GREMLIN Database
AzlC - AzlC protein
PFAM: PF03591 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 136 (136)
Sequences: 20568 (12744)
Seq/√Len: 1092.8
META: 0.824

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_S26_E3.7011.00
28_L127_L3.3991.00
92_L115_G3.3211.00
17_A27_A3.1021.00
29_L33_L2.4451.00
83_G87_L2.1791.00
36_A64_N2.1311.00
46_L51_A2.1221.00
24_P130_A2.0921.00
32_L123_V2.0251.00
119_Y123_V1.9671.00
31_S126_T1.9611.00
109_A113_G1.9461.00
73_S98_F1.8781.00
30_M43_A1.8671.00
85_R108_R1.8481.00
42_A63_V1.8331.00
82_P85_R1.7591.00
10_G125_G1.7371.00
36_A39_A1.6491.00
7_I125_G1.6331.00
53_L57_V1.5891.00
3_A117_L1.5551.00
91_F119_Y1.5511.00
30_M34_V1.5421.00
42_A59_T1.5051.00
132_L135_A1.4841.00
121_A125_G1.4801.00
81_L85_R1.4781.00
111_F115_G1.4391.00
39_A60_T1.4221.00
3_A121_A1.4111.00
6_Y94_T1.4111.00
13_F44_V1.4001.00
65_L68_L1.3731.00
83_G86_R1.3631.00
18_V130_A1.3601.00
28_L123_V1.3571.00
120_L124_L1.3161.00
45_G49_A1.3061.00
88_L119_Y1.2841.00
113_G117_L1.2691.00
27_A130_A1.2581.00
110_Y113_G1.2571.00
43_A47_L1.2441.00
32_L119_Y1.2381.00
35_F119_Y1.2091.00
127_L131_L1.2041.00
67_H96_E1.2041.00
28_L130_A1.2031.00
56_I60_T1.1871.00
52_P55_A1.1801.00
43_A60_T1.1741.00
92_L119_Y1.1631.00
46_L56_I1.1391.00
4_L8_P1.1341.00
13_F17_A1.1221.00
13_F41_F1.1161.00
89_L108_R1.0951.00
85_R89_L1.0931.00
28_L32_L1.0921.00
85_R112_L1.0641.00
116_L120_L1.0631.00
97_S114_A1.0531.00
84_W88_L1.0471.00
76_P79_R1.0361.00
6_Y118_L1.0221.00
98_F102_I1.0211.00
67_H70_Y1.0191.00
101_A111_F1.0061.00
97_S118_L1.0051.00
13_F126_T1.0021.00
81_L108_R0.9891.00
117_L121_A0.9881.00
24_P28_L0.9841.00
57_V60_T0.9821.00
97_S115_G0.9781.00
6_Y9_F0.9641.00
22_L26_E0.9631.00
100_L114_A0.9541.00
108_R112_L0.9501.00
84_W87_L0.9451.00
12_A16_L0.9421.00
124_L128_L0.9251.00
55_A59_T0.9191.00
100_L110_Y0.9051.00
110_Y114_A0.9011.00
11_L128_L0.8891.00
75_A79_R0.8881.00
94_T97_S0.8871.00
125_G128_L0.8851.00
20_A48_A0.8761.00
67_H93_L0.8691.00
45_G48_A0.8681.00
25_L29_L0.8601.00
128_L132_L0.8451.00
39_A64_N0.8451.00
89_L112_L0.8411.00
8_P12_A0.8391.00
24_P27_A0.8351.00
34_V60_T0.8241.00
46_L59_T0.8191.00
18_V23_S0.8061.00
101_A114_A0.8031.00
39_A43_A0.8031.00
113_G116_L0.8011.00
36_A63_V0.7991.00
124_L127_L0.7961.00
120_L123_V0.7891.00
44_V48_A0.7841.00
87_L90_A0.7821.00
20_A44_V0.7801.00
43_A56_I0.7771.00
115_G119_Y0.7751.00
77_Y107_D0.7741.00
13_F40_Q0.7731.00
93_L111_F0.7641.00
128_L131_L0.7631.00
35_F94_T0.7581.00
95_D122_W0.7551.00
74_L93_L0.7451.00
123_V127_L0.7421.00
71_S93_L0.7391.00
90_A93_L0.7381.00
73_S76_P0.7351.00
88_L92_L0.7251.00
51_A56_I0.7241.00
85_R109_A0.7221.00
70_Y98_F0.7201.00
36_A60_T0.7111.00
35_F92_L0.7081.00
51_A55_A0.7061.00
42_A45_G0.7061.00
12_A41_F0.7051.00
9_F12_A0.7051.00
82_P87_L0.7021.00
24_P131_L0.7021.00
7_I11_L0.7021.00
133_G136_I0.6981.00
37_G95_D0.6881.00
16_L44_V0.6831.00
8_P11_L0.6831.00
18_V24_P0.6751.00
40_Q126_T0.6731.00
86_R90_A0.6731.00
37_G122_W0.6711.00
127_L130_A0.6691.00
23_S27_A0.6671.00
31_S40_Q0.6621.00
3_A6_Y0.6571.00
24_P127_L0.6571.00
93_L98_F0.6571.00
49_A52_P0.6541.00
30_M44_V0.6531.00
104_R110_Y0.6501.00
35_F123_V0.6451.00
13_F30_M0.6411.00
118_L121_A0.6381.00
27_A126_T0.6381.00
94_T118_L0.6341.00
3_A7_I0.6321.00
2_I118_L0.6311.00
47_L56_I0.6311.00
2_I5_G0.6291.00
80_G84_W0.6261.00
117_L120_L0.6251.00
16_L20_A0.6221.00
131_L135_A0.6201.00
10_G122_W0.6201.00
25_L28_L0.6191.00
67_H95_D0.6161.00
2_I6_Y0.6061.00
54_L58_L0.6051.00
7_I128_L0.6021.00
55_A58_L0.5991.00
28_L126_T0.5981.00
41_F96_E0.5961.00
115_G118_L0.5911.00
121_A124_L0.5851.00
15_V18_V0.5821.00
89_L111_F0.5781.00
77_Y102_I0.5771.00
73_S102_I0.5721.00
61_L65_L0.5701.00
64_N67_H0.5611.00
74_L101_A0.5511.00
10_G95_D0.5471.00
16_L19_A0.5471.00
69_L72_A0.5461.00
9_F16_L0.5461.00
37_G96_E0.5441.00
105_R109_A0.5391.00
101_A110_Y0.5371.00
123_V126_T0.5371.00
6_Y96_E0.5351.00
98_F103_A0.5311.00
14_G27_A0.5161.00
11_L125_G0.5131.00
78_L101_A0.5121.00
109_A112_L0.5121.00
106_L109_A0.5081.00
13_F27_A0.5061.00
9_F37_G0.5011.00
34_V39_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eneA 2 0.625 3.5 0.935 Contact Map
4p6vB 1 0.875 0.9 0.954 Contact Map
2gagA 1 0.3382 0.8 0.954 Contact Map
3nq4A 6 0.3235 0.8 0.955 Contact Map
2i0fA 3 0.3382 0.8 0.955 Contact Map
1rh5B 1 0.3529 0.8 0.955 Contact Map
1q90M 1 0.1838 0.8 0.955 Contact Map
3pjzA 2 0.5735 0.7 0.956 Contact Map
1lnqA 6 0.3235 0.7 0.956 Contact Map
3wu2J 1 0.1765 0.7 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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