GREMLIN Database
CxxCxxCC - Putative zinc- or iron-chelating domain
PFAM: PF03692 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (71)
Sequences: 61160 (36263)
Seq/√Len: 4303.6
META: 0.934

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_Y62_R3.6151.00
50_D57_S3.2591.00
64_L68_L2.9381.00
27_H61_V2.6901.00
50_D53_T2.0641.00
48_F58_I1.9811.00
50_D55_R1.9011.00
4_G55_R1.8731.00
17_T20_D1.6821.00
10_R45_P1.6641.00
58_I61_V1.6331.00
48_F57_S1.5781.00
36_L40_T1.5171.00
6_G49_L1.5161.00
7_A10_R1.3091.00
65_A72_W1.2581.00
34_E38_R1.2511.00
19_E22_E1.2381.00
35_F38_R1.2301.00
42_E45_P1.2221.00
31_S34_E1.2081.00
35_F39_Y1.1681.00
6_G55_R1.1651.00
27_H60_E1.1401.00
34_E39_Y1.1301.00
45_P49_L1.1271.00
31_S35_F1.0991.00
52_D55_R1.0411.00
18_P22_E1.0301.00
23_R26_K1.0221.00
25_A28_L1.0171.00
35_F40_T0.9971.00
50_D54_G0.9901.00
32_E36_L0.9631.00
26_K29_G0.9551.00
51_D54_G0.9391.00
38_R41_R0.9321.00
14_V17_T0.9291.00
51_D55_R0.9231.00
34_E37_E0.9201.00
36_L39_Y0.9201.00
12_G15_P0.9151.00
65_A68_L0.9101.00
25_A29_G0.9061.00
45_P51_D0.8801.00
24_L28_L0.8801.00
3_D55_R0.8791.00
14_V20_D0.8781.00
11_P14_V0.8591.00
14_V65_A0.8411.00
6_G10_R0.8401.00
17_T64_L0.8361.00
16_L20_D0.8351.00
11_P15_P0.8321.00
33_E36_L0.8301.00
28_L31_S0.8291.00
62_R67_R0.8261.00
22_E26_K0.8261.00
68_L72_W0.8231.00
68_L71_F0.8221.00
16_L21_I0.8201.00
10_R54_G0.8141.00
21_I25_A0.8091.00
20_D23_R0.7961.00
32_E35_F0.7881.00
37_E40_T0.7841.00
10_R49_L0.7841.00
65_A69_Y0.7801.00
24_L58_I0.7771.00
6_G54_G0.7741.00
19_E23_R0.7681.00
30_L35_F0.7441.00
66_C69_Y0.7341.00
37_E41_R0.7301.00
30_L33_E0.7181.00
49_L54_G0.7101.00
13_G17_T0.7071.00
22_E25_A0.6951.00
16_L24_L0.6921.00
11_P44_G0.6891.00
33_E38_R0.6831.00
30_L34_E0.6721.00
17_T22_E0.6711.00
30_L39_Y0.6681.00
7_A70_P0.6661.00
7_A69_Y0.6501.00
49_L55_R0.6491.00
30_L38_R0.6491.00
44_G47_P0.6461.00
6_G52_D0.6441.00
33_E37_E0.6321.00
13_G44_G0.6281.00
18_P21_I0.5971.00
3_D6_G0.5931.00
19_E64_L0.5911.00
34_E40_T0.5821.00
4_G49_L0.5701.00
36_L41_R0.5621.00
24_L27_H0.5591.00
29_G32_E0.5541.00
12_G17_T0.5521.00
20_D24_L0.5421.00
42_E47_P0.5311.00
26_K30_L0.5121.00
10_R53_T0.5031.00
23_R61_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gteA 4 0.3647 4.5 0.868 Contact Map
1bc6A 1 0.4353 3.5 0.875 Contact Map
4p3xA 1 0.9882 3.1 0.878 Contact Map
2gmhA 1 0.3529 3.1 0.878 Contact Map
1h98A 1 0.4353 3 0.879 Contact Map
1m4fA 1 0.1176 2.8 0.881 Contact Map
2h88B 1 0.3882 2.8 0.881 Contact Map
2wdqB 1 0.3882 2.4 0.885 Contact Map
2bs2B 1 0.3765 2 0.889 Contact Map
1sj1A 2 0.2588 2 0.891 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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