GREMLIN Database
UPF0180 - Uncharacterised protein family (UPF0180)
PFAM: PF03698 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (76)
Sequences: 1116 (882)
Seq/√Len: 101.1
META: 0.667

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_A74_V3.3311.00
2_K22_E2.8681.00
65_K73_E2.7541.00
15_A71_V2.7061.00
13_K17_E2.6601.00
40_V45_S2.3971.00
24_V35_V2.3891.00
19_K71_V2.2151.00
5_V12_V1.9801.00
65_K70_V1.8991.00
73_E77_R1.8711.00
2_K34_G1.8431.00
19_K75_E1.8341.00
13_K25_E1.8241.00
11_N67_A1.8101.00
39_V62_A1.7481.00
71_V75_E1.7041.00
3_I21_Y1.6861.00
15_A68_E1.6151.00
40_V59_V1.5051.00
15_A19_K1.4681.00
7_E25_E1.4181.00
15_A67_A1.4011.00
7_E27_D1.4011.00
69_E72_Q1.3410.99
39_V60_I1.3290.99
12_V70_V1.2450.99
43_Q47_V1.1890.98
53_T56_K1.1160.98
73_E76_N1.0780.97
14_E17_E1.0140.96
5_V16_L1.0080.96
63_S75_E1.0010.96
67_A70_V0.9860.95
6_E41_S0.9660.95
27_D32_A0.9620.95
66_T69_E0.9520.94
72_Q76_N0.9440.94
4_A36_D0.9360.94
26_L38_I0.9260.93
34_G57_A0.9170.93
39_V74_V0.9110.93
19_K39_V0.9080.93
37_A58_P0.8990.92
49_G64_G0.8940.92
5_V13_K0.8900.92
22_E30_S0.8800.91
49_G52_D0.8770.91
46_N49_G0.7980.87
12_V74_V0.7940.87
24_V29_E0.7920.87
65_K69_E0.7830.86
18_E74_V0.7800.86
30_S56_K0.7650.85
68_E71_V0.7640.85
5_V25_E0.7460.83
4_A35_V0.7390.83
41_S47_V0.7260.81
42_G46_N0.7220.81
68_E72_Q0.7210.81
33_Q56_K0.7130.80
42_G64_G0.7110.80
30_S54_S0.7080.80
4_A24_V0.6980.79
71_V74_V0.6950.79
45_S61_N0.6920.78
40_V58_P0.6890.78
21_Y75_E0.6860.78
6_E11_N0.6840.77
35_V71_V0.6740.76
72_Q75_E0.6670.76
40_V61_N0.6640.75
34_G56_K0.6620.75
45_S63_S0.6600.75
3_I71_V0.6540.74
32_A55_T0.6480.74
33_Q54_S0.6440.73
11_N17_E0.6380.72
40_V56_K0.6370.72
2_K35_V0.6320.72
16_L66_T0.6310.72
46_N51_Q0.6310.72
70_V76_N0.6210.70
43_Q63_S0.6200.70
12_V67_A0.6180.70
65_K75_E0.6120.69
54_S63_S0.6030.68
41_S61_N0.5920.67
35_V38_I0.5920.67
39_V66_T0.5870.66
27_D31_D0.5860.66
48_M52_D0.5840.66
44_D49_G0.5690.64
7_E10_T0.5660.63
14_E18_E0.5590.62
66_T76_N0.5560.62
2_K57_A0.5560.62
8_G11_N0.5490.61
7_E30_S0.5470.61
13_K30_S0.5430.60
3_I20_G0.5420.60
44_D48_M0.5350.59
9_L62_A0.5350.59
67_A74_V0.5280.58
43_Q61_N0.5200.57
35_V57_A0.5110.56
38_I57_A0.5100.55
45_S49_G0.5070.55
39_V58_P0.5050.55
41_S49_G0.5040.55
43_Q46_N0.5030.54
29_E35_V0.5010.54
4_A27_D0.5000.54
18_E22_E0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ywdA 1 0.8831 62.3 0.812 Contact Map
2issD 1 0.8831 61.4 0.814 Contact Map
4fccA 5 0.6494 59.7 0.816 Contact Map
1q7rA 1 0.8831 58.9 0.816 Contact Map
1jvnA 1 0.8831 57.8 0.817 Contact Map
4gudA 1 0.8442 55.5 0.82 Contact Map
4jc0A 1 0.9091 53.9 0.822 Contact Map
1ka9H 1 0.8701 52 0.824 Contact Map
2nv0A 1 0.8831 48.7 0.827 Contact Map
2abwA 1 0.8961 48.5 0.827 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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