GREMLIN Database
UPF0154 - Uncharacterised protein family (UPF0154)
PFAM: PF03672 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (59)
Sequences: 1183 (550)
Seq/√Len: 71.6
META: 0.678

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_R50_Q3.0811.00
22_K26_K2.8431.00
36_R48_E2.3491.00
48_E52_N2.2261.00
11_I15_I2.1451.00
18_K21_K2.0481.00
8_G12_G1.9551.00
40_M45_K1.9471.00
56_K59_K1.8061.00
15_I19_Y1.6881.00
17_R21_K1.6611.00
33_K36_R1.5340.99
50_Q53_Q1.5190.99
41_Q57_S1.4650.99
35_I54_M1.3580.98
12_G16_A1.3290.98
39_M51_I1.2940.97
36_R52_N1.2460.97
20_M23_Y1.2340.96
15_I18_K1.1680.95
37_A40_M1.1630.95
41_Q54_M1.1350.94
54_M57_S1.1350.94
9_A15_I1.1040.93
35_I51_I1.0960.93
16_A20_M1.0670.92
32_E52_N1.0660.92
7_V10_V1.0570.92
31_N34_M1.0430.91
49_K53_Q0.9940.89
18_K22_K0.9710.88
5_L12_G0.9490.87
39_M46_P0.9430.86
5_L8_G0.9350.86
40_M51_I0.9210.85
3_L7_V0.9200.85
18_K26_K0.9100.84
45_K49_K0.9050.84
33_K37_A0.8900.83
33_K52_N0.8750.82
52_N56_K0.8670.81
11_I14_F0.8440.80
38_M42_M0.8340.79
36_R45_K0.8020.76
10_V14_F0.8010.76
38_M54_M0.8000.76
32_E55_M0.7990.76
47_S51_I0.7850.74
39_M54_M0.7840.74
27_N31_N0.7800.74
35_I39_M0.7680.73
33_K39_M0.7630.72
25_K59_K0.7620.72
23_Y26_K0.7380.70
4_G8_G0.7350.69
56_K60_K0.7340.69
37_A41_Q0.7110.67
34_M58_M0.7080.67
19_Y23_Y0.6980.65
39_M49_K0.6910.65
21_K25_K0.6830.64
39_M57_S0.6530.60
17_R34_M0.6480.60
30_I34_M0.6480.60
39_M58_M0.6450.59
10_V15_I0.6420.59
11_I18_K0.6360.58
9_A12_G0.6360.58
23_Y49_K0.6360.58
53_Q56_K0.6350.58
5_L11_I0.6340.58
4_G7_V0.6200.56
23_Y39_M0.6190.56
5_L9_A0.6060.55
16_A23_Y0.5940.53
19_Y51_I0.5920.53
21_K24_L0.5900.53
16_A21_K0.5660.50
46_P51_I0.5630.49
13_F19_Y0.5580.49
6_I9_A0.5500.48
2_I5_L0.5430.47
31_N59_K0.5350.46
16_A19_Y0.5270.45
14_F18_K0.5270.45
21_K51_I0.5260.45
3_L18_K0.5080.43
28_P42_M0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n5xA 1 0.7333 24.8 0.871 Contact Map
4wl1A 3 0 24.6 0.871 Contact Map
2i7aA 2 0.6333 22.9 0.873 Contact Map
2kldA 1 0 22.9 0.873 Contact Map
3zg1A 2 0.45 21.4 0.875 Contact Map
1bu3A 2 0.3333 18.8 0.878 Contact Map
1rroA 1 0.3333 18.6 0.878 Contact Map
5palA 1 0.3333 18.1 0.879 Contact Map
3qnqA 2 0.5833 16.8 0.881 Contact Map
2rsyB 1 0.6333 16 0.882 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0042 seconds.