GREMLIN Database
UPF0158 - Uncharacterised protein family (UPF0158)
PFAM: PF03682 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 157 (131)
Sequences: 2974 (2066)
Seq/√Len: 180.5
META: 0.927

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_D58_R4.2391.00
78_A95_I4.0241.00
115_R119_F3.4821.00
73_I129_R3.3631.00
29_E58_R2.8081.00
116_E120_A2.3621.00
125_R128_E2.2031.00
127_R131_I2.1171.00
87_L114_E2.0951.00
71_Y101_F2.0171.00
102_R106_D1.8771.00
76_D125_R1.8501.00
14_A19_S1.8481.00
71_Y75_E1.8391.00
70_E122_R1.7741.00
105_K119_F1.7611.00
72_R75_E1.7471.00
60_L137_N1.7371.00
16_E19_S1.7061.00
15_L130_A1.6911.00
71_Y96_R1.6711.00
24_S35_F1.6581.00
109_Y115_R1.6571.00
43_E46_D1.6211.00
23_E61_R1.5991.00
66_F69_E1.5861.00
87_L111_Y1.5501.00
14_A33_V1.4671.00
76_D121_F1.4471.00
45_E48_L1.4321.00
70_E73_I1.3931.00
78_A92_L1.3851.00
124_E127_R1.3681.00
90_R93_R1.3651.00
100_A103_R1.3471.00
64_P67_S1.3021.00
28_L60_L1.2901.00
73_I126_L1.2901.00
97_G103_R1.2811.00
90_R111_Y1.2811.00
14_A18_A1.2761.00
109_Y119_F1.2721.00
74_M104_F1.2721.00
73_I125_R1.2651.00
71_Y103_R1.2631.00
26_L31_G1.2461.00
71_Y95_I1.2241.00
48_L51_E1.2021.00
22_H35_F1.2011.00
95_I100_A1.1781.00
42_D45_E1.1521.00
27_D59_Y1.1511.00
82_V87_L1.1261.00
74_M95_I1.1131.00
131_I135_E1.0851.00
103_R106_D1.0811.00
88_R92_L1.0681.00
12_I18_A1.0621.00
108_L112_P1.0621.00
114_E117_R1.0531.00
15_L19_S1.0451.00
50_E53_E1.0441.00
12_I15_L1.0381.00
25_Y61_R1.0321.00
99_G103_R1.0170.99
10_D14_A0.9990.99
135_E141_P0.9930.99
99_G118_W0.9880.99
74_M101_F0.9880.99
90_R107_V0.9860.99
82_V91_L0.9800.99
108_L111_Y0.9740.99
15_L18_A0.9630.99
94_A107_V0.9530.99
120_A123_D0.9510.99
26_L133_W0.9470.99
14_A17_F0.9310.99
79_A92_L0.9220.99
41_D45_E0.9210.99
75_E95_I0.9160.99
86_D90_R0.9010.99
17_F20_D0.9000.99
122_R126_L0.8880.99
134_L137_N0.8770.98
91_L107_V0.8760.98
129_R134_L0.8750.98
87_L107_V0.8690.98
28_L59_Y0.8640.98
28_L58_R0.8630.98
67_S71_Y0.8630.98
69_E72_R0.8620.98
67_S101_F0.8590.98
49_E53_E0.8520.98
72_R76_D0.8480.98
44_E48_L0.8340.98
18_A24_S0.8280.98
101_F105_K0.8260.98
59_Y63_P0.8180.98
27_D33_V0.8170.97
13_D17_F0.8160.97
65_L70_E0.8150.97
40_D43_E0.8140.97
71_Y100_A0.8070.97
124_E128_E0.8000.97
67_S70_E0.7980.97
85_P89_E0.7960.97
65_L73_I0.7870.97
41_D48_L0.7850.97
74_M91_L0.7840.97
93_R110_R0.7790.97
49_E52_I0.7760.97
10_D13_D0.7720.96
42_D46_D0.7690.96
130_A134_L0.7670.96
128_E132_E0.7590.96
75_E78_A0.7550.96
106_D109_Y0.7490.96
63_P67_S0.7350.95
26_L134_L0.7330.95
11_L134_L0.7310.95
82_V85_P0.7300.95
78_A89_E0.7270.95
102_R105_K0.7070.94
71_Y99_G0.6950.94
107_V111_Y0.6930.94
80_S121_F0.6790.93
70_E105_K0.6760.93
15_L20_D0.6760.93
46_D49_E0.6680.92
11_L17_F0.6620.92
51_E55_D0.6590.92
60_L139_I0.6520.91
104_F118_W0.6500.91
70_E137_N0.6500.91
12_I19_S0.6490.91
14_A24_S0.6470.91
62_I65_L0.6440.91
19_S22_H0.6410.91
75_E79_A0.6390.91
123_D126_L0.6270.90
63_P133_W0.6270.90
22_H25_Y0.6270.90
71_Y78_A0.6240.90
123_D127_R0.6210.89
27_D32_E0.6210.89
10_D18_A0.6200.89
91_L94_A0.6180.89
16_E130_A0.6180.89
78_A88_R0.6140.89
59_Y62_I0.6140.89
13_D18_A0.6090.88
120_A124_E0.6080.88
100_A118_W0.6070.88
62_I67_S0.6060.88
131_I141_P0.6030.88
18_A35_F0.5990.88
17_F22_H0.5930.87
87_L108_L0.5920.87
108_L115_R0.5920.87
78_A82_V0.5890.87
26_L131_I0.5850.86
86_D89_E0.5770.86
117_R120_A0.5760.86
33_V96_R0.5760.86
75_E96_R0.5750.85
63_P73_I0.5740.85
93_R108_L0.5720.85
128_E131_I0.5680.85
33_V62_I0.5670.85
105_K109_Y0.5630.84
15_L133_W0.5600.84
84_D91_L0.5520.83
22_H127_R0.5510.83
47_E51_E0.5430.82
55_D59_Y0.5410.82
11_L14_A0.5370.81
67_S119_F0.5360.81
84_D87_L0.5350.81
11_L18_A0.5280.80
78_A105_K0.5240.80
114_E121_F0.5230.80
17_F24_S0.5230.80
71_Y74_M0.5220.80
94_A102_R0.5180.79
89_E99_G0.5180.79
117_R124_E0.5130.78
71_Y105_K0.5110.78
41_D54_E0.5080.78
20_D65_L0.5070.78
124_E131_I0.5060.77
11_L19_S0.5050.77
38_D41_D0.5030.77
97_G100_A0.5020.77
79_A85_P0.5020.77
43_E52_I0.5020.77
16_E20_D0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cmuA 1 0.8471 31.8 0.917 Contact Map
4jrbA 1 0.9236 28.7 0.919 Contact Map
2yfvC 1 0.2102 27.9 0.92 Contact Map
3tbiA 1 0.3439 27.1 0.92 Contact Map
3ka5A 2 0.3185 13.2 0.931 Contact Map
3lyvA 2 0.3185 13 0.931 Contact Map
3kb4A 2 0.6051 12.7 0.931 Contact Map
3k2tA 1 0.293 11.6 0.932 Contact Map
2cqaA 1 0.3121 10 0.934 Contact Map
2w3qA 2 0.2739 9.6 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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