GREMLIN Database
UPF0126 - UPF0126 domain
PFAM: PF03458 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (71)
Sequences: 33689 (15644)
Seq/√Len: 1856.6
META: 0.856

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_L26_G2.9141.00
40_T54_L2.8071.00
16_A27_A2.3071.00
17_L21_R2.2861.00
9_A66_G2.0441.00
5_A8_L1.8531.00
63_A67_A1.8271.00
47_G50_V1.7991.00
50_V55_R1.7871.00
23_D26_G1.7011.00
14_S17_L1.5991.00
52_V55_R1.5491.00
24_L71_F1.4911.00
28_V68_L1.4871.00
7_G11_F1.4811.00
18_K21_R1.4351.00
6_L10_A1.4201.00
12_A63_A1.4201.00
12_A67_A1.3891.00
33_V37_G1.3891.00
26_G30_L1.3811.00
12_A16_A1.3691.00
20_L27_A1.3431.00
40_T53_V1.3281.00
52_V56_R1.3051.00
15_G19_A1.2761.00
16_A31_G1.2681.00
58_L61_T1.2511.00
61_T65_A1.2321.00
51_P54_L1.2181.00
44_V47_G1.2141.00
64_L68_L1.2071.00
62_A66_G1.1741.00
32_V36_V1.1181.00
9_A13_V1.1091.00
68_L72_L1.1051.00
15_G34_T1.0971.00
10_A14_S1.0821.00
28_V67_A1.0681.00
4_D11_F1.0671.00
28_V64_L1.0411.00
17_L70_V1.0331.00
16_A70_V1.0271.00
19_A22_L1.0221.00
13_V70_V1.0181.00
19_A27_A0.9991.00
11_F14_S0.9491.00
27_A71_F0.9441.00
31_G67_A0.9161.00
36_V63_A0.9021.00
37_G41_L0.9011.00
16_A67_A0.8981.00
53_V56_R0.8951.00
32_V60_A0.8481.00
28_V32_V0.8331.00
67_A71_F0.8251.00
50_V54_L0.8201.00
48_R51_P0.8171.00
50_V56_R0.8121.00
19_A30_L0.8081.00
58_L62_A0.7871.00
11_F35_A0.7401.00
5_A58_L0.7281.00
47_G51_P0.7261.00
14_S18_K0.7151.00
41_L45_L0.7151.00
30_L33_V0.7091.00
54_L57_D0.7001.00
59_Y62_A0.6991.00
65_A68_L0.6981.00
14_S34_T0.6961.00
70_V73_L0.6851.00
28_V71_F0.6731.00
32_V63_A0.6671.00
52_V57_D0.6661.00
66_G70_V0.6351.00
24_L28_V0.6341.00
25_F29_V0.6211.00
48_R53_V0.5921.00
18_K30_L0.5891.00
41_L44_V0.5851.00
30_L34_T0.5841.00
65_A69_V0.5661.00
60_A70_V0.5621.00
14_S30_L0.5611.00
5_A62_A0.5531.00
6_L9_A0.5491.00
8_L11_F0.5451.00
47_G52_V0.5451.00
8_L63_A0.5331.00
40_T44_V0.5281.00
5_A9_A0.5261.00
59_Y63_A0.5251.00
4_D59_Y0.5251.00
2_V5_A0.5251.00
40_T52_V0.5231.00
62_A65_A0.5211.00
16_A19_A0.5151.00
11_F18_K0.5111.00
22_L25_F0.5101.00
19_A26_G0.5101.00
16_A20_L0.5081.00
48_R55_R0.5031.00
20_L71_F0.5021.00
26_G29_V0.5011.00
4_D8_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wbyA 1 0.7067 4.9 0.87 Contact Map
1miwA 2 0.68 4.9 0.87 Contact Map
3wfpA 2 0.7333 3.4 0.879 Contact Map
3orgA 2 0.8 3.2 0.881 Contact Map
4x4wA 2 0.6933 2.7 0.885 Contact Map
3aqlA 2 0.6533 2.4 0.888 Contact Map
3rceA 1 0.9867 2.3 0.889 Contact Map
3h38A 1 0.84 2 0.893 Contact Map
3wfsC 1 0.7333 2 0.893 Contact Map
3wfrE 1 0.7333 1.9 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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