GREMLIN Database
UPF0167 - Uncharacterised protein family (UPF0167)
PFAM: PF03691 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 176 (176)
Sequences: 1100 (908)
Seq/√Len: 68.4
META: 0.818

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_A165_L5.4791.00
83_E87_E4.2451.00
38_V63_A3.4521.00
7_H13_T3.0531.00
85_L107_A3.0431.00
5_K84_E2.7491.00
164_C167_C2.6491.00
78_P81_V2.5211.00
147_L174_V2.4511.00
115_G118_E2.3881.00
101_L171_R2.3551.00
9_D12_A2.3501.00
114_V161_L2.2591.00
6_Y106_D2.2461.00
92_Y173_Y2.1461.00
94_S97_Q2.1411.00
5_K165_L2.0661.00
19_S31_G2.0281.00
77_V81_V1.9241.00
10_P13_T1.8891.00
81_V107_A1.8661.00
84_E88_R1.8651.00
40_A63_A1.7961.00
94_S98_E1.7931.00
110_F113_Y1.7661.00
44_L61_F1.7471.00
64_E68_D1.7451.00
103_H171_R1.7311.00
104_C167_C1.7251.00
25_C47_L1.7231.00
106_D166_H1.7201.00
7_H10_P1.6861.00
50_W54_D1.6790.99
104_C164_C1.6430.99
113_Y158_T1.5740.99
13_T112_G1.5520.99
151_L154_D1.5120.99
108_C171_R1.4840.99
24_E46_A1.4610.99
16_F32_Y1.4460.98
8_P109_A1.4370.98
113_Y153_K1.4340.98
108_C172_L1.4050.98
115_G151_L1.3750.98
67_D70_G1.3580.98
23_C26_C1.3320.97
161_L170_Y1.3060.97
131_L135_R1.3050.97
37_P94_S1.3040.97
34_Y52_I1.3030.97
103_H167_C1.3010.97
66_T85_L1.2960.97
110_F160_Y1.2910.97
82_V107_A1.2900.97
57_A65_F1.2670.96
79_E83_E1.2670.96
101_L172_L1.2420.96
67_D97_Q1.2260.96
22_T29_A1.2250.96
58_A87_E1.2230.96
111_L163_R1.2230.96
81_V106_D1.2220.96
35_T38_V1.2010.95
74_V102_T1.1980.95
114_V159_A1.1840.95
116_W120_E1.1800.95
103_H169_K1.1760.95
95_W160_Y1.1560.94
30_R50_W1.1520.94
159_A172_L1.1470.94
64_E87_E1.1460.94
34_Y37_P1.1140.93
118_E121_A1.1110.93
25_C56_S1.1100.93
103_H164_C1.1070.93
108_C159_A1.1050.92
163_R170_Y1.1040.92
17_E35_T1.0790.92
99_R173_Y1.0620.91
40_A62_D1.0600.91
133_A136_D1.0370.90
92_Y172_L1.0350.90
153_K158_T1.0270.89
6_Y107_A1.0130.89
19_S33_I1.0100.89
119_L126_L0.9890.88
135_R139_G0.9590.86
115_G158_T0.9550.86
66_T91_G0.9500.85
116_W149_E0.9490.85
7_H15_S0.9480.85
151_L159_A0.9460.85
115_G159_A0.9390.85
124_I127_E0.9370.85
20_D29_A0.9250.84
101_L173_Y0.9190.83
108_C161_L0.9150.83
127_E130_A0.9130.83
123_G126_L0.9130.83
58_A63_A0.9030.82
20_D31_G0.9020.82
70_G97_Q0.8960.82
9_D13_T0.8910.82
31_G50_W0.8880.81
81_V85_L0.8870.81
47_L57_A0.8870.81
134_I139_G0.8870.81
56_S59_E0.8830.81
132_Y135_R0.8740.80
119_L130_A0.8720.80
157_P176_C0.8700.80
134_I137_D0.8700.80
113_Y154_D0.8670.80
24_E61_F0.8620.79
131_L137_D0.8550.79
30_R49_P0.8550.79
34_Y49_P0.8530.79
115_G153_K0.8490.78
161_L172_L0.8460.78
24_E44_L0.8460.78
58_A101_L0.8410.78
105_G166_H0.8310.77
7_H91_G0.8170.76
109_A163_R0.8150.75
26_C51_C0.8080.75
152_D158_T0.8070.75
95_W115_G0.8030.74
78_P105_G0.7970.74
11_L15_S0.7970.74
59_E79_E0.7890.73
16_F49_P0.7870.73
101_L108_C0.7820.72
16_F19_S0.7810.72
8_P13_T0.7790.72
98_E166_H0.7670.71
11_L32_Y0.7670.71
10_P15_S0.7650.71
10_P14_G0.7640.71
156_S176_C0.7540.70
95_W155_G0.7530.69
98_E160_Y0.7520.69
18_E32_Y0.7520.69
17_E20_D0.7500.69
97_Q160_Y0.7480.69
25_C28_Q0.7470.69
152_D156_S0.7400.68
22_T168_G0.7370.68
118_E153_K0.7360.68
129_L132_Y0.7350.68
19_S29_A0.7320.67
15_S93_S0.7270.67
70_G94_S0.7230.66
11_L14_G0.7220.66
163_R168_G0.7210.66
126_L130_A0.7210.66
15_S36_G0.7160.66
62_D87_E0.7130.65
12_A24_E0.7090.65
114_V118_E0.7070.65
12_A20_D0.7040.64
49_P57_A0.7020.64
135_R147_L0.6990.64
48_C51_C0.6980.64
131_L134_I0.6910.63
33_I46_A0.6880.63
16_F52_I0.6820.62
15_S113_Y0.6820.62
117_K152_D0.6820.62
24_E45_E0.6800.62
125_A130_A0.6780.61
111_L165_L0.6750.61
133_A138_L0.6730.61
83_E86_A0.6720.61
3_T56_S0.6720.61
24_E38_V0.6680.60
106_D165_L0.6680.60
154_D158_T0.6650.60
21_A29_A0.6640.60
11_L16_F0.6530.58
3_T117_K0.6520.58
131_L136_D0.6520.58
21_A33_I0.6490.58
50_W57_A0.6460.58
41_E149_E0.6440.57
113_Y159_A0.6430.57
24_E33_I0.6410.57
42_E99_R0.6400.57
132_Y136_D0.6350.56
128_A131_L0.6330.56
123_G129_L0.6320.56
127_E161_L0.6250.55
133_A137_D0.6250.55
135_R140_L0.6220.55
23_C90_P0.6220.55
25_C60_K0.6150.54
125_A129_L0.6130.54
23_C48_C0.6100.53
82_V85_L0.6070.53
49_P52_I0.6010.52
112_G123_G0.5970.52
8_P88_R0.5940.52
130_A134_I0.5930.51
134_I140_L0.5930.51
74_V77_V0.5920.51
20_D32_Y0.5920.51
130_A144_W0.5880.51
79_E139_G0.5840.50
121_A170_Y0.5830.50
151_L161_L0.5810.50
78_P110_F0.5800.50
151_L158_T0.5790.50
126_L129_L0.5770.49
40_A61_F0.5770.49
30_R34_Y0.5760.49
59_E169_K0.5740.49
70_G86_A0.5730.49
114_V122_L0.5700.49
72_E77_V0.5690.49
111_L159_A0.5680.48
139_G149_E0.5680.48
49_P65_F0.5670.48
48_C90_P0.5660.48
16_F31_G0.5660.48
59_E161_L0.5660.48
25_C30_R0.5640.48
123_G128_A0.5590.47
122_L163_R0.5570.47
141_S144_W0.5560.47
153_K157_P0.5560.47
155_G160_Y0.5560.47
132_Y137_D0.5510.46
32_Y50_W0.5470.46
125_A147_L0.5470.46
115_G161_L0.5410.45
110_F158_T0.5410.45
6_Y81_V0.5370.45
47_L168_G0.5350.44
22_T27_G0.5340.44
67_D71_L0.5340.44
59_E87_E0.5310.44
18_E21_A0.5300.44
4_F55_G0.5300.44
21_A46_A0.5290.44
95_W158_T0.5270.44
38_V44_L0.5200.43
3_T28_Q0.5190.43
82_V110_F0.5180.42
111_L170_Y0.5180.42
94_S147_L0.5170.42
71_L101_L0.5160.42
172_L176_C0.5140.42
109_A113_Y0.5110.42
135_R145_E0.5110.42
7_H14_G0.5070.41
52_I91_G0.5070.41
70_G101_L0.5050.41
127_E131_L0.5040.41
133_A139_G0.5040.41
42_E87_E0.5020.41
160_Y174_V0.5020.41
116_W148_L0.5010.40
44_L63_A0.5010.40
170_Y173_Y0.5000.40
20_D117_K0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aybP 1 0.0795 22.8 0.942 Contact Map
2ds5A 2 0.25 19.9 0.943 Contact Map
1yk4A 1 0.2273 12.6 0.948 Contact Map
4d02A 2 0 11.1 0.949 Contact Map
2v3bB 1 0.233 10.8 0.95 Contact Map
1e8jA 1 0.2273 10.6 0.95 Contact Map
4qf3A 2 0.233 9.9 0.95 Contact Map
1tfiA 1 0.2841 9.6 0.951 Contact Map
2l43A 1 0.3295 8.8 0.952 Contact Map
6rxnA 1 0.2273 8.7 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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