GREMLIN Database
EII-Sor - PTS system sorbose-specific iic component
PFAM: PF03609 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 233 (231)
Sequences: 3974 (2556)
Seq/√Len: 168.1
META: 0.609

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_D44_T5.4491.00
27_R53_E4.5341.00
128_N131_G4.0791.00
208_L229_A4.0271.00
10_V34_L3.2771.00
218_L222_A3.2251.00
119_R122_K3.0761.00
211_V226_I2.9821.00
122_K126_E2.9221.00
123_A131_G2.8601.00
37_L42_L2.8561.00
32_G45_G2.7871.00
211_V225_I2.6501.00
172_A176_N2.4981.00
4_A8_A2.4271.00
118_H121_D2.3691.00
123_A135_L2.3221.00
123_A128_N2.3181.00
130_K134_R2.3121.00
164_Q168_N2.2821.00
10_V38_I2.2411.00
7_I35_V2.1861.00
219_P222_A2.1301.00
12_G145_F2.0631.00
43_Q47_I2.0501.00
11_A152_V1.9821.00
39_L83_L1.9591.00
6_L38_I1.9561.00
119_R123_A1.9431.00
161_D164_Q1.9101.00
33_T42_L1.8791.00
8_A153_F1.8651.00
44_T47_I1.8471.00
213_A223_I1.8141.00
12_G149_A1.7471.00
122_K125_E1.7231.00
119_R135_L1.7171.00
123_A126_E1.6641.00
32_G74_G1.6511.00
39_L82_I1.6431.00
207_F225_I1.6211.00
72_L102_G1.6171.00
44_T48_I1.6111.00
145_F149_A1.5861.00
215_Y219_P1.5621.00
45_G49_G1.5271.00
44_T82_I1.4931.00
203_W207_F1.4851.00
128_N134_R1.4721.00
215_Y222_A1.4631.00
212_L216_L1.4411.00
2_I5_I1.4211.00
124_A127_G1.4001.00
218_L223_I1.4001.00
176_N179_S1.3891.00
33_T37_L1.3771.00
69_D72_L1.3761.00
134_R138_L1.3751.00
47_I50_A1.3741.00
8_A149_A1.3681.00
228_V232_L1.3461.00
87_G90_A1.3451.00
52_L74_G1.3091.00
29_L33_T1.3071.00
93_A97_P1.3021.00
170_I174_L1.2891.00
177_G181_A1.2851.00
131_G134_R1.2781.00
198_L203_W1.2771.00
120_A136_H1.2571.00
34_L38_I1.2541.00
176_N180_V1.2501.00
120_A124_A1.2461.00
165_A168_N1.2391.00
106_D110_R1.2221.00
166_L169_A1.2191.00
73_A99_A1.2151.00
180_V183_G1.2131.00
73_A77_G1.2131.00
161_D165_A1.2111.00
32_G78_T1.2081.00
86_Q90_A1.1971.00
69_D106_D1.1961.00
69_D148_R1.1871.00
165_A169_A1.1791.00
130_K133_E1.1691.00
216_L219_P1.1671.00
68_P99_A1.1341.00
79_A83_L1.1231.00
30_V33_T1.1041.00
51_T55_I1.0991.00
78_T82_I1.0981.00
126_E131_G1.0851.00
153_F157_Y1.0801.00
172_A175_T1.0731.00
13_L25_L1.0721.00
11_A75_V1.0681.00
14_A31_A1.0530.99
134_R139_G1.0440.99
68_P103_Q1.0400.99
162_A166_L1.0380.99
10_V31_A1.0310.99
43_Q46_L1.0220.99
33_T46_L1.0030.99
129_F133_E1.0030.99
131_G135_L1.0020.99
46_L49_G0.9970.99
76_I155_A0.9920.99
224_A227_G0.9880.99
181_A185_L0.9850.99
9_L13_L0.9840.99
144_G147_L0.9810.99
173_W177_G0.9770.99
10_V75_V0.9750.99
201_K205_F0.9720.99
90_A175_T0.9650.99
116_F119_R0.9650.99
10_V14_A0.9600.99
124_A128_N0.9570.99
142_L145_F0.9550.99
90_A93_A0.9540.99
81_A91_A0.9500.99
111_T114_S0.9490.99
4_A156_L0.9450.99
17_D22_Q0.9400.99
225_I228_V0.9360.99
191_A195_N0.9330.99
48_I78_T0.9300.99
52_L73_A0.9290.99
154_L162_A0.9270.99
2_I6_L0.9160.98
107_I110_R0.9050.98
114_S117_V0.9020.98
162_A165_A0.9020.98
217_G220_L0.8990.98
31_A74_G0.8940.98
204_P232_L0.8940.98
35_V78_T0.8760.98
158_F161_D0.8760.98
149_A153_F0.8660.98
27_R30_V0.8640.98
3_Q83_L0.8580.98
124_A132_I0.8570.98
74_G78_T0.8480.97
77_G81_A0.8440.97
202_L206_F0.8420.97
91_A97_P0.8410.97
31_A75_V0.8360.97
5_I153_F0.8320.97
100_L104_L0.8300.97
229_A232_L0.8290.97
24_M53_E0.8210.97
211_V218_L0.8170.97
98_L163_V0.8020.96
215_Y221_I0.7980.96
171_P177_G0.7960.96
121_D125_E0.7960.96
227_G230_I0.7940.96
33_T78_T0.7900.96
216_L221_I0.7870.96
121_D124_A0.7820.96
172_A217_G0.7810.96
42_L45_G0.7810.96
154_L157_Y0.7780.96
36_G49_G0.7730.96
124_A129_F0.7730.96
76_I80_L0.7670.95
25_L28_P0.7670.95
22_Q26_S0.7650.95
14_A71_A0.7630.95
24_M27_R0.7590.95
158_F162_A0.7580.95
207_F232_L0.7560.95
59_V70_A0.7530.95
112_I143_L0.7510.95
193_L196_M0.7480.95
210_F214_A0.7450.95
207_F229_A0.7400.95
100_L103_Q0.7400.95
104_L108_L0.7380.94
141_L144_G0.7380.94
7_I10_V0.7330.94
215_Y218_L0.7320.94
15_G18_G0.7290.94
175_T184_M0.7290.94
109_V139_G0.7290.94
164_Q217_G0.7280.94
81_A87_G0.7240.94
14_A26_S0.7220.94
7_I75_V0.7170.94
99_A190_F0.7120.93
35_V82_I0.7040.93
79_A156_L0.7030.93
199_K202_L0.7030.93
4_A157_Y0.7010.93
191_A194_L0.7010.93
105_L151_P0.7000.93
8_A156_L0.7000.93
5_I8_A0.6890.92
34_L45_G0.6890.92
175_T178_L0.6850.92
154_L158_F0.6840.92
109_V113_N0.6830.92
8_A12_G0.6820.92
84_S157_Y0.6820.92
186_P189_G0.6800.92
37_L41_D0.6790.92
225_I229_A0.6780.92
35_V75_V0.6750.91
3_Q38_I0.6750.91
85_G89_E0.6740.91
6_L9_L0.6730.91
143_L146_L0.6730.91
29_L50_A0.6720.91
120_A132_I0.6700.91
116_F143_L0.6680.91
76_I79_A0.6670.91
14_A34_L0.6670.91
11_A15_G0.6630.91
127_G132_I0.6630.91
198_L206_F0.6630.91
204_P229_A0.6610.91
110_R113_N0.6610.91
33_T43_Q0.6590.90
212_L226_I0.6580.90
171_P181_A0.6560.90
153_F158_F0.6550.90
31_A71_A0.6540.90
150_I154_L0.6520.90
35_V79_A0.6500.90
104_L107_I0.6470.90
12_G144_G0.6470.90
3_Q6_L0.6470.90
146_L150_I0.6450.89
89_E217_G0.6430.89
137_L140_P0.6410.89
202_L207_F0.6400.89
151_P155_A0.6390.89
98_L155_A0.6370.89
47_I51_T0.6340.89
152_V156_L0.6320.88
21_G27_R0.6320.88
111_T115_F0.6300.88
10_V13_L0.6290.88
17_D26_S0.6280.88
42_L46_L0.6280.88
75_V79_A0.6260.88
39_L79_A0.6250.88
226_I230_I0.6230.88
32_G49_G0.6200.88
26_S71_A0.6170.87
115_F119_R0.6170.87
133_E136_H0.6140.87
142_L146_L0.6100.87
220_L224_A0.6090.87
132_I135_L0.6090.87
56_Y70_A0.6070.86
3_Q39_L0.6060.86
57_L76_I0.6050.86
44_T85_G0.6000.86
76_I98_L0.6000.86
3_Q7_I0.5980.86
13_L17_D0.5980.86
22_Q30_V0.5930.85
214_A217_G0.5910.85
28_P31_A0.5880.85
102_G113_N0.5870.85
9_L149_A0.5850.84
193_L197_M0.5840.84
211_V215_Y0.5830.84
113_N116_F0.5820.84
83_L156_L0.5810.84
219_P225_I0.5790.84
140_P146_L0.5770.84
94_L97_P0.5740.83
151_P154_L0.5740.83
117_V121_D0.5730.83
119_R126_E0.5730.83
212_L218_L0.5730.83
14_A25_L0.5710.83
113_N144_G0.5710.83
56_Y96_V0.5690.83
208_L226_I0.5680.83
80_L98_L0.5680.83
80_L163_V0.5670.82
169_A176_N0.5660.82
89_E164_Q0.5640.82
26_S31_A0.5630.82
207_F211_V0.5630.82
150_I200_K0.5620.82
171_P174_L0.5610.82
120_A131_G0.5600.82
20_L55_I0.5580.81
69_D103_Q0.5580.81
132_I139_G0.5580.81
103_Q107_I0.5570.81
135_L138_L0.5540.81
178_L181_A0.5530.81
32_G52_L0.5530.81
65_A110_R0.5520.81
56_Y94_L0.5500.81
73_A100_L0.5460.80
148_R152_V0.5460.80
194_L198_L0.5450.80
99_A106_D0.5430.80
89_E168_N0.5420.80
22_Q61_P0.5410.79
39_L44_T0.5370.79
22_Q60_V0.5360.79
73_A180_V0.5360.79
124_A131_G0.5350.79
119_R134_R0.5340.79
48_I52_L0.5320.78
48_I163_V0.5300.78
17_D68_P0.5300.78
16_L22_Q0.5290.78
9_L55_I0.5270.78
21_G46_L0.5270.78
161_D168_N0.5260.78
217_G222_A0.5250.77
157_Y162_A0.5250.77
228_V231_A0.5200.77
12_G141_L0.5190.77
80_L178_L0.5190.77
153_F156_L0.5180.77
148_R155_A0.5160.76
157_Y166_L0.5160.76
68_P75_V0.5160.76
214_A222_A0.5140.76
19_L22_Q0.5140.76
32_G77_G0.5100.75
164_Q172_A0.5100.75
72_L152_V0.5080.75
38_I106_D0.5070.75
20_L23_F0.5070.75
135_L220_L0.5070.75
33_T45_G0.5070.75
127_G136_H0.5070.75
221_I225_I0.5040.75
192_M197_M0.5040.75
218_L229_A0.5040.75
146_L151_P0.5030.74
68_P188_V0.5030.74
64_G68_P0.5020.74
74_G77_G0.5020.74
17_D23_F0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1zP 8 0.7167 4 0.957 Contact Map
3qnqA 2 0.4764 2.5 0.962 Contact Map
2a9hA 4 0.3863 2.4 0.962 Contact Map
2vpbB 1 0.1502 2.4 0.962 Contact Map
3zpvB 2 0.1588 2.1 0.963 Contact Map
3tx3A 2 0.3734 1.7 0.965 Contact Map
4lz6A 1 0.7682 1.5 0.966 Contact Map
1jb0I 1 0.1631 1.5 0.966 Contact Map
4lh9A 4 0.1717 1.5 0.966 Contact Map
3o7qA 1 0.4206 1.4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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