.4491.00
94_R116_E1.4491.00
184_L187_R1.4331.00
282_A286_A1.4241.00
55_R67_F1.4141.00
53_R116_E1.4021.00
177_L181_L1.3931.00
185_L191_G1.3651.00
35_W38_L1.3631.00
33_P37_L1.3591.00
161_L165_L1.3511.00
148_L151_L1.3461.00
244_V248_A1.3431.00
82_N298_L1.3331.00
146_L150_A1.3271.00
277_V282_A1.3251.00
236_V240_A1.3191.00
52_L67_F1.3131.00
26_A29_R1.3111.00
38_L227_L1.3091.00
56_L213_L1.3071.00
251_A267_A1.3041.00
35_W230_R1.3031.00
147_L151_L1.2971.00
81_N90_G1.2971.00
248_A252_G1.2871.00
286_A290_R1.2841.00
10_A13_A1.2731.00
169_R172_R1.2651.00
229_L234_L1.2611.00
176_R179_R1.2551.00
22_A25_L1.2551.00
177_L180_R1.2551.00
4_G8_G1.2531.00
170_R173_R1.2501.00
261_L290_R1.2491.00
69_R73_A1.2391.00
172_R176_R1.2341.00
57_L210_A1.2331.00
95_A99_A1.2331.00
58_L70_L1.2261.00
56_L206_R1.2231.00
147_L150_A1.2231.00
106_A110_L1.2191.00
49_L216_L1.2091.00
230_R235_P1.2021.00
164_L167_L1.2011.00
23_E27_A1.2001.00
63_V104_V1.1981.00
171_L175_A1.1961.00
104_V109_A1.1861.00
166_L169_R1.1791.00
92_A96_Y1.1721.00
179_R182_L1.1681.00
176_R180_R1.1541.00
279_A283_L1.1421.00
146_L149_L1.1411.00
145_L149_L1.1391.00
182_L185_L1.1381.00
35_W39_A1.1361.00
245_L249_A1.1341.00
145_L148_L1.1321.00
8_G12_L1.1291.00
129_L133_L1.1201.00
226_Y241_A1.1191.00
212_L216_L1.1171.00
269_V283_L1.1171.00
133_L136_P1.1071.00
131_G135_L1.1021.00
135_L138_L1.1001.00
162_L165_L1.0941.00
164_L168_R1.0831.00
149_L153_L1.0821.00
21_L24_V1.0761.00
26_A30_S1.0731.00
174_L177_L1.0721.00
95_A110_L1.0681.00
224_A289_Y1.0651.00
169_R173_R1.0641.00
25_L28_L1.0621.00
27_A30_S1.0581.00
55_R64_R1.0551.00
51_A67_F1.0551.00
151_L155_L1.0531.00
150_A154_A1.0451.00
152_A156_L1.0451.00
41_L45_L1.0441.00
51_A70_L1.0431.00
191_G194_A1.0421.00
150_A153_L1.0361.00
43_T47_Y1.0311.00
160_A164_L1.0271.00
95_A113_V1.0241.00
225_L289_Y1.0221.00
69_R101_R1.0181.00
117_R120_D1.0131.00
96_Y99_A1.0101.00
225_L285_A1.0091.00
244_V271_L1.0061.00
181_L184_L1.0051.00
93_V97_L1.0021.00
180_R183_R0.9911.00
183_R186_R0.9891.00
287_L290_R0.9821.00
149_L152_A0.9811.00
130_L134_L0.9811.00
171_L174_L0.9651.00
228_L231_A0.9651.00
225_L268_L0.9601.00
182_L186_R0.9601.00
37_L41_L0.9601.00
229_L236_V0.9561.00
209_L213_L0.9521.00
269_V279_A0.9471.00
232_L288_L0.9451.00
187_R190_R0.9431.00
93_V96_Y0.9431.00
263_V266_A0.9431.00
43_T224_A0.9421.00
163_L166_L0.9301.00
31_A231_A0.9281.00
106_A109_A0.9271.00
273_A279_A0.9201.00
54_W94_R0.9191.00
22_A26_A0.9111.00
73_A98_L0.9111.00
206_R210_A0.9111.00
96_Y100_R0.9071.00
179_R183_R0.9041.00
281_A284_A0.9011.00
185_L189_R0.8981.00
158_L162_L0.8971.00
96_Y106_A0.8971.00
178_L184_L0.8971.00
34_G37_L0.8941.00
255_P263_V0.8901.00
119_L210_A0.8871.00
188_L191_G0.8861.00
208_L212_L0.8851.00
168_R172_R0.8751.00
35_W231_A0.8741.00
45_L220_L0.8711.00
178_L182_L0.8681.00
11_L14_L0.8641.00
123_A127_L0.8631.00
187_R192_L0.8591.00
138_L141_L0.8571.00
123_A126_L0.8561.00
6_A10_A0.8551.00
269_V282_A0.8531.00
72_R76_A0.8491.00
267_A270_A0.8441.00
181_L185_L0.8431.00
188_L194_A0.8351.00
172_R175_A0.8351.00
187_R191_G0.8341.00
159_L163_L0.8311.00
79_F83_V0.8301.00
256_P263_V0.8261.00
76_A97_L0.8211.00
27_A281_A0.8201.00
48_L71_F0.8151.00
251_A256_P0.8111.00
154_A158_L0.8081.00
135_L139_L0.8051.00
234_L281_A0.8051.00
190_R193_A0.8041.00
43_T46_S0.8011.00
180_R184_L0.7971.00
31_A36_L0.7941.00
153_L157_A0.7901.00
124_L128_A0.7891.00
49_L217_I0.7891.00
31_A35_W0.7891.00
53_R217_I0.7881.00
170_R174_L0.7871.00
120_D218_W0.7851.00
19_V24_V0.7841.00
95_A109_A0.7831.00
5_L9_A0.7801.00
60_A206_R0.7791.00
63_V108_A0.7781.00
166_L170_R0.7721.00
245_L248_A0.7711.00
75_L79_F0.7691.00
40_L292_I0.7691.00
92_A95_A0.7661.00
264_R286_A0.7641.00
37_L40_L0.7631.00
49_L52_L0.7601.00
56_L59_R0.7551.00
207_L210_A0.7541.00
213_L216_L0.7531.00
266_A269_V0.7521.00
204_P208_L0.7471.00
164_L170_R0.7461.00
53_R120_D0.7431.00
258_P290_R0.7401.00
204_P207_L0.7401.00
94_R99_A0.7391.00
250_L255_P0.7381.00
190_R194_A0.7361.00
209_L212_L0.7341.00
14_L18_G0.7241.00
59_R206_R0.7241.00
260_G264_R0.7231.00
31_A288_L0.7221.00
167_L173_R0.7201.00
186_R190_R0.7191.00
99_A109_A0.7161.00
228_L288_L0.7151.00
109_A113_V0.7141.00
177_L182_L0.7131.00
66_S70_L0.7111.00
120_D124_L0.7061.00
97_L100_R0.7051.00
31_A232_L0.7031.00
63_V105_P0.7021.00
72_R75_L0.7021.00
32_N233_G0.7011.00
234_L285_A0.6991.00
16_L21_L0.6991.00
123_A215_L0.6971.00
248_A268_L0.6961.00
76_A80_A0.6951.00
217_I221_Y0.6951.00
151_L154_A0.6931.00
73_A77_G0.6871.00
228_L285_A0.6871.00
50_R217_I0.6831.00
296_L299_L0.6821.00
175_A179_R0.6811.00
50_R53_R0.6811.00
23_E280_A0.6801.00
222_A242_L0.6791.00
56_L60_A0.6761.00
50_R120_D0.6761.00
284_A287_L0.6751.00
116_E120_D0.6721.00
256_P260_G0.6721.00
242_L246_L0.6711.00
126_L211_L0.6711.00
9_A12_L0.6671.00
244_V251_A0.6621.00
174_L178_L0.6611.00
223_L226_Y0.6591.00
119_L123_A0.6571.00
161_L164_L0.6571.00
186_R189_R0.6561.00
236_V241_A0.6541.00
54_W58_L0.6531.00
132_L136_P0.6481.00
285_A289_Y0.6481.00
265_E287_L0.6471.00
219_L223_L0.6471.00
264_R289_Y0.6471.00
283_L286_A0.6431.00
73_A102_E0.6421.00
168_R173_R0.6411.00
33_P38_L0.6351.00
183_R187_R0.6351.00
75_L300_L0.6331.00
165_L169_R0.6331.00
238_L242_L0.6321.00
57_L112_S0.6321.00
42_L224_A0.6291.00
280_A284_A0.6281.00
39_A231_A0.6251.00
14_L17_R0.6251.00
94_R97_L0.6251.00
246_L250_L0.6241.00
27_A284_A0.6231.00
41_L44_L0.6181.00
268_L285_A0.6181.00
214_S217_I0.6171.00
90_G94_R0.6131.00
87_R91_E0.6131.00
235_P239_A0.6121.00
198_L201_L0.6111.00
51_A55_R0.6101.00
220_L223_L0.6081.00
188_L192_L0.6071.00
264_R268_L0.6071.00
175_A178_L0.6071.00
125_L129_L0.6061.00
272_L277_V0.6041.00
20_D24_V0.6031.00
79_F85_P0.6031.00
226_Y238_L0.6031.00
107_A111_A0.6031.00
185_L188_L0.6031.00
38_L41_L0.6021.00
51_A74_Y0.6001.00
173_R179_R0.5991.00
74_Y78_Y0.5971.00
38_L42_L0.5961.00
175_A180_R0.5961.00
174_L182_L0.5951.00
255_P258_P0.5901.00
157_A160_A0.5891.00
269_V286_A0.5891.00
173_R178_L0.5891.00
248_A251_A0.5881.00
184_L188_L0.5881.00
238_L241_A0.5881.00
159_L162_L0.5851.00
180_R185_L0.5851.00
80_A84_L0.5851.00
227_L230_R0.5831.00
200_L204_P0.5811.00
276_G282_A0.5791.00
154_A157_A0.5791.00
156_L160_A0.5751.00
121_L124_L0.5731.00
168_R174_L0.5711.00
167_L175_A0.5681.00
117_R121_L0.5671.00
27_A31_A0.5661.00
289_Y293_T0.5661.00
84_L89_G0.5661.00
155_L159_L0.5661.00
235_P238_L0.5651.00
198_L202_R0.5651.00
40_L44_L0.5651.00
16_L19_V0.5631.00
252_G263_V0.5631.00
84_L92_A0.5621.00
116_E214_S0.5621.00
137_G140_G0.5601.00
281_A285_A0.5571.00
169_R175_A0.5561.00
187_R194_A0.5541.00
178_L181_L0.5531.00
47_Y75_L0.5521.00
246_L249_A0.5511.00
166_L171_L0.5501.00
223_L227_L0.5491.00
32_N231_A0.5471.00
216_L220_L0.5471.00
168_R175_A0.5461.00
221_Y225_L0.5461.00
271_L274_L0.5461.00
215_L219_L0.5441.00
52_L56_L0.5441.00
43_T221_Y0.5421.00
50_R116_E0.5421.00
95_A106_A0.5421.00
17_R21_L0.5411.00
66_S102_E0.5411.00
53_R57_L0.5401.00
224_A292_I0.5391.00
45_L48_L0.5381.00
8_G13_A0.5351.00
259_G294_L0.5331.00
131_G134_L0.5321.00
50_R54_W0.5271.00
268_L272_L0.5271.00
265_E268_L0.5231.00
239_A242_L0.5221.00
203_S209_L0.5221.00
220_L224_A0.5201.00
131_G246_L0.5201.00
145_L152_A0.5191.00
7_L11_L0.5191.00
4_G15_L0.5181.00
189_R192_L0.5161.00
171_L179_R0.5161.00
219_L222_A0.5161.00
47_Y50_R0.5161.00
150_A157_A0.5151.00
126_L130_L0.5141.00
42_L223_L0.5121.00
46_S220_L0.5051.00
289_Y292_I0.5051.00
176_R181_L0.5051.00
262_G265_E0.5011.00
218_W222_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ytpC 1 0.2957 4 0.946 Contact Map
3wu2Z 1 0.1628 3.9 0.946 Contact Map
3j01B 1 0.3787 3.4 0.947 Contact Map
2qksA 4 0.3223 3.3 0.947 Contact Map
3w9iA 3 0.5116 2.8 0.949 Contact Map
2h88C 2 0.2957 2.8 0.95 Contact Map
4k0jA 3 0.4684 2.7 0.95 Contact Map
3ne5A 3 0.515 2.6 0.95 Contact Map
4ysxC 1 0.3389 2.5 0.951 Contact Map
4gx0A 3 0.3023 2.4 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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