GREMLIN Database
UPF0179 - Uncharacterised protein family (UPF0179)
PFAM: PF03684 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 140 (137)
Sequences: 1201 (811)
Seq/√Len: 69.3
META: 0.872

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_E44_R4.7711.00
47_G67_E3.8341.00
15_E42_R3.0611.00
100_C129_C2.8601.00
100_C106_C2.7471.00
5_I45_I2.7071.00
44_R69_E2.4001.00
7_E53_T2.3721.00
6_G59_H2.3291.00
18_Y35_L2.3291.00
84_E121_K2.2821.00
76_A126_P2.2191.00
30_L54_H2.1191.00
12_E47_G1.9221.00
74_E137_L1.8501.00
38_E70_E1.8301.00
59_H62_G1.8041.00
7_E64_R1.7511.00
46_V69_E1.7401.00
103_Y107_H1.7351.00
4_L63_V1.7311.00
121_K139_E1.7061.00
105_L137_L1.6801.00
54_H65_V1.6771.00
8_R60_E1.6610.99
92_P113_E1.6420.99
14_L45_I1.6340.99
79_S136_K1.5630.99
22_A35_L1.5410.99
9_L14_L1.5290.99
95_C106_C1.5280.99
82_A122_V1.4990.99
111_L117_Y1.4720.99
93_P107_H1.4520.99
123_L137_L1.4240.98
74_E139_E1.4160.98
17_V42_R1.4040.98
125_D136_K1.3700.98
3_T68_V1.3580.98
6_G9_L1.3550.98
31_K36_N1.3420.98
124_G137_L1.3290.97
97_E130_P1.3250.97
87_K118_K1.3070.97
78_P91_E1.3030.97
27_G57_P1.2630.96
21_P35_L1.2290.96
76_A105_L1.2230.96
6_G62_G1.2000.95
101_P128_H1.1980.95
122_V136_K1.1980.95
51_K54_H1.1970.95
72_P139_E1.1720.95
53_T62_G1.1510.94
53_T64_R1.1180.93
49_R66_V1.1110.93
13_G16_F1.0990.93
3_T6_G1.0890.92
39_P124_G1.0820.92
38_E110_G1.0590.91
74_E123_L1.0520.91
22_A58_V1.0510.91
102_N126_P1.0100.89
111_L115_D1.0090.89
18_Y33_V1.0080.89
77_I82_A1.0060.89
41_R71_A0.9990.88
7_E61_G0.9960.88
106_C129_C0.9940.88
78_P81_K0.9850.88
87_K116_K0.9730.87
82_A108_P0.9720.87
5_I9_L0.9640.87
75_A117_Y0.9570.86
49_R65_V0.9520.86
40_G124_G0.9500.86
38_E41_R0.9490.86
44_R72_P0.9370.85
25_C28_C0.9340.85
102_N124_G0.9260.84
40_G82_A0.9180.84
83_I86_S0.9180.84
2_I65_V0.9040.83
41_R111_L0.8970.82
71_A110_G0.8810.81
55_E62_G0.8770.81
81_K88_I0.8740.81
82_A88_I0.8390.78
41_R115_D0.8380.78
96_D131_K0.8370.78
71_A79_S0.8340.77
2_I36_N0.8290.77
93_P133_R0.8290.77
79_S125_D0.8220.76
80_K85_G0.8200.76
77_I119_I0.8190.76
75_A90_F0.8170.76
31_K70_E0.8160.76
121_K125_D0.8150.76
4_L29_K0.8070.75
82_A138_V0.7950.74
30_L71_A0.7900.74
8_R77_I0.7770.72
122_V138_V0.7760.72
67_E106_C0.7720.72
126_P137_L0.7680.71
28_C34_C0.7660.71
95_C100_C0.7650.71
21_P24_E0.7610.71
46_V71_A0.7490.70
86_S117_Y0.7450.69
95_C129_C0.7290.67
58_V135_L0.7270.67
90_F133_R0.7270.67
10_A13_G0.7220.67
110_G115_D0.7220.67
123_L139_E0.7210.67
22_A86_S0.7150.66
5_I10_A0.7120.66
85_G112_K0.7120.66
32_K36_N0.7110.66
18_Y36_N0.7070.65
48_V57_P0.7020.65
72_P112_K0.7010.64
46_V49_R0.7000.64
93_P97_E0.6920.63
59_H110_G0.6860.63
24_E103_Y0.6840.63
55_E59_H0.6830.62
24_E83_I0.6810.62
70_E127_P0.6800.62
90_F93_P0.6790.62
88_I136_K0.6690.61
124_G127_P0.6580.60
18_Y31_K0.6530.59
4_L10_A0.6530.59
122_V125_D0.6510.59
41_R110_G0.6500.59
4_L30_L0.6490.59
12_E44_R0.6480.58
31_K54_H0.6480.58
16_F43_Y0.6460.58
78_P92_P0.6450.58
41_R73_I0.6430.58
65_V112_K0.6430.58
8_R61_G0.6430.58
10_A16_F0.6390.57
101_P105_L0.6320.57
6_G14_L0.6310.56
55_E63_V0.6170.55
7_E62_G0.6140.54
107_H110_G0.6130.54
81_K119_I0.6080.54
92_P107_H0.6080.54
82_A119_I0.6040.53
67_E95_C0.6040.53
41_R48_V0.5990.53
102_N127_P0.5960.52
60_E65_V0.5960.52
39_P101_P0.5890.51
92_P115_D0.5890.51
71_A115_D0.5890.51
11_K14_L0.5860.51
31_K84_E0.5840.51
31_K75_A0.5830.51
49_R54_H0.5820.51
5_I14_L0.5820.51
9_L21_P0.5820.51
5_I21_P0.5820.51
60_E63_V0.5810.50
5_I8_R0.5810.50
113_E124_G0.5770.50
45_I132_G0.5740.50
14_L57_P0.5740.50
91_E113_E0.5730.49
23_P32_K0.5720.49
102_N106_C0.5650.48
75_A124_G0.5650.48
92_P110_G0.5620.48
108_P111_L0.5560.47
91_E96_D0.5540.47
59_H66_V0.5530.47
30_L63_V0.5520.47
44_R71_A0.5510.47
19_L79_S0.5450.46
40_G84_E0.5420.46
136_K139_E0.5400.45
17_V111_L0.5370.45
108_P115_D0.5360.45
19_L109_E0.5330.45
36_N65_V0.5270.44
11_K19_L0.5260.44
96_D130_P0.5220.43
36_N86_S0.5210.43
8_R119_I0.5200.43
58_V93_P0.5130.42
30_L35_L0.5120.42
94_E113_E0.5100.42
59_H63_V0.5090.42
21_P26_E0.5090.42
26_E39_P0.5080.42
29_K49_R0.5080.42
58_V117_Y0.5070.42
20_G31_K0.5040.41
89_T116_K0.5000.41
73_I98_T0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1d2vC 2 0.3357 10.3 0.944 Contact Map
4j80A 2 0.8 7.3 0.947 Contact Map
2p28B 1 0.4786 5.7 0.95 Contact Map
2zwsA 2 0.3286 2.9 0.956 Contact Map
1wspA 3 0.4 2.8 0.957 Contact Map
2lx9A 1 0.4143 2.7 0.957 Contact Map
1c3gA 2 0.5143 2.4 0.958 Contact Map
2gcxA 1 0.4143 2 0.96 Contact Map
1kg2A 1 0.3429 1.6 0.962 Contact Map
3i38A 5 0.5286 1.6 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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