GREMLIN Database
TCP - TCP family transcription factor
PFAM: PF03634 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 156 (152)
Sequences: 701 (576)
Seq/√Len: 46.7
META: 0.029

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_V25_I5.0511.00
25_I47_L4.2741.00
21_V47_L3.1181.00
86_E89_S2.9911.00
81_S84_E2.1501.00
16_P56_P2.1421.00
80_S83_S2.1371.00
32_F46_T2.1281.00
138_R145_A2.0591.00
138_R141_A2.0581.00
36_D43_A2.0390.99
81_S85_C2.0360.99
141_A145_A2.0230.99
11_Y16_P1.9530.99
29_R33_D1.8980.99
4_K7_H1.8660.99
136_E140_K1.8460.99
127_L130_S1.7500.98
27_I53_K1.7250.98
141_A144_R1.7060.98
47_L51_L1.6960.98
80_S84_E1.6760.98
54_S57_A1.6750.98
143_A146_R1.6340.97
6_R33_D1.5920.97
91_E94_E1.5520.97
25_I62_V1.5510.97
21_V33_D1.5410.96
104_N107_S1.5030.96
26_G43_A1.4590.95
26_G47_L1.4530.95
138_R144_R1.4390.95
126_K129_A1.4340.95
73_N81_S1.4060.94
119_K122_K1.4020.94
107_S110_K1.3980.94
141_A146_R1.3800.93
125_S129_A1.3790.93
40_F54_S1.3430.92
48_E53_K1.3220.92
103_G106_S1.2940.91
145_A148_R1.2920.91
4_K33_D1.2910.91
77_L83_S1.2890.91
48_E52_T1.2780.90
136_E146_R1.2780.90
130_S134_A1.2730.90
67_T72_A1.2700.90
73_N76_S1.2600.90
54_S60_E1.2480.89
125_S130_S1.2420.89
11_Y64_S1.2350.89
5_D9_K1.2210.88
77_L81_S1.2180.88
12_T15_G1.1930.87
144_R148_R1.1920.87
27_I64_S1.1910.87
30_K51_L1.1790.86
138_R146_R1.1790.86
100_F103_G1.1550.85
101_D104_N1.1440.85
60_E139_A1.1400.85
149_T152_K1.1340.84
37_M42_K1.1310.84
130_S133_L1.1260.84
84_E89_S1.1170.83
79_S82_R1.1050.83
138_R143_A1.1040.83
21_V43_A1.0920.82
82_R85_C1.0860.81
74_F77_L1.0800.81
138_R142_R1.0750.81
124_S127_L1.0730.81
32_F42_K1.0550.80
31_F41_D1.0320.78
6_R9_K1.0280.78
104_N108_S1.0130.77
77_L82_R1.0030.76
138_R148_R1.0030.76
30_K54_S1.0020.76
42_K46_T0.9880.75
45_K150_R0.9830.75
106_S109_L0.9800.74
13_A131_S0.9790.74
82_R86_E0.9790.74
26_G63_Q0.9720.74
75_S79_S0.9680.73
2_S51_L0.9550.72
10_I37_M0.9460.72
43_A61_L0.9420.71
52_T55_K0.9410.71
133_L139_A0.9310.70
80_S85_C0.9300.70
90_G94_E0.9290.70
141_A148_R0.9280.70
145_A149_T0.9160.69
135_K138_R0.9090.69
30_K52_T0.9050.68
21_V65_K0.9050.68
121_S124_S0.9040.68
105_S109_L0.8990.68
118_K122_K0.8880.67
32_F37_M0.8730.65
26_G62_V0.8620.64
112_S115_S0.8580.64
51_L139_A0.8550.64
84_E88_V0.8520.64
114_C119_K0.8510.63
59_K153_M0.8500.63
48_E66_S0.8470.63
115_S118_K0.8440.63
26_G33_D0.8440.63
29_R32_F0.8400.62
92_D95_E0.8360.62
11_Y150_R0.8290.61
113_G116_S0.8270.61
103_G114_C0.8200.61
4_K9_K0.8180.60
110_K116_S0.8000.59
115_S119_K0.7950.58
10_I42_K0.7930.58
73_N83_S0.7900.58
29_R42_K0.7900.58
115_S121_S0.7820.57
25_I55_K0.7740.56
126_K130_S0.7740.56
52_T66_S0.7720.56
105_S110_K0.7670.55
118_K121_S0.7650.55
27_I54_S0.7580.55
46_T51_L0.7560.54
14_Q47_L0.7490.54
40_F45_K0.7480.54
56_P65_K0.7450.53
66_S150_R0.7440.53
77_L84_E0.7440.53
138_R149_T0.7420.53
84_E87_V0.7410.53
83_S89_S0.7410.53
109_L112_S0.7300.52
109_L113_G0.7250.51
57_A60_E0.7220.51
62_V65_K0.7210.51
73_N79_S0.7210.51
27_I60_E0.7210.51
16_P48_E0.7160.50
148_R152_K0.7130.50
36_D47_L0.7120.50
116_S121_S0.7040.49
98_L115_S0.7020.49
56_P64_S0.7020.49
29_R46_T0.7020.49
112_S121_S0.7000.49
67_T70_I0.6990.49
72_A82_R0.6940.48
52_T61_L0.6880.48
115_S120_K0.6880.48
11_Y47_L0.6870.48
120_K126_K0.6860.47
35_Q44_S0.6850.47
14_Q33_D0.6780.47
3_K42_K0.6740.46
58_I143_A0.6730.46
76_S79_S0.6720.46
77_L80_S0.6680.46
120_K123_K0.6670.46
136_E148_R0.6670.46
30_K146_R0.6610.45
116_S119_K0.6580.45
37_M46_T0.6510.44
26_G51_L0.6500.44
30_K60_E0.6450.43
58_I144_R0.6450.43
17_R20_R0.6430.43
104_N109_L0.6430.43
144_R149_T0.6430.43
133_L151_E0.6390.43
71_P82_R0.6370.43
5_D8_S0.6370.43
97_L100_F0.6300.42
15_G18_D0.6290.42
112_S116_S0.6250.41
142_R148_R0.6200.41
10_I29_R0.6190.41
72_A77_L0.6130.40
136_E144_R0.6120.40
111_S114_C0.6100.40
53_K60_E0.6070.40
27_I40_F0.6060.40
36_D51_L0.5990.39
32_F43_A0.5960.39
99_N103_G0.5910.38
27_I32_F0.5850.38
31_F44_S0.5780.37
90_G93_E0.5780.37
13_A41_D0.5770.37
27_I42_K0.5770.37
109_L114_C0.5740.37
114_C117_K0.5740.37
21_V41_D0.5730.37
104_N116_S0.5730.37
78_S85_C0.5730.37
74_F79_S0.5720.36
80_S87_V0.5690.36
87_V91_E0.5630.36
138_R152_K0.5510.35
26_G36_D0.5480.34
75_S78_S0.5480.34
16_P62_V0.5460.34
117_K122_K0.5450.34
68_G72_A0.5320.33
27_I30_K0.5280.33
45_K51_L0.5270.32
99_N153_M0.5240.32
22_R28_A0.5210.32
132_P139_A0.5200.32
125_S128_S0.5150.31
71_P77_L0.5110.31
73_N80_S0.5110.31
40_F43_A0.5100.31
25_I42_K0.5060.31
27_I43_A0.5050.31
108_S111_S0.5050.31
140_K143_A0.5030.30
27_I37_M0.5020.30
125_S131_S0.5020.30
74_F80_S0.5010.30
80_S86_E0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2g3qA 1 0.1923 39.2 0.943 Contact Map
1z96A 1 0.1603 22.1 0.949 Contact Map
2dakA 1 0.3205 20.6 0.95 Contact Map
2knzA 1 0.25 20.5 0.95 Contact Map
2dagA 1 0.3782 19.9 0.95 Contact Map
2cwbA 1 0.2051 18.2 0.951 Contact Map
4dx8H 1 0.3462 15.4 0.953 Contact Map
4un2B 1 0.1859 14.4 0.953 Contact Map
1ifyA 1 0.2308 14 0.954 Contact Map
2mr9A 1 0.1987 13.4 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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