GREMLIN Database
EIIBC-GUT_N - Sorbitol phosphotransferase enzyme II N-terminus
PFAM: PF03612 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 184 (183)
Sequences: 715 (483)
Seq/√Len: 35.7
META: 0.47

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_I63_A3.9081.00
111_K114_N3.8811.00
82_R105_I3.2451.00
28_S35_P3.2151.00
39_D43_E3.1561.00
44_L117_L3.1331.00
84_P105_I3.1271.00
22_E60_E3.0991.00
4_I86_I3.0901.00
82_R104_D3.0501.00
27_V62_I3.0271.00
59_D81_K3.0061.00
25_K61_E2.7121.00
3_K16_V2.6101.00
5_E116_S2.6061.00
102_T105_I2.3020.99
26_I41_I2.1490.99
41_I64_C2.0690.99
92_G106_Y2.0120.98
82_R102_T2.0020.98
9_G109_G1.9170.98
171_V175_F1.8480.97
33_G51_D1.8400.97
179_G183_I1.8270.97
73_L77_V1.8190.97
44_L115_I1.7630.96
34_I39_D1.7540.96
87_N106_Y1.7350.96
93_K106_Y1.6920.95
37_V115_I1.6880.95
5_E114_N1.6680.95
20_T24_N1.6630.95
4_I41_I1.6420.95
27_V65_A1.6350.94
164_I168_M1.6340.94
42_A49_A1.6020.94
75_C87_N1.5920.94
28_S34_I1.5730.93
47_A63_A1.5580.93
59_D62_I1.5430.92
19_P45_T1.5290.92
40_K44_L1.5070.92
4_I17_I1.4880.91
175_F178_A1.4800.91
40_K43_E1.4610.90
35_P38_A1.3990.88
59_D82_R1.3840.88
64_C67_I1.3670.87
177_Q181_D1.3450.86
37_V66_V1.3130.85
24_N48_E1.3120.85
41_I86_I1.2900.84
80_K165_G1.2690.83
28_S33_G1.2430.81
26_I63_A1.2180.80
43_E180_R1.1900.78
160_L164_I1.1810.78
176_Y179_G1.1810.78
34_I38_A1.1770.77
26_I47_A1.1750.77
142_Y148_I1.1740.77
14_P75_C1.1710.77
162_A173_A1.1520.76
36_P112_E1.1420.75
148_I151_Q1.1340.75
81_K106_Y1.1210.74
26_I64_C1.1140.73
11_W49_A1.0980.72
4_I112_E1.0550.69
62_I77_V1.0510.69
40_K112_E1.0480.69
22_E61_E1.0460.69
33_G73_L1.0360.68
11_W51_D1.0350.68
142_Y145_S1.0290.67
173_A176_Y1.0220.67
146_K149_T1.0210.67
87_N92_G1.0080.66
121_S128_A0.9990.65
41_I115_I0.9950.65
125_A128_A0.9850.64
158_K162_A0.9830.64
147_K150_E0.9740.63
29_V65_A0.9690.63
59_D83_I0.9590.62
13_G75_C0.9530.61
40_K115_I0.9510.61
83_I105_I0.9510.61
4_I64_C0.9490.61
28_S49_A0.9470.61
80_K100_F0.9470.61
80_K182_T0.9340.60
38_A49_A0.9310.59
93_K102_T0.9210.59
28_S39_D0.9190.58
122_E127_A0.9170.58
2_V47_A0.9140.58
24_N47_A0.9080.58
11_W33_G0.9080.58
27_V61_E0.9060.57
25_K81_K0.9030.57
62_I65_A0.8910.56
86_I89_T0.8870.56
2_V26_I0.8850.56
6_K9_G0.8850.56
11_W102_T0.8800.55
54_K115_I0.8780.55
34_I51_D0.8700.54
170_K182_T0.8700.54
14_P87_N0.8690.54
59_D65_A0.8680.54
29_V73_L0.8590.53
38_A42_A0.8560.53
133_E136_A0.8540.53
129_A133_E0.8490.52
126_A132_A0.8490.52
163_K183_I0.8490.52
7_G10_G0.8480.52
169_G180_R0.8480.52
113_E128_A0.8480.52
168_M182_T0.8440.52
178_A181_D0.8430.52
68_D176_Y0.8420.52
180_R183_I0.8370.51
20_T23_K0.8340.51
161_I177_Q0.8140.49
179_G182_T0.8120.49
143_D146_K0.8080.49
62_I83_I0.8030.48
56_S59_D0.8020.48
13_G87_N0.8000.48
63_A66_V0.7960.48
49_A52_G0.7960.48
118_A122_E0.7900.47
3_K118_A0.7800.46
33_G77_V0.7790.46
130_A133_E0.7770.46
178_A182_T0.7770.46
43_E48_E0.7710.46
112_E115_I0.7680.45
36_P63_A0.7680.45
29_V51_D0.7630.45
120_G141_K0.7630.45
131_A139_E0.7560.44
28_S38_A0.7550.44
35_P88_I0.7540.44
170_K174_T0.7520.44
27_V42_A0.7510.44
81_K92_G0.7460.44
75_C106_Y0.7450.43
63_A84_P0.7430.43
147_K151_Q0.7400.43
166_R172_V0.7390.43
75_C92_G0.7380.43
66_V86_I0.7380.43
165_G172_V0.7330.42
28_S36_P0.7320.42
99_Q102_T0.7280.42
23_K127_A0.7250.42
51_D182_T0.7250.42
138_K141_K0.7230.42
72_T77_V0.7220.42
67_I174_T0.7210.41
19_P63_A0.7160.41
30_T94_S0.7150.41
27_V57_V0.7140.41
27_V52_G0.7130.41
77_V80_K0.7120.41
26_I38_A0.7110.41
160_L168_M0.7090.40
169_G178_A0.7020.40
83_I98_A0.6990.40
165_G169_G0.6940.39
123_A126_A0.6920.39
127_A130_A0.6850.38
144_T149_T0.6830.38
169_G172_V0.6780.38
118_A124_A0.6750.38
58_P61_E0.6680.37
127_A132_A0.6660.37
86_I113_E0.6630.37
147_K180_R0.6620.37
34_I93_K0.6620.37
144_T148_I0.6580.36
39_D115_I0.6560.36
91_T173_A0.6520.36
133_E137_E0.6500.36
142_Y146_K0.6490.36
142_Y147_K0.6480.35
168_M176_Y0.6410.35
145_S149_T0.6370.35
68_D89_T0.6360.35
20_T63_A0.6340.34
167_G171_V0.6330.34
113_E122_E0.6290.34
30_T109_G0.6170.33
168_M179_G0.6170.33
8_S114_N0.6110.33
2_V18_T0.6100.33
92_G98_A0.6050.32
65_A168_M0.6040.32
7_G12_G0.6020.32
101_I105_I0.6020.32
125_A133_E0.6020.32
125_A132_A0.6010.32
99_Q150_E0.6010.32
131_A135_A0.6000.32
72_T96_P0.5980.32
38_A111_K0.5970.32
51_D159_G0.5950.31
126_A129_A0.5930.31
28_S73_L0.5920.31
66_V131_A0.5910.31
33_G49_A0.5900.31
156_G162_A0.5800.30
9_G18_T0.5780.30
59_D106_Y0.5770.30
161_I171_V0.5750.30
24_N81_K0.5750.30
16_V20_T0.5730.30
47_A57_V0.5720.30
19_P98_A0.5700.30
84_P104_D0.5670.29
158_K166_R0.5670.29
68_D166_R0.5670.29
64_C86_I0.5660.29
118_A171_V0.5630.29
169_G175_F0.5630.29
131_A138_K0.5600.29
87_N93_K0.5600.29
176_Y181_D0.5590.29
86_I107_V0.5580.29
175_F180_R0.5570.29
4_I62_I0.5560.29
19_P23_K0.5560.29
14_P92_G0.5540.28
45_T58_P0.5510.28
143_D151_Q0.5500.28
141_K144_T0.5490.28
29_V37_V0.5490.28
2_V64_C0.5480.28
54_K90_P0.5480.28
91_T106_Y0.5460.28
175_F179_G0.5410.28
119_D123_A0.5410.28
34_I49_A0.5390.27
132_A135_A0.5370.27
162_A168_M0.5360.27
44_L66_V0.5350.27
52_G81_K0.5350.27
3_K116_S0.5310.27
141_K148_I0.5310.27
25_K48_E0.5290.27
157_K167_G0.5290.27
35_P39_D0.5270.27
43_E112_E0.5200.26
129_A136_A0.5180.26
81_K105_I0.5170.26
67_I99_Q0.5170.26
164_I169_G0.5130.26
118_A123_A0.5120.26
109_G114_N0.5110.25
24_N57_V0.5110.25
77_V101_I0.5110.25
172_V175_F0.5080.25
81_K98_A0.5070.25
68_D178_A0.5070.25
176_Y180_R0.5060.25
14_P106_Y0.5030.25
30_T88_I0.5030.25
30_T51_D0.5020.25
16_V119_D0.5010.25
11_W73_L0.5000.25
123_A131_A0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1um1A 1 0.4674 48.8 0.956 Contact Map
4h11A 2 0.4293 31.8 0.96 Contact Map
1uitA 1 0.4891 28 0.961 Contact Map
2dazA 1 0.4565 24.7 0.962 Contact Map
1um7A 1 0.4674 22.6 0.963 Contact Map
2csjA 1 0.4728 19.4 0.964 Contact Map
2i1nA 4 0.4293 17.6 0.965 Contact Map
2enoA 1 0.462 17.6 0.965 Contact Map
1uhpA 1 0.4293 15.9 0.965 Contact Map
2v90A 4 0.4293 14.6 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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