GREMLIN Database
Cad - Cadmium resistance transporter
PFAM: PF03596 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 192 (184)
Sequences: 2043 (1593)
Seq/√Len: 117.4
META: 0.671

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_I118_V4.5861.00
15_F104_V4.5801.00
37_A137_L4.1781.00
33_Y141_A4.1441.00
29_V144_C3.6911.00
175_L179_I3.5181.00
54_P57_W3.2621.00
54_P58_I3.2581.00
38_A106_I3.1761.00
36_F140_V2.8691.00
40_V137_L2.6451.00
33_Y140_V2.5741.00
51_L54_P2.4851.00
124_S132_I2.4381.00
71_I75_L2.2441.00
72_K76_R2.2171.00
113_N117_Y2.2151.00
47_A50_A2.1351.00
111_G115_G2.0361.00
149_W153_H2.0161.00
166_W170_F2.0041.00
180_L186_F1.9301.00
139_L142_V1.8931.00
13_T147_A1.8021.00
112_D136_F1.7481.00
4_T7_D1.6551.00
5_N8_D1.6401.00
36_F39_L1.6281.00
125_S128_E1.6251.00
67_I173_I1.6141.00
64_L68_A1.6001.00
175_L178_Y1.5921.00
5_N9_I1.5651.00
40_V133_L1.5621.00
39_L110_G1.5611.00
177_L181_V1.5351.00
129_L132_I1.4161.00
126_L130_L1.4121.00
49_G52_L1.3841.00
39_L106_I1.3831.00
174_G178_Y1.3621.00
8_D143_W1.3551.00
77_G80_D1.3411.00
46_G118_V1.3311.00
16_F29_V1.3261.00
26_R30_A1.3161.00
62_L143_W1.2851.00
180_L185_T1.2770.99
8_D108_N1.2670.99
32_Q36_F1.2610.99
115_G119_P1.2580.99
60_G183_S1.2550.99
108_N143_W1.2480.99
11_V15_F1.2480.99
9_I150_L1.2410.99
70_G173_I1.2400.99
27_H97_L1.2340.99
5_N108_N1.2300.99
55_E58_I1.2270.99
23_F27_H1.2010.99
134_A138_V1.2000.99
43_S115_G1.1900.99
78_R81_D1.1830.99
8_D16_F1.1800.99
148_Y152_R1.1740.99
154_P158_R1.1730.99
68_A72_K1.1680.99
125_S129_L1.1670.99
14_L18_Q1.1540.99
35_G105_T1.1400.99
113_N118_V1.1390.99
106_I114_I1.1240.99
8_D36_F1.1240.99
87_E90_S1.1190.99
9_I147_A1.1030.99
174_G177_L1.0950.98
105_T113_N1.0840.98
80_D86_D1.0820.98
8_D113_N1.0800.98
156_I172_L1.0760.98
8_D105_T1.0720.98
5_N36_F1.0710.98
44_L133_L1.0500.98
5_N32_Q1.0390.98
79_R87_E1.0330.98
2_A6_I1.0280.98
108_N112_D1.0270.98
63_G176_G1.0260.98
9_I13_T1.0170.97
8_D117_Y0.9990.97
5_N117_Y0.9850.97
63_G70_G0.9810.97
157_A172_L0.9780.97
15_F18_Q0.9760.97
99_L103_A0.9700.97
5_N139_L0.9680.97
48_L52_L0.9560.96
8_D32_Q0.9460.96
15_F101_V0.9420.96
36_F137_L0.9380.96
110_G113_N0.9360.96
131_V135_V0.9160.95
139_L143_W0.9130.95
141_A144_C0.9040.95
67_I71_I0.9020.95
50_A172_L0.8950.95
169_P172_L0.8930.95
75_L84_E0.8850.94
40_V140_V0.8820.94
54_P59_I0.8740.94
36_F108_N0.8720.94
77_G82_D0.8690.94
34_L99_L0.8490.93
158_R161_E0.8490.93
10_V13_T0.8380.93
48_L114_I0.8370.93
42_V106_I0.8370.93
100_T103_A0.8360.92
115_G154_P0.8340.92
8_D15_F0.8320.92
84_E89_L0.8280.92
133_L137_L0.8210.92
45_L161_E0.8190.92
13_T151_A0.8190.92
85_A88_E0.8050.91
33_Y168_V0.8020.91
123_T183_S0.8020.91
84_E88_E0.8010.91
77_G81_D0.8000.91
115_G118_V0.7990.91
37_A103_A0.7980.91
24_R27_H0.7980.91
171_V175_L0.7930.90
84_E87_E0.7910.90
127_A130_L0.7890.90
75_L78_R0.7830.90
42_V46_G0.7740.89
69_L111_G0.7660.89
82_D85_A0.7610.88
32_Q113_N0.7540.88
14_L17_A0.7510.88
177_L180_L0.7490.88
44_L121_F0.7400.87
50_A122_A0.7380.87
65_L73_A0.7340.87
97_L100_T0.7320.86
46_G50_A0.7300.86
30_A98_V0.7290.86
44_L129_L0.7290.86
50_A54_P0.7270.86
98_V170_F0.7260.86
105_T110_G0.7240.86
36_F117_Y0.7210.86
49_G55_E0.7170.85
60_G185_T0.7140.85
120_L132_I0.7090.85
67_I158_R0.7070.85
35_G110_G0.7010.84
170_F174_G0.6980.84
47_A129_L0.6960.84
17_A28_I0.6950.84
104_V142_V0.6890.83
122_A157_A0.6890.83
70_G121_F0.6830.82
79_R82_D0.6780.82
105_T117_Y0.6760.82
23_F26_R0.6730.82
42_V45_L0.6730.82
93_G97_L0.6730.82
10_V135_V0.6720.81
157_A160_L0.6720.81
29_V141_A0.6710.81
3_A18_Q0.6680.81
161_E164_G0.6650.81
32_Q139_L0.6580.80
67_I175_L0.6540.80
36_F143_W0.6530.80
131_V137_L0.6530.80
56_E184_G0.6520.79
8_D169_P0.6490.79
124_S155_A0.6490.79
81_D87_E0.6490.79
145_L163_Y0.6440.79
176_G179_I0.6420.78
35_G136_F0.6400.78
86_D89_L0.6350.78
43_S110_G0.6320.77
102_A147_A0.6260.77
68_A174_G0.6250.77
136_F139_L0.6240.76
151_A157_A0.6200.76
47_A51_L0.6150.75
65_L124_S0.6150.75
32_Q175_L0.6100.75
14_L156_I0.6080.75
121_F173_I0.6060.74
116_V182_E0.6040.74
25_R65_L0.6010.74
67_I98_V0.5990.73
122_A172_L0.5990.73
4_T8_D0.5950.73
51_L58_I0.5930.73
51_L57_W0.5920.73
9_I29_V0.5920.73
155_A159_V0.5900.72
47_A57_W0.5890.72
53_I57_W0.5870.72
11_V108_N0.5850.72
60_G120_L0.5840.72
111_G169_P0.5840.72
137_L149_W0.5830.71
42_V78_R0.5830.71
130_L134_A0.5770.71
67_I177_L0.5740.70
3_A36_F0.5740.70
17_A151_A0.5720.70
32_Q112_D0.5720.70
53_I78_R0.5710.70
82_D90_S0.5690.70
178_Y182_E0.5660.69
125_S132_I0.5650.69
31_G143_W0.5630.69
36_F40_V0.5630.69
135_V142_V0.5610.69
34_L167_L0.5600.68
34_L40_V0.5600.68
103_A108_N0.5580.68
40_V121_F0.5570.68
160_L172_L0.5540.68
117_Y175_L0.5500.67
53_I61_L0.5470.67
5_N11_V0.5470.67
123_T132_I0.5460.67
67_I180_L0.5450.66
26_R98_V0.5430.66
51_L59_I0.5400.66
138_V142_V0.5390.66
152_R161_E0.5390.66
144_C168_V0.5380.65
115_G129_L0.5370.65
6_I174_G0.5370.65
17_A157_A0.5370.65
57_W116_V0.5330.65
85_A131_V0.5320.65
117_Y144_C0.5300.64
124_S128_E0.5280.64
113_N139_L0.5280.64
62_L163_Y0.5270.64
91_S181_V0.5260.64
168_V172_L0.5240.63
11_V112_D0.5240.63
48_L54_P0.5240.63
153_H157_A0.5220.63
136_F168_V0.5200.63
27_H61_L0.5200.63
179_I183_S0.5200.63
81_D90_S0.5180.62
23_F28_I0.5180.62
48_L141_A0.5180.62
95_S98_V0.5150.62
74_L173_I0.5150.62
28_I157_A0.5130.62
155_A158_R0.5130.62
13_T160_L0.5120.62
70_G168_V0.5110.61
101_V140_V0.5100.61
68_A134_A0.5090.61
163_Y170_F0.5080.61
84_E95_S0.5070.61
75_L79_R0.5060.61
34_L84_E0.5040.60
33_Y36_F0.5030.60
25_R148_Y0.5020.60
46_G157_A0.5020.60
63_G160_L0.5010.60
81_D95_S0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gfpA 2 0.9479 32.6 0.937 Contact Map
4ikvA 1 0.5573 21.9 0.943 Contact Map
1pw4A 1 0.5625 20.8 0.943 Contact Map
3o7qA 1 0.9635 20.2 0.944 Contact Map
2wswA 3 0.401 15.1 0.947 Contact Map
3wdoA 1 0.5052 12.7 0.949 Contact Map
4xnjA 1 0.9688 10.9 0.95 Contact Map
2cfqA 1 0.9271 10.3 0.951 Contact Map
4ldsA 2 0.4531 6.4 0.955 Contact Map
4tphA 2 0.474 6.3 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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