GREMLIN Database
EII-GUT - PTS system enzyme II sorbitol-specific factor
PFAM: PF03608 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 167 (167)
Sequences: 585 (282)
Seq/√Len: 21.8
META: 0.624

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_V103_V5.0181.00
4_L7_G4.5081.00
69_F147_L4.0911.00
144_L148_V4.0811.00
14_A17_E3.4801.00
106_I113_A3.3491.00
16_G29_L3.2611.00
71_A83_F3.2131.00
118_L122_L3.0391.00
46_E50_E2.2440.96
3_K6_E2.1360.95
96_Y100_V2.0030.93
151_F155_I1.9670.92
18_T21_G1.9200.91
7_G11_L1.8210.89
20_V23_V1.8160.88
152_I156_V1.8010.88
160_I164_M1.7590.87
19_F23_V1.7500.86
51_R54_Q1.7270.86
19_F27_I1.7220.86
93_P161_T1.7060.85
128_I133_L1.7060.85
134_S137_D1.6950.85
22_L30_L1.6630.83
23_V27_I1.6330.82
99_A103_V1.6230.82
107_T122_L1.6110.81
22_L27_I1.5880.80
13_Q29_L1.5700.80
6_E134_S1.5180.77
80_A103_V1.5070.77
72_V80_A1.4660.75
41_I86_F1.4500.74
101_S153_R1.4490.74
65_T147_L1.4490.74
69_F143_F1.4340.73
107_T113_A1.4280.73
27_I31_I1.4070.72
88_P91_Y1.4000.71
53_A67_L1.3860.70
11_L19_F1.3690.69
16_G30_L1.3580.69
131_L134_S1.3510.68
2_V137_D1.3180.66
159_F162_A1.3120.66
109_L136_G1.3030.66
128_I131_L1.2930.65
77_N114_N1.2710.64
20_V24_T1.2660.63
40_L44_I1.2650.63
161_T165_M1.2550.63
22_L76_T1.2380.61
66_V69_F1.2340.61
10_G14_A1.2320.61
113_A121_W1.2270.61
80_A99_A1.2230.60
116_G120_V1.1970.59
17_E29_L1.1870.58
21_G25_G1.1780.58
52_L56_A1.1740.57
62_L66_V1.1690.57
102_F143_F1.1650.57
71_A95_F1.1550.56
40_L51_R1.1530.56
77_N81_Y1.1450.55
128_I138_L1.1320.54
155_I159_F1.1210.54
19_F31_I1.1140.53
51_R55_K1.1070.53
97_D105_P1.1040.53
102_F106_I1.0940.52
36_A40_L1.0820.51
1_L73_F1.0800.51
14_A18_T1.0520.49
121_W125_A1.0520.49
73_F112_H1.0480.49
94_A160_I1.0390.48
81_Y100_V1.0270.47
89_E92_K1.0190.47
66_V152_I1.0190.47
5_A73_F1.0080.46
36_A44_I1.0010.46
109_L143_F0.9830.44
21_G24_T0.9780.44
16_G32_V0.9540.42
52_L67_L0.9520.42
113_A143_F0.9520.42
16_G115_P0.9490.42
52_L62_L0.9480.42
9_I76_T0.9350.41
5_A112_H0.9350.41
164_M167_Q0.9320.41
121_W135_L0.9270.41
10_G13_Q0.9200.40
125_A129_T0.9040.39
30_L76_T0.9030.39
52_L55_K0.9030.39
17_E21_G0.9000.39
53_A59_N0.8890.38
56_A62_L0.8880.38
75_L83_F0.8810.38
63_R108_G0.8780.38
137_D141_R0.8770.37
126_A130_T0.8740.37
122_L126_A0.8720.37
51_R65_T0.8660.37
107_T118_L0.8600.36
49_V88_P0.8550.36
18_T26_I0.8500.36
94_A161_T0.8490.36
121_W136_G0.8470.36
61_I85_R0.8410.35
63_R91_Y0.8320.35
37_V164_M0.8280.34
42_A121_W0.8130.34
101_S150_I0.8120.33
1_L4_L0.8030.33
159_F163_Y0.8000.33
53_A83_F0.7960.33
143_F150_I0.7900.32
149_V153_R0.7810.32
10_G76_T0.7810.32
15_G108_G0.7760.31
50_E124_I0.7750.31
47_E162_A0.7740.31
101_S149_V0.7730.31
94_A158_E0.7720.31
97_D153_R0.7690.31
18_T43_L0.7680.31
81_Y101_S0.7670.31
126_A129_T0.7660.31
73_F106_I0.7650.31
64_Y84_G0.7630.31
134_S148_V0.7580.30
149_V152_I0.7480.30
55_K62_L0.7340.29
101_S105_P0.7310.29
128_I141_R0.7270.29
80_A115_P0.7250.28
74_F112_H0.7250.28
4_L11_L0.7230.28
97_D150_I0.7200.28
122_L125_A0.7180.28
6_E13_Q0.7100.28
21_G69_F0.7090.28
36_A167_Q0.7060.27
90_K162_A0.7040.27
13_Q17_E0.7020.27
54_Q65_T0.6990.27
97_D107_T0.6980.27
30_L128_I0.6980.27
97_D101_S0.6960.27
51_R129_T0.6910.27
12_F16_G0.6790.26
14_A24_T0.6790.26
39_A161_T0.6780.26
96_Y101_S0.6720.26
74_F128_I0.6700.26
38_N41_I0.6660.25
6_E128_I0.6650.25
136_G140_V0.6610.25
50_E54_Q0.6570.25
10_G29_L0.6560.25
96_Y99_A0.6530.25
61_I66_V0.6380.24
46_E54_Q0.6370.24
74_F109_L0.6370.24
138_L142_Y0.6350.24
2_V11_L0.6340.24
160_I163_Y0.6340.24
34_L58_K0.6270.23
79_M82_T0.6240.23
121_W165_M0.6160.23
121_W138_L0.6150.23
66_V165_M0.6150.23
141_R144_L0.6140.23
8_F12_F0.6130.23
116_G142_Y0.6130.23
17_E129_T0.6090.22
17_E140_V0.6090.22
32_V46_E0.6090.22
33_L79_M0.6090.22
11_L91_Y0.6070.22
32_V62_L0.6060.22
92_K104_H0.6040.22
72_V149_V0.6020.22
13_Q34_L0.6010.22
27_I52_L0.6010.22
51_R148_V0.5960.22
34_L107_T0.5950.22
155_I167_Q0.5950.22
95_F155_I0.5910.22
81_Y97_D0.5900.22
106_I121_W0.5890.22
16_G131_L0.5860.21
31_I144_L0.5860.21
72_V102_F0.5860.21
48_R164_M0.5850.21
34_L118_L0.5760.21
34_L159_F0.5760.21
37_V135_L0.5740.21
97_D100_V0.5740.21
30_L34_L0.5730.21
104_H142_Y0.5720.21
107_T115_P0.5690.21
2_V5_A0.5690.21
65_T69_F0.5650.20
101_S106_I0.5640.20
102_F113_A0.5630.20
13_Q148_V0.5620.20
76_T161_T0.5590.20
60_P155_I0.5590.20
35_T94_A0.5560.20
24_T27_I0.5550.20
37_V67_L0.5550.20
3_K7_G0.5520.20
27_I51_R0.5480.20
74_F136_G0.5460.20
46_E83_F0.5440.20
67_L95_F0.5430.20
2_V13_Q0.5430.20
32_V35_T0.5430.20
62_L141_R0.5420.19
2_V98_A0.5420.19
89_E93_P0.5370.19
44_I74_F0.5370.19
105_P153_R0.5360.19
122_L132_G0.5340.19
106_I149_V0.5310.19
48_R137_D0.5280.19
2_V66_V0.5270.19
10_G17_E0.5250.19
42_A161_T0.5250.19
2_V16_G0.5220.19
71_A100_V0.5220.19
1_L147_L0.5210.19
48_R156_V0.5190.19
76_T149_V0.5160.18
9_I13_Q0.5160.18
17_E148_V0.5160.18
4_L54_Q0.5130.18
17_E42_A0.5110.18
38_N52_L0.5090.18
90_K159_F0.5090.18
116_G126_A0.5080.18
12_F145_V0.5050.18
50_E58_K0.5020.18
6_E10_G0.5010.18
17_E130_T0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd6A 3 0.9102 19.8 0.962 Contact Map
3qnqA 2 0.7186 5.4 0.971 Contact Map
2kv5A 1 0.1677 4.6 0.972 Contact Map
3tx3A 2 0.5629 4.4 0.972 Contact Map
2nwlA 3 0.8443 3.6 0.973 Contact Map
2nrgA 1 0.4072 3.5 0.973 Contact Map
3l6tA 2 0.4371 2.8 0.974 Contact Map
3m91B 1 0.0299 2.6 0.975 Contact Map
2a65A 2 0.479 2.5 0.975 Contact Map
4hw9A 3 0.1796 2.5 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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