GREMLIN Database
EIID-AGA - PTS system mannose/fructose/sorbose family IID component
PFAM: PF03613 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 265 (263)
Sequences: 3310 (2134)
Seq/√Len: 131.6
META: 0.544

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
244_S247_K4.0341.00
46_D49_E3.9861.00
63_T104_A3.9581.00
39_L50_L3.9371.00
6_D41_K3.6901.00
47_K51_K3.5031.00
213_T216_D3.2851.00
3_T6_D3.2371.00
38_A76_L3.1981.00
250_L254_V2.8911.00
31_F75_T2.7191.00
52_E89_D2.6961.00
229_L233_L2.6721.00
40_K50_L2.6481.00
243_V251_G2.6341.00
215_Q219_D2.6001.00
234_C252_L2.5701.00
233_L236_W2.4551.00
255_I259_G2.4311.00
137_L141_L2.2581.00
123_G134_G2.2571.00
259_G265_L2.1901.00
201_T214_L2.1101.00
80_E158_Y2.0881.00
2_L38_A2.0571.00
216_D219_D2.0071.00
151_Y155_K1.9871.00
4_K155_K1.9851.00
13_R33_Y1.9811.00
2_L76_L1.9491.00
3_T41_K1.9091.00
44_P49_E1.8681.00
193_I231_T1.8441.00
156_L159_K1.8361.00
59_E93_N1.8151.00
34_A72_L1.8111.00
132_I135_P1.8041.00
10_V38_A1.7951.00
258_V262_L1.7841.00
119_L141_L1.7581.00
49_E52_E1.7411.00
32_A54_L1.7361.00
44_P47_K1.7091.00
203_L214_L1.6691.00
39_L53_A1.6591.00
222_M225_L1.6441.00
48_E52_E1.6411.00
18_Q21_W1.6281.00
10_V76_L1.6271.00
20_S29_L1.6071.00
243_V247_K1.6001.00
57_H96_K1.5851.00
38_A42_L1.5831.00
160_L163_K1.5681.00
63_T71_I1.5491.00
61_F68_G1.5411.00
204_V211_V1.5301.00
8_R155_K1.5231.00
199_I265_L1.5191.00
7_L154_F1.5191.00
53_A56_R1.4831.00
4_K8_R1.4701.00
7_L155_K1.4611.00
48_E51_K1.4561.00
36_I54_L1.4521.00
51_K55_K1.4471.00
206_S211_V1.4051.00
31_F35_M1.3831.00
45_D49_E1.3831.00
82_R92_I1.3741.00
78_M91_A1.3741.00
230_L252_L1.3591.00
57_H79_E1.3331.00
234_C248_I1.3301.00
136_I140_L1.3231.00
82_R89_D1.3141.00
44_P50_L1.3101.00
9_K13_R1.3051.00
11_F151_Y1.2881.00
235_Y239_K1.2871.00
50_L54_L1.2791.00
201_T226_L1.2771.00
120_A138_F1.2491.00
8_R151_Y1.2091.00
204_V213_T1.2040.99
259_G264_I1.2020.99
135_P138_F1.1990.99
2_L7_L1.1990.99
61_F71_I1.1990.99
227_P231_T1.1980.99
124_A128_L1.1960.99
70_F153_L1.1940.99
145_I148_L1.1910.99
262_L265_L1.1880.99
155_K159_K1.1870.99
115_L145_I1.1840.99
74_I95_V1.1650.99
82_R87_I1.1600.99
57_H75_T1.1440.99
237_L251_G1.1350.99
199_I230_L1.1340.99
32_A36_I1.1320.99
258_V261_L1.1310.99
10_V154_F1.1250.99
13_R37_P1.1210.99
11_F150_R1.1160.99
228_L232_L1.1060.99
61_F72_L1.0980.99
247_K251_G1.0840.99
55_K58_L1.0830.99
139_L143_N1.0690.99
120_A124_A1.0690.99
17_L68_G1.0650.99
126_L129_Q1.0530.99
35_M39_L1.0490.99
160_L167_K1.0320.98
199_I226_L1.0310.98
82_R85_G1.0280.98
16_F33_Y1.0240.98
36_I50_L1.0200.98
71_I103_L1.0140.98
27_Q63_T1.0120.98
132_I136_I1.0100.98
47_K50_L1.0080.98
43_Y53_A1.0060.98
123_G137_L1.0030.98
22_N25_R1.0000.98
8_R12_W0.9970.98
2_L6_D0.9870.98
144_I148_L0.9810.98
148_L152_Y0.9780.98
17_L27_Q0.9640.98
236_W241_K0.9620.98
46_D51_K0.9560.97
115_L119_L0.9530.97
72_L75_T0.9520.97
25_R28_A0.9500.97
93_N97_T0.9490.97
225_L229_L0.9460.97
71_I104_A0.9460.97
22_N28_A0.9440.97
28_A58_L0.9430.97
40_K47_K0.9410.97
6_D9_K0.9400.97
116_R138_F0.9400.97
251_G255_I0.9290.97
248_I252_L0.9260.97
237_L243_V0.9230.97
257_I261_L0.9220.97
216_D220_S0.9180.97
17_L30_G0.9160.97
63_T68_G0.9140.97
67_L103_L0.9140.97
256_G260_S0.9050.96
76_L154_F0.8950.96
134_G137_L0.8900.96
149_L153_L0.8860.96
251_G254_V0.8850.96
133_L136_I0.8840.96
7_L76_L0.8820.96
230_L255_I0.8810.96
5_K9_K0.8810.96
71_I75_T0.8800.96
156_L160_L0.8770.96
215_Q218_L0.8760.96
180_A184_L0.8690.95
243_V248_I0.8620.95
91_A94_G0.8550.95
16_F19_A0.8530.95
233_L255_I0.8520.95
217_I220_S0.8450.95
214_L218_L0.8380.94
28_A32_A0.8370.94
18_Q27_Q0.8320.94
29_L58_L0.8310.94
56_R96_K0.8260.94
81_E85_G0.8190.94
259_G262_L0.8190.94
253_F257_I0.8170.94
237_L248_I0.8110.93
119_L140_L0.8040.93
118_I134_G0.8040.93
166_E170_E0.8010.93
10_V13_R0.8000.93
14_S20_S0.7970.93
42_L83_A0.7950.93
254_V258_V0.7920.93
32_A58_L0.7870.92
236_W239_K0.7850.92
163_K166_E0.7830.92
68_G72_L0.7830.92
94_G98_G0.7810.92
64_H69_S0.7790.92
172_G181_A0.7760.92
131_N134_G0.7660.91
31_F96_K0.7600.91
206_S209_E0.7580.91
120_A123_G0.7570.91
111_F149_L0.7560.91
202_P213_T0.7530.91
21_W26_M0.7530.91
152_Y156_L0.7520.91
236_W240_K0.7510.91
69_S153_L0.7480.90
21_W28_A0.7450.90
245_P249_I0.7450.90
133_L137_L0.7430.90
119_L145_I0.7370.90
182_S186_L0.7300.89
249_I253_F0.7300.89
226_L230_L0.7300.89
127_A131_N0.7290.89
119_L142_F0.7270.89
18_Q23_Y0.7260.89
69_S154_F0.7220.89
202_P265_L0.7180.89
199_I227_P0.7100.88
153_L156_L0.7090.88
35_M75_T0.7080.88
15_F147_L0.7070.88
5_K8_R0.7070.88
25_R58_L0.7040.88
170_E173_L0.7020.87
64_H111_F0.7010.87
49_E82_R0.7000.87
219_D227_P0.6980.87
18_Q65_P0.6970.87
143_N146_H0.6960.87
197_V231_T0.6940.87
229_L236_W0.6900.86
17_L65_P0.6880.86
204_V216_D0.6830.86
212_V224_G0.6830.86
4_K159_K0.6820.86
31_F57_H0.6820.86
56_R89_D0.6800.86
252_L256_G0.6770.85
192_L196_Y0.6750.85
31_F72_L0.6740.85
230_L253_F0.6710.85
51_K54_L0.6710.85
66_Y146_H0.6710.85
124_A127_A0.6700.85
10_V33_Y0.6680.85
201_T265_L0.6670.85
212_V217_I0.6670.85
246_T250_L0.6660.84
10_V34_A0.6650.84
204_V209_E0.6620.84
43_Y49_E0.6600.84
64_H67_L0.6590.84
233_L237_L0.6570.84
31_F34_A0.6570.84
194_A224_G0.6540.83
7_L158_Y0.6530.83
119_L137_L0.6530.83
198_S224_G0.6520.83
224_G227_P0.6500.83
14_S150_R0.6490.83
78_M95_V0.6480.83
199_I202_P0.6480.83
232_L235_Y0.6470.83
257_I260_S0.6470.83
127_A134_G0.6470.83
123_G133_L0.6460.83
78_M92_I0.6430.82
232_L236_W0.6430.82
60_F101_G0.6420.82
71_I99_L0.6410.82
126_L137_L0.6410.82
48_E209_E0.6410.82
253_F256_G0.6400.82
74_I78_M0.6370.82
214_L217_I0.6370.82
33_Y36_I0.6360.82
137_L140_L0.6340.81
129_Q225_L0.6340.81
49_E53_A0.6330.81
160_L164_A0.6320.81
34_A103_L0.6320.81
238_L248_I0.6310.81
149_L152_Y0.6280.81
109_S177_I0.6270.81
70_F74_I0.6270.81
200_S260_S0.6240.80
200_S215_Q0.6230.80
241_K244_S0.6220.80
212_V216_D0.6200.80
67_L111_F0.6190.80
201_T218_L0.6190.80
164_A174_L0.6170.80
56_R79_E0.6150.80
77_A181_A0.6130.79
29_L32_A0.6120.79
20_S33_Y0.6110.79
230_L233_L0.6090.79
18_Q26_M0.6090.79
6_D42_L0.6010.78
210_V213_T0.5980.78
64_H104_A0.5970.77
81_E86_E0.5970.77
203_L264_I0.5930.77
112_W116_R0.5930.77
233_L251_G0.5930.77
6_D38_A0.5930.77
9_K76_L0.5910.77
35_M42_L0.5900.77
143_N147_L0.5900.77
100_M130_G0.5890.77
20_S110_L0.5870.76
116_R142_F0.5850.76
173_L177_I0.5850.76
162_T174_L0.5850.76
36_I40_K0.5830.76
95_V99_L0.5800.75
59_E90_E0.5800.75
10_V61_F0.5780.75
42_L50_L0.5760.75
66_Y112_W0.5760.75
12_W15_F0.5740.75
117_P145_I0.5740.75
215_Q227_P0.5710.74
21_W212_V0.5710.74
173_L176_K0.5690.74
5_K41_K0.5660.74
119_L123_G0.5650.74
39_L42_L0.5650.74
128_L171_S0.5650.74
66_Y142_F0.5640.73
106_I109_S0.5640.73
140_L144_I0.5640.73
199_I259_G0.5630.73
164_A169_S0.5630.73
188_V191_A0.5610.73
2_L41_K0.5600.73
112_W142_F0.5590.73
226_L259_G0.5570.73
152_Y155_K0.5570.73
42_L84_N0.5550.72
162_T165_I0.5550.72
229_L232_L0.5540.72
206_S210_V0.5530.72
14_S17_L0.5530.72
122_I137_L0.5520.72
27_Q104_A0.5510.72
80_E84_N0.5470.71
201_T215_Q0.5460.71
246_T253_F0.5460.71
205_I211_V0.5450.71
18_Q62_N0.5440.71
219_D223_P0.5420.70
42_L80_E0.5410.70
9_K37_P0.5410.70
25_R29_L0.5400.70
66_Y69_S0.5390.70
218_L225_L0.5370.70
6_D80_E0.5350.70
201_T213_T0.5320.69
65_P146_H0.5320.69
34_A154_F0.5320.69
109_S189_V0.5310.69
250_L253_F0.5300.69
218_L226_L0.5290.69
21_W27_Q0.5280.69
17_L66_Y0.5270.68
95_V204_V0.5270.68
207_S210_V0.5260.68
95_V210_V0.5260.68
28_A156_L0.5250.68
206_S213_T0.5240.68
42_L76_L0.5230.68
14_S98_G0.5230.68
229_L237_L0.5230.68
52_E82_R0.5210.68
69_S146_H0.5180.67
118_I121_G0.5160.67
174_L178_T0.5160.67
73_G154_F0.5150.67
21_W112_W0.5110.66
254_V259_G0.5090.66
23_Y113_G0.5090.66
64_H68_G0.5060.65
248_I253_F0.5060.65
45_D52_E0.5060.65
201_T249_I0.5060.65
30_G37_P0.5050.65
27_Q61_F0.5040.65
153_L160_L0.5030.65
111_F119_L0.5020.65
178_T186_L0.5020.65
82_R88_D0.5010.65
180_A183_I0.5010.65
16_F20_S0.5000.64
42_L49_E0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tu9A 1 0.4642 8.2 0.97 Contact Map
3g06A 1 0.4226 6.8 0.971 Contact Map
2dlaA 2 0.2264 5.6 0.972 Contact Map
2kbwB 1 0.117 4.9 0.973 Contact Map
4hygA 3 0.317 4.6 0.973 Contact Map
3wcaA 1 0.2264 4.4 0.973 Contact Map
4pj6A 2 0.3509 4.4 0.973 Contact Map
1p2xA 1 0.3321 3.7 0.975 Contact Map
4afiA 2 0.2415 3.5 0.975 Contact Map
2jttC 1 0.117 3.5 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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