GREMLIN Database
DUF1759 - Protein of unknown function (DUF1759)
PFAM: PF03564 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 148 (142)
Sequences: 4533 (3975)
Seq/√Len: 333.6
META: 0.678

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_W60_W3.5771.00
27_D57_E3.3651.00
20_H56_Y3.3421.00
2_S7_E2.6781.00
12_W64_K2.5891.00
4_D7_E2.5891.00
16_E21_D2.5871.00
138_E141_R2.4131.00
61_E65_E2.2601.00
27_D53_D2.2581.00
77_H105_H2.2381.00
66_R100_D2.1461.00
16_E60_W2.1231.00
82_L126_L2.0811.00
45_L62_L2.0561.00
91_D94_S2.0041.00
114_V121_P1.9991.00
2_S39_K1.9831.00
58_E61_E1.8821.00
8_W64_K1.8491.00
44_E47_K1.8101.00
79_K83_N1.7581.00
132_P135_T1.7451.00
57_E61_E1.6911.00
46_I59_A1.6461.00
42_A45_L1.6261.00
43_L47_K1.5941.00
6_L80_K1.5761.00
80_K105_H1.5751.00
38_L43_L1.5641.00
128_L136_R1.5491.00
31_L59_A1.5181.00
12_W16_E1.5061.00
77_H108_A1.4981.00
44_E97_K1.4871.00
49_L62_L1.4401.00
58_E110_E1.4351.00
79_K129_S1.4281.00
26_S29_E1.4231.00
8_W12_W1.3851.00
75_Q125_H1.3751.00
80_K101_T1.3601.00
16_E20_H1.3521.00
11_F37_S1.3451.00
41_E67_Y1.3451.00
20_H60_W1.3311.00
116_V119_W1.3071.00
102_L127_I1.3041.00
66_R96_R1.3011.00
64_K68_G1.2601.00
45_L67_Y1.2601.00
49_L58_E1.2421.00
7_E47_K1.2421.00
134_E137_R1.2341.00
38_L46_I1.2091.00
35_K43_L1.2061.00
28_V53_D1.1941.00
27_D30_K1.1911.00
10_S35_K1.1741.00
82_L125_H1.1571.00
6_L76_A1.1301.00
97_K101_T1.1211.00
84_L130_K1.1151.00
128_L139_W1.0941.00
42_A67_Y1.0891.00
84_L101_T1.0791.00
55_N58_E1.0741.00
41_E44_E1.0331.00
94_S97_K1.0241.00
69_N72_L0.9901.00
87_I94_S0.9661.00
49_L59_A0.9661.00
30_K56_Y0.9581.00
79_K125_H0.9321.00
83_N129_S0.9271.00
44_E101_T0.9251.00
18_L32_H0.9191.00
44_E104_S0.9141.00
74_I114_V0.9041.00
106_L123_L0.8991.00
56_Y59_A0.8991.00
19_I33_Y0.8911.00
25_L33_Y0.8891.00
20_H30_K0.8861.00
87_I98_L0.8811.00
124_V128_L0.8811.00
95_L131_L0.8791.00
61_E64_K0.8691.00
15_F19_I0.8681.00
16_E64_K0.8681.00
103_E107_R0.8551.00
85_P130_K0.8431.00
101_T104_S0.8431.00
15_F20_H0.8431.00
13_D53_D0.8411.00
115_P118_L0.8381.00
41_E93_S0.8151.00
35_K46_I0.8111.00
7_E10_S0.8031.00
5_P72_L0.7981.00
133_P137_R0.7971.00
78_L82_L0.7961.00
14_L29_E0.7891.00
22_N25_L0.7881.00
99_L102_L0.7851.00
99_L103_E0.7841.00
78_L122_L0.7781.00
41_E97_K0.7781.00
107_R110_E0.7721.00
11_F34_L0.7661.00
31_L51_L0.7611.00
9_P13_D0.7561.00
75_Q128_L0.7440.99
14_L35_K0.7430.99
122_L126_L0.7390.99
77_H80_K0.7370.99
56_Y60_W0.7360.99
87_I132_P0.7330.99
88_K98_L0.7290.99
45_L100_D0.7280.99
71_R74_I0.7270.99
73_I77_H0.7250.99
27_D54_E0.7250.99
41_E96_R0.7190.99
58_E107_R0.7180.99
43_L46_I0.7170.99
11_F15_F0.7160.99
17_S29_E0.7140.99
124_V139_W0.7050.99
28_V51_L0.7050.99
9_P73_I0.6970.99
96_R100_D0.6950.99
62_L103_E0.6950.99
71_R140_E0.6940.99
14_L32_H0.6910.99
105_H108_A0.6890.99
60_W64_K0.6830.99
121_P124_V0.6760.99
51_L55_N0.6730.99
55_N59_A0.6670.99
5_P9_P0.6670.99
8_W11_F0.6550.99
48_G104_S0.6520.99
15_F34_L0.6440.98
136_R140_E0.6390.98
74_I121_P0.6360.98
115_P119_W0.6310.98
9_P12_W0.6300.98
8_W60_W0.6290.98
89_K94_S0.6260.98
90_E137_R0.6230.98
130_K139_W0.6230.98
39_K43_L0.6160.98
98_L130_K0.6160.98
8_W63_L0.6150.98
82_L129_S0.6140.98
129_S136_R0.6080.98
32_H37_S0.6080.98
70_K113_G0.6050.98
23_P26_S0.6030.98
35_K51_L0.6030.98
85_P97_K0.6030.98
109_L117_D0.6030.98
84_L102_L0.6010.98
78_L125_H0.5990.98
98_L131_L0.5930.97
81_L105_H0.5920.97
32_H51_L0.5890.97
76_A80_K0.5890.97
110_E115_P0.5890.97
13_D17_S0.5890.97
78_L109_L0.5810.97
84_L98_L0.5780.97
73_I76_A0.5750.97
33_Y36_S0.5750.97
133_P136_R0.5750.97
98_L102_L0.5740.97
134_E141_R0.5730.97
98_L127_I0.5730.97
10_S47_K0.5710.97
84_L127_I0.5690.97
90_E134_E0.5670.97
124_V136_R0.5660.97
95_L135_T0.5630.96
80_K104_S0.5560.96
21_D24_S0.5550.96
26_S53_D0.5530.96
33_Y37_S0.5510.96
15_F31_L0.5510.96
75_Q78_L0.5470.96
25_L30_K0.5470.96
89_K133_P0.5450.96
8_W18_L0.5450.96
44_E100_D0.5410.96
87_I90_E0.5400.96
131_L139_W0.5360.95
14_L18_L0.5350.95
35_K38_L0.5350.95
1_F67_Y0.5330.95
52_T55_N0.5330.95
17_S33_Y0.5290.95
93_S97_K0.5260.95
137_R140_E0.5220.95
135_T140_E0.5210.95
5_P68_G0.5160.94
45_L48_G0.5160.94
11_F55_N0.5150.94
73_I111_A0.5110.94
21_D30_K0.5080.94
106_L110_E0.5050.94
115_P121_P0.5010.93
28_V31_L0.5010.93
20_H23_P0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m7cA 2 0.8243 16.5 0.904 Contact Map
3bqoA 2 0.8581 15 0.907 Contact Map
1txdA 1 0.8311 14.9 0.907 Contact Map
1rcdA 6 0.8378 12.1 0.91 Contact Map
1vlgA 6 0.8243 11.5 0.911 Contact Map
3sylA 2 0.7095 9.4 0.915 Contact Map
4fkeA 1 0.9527 8.3 0.917 Contact Map
2v2pA 6 0.8311 8 0.917 Contact Map
1f75A 2 0.2905 8 0.917 Contact Map
4q9mA 2 0.2973 7.7 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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