GREMLIN Database
Virul_fac_BrkB - Virulence factor BrkB
PFAM: PF03631 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 258 (252)
Sequences: 64800 (45751)
Seq/√Len: 2882.0
META: 0.878

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_D249_E3.3871.00
4_D98_R3.2511.00
7_L11_A2.6861.00
176_A189_W2.6561.00
6_T242_L2.6111.00
90_G112_R2.5881.00
176_A196_A2.5241.00
96_L248_A2.5191.00
195_G251_N2.4401.00
160_R163_R2.3721.00
10_A15_Y2.2921.00
172_T200_A2.2141.00
203_W240_S2.1651.00
43_Q46_D2.1111.00
4_D94_R2.0981.00
66_S69_S2.0841.00
55_E58_D2.0601.00
206_A239_L2.0361.00
97_N184_N2.0311.00
188_R191_D1.9981.00
61_Q65_E1.9831.00
95_A245_L1.9531.00
202_L243_I1.9261.00
12_L241_A1.8931.00
175_F199_A1.8511.00
112_R115_S1.8461.00
199_A247_G1.8391.00
58_D61_Q1.8271.00
172_T197_L1.7921.00
212_L216_N1.7731.00
8_L98_R1.7631.00
180_R189_W1.7421.00
58_D62_D1.7191.00
116_L120_L1.7031.00
204_E207_S1.7031.00
74_G77_G1.6571.00
210_F214_L1.6551.00
93_E115_S1.6551.00
191_D254_L1.6521.00
7_L94_R1.6391.00
107_S110_R1.6341.00
47_Q50_G1.6331.00
113_L117_G1.6321.00
37_D41_Q1.6161.00
110_R114_L1.5981.00
172_T193_L1.5791.00
74_G81_L1.5781.00
4_D8_L1.5741.00
194_P197_L1.5731.00
54_G58_D1.5701.00
57_A61_Q1.5471.00
252_A256_R1.5261.00
38_P41_Q1.5201.00
198_V250_L1.5111.00
179_Y247_G1.5091.00
176_A192_V1.5011.00
42_D46_D1.4991.00
75_L79_G1.4961.00
9_A242_L1.4951.00
66_S70_S1.4871.00
39_A43_Q1.4851.00
177_L181_F1.4761.00
59_L62_D1.4741.00
3_D101_G1.4701.00
62_D65_E1.4621.00
179_Y199_A1.4611.00
77_G80_L1.4561.00
86_S112_R1.4451.00
192_V196_A1.4441.00
145_R148_G1.4361.00
168_L200_A1.4321.00
4_D7_L1.4291.00
8_L95_A1.4251.00
43_Q47_Q1.4221.00
63_L66_S1.4141.00
198_V202_L1.4001.00
85_A119_T1.3931.00
161_L165_L1.3821.00
65_E69_S1.3771.00
191_D255_E1.3641.00
46_D49_A1.3531.00
102_V185_R1.3281.00
39_A42_D1.3231.00
175_F244_L1.3121.00
219_S222_S1.3101.00
99_I249_E1.3021.00
93_E111_R1.2861.00
73_A76_L1.2581.00
108_F112_R1.2581.00
172_T196_A1.2521.00
208_L212_L1.2461.00
178_L182_L1.2451.00
146_L150_G1.2381.00
41_Q45_L1.2321.00
67_L70_S1.2051.00
176_A193_L1.1961.00
250_L254_L1.1851.00
38_P42_D1.1781.00
187_V192_V1.1781.00
65_E68_A1.1741.00
45_L61_Q1.1671.00
100_W251_N1.1671.00
97_N183_P1.1641.00
7_L98_R1.1511.00
175_F203_W1.1451.00
77_G81_L1.1451.00
226_S229_A1.1291.00
106_R114_L1.1191.00
172_T176_A1.1071.00
83_W87_G1.1021.00
199_A243_I1.0991.00
72_S81_L1.0991.00
52_L56_A1.0901.00
49_A57_A1.0831.00
63_L67_L1.0821.00
96_L182_L1.0811.00
90_G94_R1.0781.00
56_A59_L1.0781.00
72_S77_G1.0711.00
96_L244_L1.0711.00
46_D50_G1.0711.00
68_A71_A1.0681.00
152_A155_T1.0671.00
204_E208_L1.0661.00
42_D45_L1.0651.00
41_Q44_L1.0621.00
93_E182_L1.0601.00
12_L245_L1.0601.00
109_L113_L1.0521.00
14_Y234_L1.0511.00
29_A33_L1.0481.00
207_S236_W1.0471.00
16_T88_V1.0411.00
62_D66_S1.0341.00
45_L49_A1.0341.00
194_P254_L1.0341.00
141_E145_R1.0201.00
72_S75_L1.0151.00
99_I245_L1.0021.00
7_L91_A1.0011.00
110_R113_L0.9981.00
8_L11_A0.9941.00
202_L206_A0.9921.00
253_V256_R0.9911.00
176_A180_R0.9801.00
16_T241_A0.9791.00
162_L165_L0.9771.00
196_A200_A0.9771.00
171_L200_A0.9741.00
11_A91_A0.9711.00
40_L43_Q0.9661.00
242_L246_L0.9661.00
76_L79_G0.9651.00
37_D40_L0.9591.00
5_G245_L0.9581.00
16_T237_L0.9581.00
75_L78_L0.9551.00
59_L63_L0.9551.00
155_T160_R0.9531.00
194_P198_V0.9481.00
237_L241_A0.9411.00
87_G112_R0.9371.00
146_L149_L0.9351.00
142_W146_L0.9331.00
206_A243_I0.9321.00
90_G115_S0.9251.00
102_V184_N0.9231.00
163_R167_S0.9181.00
74_G78_L0.9161.00
12_L95_A0.9141.00
238_Y242_L0.8971.00
97_N102_V0.8961.00
10_A14_Y0.8961.00
147_L150_G0.8901.00
135_A138_A0.8851.00
54_G57_A0.8841.00
151_L154_V0.8831.00
73_A79_G0.8761.00
104_E111_R0.8741.00
195_G199_A0.8701.00
60_I63_L0.8641.00
5_G242_L0.8531.00
161_L164_W0.8521.00
5_G246_L0.8501.00
166_V169_L0.8421.00
111_R114_L0.8421.00
133_S137_P0.8361.00
213_Y217_F0.8351.00
105_R184_N0.8321.00
86_S116_L0.8311.00
73_A77_G0.8311.00
209_L212_L0.8311.00
5_G249_E0.8291.00
109_L112_R0.8291.00
72_S76_L0.8241.00
151_L155_T0.8211.00
168_L172_T0.8131.00
169_L173_L0.8121.00
172_T201_V0.8111.00
236_W240_S0.8081.00
180_R192_V0.8061.00
190_R194_P0.8051.00
148_G151_L0.8051.00
90_G111_R0.8031.00
23_L27_L0.7971.00
138_A141_E0.7971.00
31_L35_G0.7961.00
17_L234_L0.7911.00
125_L129_S0.7881.00
249_E253_V0.7841.00
66_S71_A0.7831.00
47_Q51_L0.7811.00
142_W145_R0.7811.00
7_L10_A0.7791.00
173_L176_A0.7741.00
214_L217_F0.7731.00
12_L92_L0.7691.00
41_Q65_E0.7681.00
171_L204_E0.7651.00
93_E184_N0.7641.00
246_L249_E0.7571.00
165_L169_L0.7571.00
15_Y19_S0.7531.00
55_E59_L0.7521.00
200_A204_E0.7481.00
175_F200_A0.7471.00
15_Y91_A0.7461.00
159_L162_L0.7361.00
175_F196_A0.7341.00
84_S87_G0.7331.00
145_R150_G0.7301.00
168_L201_V0.7251.00
212_L215_A0.7231.00
156_L161_L0.7201.00
210_F232_V0.7181.00
223_T226_S0.7161.00
150_G153_L0.7131.00
208_L211_G0.7121.00
17_L230_V0.7111.00
94_R98_R0.7111.00
138_A142_W0.7111.00
185_R255_E0.7101.00
160_R164_W0.7071.00
194_P251_N0.7041.00
14_Y18_L0.6981.00
137_P141_E0.6961.00
67_L71_A0.6941.00
6_T9_A0.6921.00
18_L235_L0.6901.00
224_Y231_I0.6891.00
193_L197_L0.6881.00
101_G252_A0.6881.00
145_R149_L0.6871.00
180_R186_R0.6861.00
158_L162_L0.6811.00
57_A60_I0.6781.00
48_L52_L0.6781.00
209_L213_Y0.6761.00
201_V205_L0.6751.00
140_L159_L0.6731.00
128_V131_A0.6721.00
86_S115_S0.6711.00
108_F111_R0.6671.00
148_G152_A0.6661.00
168_L204_E0.6661.00
49_A54_G0.6631.00
52_L57_A0.6621.00
10_A238_Y0.6611.00
198_V247_G0.6591.00
73_A81_L0.6571.00
76_L80_L0.6541.00
228_G232_V0.6541.00
193_L196_A0.6521.00
63_L68_A0.6491.00
100_W187_V0.6491.00
155_T158_L0.6471.00
11_A15_Y0.6421.00
26_L30_L0.6411.00
45_L48_L0.6391.00
187_V191_D0.6321.00
191_D195_G0.6311.00
141_E144_A0.6311.00
169_L172_T0.6311.00
5_G8_L0.6311.00
233_L237_L0.6271.00
129_S132_L0.6231.00
197_L201_V0.6231.00
35_G38_P0.6201.00
13_A241_A0.6181.00
99_I252_A0.6171.00
205_L209_L0.6121.00
189_W193_L0.6101.00
18_L231_I0.6071.00
220_Y224_Y0.6041.00
215_A218_A0.6031.00
78_L81_L0.6021.00
96_L99_I0.6021.00
78_L82_L0.5991.00
139_L142_W0.5961.00
29_A74_G0.5941.00
158_L161_L0.5921.00
118_L182_L0.5921.00
90_G93_E0.5921.00
130_L134_V0.5921.00
48_L51_L0.5911.00
214_L232_V0.5901.00
235_L239_L0.5901.00
241_A245_L0.5881.00
102_V187_V0.5851.00
15_Y87_G0.5831.00
75_L80_L0.5811.00
133_S204_E0.5801.00
49_A61_Q0.5801.00
190_R193_L0.5771.00
45_L57_A0.5741.00
201_V204_E0.5701.00
89_F118_L0.5701.00
133_S207_S0.5691.00
123_G127_L0.5681.00
221_N226_S0.5661.00
79_G83_W0.5661.00
76_L81_L0.5651.00
72_S79_G0.5631.00
224_Y228_G0.5621.00
121_L125_L0.5621.00
29_A32_G0.5611.00
149_L153_L0.5601.00
91_A94_R0.5581.00
194_P250_L0.5571.00
40_L44_L0.5551.00
153_L156_L0.5551.00
61_Q64_L0.5531.00
89_F93_E0.5531.00
179_Y248_A0.5511.00
164_W167_S0.5511.00
113_L116_L0.5501.00
99_I248_A0.5501.00
206_A236_W0.5461.00
92_L178_L0.5451.00
117_G121_L0.5451.00
218_A222_S0.5441.00
222_S226_S0.5441.00
167_S171_L0.5421.00
93_E114_L0.5411.00
90_G108_F0.5401.00
5_G99_I0.5401.00
83_W112_R0.5401.00
23_L26_L0.5391.00
121_L177_L0.5381.00
86_S119_T0.5381.00
18_L84_S0.5381.00
88_V241_A0.5371.00
18_L234_L0.5361.00
48_L57_A0.5321.00
91_A95_A0.5311.00
117_G120_L0.5291.00
21_F25_L0.5281.00
235_L238_Y0.5281.00
231_I234_L0.5261.00
229_A232_V0.5251.00
147_L151_L0.5241.00
205_L208_L0.5221.00
159_L163_R0.5221.00
42_D61_Q0.5211.00
10_A13_A0.5191.00
149_L152_A0.5161.00
44_L47_Q0.5161.00
104_E184_N0.5151.00
131_A134_V0.5151.00
134_V137_P0.5131.00
179_Y196_A0.5091.00
143_L146_L0.5081.00
180_R187_V0.5061.00
86_S90_G0.5051.00
50_G57_A0.5041.00
3_D252_A0.5031.00
75_L81_L0.5011.00
191_D194_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nv5A 1 0.5349 14.7 0.937 Contact Map
3rlfF 1 0.4574 7.2 0.945 Contact Map
4humA 1 0.8295 5.3 0.948 Contact Map
3mktA 1 0.8372 5.1 0.949 Contact Map
3ne5A 3 0.6318 5.1 0.949 Contact Map
4q65A 1 0.2636 3.8 0.952 Contact Map
4p02A 1 0.4457 2.7 0.955 Contact Map
4mycA 2 0.3062 2.6 0.956 Contact Map
4httA 1 0.8256 2.5 0.956 Contact Map
4uvmA 1 0.2752 2.2 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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