GREMLIN Database
Solute_trans_a - Organic solute transporter Ostalpha
PFAM: PF03619 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 253 (252)
Sequences: 1518 (993)
Seq/√Len: 62.6
META: 0.171

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
204_Q236_E5.1951.00
119_G170_C4.6221.00
137_L152_G3.7741.00
130_L156_I3.6691.00
6_G51_W2.9741.00
154_L158_I2.9591.00
137_L142_V2.8971.00
27_Y33_Q2.8041.00
79_F120_V2.6901.00
211_L216_V2.6891.00
52_L56_F2.6731.00
27_Y34_R2.6251.00
106_V109_G2.5771.00
81_L85_Y2.5441.00
71_E195_K2.4541.00
199_F203_W2.3631.00
144_C151_S2.3431.00
89_E93_I2.3131.00
42_M46_Y2.2731.00
196_L240_F2.2581.00
142_V152_G2.1851.00
122_Q163_S2.1521.00
239_I243_A2.1291.00
5_A231_F2.0951.00
9_T13_L2.0711.00
81_L185_F1.9511.00
197_V237_M1.9121.00
146_D151_S1.9101.00
224_I227_G1.9001.00
146_D154_L1.8961.00
127_K160_Y1.8591.00
7_V11_L1.8421.00
13_L48_I1.8341.00
189_P247_A1.8141.00
152_G156_I1.8121.00
30_P33_Q1.7951.00
105_P108_L1.7881.00
104_P108_L1.7731.00
205_G229_Q1.7570.99
133_L137_L1.7250.99
208_I232_L1.6500.99
27_Y38_R1.6440.99
8_F238_F1.6430.99
16_S20_I1.6370.99
51_W55_L1.6290.99
198_V201_S1.5810.99
32_E253_Y1.5810.99
193_C243_A1.5110.98
238_F242_I1.4980.98
33_Q38_R1.4820.98
35_Y77_S1.4730.98
151_S154_L1.4700.98
130_L159_I1.4610.98
12_A43_V1.4470.98
169_Y173_L1.4440.98
22_Q26_N1.4440.98
23_H33_Q1.4440.98
82_L123_Y1.4260.98
88_G93_I1.4240.98
3_I7_V1.4060.97
143_Y153_Y1.4020.97
103_L108_L1.4010.97
74_V117_K1.3550.97
26_N250_Y1.3510.97
59_A66_I1.3230.96
67_R70_Y1.3230.96
89_E92_L1.3190.96
35_Y38_R1.3150.96
243_A247_A1.3140.96
27_Y35_Y1.3090.96
249_P252_P1.3030.96
12_A47_A1.2930.96
105_P109_G1.2910.96
87_G93_I1.2900.96
146_D149_P1.2820.96
196_L200_L1.2800.96
93_I96_L1.2730.95
242_I246_Y1.2620.95
65_T194_I1.2560.95
59_A63_L1.2550.95
9_T17_L1.2460.95
90_R93_I1.2440.95
137_L156_I1.2340.95
92_L96_L1.2250.94
120_V123_Y1.2250.94
207_I211_L1.2040.94
23_H38_R1.2020.94
20_I37_I1.1960.94
27_Y37_I1.1890.93
178_T182_L1.1860.93
24_L37_I1.1720.93
127_K131_A1.1520.92
38_R195_K1.1510.92
119_G123_Y1.1450.92
182_L190_K1.1450.92
2_W55_L1.1410.92
104_P107_R1.1330.92
228_I232_L1.1290.92
158_I242_I1.1260.91
74_V77_S1.1240.91
186_K252_P1.1180.91
133_L156_I1.1180.91
136_I141_G1.1170.91
46_Y71_E1.1170.91
117_K128_P1.0760.89
9_T51_W1.0730.89
9_T12_A1.0720.89
50_S68_D1.0710.89
191_F195_K1.0690.89
3_I11_L1.0690.89
149_P154_L1.0680.89
195_K202_F1.0680.89
210_I232_L1.0630.89
182_L191_F1.0610.89
11_L14_L1.0550.89
5_A234_C1.0480.88
223_D227_G1.0450.88
197_V240_F1.0380.88
152_G155_Y1.0370.88
9_T14_L1.0300.87
6_G10_L1.0180.87
6_G9_T1.0170.87
123_Y172_V1.0110.86
87_G90_R1.0000.86
125_I157_T0.9940.85
90_R94_R0.9880.85
150_K207_I0.9820.85
22_Q25_R0.9800.85
175_Y188_L0.9770.84
130_L160_Y0.9760.84
128_P194_I0.9750.84
166_L170_C0.9750.84
201_S240_F0.9720.84
87_G92_L0.9700.84
27_Y30_P0.9650.84
176_V228_I0.9650.84
229_Q233_I0.9650.84
52_L179_K0.9630.83
43_V244_H0.9620.83
8_F235_I0.9600.83
111_R115_L0.9360.82
76_Y240_F0.9360.82
126_V159_I0.9330.81
95_E186_K0.9310.81
164_V198_V0.9140.80
121_L128_P0.9120.80
27_Y168_L0.9090.80
185_F253_Y0.9090.80
159_I162_I0.9060.80
19_L40_L0.9030.79
233_I246_Y0.9000.79
15_I91_A0.8970.79
120_V170_C0.8970.79
88_G92_L0.8960.79
217_I224_I0.8920.78
150_K251_K0.8910.78
79_F174_F0.8840.78
120_V168_L0.8840.78
87_G96_L0.8820.78
56_F63_L0.8730.77
18_Y22_Q0.8710.77
229_Q240_F0.8670.76
13_L17_L0.8650.76
172_V241_A0.8610.76
113_L117_K0.8580.76
187_P199_F0.8570.76
80_S248_F0.8570.76
124_V128_P0.8560.76
49_D64_D0.8520.75
103_L106_V0.8510.75
36_I85_Y0.8510.75
88_G95_E0.8490.75
10_L17_L0.8490.75
175_Y182_L0.8450.75
142_V224_I0.8390.74
74_V194_I0.8360.74
69_C131_A0.8360.74
154_L157_T0.8330.74
120_V252_P0.8290.73
53_S68_D0.8290.73
243_A246_Y0.8280.73
22_Q250_Y0.8280.73
79_F167_A0.8260.73
38_R77_S0.8230.73
59_A129_L0.8100.71
149_P155_Y0.8100.71
82_L100_P0.8070.71
102_C173_L0.8030.71
6_G132_I0.7990.70
123_Y128_P0.7970.70
229_Q234_C0.7960.70
15_I43_V0.7910.70
78_F82_L0.7900.70
83_I91_A0.7880.69
116_C125_I0.7860.69
23_H195_K0.7840.69
52_L59_A0.7830.69
87_G91_A0.7830.69
175_Y195_K0.7820.69
146_D153_Y0.7820.69
68_D127_K0.7800.69
88_G91_A0.7780.68
119_G166_L0.7760.68
153_Y209_S0.7730.68
75_I205_G0.7720.68
89_E94_R0.7660.67
211_L217_I0.7630.67
178_T181_E0.7630.67
67_R203_W0.7620.67
16_S44_P0.7580.66
146_D213_S0.7570.66
88_G96_L0.7560.66
19_L69_C0.7550.66
20_I40_L0.7510.66
201_S233_I0.7490.65
23_H27_Y0.7490.65
142_V239_I0.7480.65
141_G170_C0.7470.65
12_A196_L0.7430.65
132_I209_S0.7410.65
100_P249_P0.7350.64
16_S23_H0.7260.63
28_T33_Q0.7230.63
174_F234_C0.7210.62
26_N55_L0.7180.62
102_C109_G0.7170.62
182_L187_P0.7140.62
93_I113_L0.7090.61
81_L109_G0.7090.61
87_G191_F0.7060.61
38_R71_E0.7040.61
217_I239_I0.6960.60
230_N236_E0.6960.60
193_C244_H0.6950.60
167_A198_V0.6950.60
147_F155_Y0.6930.59
225_A252_P0.6860.59
10_L31_E0.6850.59
200_L224_I0.6820.58
148_S151_S0.6760.58
129_L210_I0.6750.57
68_D202_F0.6740.57
3_I14_L0.6630.56
97_E141_G0.6630.56
192_L195_K0.6630.56
225_A246_Y0.6590.56
81_L208_I0.6580.56
208_I228_I0.6580.56
193_C196_L0.6570.55
226_A241_A0.6570.55
144_C220_T0.6560.55
121_L147_F0.6480.54
228_I233_I0.6470.54
10_L41_L0.6420.54
85_Y185_F0.6410.54
3_I6_G0.6380.53
79_F113_L0.6360.53
123_Y127_K0.6360.53
32_E35_Y0.6360.53
29_K82_L0.6340.53
135_I241_A0.6340.53
46_Y52_L0.6310.52
209_S229_Q0.6300.52
4_I50_S0.6290.52
132_I210_I0.6270.52
187_P195_K0.6260.52
78_F190_K0.6260.52
18_Y21_F0.6250.52
133_L245_R0.6250.52
174_F203_W0.6240.52
199_F248_F0.6230.52
46_Y187_P0.6230.52
126_V150_K0.6230.52
94_R129_L0.6180.51
187_P190_K0.6170.51
241_A244_H0.6150.51
32_E85_Y0.6120.50
143_Y155_Y0.6110.50
161_N165_T0.6080.50
34_R54_L0.6080.50
126_V130_L0.6070.50
83_I113_L0.6070.50
161_N199_F0.6060.50
226_A229_Q0.6050.49
136_I210_I0.6020.49
135_I165_T0.6010.49
155_Y178_T0.6010.49
14_L25_R0.5970.49
28_T36_I0.5950.48
123_Y175_Y0.5950.48
86_L92_L0.5950.48
85_Y202_F0.5940.48
103_L107_R0.5940.48
208_I225_A0.5920.48
123_Y131_A0.5920.48
7_V26_N0.5900.48
113_L197_V0.5900.48
84_E88_G0.5900.48
114_R118_R0.5890.48
61_V65_T0.5870.47
245_R250_Y0.5860.47
213_S218_K0.5850.47
186_K232_L0.5840.47
108_L112_F0.5820.47
136_I207_I0.5810.47
29_K32_E0.5800.47
98_P166_L0.5780.46
206_V235_I0.5780.46
90_R114_R0.5760.46
160_Y168_L0.5750.46
60_A152_G0.5730.46
35_Y198_V0.5730.46
82_L164_V0.5720.46
104_P109_G0.5700.45
97_E108_L0.5680.45
74_V78_F0.5680.45
127_K168_L0.5670.45
165_T202_F0.5660.45
41_L253_Y0.5650.45
31_E84_E0.5640.45
24_L35_Y0.5640.45
210_I226_A0.5620.45
164_V185_F0.5600.44
100_P246_Y0.5590.44
153_Y157_T0.5590.44
136_I142_V0.5550.44
73_F89_E0.5550.44
127_K202_F0.5530.44
65_T68_D0.5530.44
104_P111_R0.5510.43
44_P122_Q0.5510.43
102_C207_I0.5480.43
132_I136_I0.5470.43
191_F229_Q0.5470.43
123_Y244_H0.5470.43
45_I49_D0.5460.43
168_L203_W0.5450.43
18_Y245_R0.5430.42
9_T47_A0.5430.42
112_F117_K0.5420.42
168_L191_F0.5410.42
5_A54_L0.5400.42
126_V200_L0.5390.42
172_V175_Y0.5380.42
40_L51_W0.5340.41
4_I231_F0.5330.41
25_R34_R0.5320.41
27_Y41_L0.5310.41
190_K195_K0.5310.41
86_L181_E0.5290.41
70_Y73_F0.5290.41
154_L207_I0.5280.41
123_Y164_V0.5260.41
199_F202_F0.5230.40
117_K121_L0.5230.40
121_L193_C0.5230.40
113_L116_C0.5210.40
2_W6_G0.5210.40
68_D199_F0.5210.40
172_V206_V0.5200.40
118_R121_L0.5200.40
156_I211_L0.5200.40
53_S60_A0.5170.40
139_A162_I0.5160.39
52_L55_L0.5160.39
6_G14_L0.5150.39
81_L165_T0.5110.39
188_L239_I0.5090.39
141_G246_Y0.5050.38
159_I214_L0.5040.38
126_V239_I0.5040.38
100_P169_Y0.5030.38
206_V209_S0.5030.38
176_V253_Y0.5030.38
206_V210_I0.5030.38
233_I237_M0.5030.38
20_I43_V0.5010.38
14_L17_L0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a65A 2 0.664 22.4 0.944 Contact Map
4yayA 1 0.3953 5.5 0.958 Contact Map
4k5yA 1 0.332 5 0.958 Contact Map
4hfiA 3 0.2292 3.2 0.962 Contact Map
2jwaA 2 0.1146 2.9 0.963 Contact Map
3x29A 1 0.2372 2.8 0.963 Contact Map
2ks1B 1 0.1186 2.8 0.964 Contact Map
3m73A 3 0.585 2.4 0.965 Contact Map
4knfA 3 0.6838 2.1 0.966 Contact Map
1pi7A 1 0.0751 2 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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