UPF0160 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

UPF0160 - Uncharacterised protein family (UPF0160)

PFAM:	PF03690	Sequences: KIGTHSGSFHADEVFAVALLRLLPEFPDAEIVRTRDPEVLATADIVVDVGGVYDPEKGRFDHHQRGFAGTRENGFIPYSSAGLVWKHFGKEIIASLLGLDLDDEDVEEVADKIDESFVEPIDAIDNGISIYDPIEPGYKIGTTLSSLISSFNPTWDEASDEDEDEAFLKAVEFAGEILEREIKRYAKAWLPAREIVEEAIEKAFEVDEDGRILVLDKGMPWKEHLFELEKELPIEPEILFVVYPDRGGGWRVQAVPVSPGSFENRKPLPEAWAGLRDEELSKVSGVPGAVFCHNGGFIAGAKTKEGALKMAELAL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	315 (301)
Sequences:	2171 (1580)
Seq/√Len:	91.0
META:	0.615

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
273_A	296_G	5.085	1.00
17_V	47_V	3.806	1.00
275_L	283_V	3.611	1.00
3_G	43_A	3.529	1.00
264_N	267_P	3.396	1.00
281_S	288_G	3.309	1.00
309_K	312_E	3.258	1.00
211_R	239_L	3.216	1.00
254_A	264_N	2.941	1.00
3_G	40_L	2.875	1.00
288_G	306_G	2.819	1.00
252_V	307_A	2.806	1.00
37_P	41_A	2.719	1.00
279_E	282_K	2.683	1.00
81_A	118_V	2.653	1.00
252_V	268_L	2.649	1.00
55_P	60_F	2.568	1.00
309_K	313_L	2.538	1.00
53_Y	87_H	2.475	1.00
2_I	47_V	2.464	1.00
198_E	202_K	2.345	1.00
257_V	263_E	2.341	1.00
90_K	107_E	2.323	1.00
166_A	169_K	2.227	1.00
156_D	191_P	2.133	1.00
278_E	282_K	2.123	1.00
2_I	17_V	2.094	1.00
17_V	31_I	2.093	1.00
71_R	114_D	2.079	1.00
34_T	39_V	2.020	1.00
281_S	289_A	2.008	1.00
212_I	311_A	2.006	1.00
58_G	88_F	1.996	1.00
52_V	57_K	1.983	1.00
169_K	176_E	1.981	1.00
240_F	254_A	1.971	1.00
288_G	303_T	1.937	1.00
239_L	266_K	1.901	1.00
60_F	87_H	1.853	1.00
46_V	59_R	1.831	1.00
16_A	47_V	1.817	1.00
40_L	43_A	1.791	1.00
113_I	182_I	1.781	1.00
301_A	310_M	1.768	1.00
52_V	59_R	1.753	1.00
151_F	173_F	1.750	1.00
77_P	128_I	1.738	1.00
214_V	304_K	1.727	1.00
14_V	148_I	1.691	1.00
55_P	88_F	1.680	1.00
226_F	256_P	1.680	1.00
148_I	174_A	1.665	1.00
38_E	41_A	1.647	1.00
269_P	314_A	1.631	1.00
289_A	301_A	1.626	1.00
240_F	266_K	1.608	1.00
195_I	217_K	1.605	1.00
301_A	306_G	1.595	1.00
303_T	306_G	1.559	1.00
76_I	119_E	1.534	1.00
54_D	57_K	1.516	1.00
200_I	238_I	1.515	1.00
250_W	304_K	1.511	1.00
273_A	295_G	1.503	1.00
281_S	306_G	1.503	1.00
19_L	81_A	1.496	1.00
192_A	220_P	1.481	1.00
270_E	296_G	1.448	0.99
290_V	302_K	1.446	0.99
14_V	171_V	1.437	0.99
39_V	42_T	1.429	0.99
69_G	86_K	1.415	0.99
111_D	115_E	1.409	0.99
19_L	118_V	1.401	0.99
150_S	181_E	1.399	0.99
114_D	119_E	1.396	0.99
40_L	46_V	1.388	0.99
240_F	267_P	1.369	0.99
197_E	201_E	1.365	0.99
31_I	171_V	1.359	0.99
304_K	308_L	1.352	0.99
21_R	175_G	1.344	0.99
203_A	238_I	1.341	0.99
286_V	310_M	1.330	0.99
47_V	84_V	1.329	0.99
17_V	171_V	1.326	0.99
65_R	275_L	1.313	0.99
55_P	58_G	1.311	0.99
194_E	198_E	1.311	0.99
251_R	300_G	1.310	0.99
164_D	168_L	1.309	0.99
34_T	40_L	1.300	0.99
252_V	299_A	1.295	0.99
71_R	74_G	1.277	0.99
288_G	302_K	1.272	0.99
293_H	297_F	1.272	0.99
252_V	311_A	1.262	0.99
154_T	157_E	1.259	0.99
178_L	182_I	1.248	0.98
2_I	29_A	1.243	0.98
156_D	188_A	1.243	0.98
213_L	238_I	1.236	0.98
284_S	289_A	1.225	0.98
286_V	301_A	1.221	0.98
11_A	145_S	1.216	0.98
275_L	279_E	1.213	0.98
19_L	92_I	1.211	0.98
172_E	176_E	1.203	0.98
245_D	251_R	1.193	0.98
221_W	253_Q	1.182	0.98
289_A	306_G	1.161	0.97
13_E	17_V	1.160	0.97
18_A	175_G	1.158	0.97
257_V	264_N	1.144	0.97
36_D	39_V	1.144	0.97
153_P	163_E	1.144	0.97
214_V	242_V	1.142	0.97
147_L	177_I	1.138	0.97
73_N	119_E	1.134	0.97
41_A	52_V	1.131	0.97
243_Y	253_Q	1.130	0.97
222_K	253_Q	1.122	0.97
286_V	306_G	1.120	0.97
292_C	299_A	1.115	0.97
272_W	310_M	1.115	0.97
113_I	117_F	1.111	0.97
268_L	299_A	1.111	0.97
258_S	261_S	1.108	0.97
148_I	170_A	1.106	0.97
35_R	49_V	1.105	0.97
301_A	307_A	1.102	0.97
299_A	310_M	1.097	0.96
124_I	143_T	1.096	0.96
16_A	84_V	1.090	0.96
77_P	294_N	1.086	0.96
152_N	163_E	1.082	0.96
21_R	29_A	1.074	0.96
85_W	114_D	1.070	0.96
284_S	310_M	1.068	0.96
51_G	276_R	1.061	0.96
124_I	145_S	1.061	0.96
40_L	59_R	1.060	0.96
71_R	78_Y	1.056	0.96
286_V	313_L	1.052	0.96
48_D	62_H	1.050	0.95
159_S	162_D	1.045	0.95
278_E	281_S	1.036	0.95
288_G	301_A	1.035	0.95
90_K	110_A	1.032	0.95
175_G	179_E	1.029	0.95
132_D	137_G	1.029	0.95
280_L	310_M	1.022	0.95
162_D	165_E	1.019	0.95
155_W	192_A	1.011	0.94
154_T	188_A	0.991	0.94
221_W	256_P	0.990	0.94
270_E	273_A	0.987	0.94
221_W	241_V	0.983	0.94
22_L	92_I	0.981	0.93
199_A	203_A	0.981	0.93
291_F	297_F	0.967	0.93
26_F	29_A	0.966	0.93
58_G	87_H	0.964	0.93
113_I	186_A	0.961	0.93
94_A	103_D	0.958	0.93
18_A	22_L	0.956	0.93
18_A	178_L	0.954	0.93
59_R	87_H	0.950	0.92
139_K	142_T	0.949	0.92
14_V	174_A	0.937	0.92
33_R	36_D	0.931	0.92
29_A	32_V	0.926	0.91
15_F	117_F	0.922	0.91
78_Y	114_D	0.918	0.91
200_I	225_L	0.917	0.91
239_L	315_L	0.915	0.91
5_H	10_H	0.915	0.91
241_V	255_V	0.912	0.91
289_A	310_M	0.909	0.91
290_V	300_G	0.903	0.90
243_Y	251_R	0.895	0.90
183_K	187_K	0.894	0.90
15_F	174_A	0.888	0.90
268_L	314_A	0.887	0.89
198_E	201_E	0.884	0.89
22_L	175_G	0.884	0.89
21_R	168_L	0.877	0.89
91_E	94_A	0.873	0.89
147_L	173_F	0.872	0.89
284_S	313_L	0.867	0.88
53_Y	86_K	0.865	0.88
73_N	76_I	0.863	0.88
108_E	193_R	0.857	0.88
240_F	269_P	0.855	0.88
168_L	171_V	0.854	0.88
197_E	232_L	0.854	0.88
38_E	42_T	0.851	0.87
240_F	314_A	0.849	0.87
34_T	49_V	0.848	0.87
91_E	95_S	0.845	0.87
15_F	121_I	0.843	0.87
92_I	182_I	0.840	0.87
225_L	238_I	0.833	0.86
213_L	225_L	0.832	0.86
215_L	221_W	0.832	0.86
25_E	91_E	0.832	0.86
286_V	289_A	0.828	0.86
22_L	179_E	0.826	0.86
69_G	77_P	0.820	0.85
29_A	33_R	0.819	0.85
6_S	35_R	0.818	0.85
284_S	301_A	0.818	0.85
90_K	96_L	0.808	0.85
4_T	47_V	0.803	0.84
196_V	215_L	0.803	0.84
193_R	197_E	0.797	0.84
200_I	228_L	0.796	0.84
67_F	77_P	0.795	0.84
8_S	149_S	0.794	0.84
249_G	290_V	0.792	0.83
14_V	170_A	0.792	0.83
96_L	111_D	0.788	0.83
233_P	236_P	0.788	0.83
267_P	273_A	0.780	0.83
163_E	246_R	0.777	0.82
271_A	283_V	0.776	0.82
116_S	181_E	0.776	0.82
230_K	233_P	0.774	0.82
272_W	292_C	0.769	0.82
23_L	91_E	0.769	0.82
20_L	47_V	0.767	0.81
251_R	298_I	0.766	0.81
26_F	45_I	0.766	0.81
244_P	248_G	0.763	0.81
151_F	180_R	0.762	0.81
162_D	166_A	0.757	0.81
226_F	259_P	0.755	0.80
93_I	109_V	0.755	0.80
104_E	107_E	0.753	0.80
244_P	249_G	0.751	0.80
85_W	89_G	0.749	0.80
144_L	177_I	0.746	0.80
192_A	215_L	0.740	0.79
64_Q	294_N	0.738	0.79
15_F	144_L	0.738	0.79
157_E	166_A	0.737	0.79
123_A	128_I	0.736	0.79
76_I	128_I	0.733	0.78
281_S	301_A	0.733	0.78
13_E	47_V	0.730	0.78
186_A	190_L	0.729	0.78
15_F	81_A	0.727	0.78
31_I	168_L	0.725	0.78
242_V	308_L	0.723	0.77
19_L	22_L	0.722	0.77
260_G	263_E	0.722	0.77
4_T	80_S	0.718	0.77
248_G	253_Q	0.717	0.77
150_S	180_R	0.714	0.77
176_E	180_R	0.709	0.76
276_R	300_G	0.703	0.75
269_P	272_W	0.698	0.75
13_E	16_A	0.696	0.75
66_G	294_N	0.695	0.75
5_H	12_D	0.695	0.75
5_H	48_D	0.695	0.75
155_W	188_A	0.694	0.75
173_F	176_E	0.690	0.74
23_L	95_S	0.689	0.74
201_E	232_L	0.689	0.74
166_A	170_A	0.686	0.74
198_E	216_D	0.684	0.73
83_L	89_G	0.684	0.73
257_V	261_S	0.684	0.73
124_I	149_S	0.683	0.73
3_G	34_T	0.682	0.73
279_E	283_V	0.682	0.73
306_G	309_K	0.679	0.73
249_G	302_K	0.679	0.73
157_E	180_R	0.679	0.73
77_P	126_N	0.677	0.73
195_I	219_M	0.677	0.73
96_L	183_K	0.676	0.73
82_G	122_D	0.674	0.72
112_K	189_W	0.673	0.72
87_H	91_E	0.672	0.72
287_P	309_K	0.669	0.72
135_E	138_Y	0.669	0.72
275_L	294_N	0.666	0.71
188_A	192_A	0.663	0.71
223_E	259_P	0.661	0.71
55_P	87_H	0.660	0.71
93_I	106_V	0.660	0.71
281_S	284_S	0.659	0.71
66_G	70_T	0.654	0.70
74_G	86_K	0.651	0.70
46_V	52_V	0.651	0.70
242_V	252_V	0.651	0.70
222_K	256_P	0.649	0.70
43_A	46_V	0.648	0.69
3_G	46_V	0.648	0.69
62_H	125_D	0.647	0.69
103_D	106_V	0.647	0.69
6_S	36_D	0.646	0.69
194_E	197_E	0.645	0.69
252_V	310_M	0.644	0.69
79_S	119_E	0.644	0.69
149_S	152_N	0.641	0.69
48_D	125_D	0.641	0.69
308_L	312_E	0.641	0.69
145_S	152_N	0.640	0.68
81_A	174_A	0.637	0.68
188_A	191_P	0.631	0.67
72_E	86_K	0.631	0.67
253_Q	298_I	0.631	0.67
64_Q	69_G	0.630	0.67
115_E	119_E	0.629	0.67
242_V	250_W	0.624	0.67
245_D	249_G	0.624	0.67
151_F	177_I	0.623	0.66
240_F	265_R	0.622	0.66
101_L	113_I	0.619	0.66
190_L	193_R	0.619	0.66
19_L	178_L	0.618	0.66
216_D	304_K	0.617	0.66
291_F	300_G	0.614	0.65
6_S	247_G	0.614	0.65
13_E	163_E	0.612	0.65
2_I	23_L	0.610	0.65
273_A	294_N	0.604	0.64
127_G	297_F	0.602	0.64
68_A	77_P	0.601	0.64
136_P	139_K	0.601	0.64
221_W	255_V	0.601	0.64
31_I	141_G	0.598	0.63
10_H	62_H	0.597	0.63
44_D	58_G	0.596	0.63
66_G	69_G	0.596	0.63
307_A	310_M	0.595	0.63
5_H	62_H	0.595	0.63
242_V	307_A	0.593	0.63
212_I	312_E	0.592	0.62
50_G	59_R	0.592	0.62
19_L	85_W	0.591	0.62
243_Y	298_I	0.590	0.62
90_K	106_V	0.589	0.62
127_G	262_F	0.589	0.62
238_I	255_V	0.587	0.62
203_A	209_D	0.586	0.62
145_S	149_S	0.586	0.62
161_E	164_D	0.585	0.62
124_I	146_S	0.580	0.61
10_H	48_D	0.580	0.61
160_D	163_E	0.578	0.61
267_P	296_G	0.574	0.60
100_D	104_E	0.574	0.60
100_D	103_D	0.573	0.60
9_F	12_D	0.571	0.60
214_V	250_W	0.567	0.59
10_H	80_S	0.567	0.59
296_G	299_A	0.567	0.59
196_V	219_M	0.567	0.59
224_H	229_E	0.567	0.59
23_L	26_F	0.566	0.59
76_I	123_A	0.565	0.59
307_A	311_A	0.564	0.59
117_F	181_E	0.564	0.59
215_L	220_P	0.561	0.58
70_T	77_P	0.560	0.58
13_E	171_V	0.559	0.58
202_K	216_D	0.558	0.58
176_E	179_E	0.558	0.58
71_R	86_K	0.558	0.58
266_K	314_A	0.557	0.58
153_P	220_P	0.557	0.58
40_L	49_V	0.557	0.58
181_E	186_A	0.556	0.58
266_K	309_K	0.554	0.57
51_G	84_V	0.553	0.57
256_P	259_P	0.552	0.57
109_V	239_L	0.552	0.57
254_A	296_G	0.551	0.57
215_L	244_P	0.551	0.57
65_R	210_G	0.550	0.57
157_E	161_E	0.550	0.57
73_N	114_D	0.548	0.57
228_L	238_I	0.547	0.56
169_K	172_E	0.546	0.56
11_A	174_A	0.541	0.56
112_K	116_S	0.541	0.56
85_W	113_I	0.540	0.56
159_S	163_E	0.540	0.56
306_G	312_E	0.540	0.56
151_F	170_A	0.540	0.56
165_E	169_K	0.539	0.55
146_S	149_S	0.539	0.55
238_I	259_P	0.539	0.55
3_G	13_E	0.539	0.55
77_P	114_D	0.538	0.55
214_V	308_L	0.536	0.55
150_S	177_I	0.536	0.55
212_I	268_L	0.534	0.55
152_N	170_A	0.533	0.55
102_D	105_D	0.533	0.55
18_A	179_E	0.531	0.54
65_R	294_N	0.530	0.54
46_V	126_N	0.529	0.54
79_S	298_I	0.528	0.54
44_D	59_R	0.528	0.54
117_F	174_A	0.528	0.54
154_T	183_K	0.528	0.54
19_L	84_V	0.527	0.54
189_W	224_H	0.526	0.54
254_A	267_P	0.526	0.54
193_R	221_W	0.524	0.53
283_V	292_C	0.524	0.53
268_L	313_L	0.523	0.53
213_L	241_V	0.523	0.53
155_W	195_I	0.523	0.53
112_K	190_L	0.523	0.53
52_V	66_G	0.521	0.53
2_I	5_H	0.520	0.53
196_V	241_V	0.520	0.53
143_T	146_S	0.520	0.53
117_F	177_I	0.519	0.53
264_N	295_G	0.519	0.53
4_T	10_H	0.517	0.52
66_G	77_P	0.517	0.52
170_A	173_F	0.516	0.52
11_A	121_I	0.516	0.52
155_W	220_P	0.515	0.52
67_F	70_T	0.515	0.52
242_V	304_K	0.515	0.52
198_E	270_E	0.514	0.52
23_L	27_P	0.513	0.52
244_P	247_G	0.511	0.52
120_P	142_T	0.511	0.52
84_V	255_V	0.511	0.52
79_S	250_W	0.510	0.51
109_V	113_I	0.510	0.51
192_A	221_W	0.506	0.51
79_S	114_D	0.505	0.51
152_N	166_A	0.504	0.51
169_K	258_S	0.504	0.51
67_F	80_S	0.503	0.50
283_V	288_G	0.502	0.50
96_L	201_E	0.502	0.50
157_E	183_K	0.502	0.50
4_T	79_S	0.502	0.50
277_D	300_G	0.501	0.50
15_F	29_A	0.501	0.50
209_D	312_E	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2p22C	2	0.2286	19.5	0.97	Contact Map
1wv8A	2	0.1365	16.7	0.971	Contact Map
2yztA	2	0.1397	15.9	0.971	Contact Map
2dsyA	3	0.1778	11.1	0.973	Contact Map
3kwrA	2	0.1302	7.3	0.975	Contact Map
4cdoA	1	0.3302	5.1	0.977	Contact Map
2ru9A	1	0.1937	4.7	0.977	Contact Map
1qgvA	1	0.3365	4.1	0.978	Contact Map
3o1fA	1	0.1968	4.1	0.978	Contact Map
3s0rA	3	0.0444	4	0.978	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.