GREMLIN Database
UPF0160 - Uncharacterised protein family (UPF0160)
PFAM: PF03690 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 315 (301)
Sequences: 2171 (1580)
Seq/√Len: 91.0
META: 0.615

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
273_A296_G5.0851.00
17_V47_V3.8061.00
275_L283_V3.6111.00
3_G43_A3.5291.00
264_N267_P3.3961.00
281_S288_G3.3091.00
309_K312_E3.2581.00
211_R239_L3.2161.00
254_A264_N2.9411.00
3_G40_L2.8751.00
288_G306_G2.8191.00
252_V307_A2.8061.00
37_P41_A2.7191.00
279_E282_K2.6831.00
81_A118_V2.6531.00
252_V268_L2.6491.00
55_P60_F2.5681.00
309_K313_L2.5381.00
53_Y87_H2.4751.00
2_I47_V2.4641.00
198_E202_K2.3451.00
257_V263_E2.3411.00
90_K107_E2.3231.00
166_A169_K2.2271.00
156_D191_P2.1331.00
278_E282_K2.1231.00
2_I17_V2.0941.00
17_V31_I2.0931.00
71_R114_D2.0791.00
34_T39_V2.0201.00
281_S289_A2.0081.00
212_I311_A2.0061.00
58_G88_F1.9961.00
52_V57_K1.9831.00
169_K176_E1.9811.00
240_F254_A1.9711.00
288_G303_T1.9371.00
239_L266_K1.9011.00
60_F87_H1.8531.00
46_V59_R1.8311.00
16_A47_V1.8171.00
40_L43_A1.7911.00
113_I182_I1.7811.00
301_A310_M1.7681.00
52_V59_R1.7531.00
151_F173_F1.7501.00
77_P128_I1.7381.00
214_V304_K1.7271.00
14_V148_I1.6911.00
55_P88_F1.6801.00
226_F256_P1.6801.00
148_I174_A1.6651.00
38_E41_A1.6471.00
269_P314_A1.6311.00
289_A301_A1.6261.00
240_F266_K1.6081.00
195_I217_K1.6051.00
301_A306_G1.5951.00
303_T306_G1.5591.00
76_I119_E1.5341.00
54_D57_K1.5161.00
200_I238_I1.5151.00
250_W304_K1.5111.00
273_A295_G1.5031.00
281_S306_G1.5031.00
19_L81_A1.4961.00
192_A220_P1.4811.00
270_E296_G1.4480.99
290_V302_K1.4460.99
14_V171_V1.4370.99
39_V42_T1.4290.99
69_G86_K1.4150.99
111_D115_E1.4090.99
19_L118_V1.4010.99
150_S181_E1.3990.99
114_D119_E1.3960.99
40_L46_V1.3880.99
240_F267_P1.3690.99
197_E201_E1.3650.99
31_I171_V1.3590.99
304_K308_L1.3520.99
21_R175_G1.3440.99
203_A238_I1.3410.99
286_V310_M1.3300.99
47_V84_V1.3290.99
17_V171_V1.3260.99
65_R275_L1.3130.99
55_P58_G1.3110.99
194_E198_E1.3110.99
251_R300_G1.3100.99
164_D168_L1.3090.99
34_T40_L1.3000.99
252_V299_A1.2950.99
71_R74_G1.2770.99
288_G302_K1.2720.99
293_H297_F1.2720.99
252_V311_A1.2620.99
154_T157_E1.2590.99
178_L182_I1.2480.98
2_I29_A1.2430.98
156_D188_A1.2430.98
213_L238_I1.2360.98
284_S289_A1.2250.98
286_V301_A1.2210.98
11_A145_S1.2160.98
275_L279_E1.2130.98
19_L92_I1.2110.98
172_E176_E1.2030.98
245_D251_R1.1930.98
221_W253_Q1.1820.98
289_A306_G1.1610.97
13_E17_V1.1600.97
18_A175_G1.1580.97
257_V264_N1.1440.97
36_D39_V1.1440.97
153_P163_E1.1440.97
214_V242_V1.1420.97
147_L177_I1.1380.97
73_N119_E1.1340.97
41_A52_V1.1310.97
243_Y253_Q1.1300.97
222_K253_Q1.1220.97
286_V306_G1.1200.97
292_C299_A1.1150.97
272_W310_M1.1150.97
113_I117_F1.1110.97
268_L299_A1.1110.97
258_S261_S1.1080.97
148_I170_A1.1060.97
35_R49_V1.1050.97
301_A307_A1.1020.97
299_A310_M1.0970.96
124_I143_T1.0960.96
16_A84_V1.0900.96
77_P294_N1.0860.96
152_N163_E1.0820.96
21_R29_A1.0740.96
85_W114_D1.0700.96
284_S310_M1.0680.96
51_G276_R1.0610.96
124_I145_S1.0610.96
40_L59_R1.0600.96
71_R78_Y1.0560.96
286_V313_L1.0520.96
48_D62_H1.0500.95
159_S162_D1.0450.95
278_E281_S1.0360.95
288_G301_A1.0350.95
90_K110_A1.0320.95
175_G179_E1.0290.95
132_D137_G1.0290.95
280_L310_M1.0220.95
162_D165_E1.0190.95
155_W192_A1.0110.94
154_T188_A0.9910.94
221_W256_P0.9900.94
270_E273_A0.9870.94
221_W241_V0.9830.94
22_L92_I0.9810.93
199_A203_A0.9810.93
291_F297_F0.9670.93
26_F29_A0.9660.93
58_G87_H0.9640.93
113_I186_A0.9610.93
94_A103_D0.9580.93
18_A22_L0.9560.93
18_A178_L0.9540.93
59_R87_H0.9500.92
139_K142_T0.9490.92
14_V174_A0.9370.92
33_R36_D0.9310.92
29_A32_V0.9260.91
15_F117_F0.9220.91
78_Y114_D0.9180.91
200_I225_L0.9170.91
239_L315_L0.9150.91
5_H10_H0.9150.91
241_V255_V0.9120.91
289_A310_M0.9090.91
290_V300_G0.9030.90
243_Y251_R0.8950.90
183_K187_K0.8940.90
15_F174_A0.8880.90
268_L314_A0.8870.89
198_E201_E0.8840.89
22_L175_G0.8840.89
21_R168_L0.8770.89
91_E94_A0.8730.89
147_L173_F0.8720.89
284_S313_L0.8670.88
53_Y86_K0.8650.88
73_N76_I0.8630.88
108_E193_R0.8570.88
240_F269_P0.8550.88
168_L171_V0.8540.88
197_E232_L0.8540.88
38_E42_T0.8510.87
240_F314_A0.8490.87
34_T49_V0.8480.87
91_E95_S0.8450.87
15_F121_I0.8430.87
92_I182_I0.8400.87
225_L238_I0.8330.86
213_L225_L0.8320.86
215_L221_W0.8320.86
25_E91_E0.8320.86
286_V289_A0.8280.86
22_L179_E0.8260.86
69_G77_P0.8200.85
29_A33_R0.8190.85
6_S35_R0.8180.85
284_S301_A0.8180.85
90_K96_L0.8080.85
4_T47_V0.8030.84
196_V215_L0.8030.84
193_R197_E0.7970.84
200_I228_L0.7960.84
67_F77_P0.7950.84
8_S149_S0.7940.84
249_G290_V0.7920.83
14_V170_A0.7920.83
96_L111_D0.7880.83
233_P236_P0.7880.83
267_P273_A0.7800.83
163_E246_R0.7770.82
271_A283_V0.7760.82
116_S181_E0.7760.82
230_K233_P0.7740.82
272_W292_C0.7690.82
23_L91_E0.7690.82
20_L47_V0.7670.81
251_R298_I0.7660.81
26_F45_I0.7660.81
244_P248_G0.7630.81
151_F180_R0.7620.81
162_D166_A0.7570.81
226_F259_P0.7550.80
93_I109_V0.7550.80
104_E107_E0.7530.80
244_P249_G0.7510.80
85_W89_G0.7490.80
144_L177_I0.7460.80
192_A215_L0.7400.79
64_Q294_N0.7380.79
15_F144_L0.7380.79
157_E166_A0.7370.79
123_A128_I0.7360.79
76_I128_I0.7330.78
281_S301_A0.7330.78
13_E47_V0.7300.78
186_A190_L0.7290.78
15_F81_A0.7270.78
31_I168_L0.7250.78
242_V308_L0.7230.77
19_L22_L0.7220.77
260_G263_E0.7220.77
4_T80_S0.7180.77
248_G253_Q0.7170.77
150_S180_R0.7140.77
176_E180_R0.7090.76
276_R300_G0.7030.75
269_P272_W0.6980.75
13_E16_A0.6960.75
66_G294_N0.6950.75
5_H12_D0.6950.75
5_H48_D0.6950.75
155_W188_A0.6940.75
173_F176_E0.6900.74
23_L95_S0.6890.74
201_E232_L0.6890.74
166_A170_A0.6860.74
198_E216_D0.6840.73
83_L89_G0.6840.73
257_V261_S0.6840.73
124_I149_S0.6830.73
3_G34_T0.6820.73
279_E283_V0.6820.73
306_G309_K0.6790.73
249_G302_K0.6790.73
157_E180_R0.6790.73
77_P126_N0.6770.73
195_I219_M0.6770.73
96_L183_K0.6760.73
82_G122_D0.6740.72
112_K189_W0.6730.72
87_H91_E0.6720.72
287_P309_K0.6690.72
135_E138_Y0.6690.72
275_L294_N0.6660.71
188_A192_A0.6630.71
223_E259_P0.6610.71
55_P87_H0.6600.71
93_I106_V0.6600.71
281_S284_S0.6590.71
66_G70_T0.6540.70
74_G86_K0.6510.70
46_V52_V0.6510.70
242_V252_V0.6510.70
222_K256_P0.6490.70
43_A46_V0.6480.69
3_G46_V0.6480.69
62_H125_D0.6470.69
103_D106_V0.6470.69
6_S36_D0.6460.69
194_E197_E0.6450.69
252_V310_M0.6440.69
79_S119_E0.6440.69
149_S152_N0.6410.69
48_D125_D0.6410.69
308_L312_E0.6410.69
145_S152_N0.6400.68
81_A174_A0.6370.68
188_A191_P0.6310.67
72_E86_K0.6310.67
253_Q298_I0.6310.67
64_Q69_G0.6300.67
115_E119_E0.6290.67
242_V250_W0.6240.67
245_D249_G0.6240.67
151_F177_I0.6230.66
240_F265_R0.6220.66
101_L113_I0.6190.66
190_L193_R0.6190.66
19_L178_L0.6180.66
216_D304_K0.6170.66
291_F300_G0.6140.65
6_S247_G0.6140.65
13_E163_E0.6120.65
2_I23_L0.6100.65
273_A294_N0.6040.64
127_G297_F0.6020.64
68_A77_P0.6010.64
136_P139_K0.6010.64
221_W255_V0.6010.64
31_I141_G0.5980.63
10_H62_H0.5970.63
44_D58_G0.5960.63
66_G69_G0.5960.63
307_A310_M0.5950.63
5_H62_H0.5950.63
242_V307_A0.5930.63
212_I312_E0.5920.62
50_G59_R0.5920.62
19_L85_W0.5910.62
243_Y298_I0.5900.62
90_K106_V0.5890.62
127_G262_F0.5890.62
238_I255_V0.5870.62
203_A209_D0.5860.62
145_S149_S0.5860.62
161_E164_D0.5850.62
124_I146_S0.5800.61
10_H48_D0.5800.61
160_D163_E0.5780.61
267_P296_G0.5740.60
100_D104_E0.5740.60
100_D103_D0.5730.60
9_F12_D0.5710.60
214_V250_W0.5670.59
10_H80_S0.5670.59
296_G299_A0.5670.59
196_V219_M0.5670.59
224_H229_E0.5670.59
23_L26_F0.5660.59
76_I123_A0.5650.59
307_A311_A0.5640.59
117_F181_E0.5640.59
215_L220_P0.5610.58
70_T77_P0.5600.58
13_E171_V0.5590.58
202_K216_D0.5580.58
176_E179_E0.5580.58
71_R86_K0.5580.58
266_K314_A0.5570.58
153_P220_P0.5570.58
40_L49_V0.5570.58
181_E186_A0.5560.58
266_K309_K0.5540.57
51_G84_V0.5530.57
256_P259_P0.5520.57
109_V239_L0.5520.57
254_A296_G0.5510.57
215_L244_P0.5510.57
65_R210_G0.5500.57
157_E161_E0.5500.57
73_N114_D0.5480.57
228_L238_I0.5470.56
169_K172_E0.5460.56
11_A174_A0.5410.56
112_K116_S0.5410.56
85_W113_I0.5400.56
159_S163_E0.5400.56
306_G312_E0.5400.56
151_F170_A0.5400.56
165_E169_K0.5390.55
146_S149_S0.5390.55
238_I259_P0.5390.55
3_G13_E0.5390.55
77_P114_D0.5380.55
214_V308_L0.5360.55
150_S177_I0.5360.55
212_I268_L0.5340.55
152_N170_A0.5330.55
102_D105_D0.5330.55
18_A179_E0.5310.54
65_R294_N0.5300.54
46_V126_N0.5290.54
79_S298_I0.5280.54
44_D59_R0.5280.54
117_F174_A0.5280.54
154_T183_K0.5280.54
19_L84_V0.5270.54
189_W224_H0.5260.54
254_A267_P0.5260.54
193_R221_W0.5240.53
283_V292_C0.5240.53
268_L313_L0.5230.53
213_L241_V0.5230.53
155_W195_I0.5230.53
112_K190_L0.5230.53
52_V66_G0.5210.53
2_I5_H0.5200.53
196_V241_V0.5200.53
143_T146_S0.5200.53
117_F177_I0.5190.53
264_N295_G0.5190.53
4_T10_H0.5170.52
66_G77_P0.5170.52
170_A173_F0.5160.52
11_A121_I0.5160.52
155_W220_P0.5150.52
67_F70_T0.5150.52
242_V304_K0.5150.52
198_E270_E0.5140.52
23_L27_P0.5130.52
244_P247_G0.5110.52
120_P142_T0.5110.52
84_V255_V0.5110.52
79_S250_W0.5100.51
109_V113_I0.5100.51
192_A221_W0.5060.51
79_S114_D0.5050.51
152_N166_A0.5040.51
169_K258_S0.5040.51
67_F80_S0.5030.50
283_V288_G0.5020.50
96_L201_E0.5020.50
157_E183_K0.5020.50
4_T79_S0.5020.50
277_D300_G0.5010.50
15_F29_A0.5010.50
209_D312_E0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p22C 2 0.2286 19.5 0.97 Contact Map
1wv8A 2 0.1365 16.7 0.971 Contact Map
2yztA 2 0.1397 15.9 0.971 Contact Map
2dsyA 3 0.1778 11.1 0.973 Contact Map
3kwrA 2 0.1302 7.3 0.975 Contact Map
4cdoA 1 0.3302 5.1 0.977 Contact Map
2ru9A 1 0.1937 4.7 0.977 Contact Map
1qgvA 1 0.3365 4.1 0.978 Contact Map
3o1fA 1 0.1968 4.1 0.978 Contact Map
3s0rA 3 0.0444 4 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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