Solute_trans_a - PFAM28P - GREMLIN Contacts

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Solute_trans_a - Organic solute transporter Ostalpha

PFAM:	PF03619	Sequences: GWIIAGVFTLLALLISLYLIFQHLRNYTKPEEQRYIIRILLMVPIYAIDSWLSLLFPRAAVYLDTIRDCYEAFVIYSFFSLLIEYLGGERALIRELEPFPLCLPPVRLGPRFLRLCKRGVLQYVIVKPLLAILAIILEAFGVYCEDFSPKSGYLYITIIYNISVTLALYCLVLFYVATKEELAPFKPLPKFLCIKLVVFLSFWQGVIISILVSLGVIKCTAEDIAAGIQNFLICIEMFIFAIAHRYAFPYKPY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	253 (252)
Sequences:	1518 (993)
Seq/√Len:	62.6
META:	0.171

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
204_Q	236_E	5.195	1.00
119_G	170_C	4.622	1.00
137_L	152_G	3.774	1.00
130_L	156_I	3.669	1.00
6_G	51_W	2.974	1.00
154_L	158_I	2.959	1.00
137_L	142_V	2.897	1.00
27_Y	33_Q	2.804	1.00
79_F	120_V	2.690	1.00
211_L	216_V	2.689	1.00
52_L	56_F	2.673	1.00
27_Y	34_R	2.625	1.00
106_V	109_G	2.577	1.00
81_L	85_Y	2.544	1.00
71_E	195_K	2.454	1.00
199_F	203_W	2.363	1.00
144_C	151_S	2.343	1.00
89_E	93_I	2.313	1.00
42_M	46_Y	2.273	1.00
196_L	240_F	2.258	1.00
142_V	152_G	2.185	1.00
122_Q	163_S	2.152	1.00
239_I	243_A	2.129	1.00
5_A	231_F	2.095	1.00
9_T	13_L	2.071	1.00
81_L	185_F	1.951	1.00
197_V	237_M	1.912	1.00
146_D	151_S	1.910	1.00
224_I	227_G	1.900	1.00
146_D	154_L	1.896	1.00
127_K	160_Y	1.859	1.00
7_V	11_L	1.842	1.00
13_L	48_I	1.834	1.00
189_P	247_A	1.814	1.00
152_G	156_I	1.812	1.00
30_P	33_Q	1.795	1.00
105_P	108_L	1.788	1.00
104_P	108_L	1.773	1.00
205_G	229_Q	1.757	0.99
133_L	137_L	1.725	0.99
208_I	232_L	1.650	0.99
27_Y	38_R	1.644	0.99
8_F	238_F	1.643	0.99
16_S	20_I	1.637	0.99
51_W	55_L	1.629	0.99
198_V	201_S	1.581	0.99
32_E	253_Y	1.581	0.99
193_C	243_A	1.511	0.98
238_F	242_I	1.498	0.98
33_Q	38_R	1.482	0.98
35_Y	77_S	1.473	0.98
151_S	154_L	1.470	0.98
130_L	159_I	1.461	0.98
12_A	43_V	1.447	0.98
169_Y	173_L	1.444	0.98
22_Q	26_N	1.444	0.98
23_H	33_Q	1.444	0.98
82_L	123_Y	1.426	0.98
88_G	93_I	1.424	0.98
3_I	7_V	1.406	0.97
143_Y	153_Y	1.402	0.97
103_L	108_L	1.401	0.97
74_V	117_K	1.355	0.97
26_N	250_Y	1.351	0.97
59_A	66_I	1.323	0.96
67_R	70_Y	1.323	0.96
89_E	92_L	1.319	0.96
35_Y	38_R	1.315	0.96
243_A	247_A	1.314	0.96
27_Y	35_Y	1.309	0.96
249_P	252_P	1.303	0.96
12_A	47_A	1.293	0.96
105_P	109_G	1.291	0.96
87_G	93_I	1.290	0.96
146_D	149_P	1.282	0.96
196_L	200_L	1.280	0.96
93_I	96_L	1.273	0.95
242_I	246_Y	1.262	0.95
65_T	194_I	1.256	0.95
59_A	63_L	1.255	0.95
9_T	17_L	1.246	0.95
90_R	93_I	1.244	0.95
137_L	156_I	1.234	0.95
92_L	96_L	1.225	0.94
120_V	123_Y	1.225	0.94
207_I	211_L	1.204	0.94
23_H	38_R	1.202	0.94
20_I	37_I	1.196	0.94
27_Y	37_I	1.189	0.93
178_T	182_L	1.186	0.93
24_L	37_I	1.172	0.93
127_K	131_A	1.152	0.92
38_R	195_K	1.151	0.92
119_G	123_Y	1.145	0.92
182_L	190_K	1.145	0.92
2_W	55_L	1.141	0.92
104_P	107_R	1.133	0.92
228_I	232_L	1.129	0.92
158_I	242_I	1.126	0.91
74_V	77_S	1.124	0.91
186_K	252_P	1.118	0.91
133_L	156_I	1.118	0.91
136_I	141_G	1.117	0.91
46_Y	71_E	1.117	0.91
117_K	128_P	1.076	0.89
9_T	51_W	1.073	0.89
9_T	12_A	1.072	0.89
50_S	68_D	1.071	0.89
191_F	195_K	1.069	0.89
3_I	11_L	1.069	0.89
149_P	154_L	1.068	0.89
195_K	202_F	1.068	0.89
210_I	232_L	1.063	0.89
182_L	191_F	1.061	0.89
11_L	14_L	1.055	0.89
5_A	234_C	1.048	0.88
223_D	227_G	1.045	0.88
197_V	240_F	1.038	0.88
152_G	155_Y	1.037	0.88
9_T	14_L	1.030	0.87
6_G	10_L	1.018	0.87
6_G	9_T	1.017	0.87
123_Y	172_V	1.011	0.86
87_G	90_R	1.000	0.86
125_I	157_T	0.994	0.85
90_R	94_R	0.988	0.85
150_K	207_I	0.982	0.85
22_Q	25_R	0.980	0.85
175_Y	188_L	0.977	0.84
130_L	160_Y	0.976	0.84
128_P	194_I	0.975	0.84
166_L	170_C	0.975	0.84
201_S	240_F	0.972	0.84
87_G	92_L	0.970	0.84
27_Y	30_P	0.965	0.84
176_V	228_I	0.965	0.84
229_Q	233_I	0.965	0.84
52_L	179_K	0.963	0.83
43_V	244_H	0.962	0.83
8_F	235_I	0.960	0.83
111_R	115_L	0.936	0.82
76_Y	240_F	0.936	0.82
126_V	159_I	0.933	0.81
95_E	186_K	0.931	0.81
164_V	198_V	0.914	0.80
121_L	128_P	0.912	0.80
27_Y	168_L	0.909	0.80
185_F	253_Y	0.909	0.80
159_I	162_I	0.906	0.80
19_L	40_L	0.903	0.79
233_I	246_Y	0.900	0.79
15_I	91_A	0.897	0.79
120_V	170_C	0.897	0.79
88_G	92_L	0.896	0.79
217_I	224_I	0.892	0.78
150_K	251_K	0.891	0.78
79_F	174_F	0.884	0.78
120_V	168_L	0.884	0.78
87_G	96_L	0.882	0.78
56_F	63_L	0.873	0.77
18_Y	22_Q	0.871	0.77
229_Q	240_F	0.867	0.76
13_L	17_L	0.865	0.76
172_V	241_A	0.861	0.76
113_L	117_K	0.858	0.76
187_P	199_F	0.857	0.76
80_S	248_F	0.857	0.76
124_V	128_P	0.856	0.76
49_D	64_D	0.852	0.75
103_L	106_V	0.851	0.75
36_I	85_Y	0.851	0.75
88_G	95_E	0.849	0.75
10_L	17_L	0.849	0.75
175_Y	182_L	0.845	0.75
142_V	224_I	0.839	0.74
74_V	194_I	0.836	0.74
69_C	131_A	0.836	0.74
154_L	157_T	0.833	0.74
120_V	252_P	0.829	0.73
53_S	68_D	0.829	0.73
243_A	246_Y	0.828	0.73
22_Q	250_Y	0.828	0.73
79_F	167_A	0.826	0.73
38_R	77_S	0.823	0.73
59_A	129_L	0.810	0.71
149_P	155_Y	0.810	0.71
82_L	100_P	0.807	0.71
102_C	173_L	0.803	0.71
6_G	132_I	0.799	0.70
123_Y	128_P	0.797	0.70
229_Q	234_C	0.796	0.70
15_I	43_V	0.791	0.70
78_F	82_L	0.790	0.70
83_I	91_A	0.788	0.69
116_C	125_I	0.786	0.69
23_H	195_K	0.784	0.69
52_L	59_A	0.783	0.69
87_G	91_A	0.783	0.69
175_Y	195_K	0.782	0.69
146_D	153_Y	0.782	0.69
68_D	127_K	0.780	0.69
88_G	91_A	0.778	0.68
119_G	166_L	0.776	0.68
153_Y	209_S	0.773	0.68
75_I	205_G	0.772	0.68
89_E	94_R	0.766	0.67
211_L	217_I	0.763	0.67
178_T	181_E	0.763	0.67
67_R	203_W	0.762	0.67
16_S	44_P	0.758	0.66
146_D	213_S	0.757	0.66
88_G	96_L	0.756	0.66
19_L	69_C	0.755	0.66
20_I	40_L	0.751	0.66
201_S	233_I	0.749	0.65
23_H	27_Y	0.749	0.65
142_V	239_I	0.748	0.65
141_G	170_C	0.747	0.65
12_A	196_L	0.743	0.65
132_I	209_S	0.741	0.65
100_P	249_P	0.735	0.64
16_S	23_H	0.726	0.63
28_T	33_Q	0.723	0.63
174_F	234_C	0.721	0.62
26_N	55_L	0.718	0.62
102_C	109_G	0.717	0.62
182_L	187_P	0.714	0.62
93_I	113_L	0.709	0.61
81_L	109_G	0.709	0.61
87_G	191_F	0.706	0.61
38_R	71_E	0.704	0.61
217_I	239_I	0.696	0.60
230_N	236_E	0.696	0.60
193_C	244_H	0.695	0.60
167_A	198_V	0.695	0.60
147_F	155_Y	0.693	0.59
225_A	252_P	0.686	0.59
10_L	31_E	0.685	0.59
200_L	224_I	0.682	0.58
148_S	151_S	0.676	0.58
129_L	210_I	0.675	0.57
68_D	202_F	0.674	0.57
3_I	14_L	0.663	0.56
97_E	141_G	0.663	0.56
192_L	195_K	0.663	0.56
225_A	246_Y	0.659	0.56
81_L	208_I	0.658	0.56
208_I	228_I	0.658	0.56
193_C	196_L	0.657	0.55
226_A	241_A	0.657	0.55
144_C	220_T	0.656	0.55
121_L	147_F	0.648	0.54
228_I	233_I	0.647	0.54
10_L	41_L	0.642	0.54
85_Y	185_F	0.641	0.54
3_I	6_G	0.638	0.53
79_F	113_L	0.636	0.53
123_Y	127_K	0.636	0.53
32_E	35_Y	0.636	0.53
29_K	82_L	0.634	0.53
135_I	241_A	0.634	0.53
46_Y	52_L	0.631	0.52
209_S	229_Q	0.630	0.52
4_I	50_S	0.629	0.52
132_I	210_I	0.627	0.52
187_P	195_K	0.626	0.52
78_F	190_K	0.626	0.52
18_Y	21_F	0.625	0.52
133_L	245_R	0.625	0.52
174_F	203_W	0.624	0.52
199_F	248_F	0.623	0.52
46_Y	187_P	0.623	0.52
126_V	150_K	0.623	0.52
94_R	129_L	0.618	0.51
187_P	190_K	0.617	0.51
241_A	244_H	0.615	0.51
32_E	85_Y	0.612	0.50
143_Y	155_Y	0.611	0.50
161_N	165_T	0.608	0.50
34_R	54_L	0.608	0.50
126_V	130_L	0.607	0.50
83_I	113_L	0.607	0.50
161_N	199_F	0.606	0.50
226_A	229_Q	0.605	0.49
136_I	210_I	0.602	0.49
135_I	165_T	0.601	0.49
155_Y	178_T	0.601	0.49
14_L	25_R	0.597	0.49
28_T	36_I	0.595	0.48
123_Y	175_Y	0.595	0.48
86_L	92_L	0.595	0.48
85_Y	202_F	0.594	0.48
103_L	107_R	0.594	0.48
208_I	225_A	0.592	0.48
123_Y	131_A	0.592	0.48
7_V	26_N	0.590	0.48
113_L	197_V	0.590	0.48
84_E	88_G	0.590	0.48
114_R	118_R	0.589	0.48
61_V	65_T	0.587	0.47
245_R	250_Y	0.586	0.47
213_S	218_K	0.585	0.47
186_K	232_L	0.584	0.47
108_L	112_F	0.582	0.47
136_I	207_I	0.581	0.47
29_K	32_E	0.580	0.47
98_P	166_L	0.578	0.46
206_V	235_I	0.578	0.46
90_R	114_R	0.576	0.46
160_Y	168_L	0.575	0.46
60_A	152_G	0.573	0.46
35_Y	198_V	0.573	0.46
82_L	164_V	0.572	0.46
104_P	109_G	0.570	0.45
97_E	108_L	0.568	0.45
74_V	78_F	0.568	0.45
127_K	168_L	0.567	0.45
165_T	202_F	0.566	0.45
41_L	253_Y	0.565	0.45
31_E	84_E	0.564	0.45
24_L	35_Y	0.564	0.45
210_I	226_A	0.562	0.45
164_V	185_F	0.560	0.44
100_P	246_Y	0.559	0.44
153_Y	157_T	0.559	0.44
136_I	142_V	0.555	0.44
73_F	89_E	0.555	0.44
127_K	202_F	0.553	0.44
65_T	68_D	0.553	0.44
104_P	111_R	0.551	0.43
44_P	122_Q	0.551	0.43
102_C	207_I	0.548	0.43
132_I	136_I	0.547	0.43
191_F	229_Q	0.547	0.43
123_Y	244_H	0.547	0.43
45_I	49_D	0.546	0.43
168_L	203_W	0.545	0.43
18_Y	245_R	0.543	0.42
9_T	47_A	0.543	0.42
112_F	117_K	0.542	0.42
168_L	191_F	0.541	0.42
5_A	54_L	0.540	0.42
126_V	200_L	0.539	0.42
172_V	175_Y	0.538	0.42
40_L	51_W	0.534	0.41
4_I	231_F	0.533	0.41
25_R	34_R	0.532	0.41
27_Y	41_L	0.531	0.41
190_K	195_K	0.531	0.41
86_L	181_E	0.529	0.41
70_Y	73_F	0.529	0.41
154_L	207_I	0.528	0.41
123_Y	164_V	0.526	0.41
199_F	202_F	0.523	0.40
117_K	121_L	0.523	0.40
121_L	193_C	0.523	0.40
113_L	116_C	0.521	0.40
2_W	6_G	0.521	0.40
68_D	199_F	0.521	0.40
172_V	206_V	0.520	0.40
118_R	121_L	0.520	0.40
156_I	211_L	0.520	0.40
53_S	60_A	0.517	0.40
139_A	162_I	0.516	0.39
52_L	55_L	0.516	0.39
6_G	14_L	0.515	0.39
81_L	165_T	0.511	0.39
188_L	239_I	0.509	0.39
141_G	246_Y	0.505	0.38
159_I	214_L	0.504	0.38
126_V	239_I	0.504	0.38
100_P	169_Y	0.503	0.38
206_V	209_S	0.503	0.38
176_V	253_Y	0.503	0.38
206_V	210_I	0.503	0.38
233_I	237_M	0.503	0.38
20_I	43_V	0.501	0.38
14_L	17_L	0.500	0.38

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2a65A	2	0.664	22.4	0.944	Contact Map
4yayA	1	0.3953	5.5	0.958	Contact Map
4k5yA	1	0.332	5	0.958	Contact Map
4hfiA	3	0.2292	3.2	0.962	Contact Map
2jwaA	2	0.1146	2.9	0.963	Contact Map
3x29A	1	0.2372	2.8	0.963	Contact Map
2ks1B	1	0.1186	2.8	0.964	Contact Map
3m73A	3	0.585	2.4	0.965	Contact Map
4knfA	3	0.6838	2.1	0.966	Contact Map
1pi7A	1	0.0751	2	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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