GREMLIN Database
Peptidase_C50 - Peptidase family C50
PFAM: PF03568 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 382 (379)
Sequences: 524 (413)
Seq/√Len: 21.2
META: 0.135

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
345_G372_G10.9011.00
274_Q278_E7.4041.00
262_Y290_G5.5081.00
265_N274_Q4.4401.00
48_E52_E4.3151.00
347_L357_G3.6901.00
265_N269_D3.6221.00
83_L87_L3.2781.00
72_W376_D3.0100.99
45_E82_R2.9990.99
289_K308_S2.8510.99
294_R300_E2.8350.99
281_F312_L2.8120.99
331_L334_C2.8110.99
345_G355_P2.7510.99
263_I311_F2.6620.99
315_G341_G2.5860.98
341_G344_S2.5750.98
208_H234_S2.5140.98
8_L95_L2.4850.98
301_F311_F2.4710.98
325_G361_N2.4430.97
236_M242_L2.2780.96
343_S378_T2.2570.96
20_L101_L2.1860.95
72_W76_R2.1740.95
277_F281_F2.1320.94
236_M241_F2.1300.94
254_V367_C2.1300.94
22_L30_R2.1240.94
76_R378_T2.1240.94
188_V225_L2.0650.93
375_W378_T2.0550.93
377_V381_D1.9770.92
237_P357_G1.9730.92
376_D381_D1.9560.91
274_Q371_V1.9560.91
51_E55_E1.9360.91
226_P305_L1.9230.90
95_L222_W1.9150.90
315_G344_S1.8810.89
53_S57_T1.8660.89
70_K367_C1.8520.89
377_V382_I1.8180.88
278_E282_E1.7770.86
235_R341_G1.7420.85
343_S376_D1.7350.85
235_R315_G1.7340.85
260_G301_F1.7280.85
32_A36_V1.7270.85
340_M371_V1.6920.84
90_I225_L1.6710.83
340_M382_I1.6480.82
373_N382_I1.6440.82
175_E354_E1.6320.81
376_D380_R1.6250.81
362_Y365_A1.6100.80
261_F304_A1.6090.80
208_H232_S1.6090.80
343_S362_Y1.6000.80
373_N381_D1.5990.80
374_L379_D1.5920.80
5_E22_L1.5850.79
379_D382_I1.5820.79
329_R380_R1.5820.79
223_E235_R1.5780.79
378_T382_I1.5740.79
222_W242_L1.5170.76
72_W343_S1.5160.76
37_F42_A1.5110.76
94_W351_G1.4900.75
328_I331_L1.4760.74
213_L334_C1.4710.74
225_L311_F1.4550.73
235_R344_S1.4530.73
272_S276_R1.4510.73
290_G293_G1.4480.73
208_H242_L1.4450.72
260_G288_W1.4360.72
326_R373_N1.4280.72
29_S32_A1.4030.70
302_E345_G1.3980.70
235_R296_P1.3850.69
215_K277_F1.3770.69
302_E372_G1.3650.68
99_K272_S1.3640.68
178_A181_E1.3620.68
343_S382_I1.3520.67
233_V313_Y1.3490.67
339_L342_C1.3480.67
305_L334_C1.3370.66
165_F170_L1.3230.66
277_F357_G1.3070.65
86_L161_D1.3050.64
375_W379_D1.3030.64
378_T381_D1.2960.64
350_N356_Y1.2950.64
375_W381_D1.2770.63
65_T337_T1.2730.62
22_L372_G1.2670.62
169_L172_F1.2640.62
136_A212_V1.2630.62
237_P366_G1.2610.62
170_L177_N1.2580.62
252_H257_R1.2520.61
290_G309_D1.2460.61
213_L218_Q1.2410.60
267_S322_Y1.2320.60
72_W363_L1.2310.60
99_K145_L1.2300.60
223_E315_G1.2160.59
138_K297_S1.2160.59
238_S322_Y1.2040.58
25_A28_N1.2000.58
319_G340_M1.1970.58
104_G208_H1.1800.57
38_T41_D1.1770.56
313_Y365_A1.1750.56
262_Y334_C1.1730.56
100_G265_N1.1720.56
12_R15_S1.1660.56
110_E255_D1.1610.55
26_R30_R1.1610.55
8_L212_V1.1540.55
161_D165_F1.1530.55
168_D181_E1.1500.55
193_D196_R1.1480.54
277_F290_G1.1430.54
363_L366_G1.1420.54
7_L25_A1.1410.54
340_M373_N1.1340.53
98_F208_H1.1330.53
302_E336_V1.1210.53
46_L219_M1.1070.52
234_S371_V1.1010.51
73_W288_W1.1010.51
102_L356_Y1.1000.51
70_K75_E1.0990.51
149_F166_V1.0980.51
76_R376_D1.0970.51
102_L231_Q1.0960.51
96_G222_W1.0940.51
21_R227_C1.0930.51
319_G362_Y1.0890.50
223_E341_G1.0840.50
316_H342_C1.0820.50
8_L101_L1.0810.50
171_Q181_E1.0790.50
313_Y319_G1.0700.49
269_D274_Q1.0680.49
97_G100_G1.0670.49
237_P347_L1.0670.49
313_Y321_Q1.0610.49
148_L152_L1.0590.48
19_V329_R1.0550.48
338_L347_L1.0530.48
130_R175_E1.0530.48
261_F373_N1.0500.48
237_P310_L1.0480.48
162_L259_S1.0480.48
164_Y168_D1.0410.47
9_S347_L1.0350.47
15_S147_E1.0320.47
261_F308_S1.0320.47
5_E21_R1.0320.47
168_D174_G1.0300.47
33_D108_D1.0220.46
359_P370_V1.0120.45
114_R333_R1.0120.45
27_H34_E1.0090.45
129_S177_N1.0060.45
268_G293_G1.0060.45
223_E344_S1.0050.45
149_F172_F1.0030.45
309_D368_P1.0000.45
22_L109_P0.9970.44
21_R354_E0.9970.44
79_L232_S0.9960.44
265_N270_L0.9960.44
94_W174_G0.9950.44
72_W366_G0.9950.44
72_W79_L0.9940.44
34_E380_R0.9920.44
11_L27_H0.9900.44
25_A30_R0.9900.44
168_D171_Q0.9880.44
345_G370_V0.9840.43
104_G231_Q0.9800.43
344_S378_T0.9790.43
313_Y341_G0.9790.43
91_E330_K0.9760.43
9_S30_R0.9730.43
315_G319_G0.9710.43
57_T320_A0.9680.42
222_W362_Y0.9670.42
223_E296_P0.9640.42
327_T330_K0.9570.42
296_P344_S0.9560.42
287_G311_F0.9540.42
95_L297_S0.9530.41
363_L381_D0.9500.41
84_K88_E0.9500.41
79_L281_F0.9490.41
374_L378_T0.9490.41
213_L372_G0.9480.41
109_P117_K0.9470.41
336_V369_A0.9470.41
214_D220_F0.9460.41
31_D60_A0.9440.41
325_G346_A0.9410.41
149_F163_L0.9390.41
189_V212_V0.9370.40
58_H311_F0.9320.40
66_K80_D0.9280.40
166_V178_A0.9240.40
263_I301_F0.9220.39
314_F340_M0.9210.39
161_D164_Y0.9170.39
170_L174_G0.9120.39
353_F357_G0.9090.39
322_Y351_G0.9090.39
354_E381_D0.9070.39
318_S330_K0.9060.38
226_P334_C0.9040.38
213_L362_Y0.9040.38
316_H344_S0.9020.38
213_L319_G0.9010.38
298_E324_R0.9000.38
229_R233_V0.8930.38
7_L12_R0.8920.38
212_V321_Q0.8910.38
76_R343_S0.8910.38
49_I83_L0.8900.37
343_S361_N0.8890.37
96_G262_Y0.8820.37
305_L331_L0.8800.37
30_R200_E0.8770.37
54_N98_F0.8750.37
220_F365_A0.8730.36
91_E99_K0.8710.36
215_K354_E0.8710.36
168_D177_N0.8670.36
51_E263_I0.8660.36
109_P365_A0.8650.36
228_L233_V0.8610.36
221_P366_G0.8590.36
108_D307_S0.8560.35
236_M367_C0.8530.35
243_R246_L0.8520.35
95_L189_V0.8510.35
116_R141_L0.8500.35
66_K247_L0.8500.35
30_R63_I0.8490.35
319_G344_S0.8450.35
297_S300_E0.8430.35
267_S314_F0.8410.34
141_L150_L0.8410.34
48_E203_S0.8400.34
38_T225_L0.8380.34
373_N380_R0.8380.34
7_L18_F0.8360.34
155_L158_E0.8350.34
162_L234_S0.8340.34
161_D168_D0.8310.34
72_W273_T0.8300.34
4_N32_A0.8270.34
236_M322_Y0.8250.33
335_A338_L0.8230.33
140_E353_F0.8220.33
191_L302_E0.8220.33
130_R179_Y0.8220.33
21_R100_G0.8210.33
61_K84_K0.8200.33
7_L27_H0.8140.33
296_P341_G0.8130.33
273_T314_F0.8130.33
92_N225_L0.8100.33
8_L12_R0.8060.32
357_G368_P0.8060.32
32_A262_Y0.8060.32
83_L86_L0.8050.32
67_E74_K0.8020.32
242_L353_F0.8000.32
210_I236_M0.8000.32
363_L373_N0.7980.32
71_A337_T0.7970.32
280_W367_C0.7960.32
6_L185_D0.7920.32
61_K272_S0.7920.32
69_K72_W0.7920.32
3_R250_R0.7870.31
335_A362_Y0.7830.31
318_S358_T0.7770.31
84_K104_G0.7760.31
309_D351_G0.7700.30
170_L175_E0.7700.30
73_W76_R0.7700.30
317_G328_I0.7680.30
90_I234_S0.7640.30
22_L26_R0.7630.30
13_A19_V0.7610.30
206_R279_P0.7590.30
236_M245_R0.7570.30
235_R319_G0.7550.29
251_G254_V0.7540.29
13_A30_R0.7540.29
314_F369_A0.7530.29
72_W320_A0.7510.29
33_D48_E0.7510.29
192_L210_I0.7470.29
5_E25_A0.7470.29
64_D68_A0.7450.29
83_L90_I0.7440.29
10_R220_F0.7440.29
159_L322_Y0.7430.29
86_L314_F0.7430.29
6_L32_A0.7430.29
252_H255_D0.7410.29
209_T362_Y0.7400.29
69_K73_W0.7400.29
45_E127_L0.7400.29
296_P315_G0.7350.28
259_S282_E0.7330.28
149_F323_I0.7320.28
217_L227_C0.7310.28
265_N340_M0.7300.28
345_G366_G0.7280.28
128_P170_L0.7280.28
311_F345_G0.7260.28
366_G377_V0.7250.28
221_P375_W0.7230.28
214_D218_Q0.7230.28
175_E179_Y0.7220.28
76_R377_V0.7190.27
224_S366_G0.7190.27
11_L212_V0.7150.27
276_R367_C0.7130.27
56_S129_S0.7120.27
216_E236_M0.7100.27
65_T132_K0.7090.27
97_G232_S0.7090.27
123_L310_L0.7090.27
313_Y316_H0.7060.27
288_W337_T0.7060.27
73_W235_R0.7060.27
293_G311_F0.7060.27
113_A145_L0.7020.27
33_D118_S0.7010.27
10_R34_E0.7000.26
191_L198_Y0.7000.26
102_L159_L0.6980.26
112_L250_R0.6980.26
270_L379_D0.6960.26
238_S354_E0.6960.26
76_R382_I0.6950.26
264_L334_C0.6930.26
8_L166_V0.6920.26
313_Y344_S0.6920.26
104_G209_T0.6920.26
160_E186_Q0.6900.26
233_V378_T0.6890.26
49_I279_P0.6890.26
28_N31_D0.6880.26
115_F298_E0.6880.26
33_D291_I0.6870.26
331_L336_V0.6860.26
296_P368_P0.6850.26
20_L68_A0.6810.26
112_L217_L0.6800.25
359_P366_G0.6790.25
245_R249_A0.6730.25
185_D193_D0.6710.25
82_R304_A0.6700.25
101_L226_P0.6700.25
82_R157_E0.6700.25
339_L344_S0.6700.25
148_L151_G0.6700.25
178_A183_D0.6680.25
239_L337_T0.6670.25
4_N36_V0.6660.25
81_R84_K0.6660.25
40_E47_D0.6650.25
227_C354_E0.6640.25
192_L338_L0.6640.25
356_Y359_P0.6640.25
32_A62_D0.6630.25
316_H341_G0.6620.25
149_F162_L0.6610.25
20_L157_E0.6600.24
261_F336_V0.6580.24
78_A282_E0.6550.24
268_G343_S0.6520.24
145_L225_L0.6490.24
90_I220_F0.6490.24
334_C345_G0.6480.24
273_T376_D0.6460.24
76_R91_E0.6460.24
167_L170_L0.6440.24
356_Y364_L0.6430.24
13_A18_F0.6420.24
204_A279_P0.6400.23
58_H67_E0.6400.23
9_S12_R0.6390.23
334_C365_A0.6390.23
210_I327_T0.6390.23
372_G380_R0.6390.23
281_F360_L0.6380.23
342_C374_L0.6370.23
102_L131_R0.6340.23
264_L273_T0.6330.23
164_Y177_N0.6310.23
213_L274_Q0.6290.23
253_G263_I0.6290.23
56_S267_S0.6280.23
158_E169_L0.6270.23
300_E334_C0.6270.23
83_L138_K0.6270.23
3_R40_E0.6240.23
312_L340_M0.6230.23
114_R228_L0.6220.23
265_N351_G0.6210.23
28_N36_V0.6200.23
344_S347_L0.6200.23
222_W321_Q0.6150.22
334_C366_G0.6150.22
341_G378_T0.6140.22
13_A22_L0.6130.22
99_K367_C0.6130.22
197_E259_S0.6110.22
200_E307_S0.6100.22
315_G342_C0.6090.22
222_W337_T0.6080.22
316_H339_L0.6080.22
237_P335_A0.6070.22
300_E330_K0.6070.22
29_S64_D0.6060.22
211_L229_R0.6020.22
347_L381_D0.6010.22
320_A348_T0.6000.22
31_D209_T0.5990.22
23_P305_L0.5990.22
256_P259_S0.5980.22
269_D322_Y0.5970.21
300_E312_L0.5960.21
119_L123_L0.5960.21
53_S325_G0.5950.21
128_P175_E0.5930.21
241_F318_S0.5910.21
69_K357_G0.5900.21
43_L133_K0.5890.21
299_E303_E0.5880.21
277_F376_D0.5860.21
267_S274_Q0.5860.21
215_K352_E0.5860.21
214_D344_S0.5840.21
143_D153_G0.5840.21
291_I294_R0.5830.21
358_T361_N0.5800.21
15_S25_A0.5770.21
339_L370_V0.5760.21
236_M272_S0.5760.21
228_L232_S0.5760.21
4_N12_R0.5760.21
46_L53_S0.5750.21
4_N7_L0.5750.21
265_N268_G0.5750.21
162_L301_F0.5750.21
167_L184_F0.5740.20
94_W98_F0.5720.20
105_H363_L0.5720.20
338_L357_G0.5720.20
318_S362_Y0.5710.20
161_D215_K0.5710.20
79_L314_F0.5700.20
5_E245_R0.5690.20
145_L220_F0.5680.20
150_L153_G0.5660.20
224_S330_K0.5660.20
132_K203_S0.5660.20
217_L374_L0.5640.20
266_P296_P0.5630.20
88_E135_K0.5620.20
54_N58_H0.5610.20
16_S301_F0.5610.20
8_L359_P0.5610.20
4_N27_H0.5600.20
47_D54_N0.5590.20
221_P377_V0.5550.20
364_L367_C0.5550.20
288_W344_S0.5550.20
76_R293_G0.5530.20
53_S69_K0.5510.19
115_F122_I0.5510.19
314_F328_I0.5500.19
60_A63_I0.5500.19
14_G289_K0.5500.19
76_R80_D0.5490.19
164_Y167_L0.5480.19
309_D353_F0.5480.19
235_R313_Y0.5450.19
19_V34_E0.5450.19
312_L367_C0.5450.19
234_S242_L0.5440.19
264_L314_F0.5440.19
8_L25_A0.5430.19
171_Q174_G0.5430.19
346_A372_G0.5430.19
322_Y328_I0.5430.19
90_I114_R0.5430.19
63_I102_L0.5430.19
172_F175_E0.5420.19
368_P374_L0.5410.19
264_L376_D0.5400.19
66_K250_R0.5400.19
49_I82_R0.5390.19
131_R363_L0.5390.19
354_E360_L0.5370.19
158_E167_L0.5360.19
330_K338_L0.5360.19
7_L52_E0.5350.19
4_N13_A0.5350.19
159_L167_L0.5330.19
265_N331_L0.5330.19
161_D167_L0.5330.19
234_S353_F0.5330.19
102_L289_K0.5320.19
360_L372_G0.5300.19
57_T381_D0.5290.19
48_E55_E0.5280.19
109_P205_S0.5280.19
164_Y174_G0.5250.18
4_N48_E0.5240.18
67_E311_F0.5240.18
166_V174_G0.5230.18
33_D36_V0.5230.18
217_L348_T0.5220.18
128_P177_N0.5210.18
302_E307_S0.5210.18
319_G341_G0.5200.18
165_F208_H0.5190.18
70_K212_V0.5190.18
69_K143_D0.5190.18
11_L36_V0.5180.18
342_C375_W0.5170.18
155_L192_L0.5160.18
149_F182_I0.5160.18
134_K282_E0.5150.18
197_E295_A0.5150.18
10_R212_V0.5140.18
160_E197_E0.5100.18
130_R170_L0.5100.18
211_L214_D0.5070.18
11_L17_P0.5070.18
281_F296_P0.5070.18
313_Y339_L0.5070.18
183_D195_L0.5060.18
235_R264_L0.5050.18
314_F372_G0.5050.18
368_P378_T0.5040.18
94_W322_Y0.5040.18
44_A133_K0.5030.18
22_L356_Y0.5030.18
88_E111_L0.5030.18
262_Y292_V0.5030.18
130_R177_N0.5020.18
364_L371_V0.5010.17
347_L373_N0.5010.17
236_M312_L0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uoaB 2 0.3403 46.5 0.967 Contact Map
3od5A 1 0.3089 32.7 0.969 Contact Map
1gpuA 2 0.288 30.3 0.97 Contact Map
4wijA 2 0.2487 30.3 0.97 Contact Map
3u61B 3 0.2932 21.3 0.972 Contact Map
1m72A 2 0.3351 20.3 0.972 Contact Map
3sirA 2 0.2827 19.5 0.973 Contact Map
2l2lB 1 0.0314 17.4 0.973 Contact Map
4jr2A 2 0.301 17.4 0.973 Contact Map
2ts1A 2 0.267 17.1 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0109 seconds.