GREMLIN Database
UPF0093 - Uncharacterised protein family (UPF0093)
PFAM: PF03653 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 146 (143)
Sequences: 17721 (10190)
Seq/√Len: 852.1
META: 0.891

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_W98_S4.4141.00
35_E120_H3.1831.00
106_R110_D2.9171.00
103_Y107_L2.7441.00
54_L105_G2.5611.00
33_H50_E2.3721.00
42_E45_R2.2711.00
22_G58_M2.2551.00
16_V65_T2.0351.00
139_I143_V1.9411.00
88_H92_A1.8591.00
110_D115_R1.8181.00
93_L136_A1.8081.00
51_R56_G1.7741.00
70_L74_A1.7681.00
43_S47_K1.7521.00
100_Y104_C1.7461.00
64_L68_F1.7321.00
118_R122_F1.7091.00
15_F64_L1.6731.00
47_K114_D1.6641.00
6_L9_K1.6601.00
103_Y126_F1.6481.00
108_L112_A1.6261.00
18_S61_A1.5871.00
32_Y48_V1.5751.00
89_A140_L1.5471.00
10_A139_I1.5181.00
107_L126_F1.5101.00
54_L108_L1.5061.00
41_E44_E1.4961.00
98_S102_G1.4781.00
48_V52_R1.4581.00
85_G89_A1.4581.00
86_W141_V1.4431.00
85_G88_H1.4221.00
121_R125_I1.4191.00
133_L137_I1.4111.00
43_S114_D1.3681.00
104_C126_F1.3681.00
36_A42_E1.3421.00
107_L122_F1.3411.00
51_R112_A1.3401.00
14_I135_I1.3021.00
109_K113_A1.2991.00
105_G108_L1.2761.00
8_I71_L1.2751.00
102_G106_R1.2741.00
17_I134_L1.2721.00
107_L110_D1.2621.00
30_F108_L1.2561.00
72_L76_N1.2301.00
62_M98_S1.2131.00
59_T102_G1.2111.00
87_L91_L1.2081.00
13_I142_V1.1981.00
93_L137_I1.1871.00
99_G102_G1.1801.00
36_A45_R1.1791.00
110_D117_T1.1751.00
52_R56_G1.1571.00
93_L133_L1.1541.00
34_A120_H1.1421.00
77_P80_V1.1381.00
111_F116_N1.1181.00
14_I138_V1.1121.00
93_L140_L1.1071.00
122_F126_F1.1041.00
103_Y122_F1.0951.00
59_T101_H1.0811.00
37_E41_E1.0701.00
107_L123_Y1.0701.00
81_W84_Q1.0661.00
39_G42_E1.0591.00
44_E47_K1.0531.00
71_L75_L1.0481.00
74_A77_P1.0481.00
4_L8_I1.0401.00
77_P81_W1.0381.00
63_I67_I1.0301.00
59_T63_I1.0001.00
109_K112_A0.9951.00
66_W70_L0.9941.00
110_D113_A0.9941.00
129_V133_L0.9771.00
7_W143_V0.9731.00
84_Q88_H0.9661.00
36_A43_S0.9591.00
11_L68_F0.9551.00
76_N79_L0.9451.00
51_R55_R0.9431.00
42_E46_F0.9301.00
78_G81_W0.9271.00
99_G103_Y0.9261.00
27_P104_C0.8901.00
73_L87_L0.8881.00
15_F68_F0.8721.00
103_Y106_R0.8711.00
116_N123_Y0.8631.00
54_L59_T0.8631.00
19_W62_M0.8571.00
107_L118_R0.8531.00
136_A140_L0.8461.00
10_A14_I0.8461.00
95_L99_G0.8401.00
10_A143_V0.8331.00
55_R108_L0.8161.00
24_F131_T0.8061.00
79_L82_L0.8041.00
59_T62_M0.8031.00
62_M102_G0.8011.00
72_L75_L0.7981.00
96_L133_L0.7861.00
39_G44_E0.7861.00
31_V34_A0.7831.00
61_A65_T0.7751.00
119_S122_F0.7721.00
41_E45_R0.7701.00
102_G105_G0.7701.00
23_L58_M0.7651.00
26_L30_F0.7651.00
65_T68_F0.7621.00
80_V84_Q0.7601.00
55_R59_T0.7601.00
77_P82_L0.7561.00
37_E43_S0.7481.00
60_P64_L0.7471.00
7_W139_I0.7441.00
36_A41_E0.7411.00
31_V123_Y0.7391.00
37_E47_K0.7381.00
46_F49_M0.7361.00
110_D116_N0.7351.00
59_T105_G0.7191.00
55_R60_P0.7181.00
94_V98_S0.7171.00
38_D41_E0.7081.00
105_G109_K0.7041.00
25_Y49_M0.7031.00
13_I17_I0.6921.00
7_W11_L0.6901.00
100_Y126_F0.6901.00
14_I134_L0.6891.00
34_A111_F0.6881.00
92_A96_L0.6801.00
13_I16_V0.6741.00
125_I129_V0.6701.00
33_H111_F0.6701.00
76_N80_V0.6691.00
110_D118_R0.6691.00
33_H47_K0.6661.00
118_R123_Y0.6621.00
63_I102_G0.6571.00
40_S43_S0.6521.00
83_S88_H0.6471.00
62_M66_W0.6471.00
39_G43_S0.6441.00
8_I72_L0.6351.00
76_N84_Q0.6301.00
47_K108_L0.6281.00
56_G61_A0.6271.00
38_D42_E0.6261.00
132_L136_A0.6181.00
76_N82_L0.6141.00
126_F129_V0.6141.00
20_F24_F0.6121.00
36_A40_S0.6111.00
73_L77_P0.6111.00
4_L7_W0.6101.00
140_L145_P0.6101.00
106_R109_K0.6081.00
7_W10_A0.6081.00
100_Y129_V0.6051.00
57_I60_P0.5931.00
102_G109_K0.5931.00
81_W87_L0.5931.00
96_L129_V0.5751.00
37_E42_E0.5751.00
130_P134_L0.5751.00
71_L74_A0.5731.00
20_F134_L0.5711.00
62_M65_T0.5701.00
120_H124_R0.5591.00
15_F18_S0.5571.00
18_S131_T0.5551.00
14_I24_F0.5511.00
31_V124_R0.5461.00
84_Q87_L0.5461.00
82_L91_L0.5401.00
131_T135_I0.5381.00
80_V83_S0.5371.00
47_K112_A0.5311.00
34_A116_N0.5311.00
82_L87_L0.5291.00
8_I68_F0.5261.00
66_W95_L0.5261.00
77_P84_Q0.5241.00
50_E111_F0.5231.00
76_N81_W0.5191.00
131_T134_L0.5161.00
103_Y118_R0.5151.00
14_I139_I0.5141.00
58_M101_H0.5141.00
141_V144_K0.5121.00
94_V137_I0.5111.00
29_L50_E0.5091.00
4_L75_L0.5091.00
17_I20_F0.5091.00
104_C107_L0.5081.00
18_S24_F0.5071.00
37_E40_S0.5061.00
79_L84_Q0.5021.00
11_L64_L0.5001.00
25_Y29_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.7877 17.7 0.904 Contact Map
3dh4A 3 0.6575 9.7 0.914 Contact Map
1eysL 1 0.589 4.2 0.928 Contact Map
2wdqD 2 0.6849 3 0.933 Contact Map
2wswA 3 0.7123 3 0.933 Contact Map
4c7rA 3 0.6438 2.8 0.934 Contact Map
2wjnL 1 0.5959 2.2 0.938 Contact Map
4lz6A 1 0.7466 2 0.939 Contact Map
4b4aA 1 0.5753 1.8 0.94 Contact Map
4o6yA 2 0.9178 1.8 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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