GREMLIN Database
Peptidase_S77 - Prohead core protein serine protease
PFAM: PF03420 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 185 (148)
Sequences: 4922 (2117)
Seq/√Len: 174.0
META: 0.988

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_E103_N2.8631.00
138_G156_F2.6601.00
54_K58_E2.5041.00
75_L130_V2.4731.00
170_A173_A2.4581.00
122_V164_I2.3981.00
36_E108_K2.3581.00
120_K123_K2.3021.00
60_E63_R2.1501.00
100_W105_V2.1141.00
143_K153_Q2.0811.00
45_K49_G1.9631.00
45_K149_V1.9591.00
58_E100_W1.9561.00
42_A54_K1.9481.00
54_K103_N1.8731.00
113_D128_S1.8631.00
125_L130_V1.8551.00
97_E108_K1.8461.00
54_K100_W1.7601.00
71_E131_K1.7411.00
32_N110_K1.7081.00
141_S155_D1.6731.00
40_Q136_S1.6671.00
41_Q104_N1.6611.00
66_K70_K1.6601.00
94_M110_K1.6301.00
111_I122_V1.6291.00
89_D116_M1.6201.00
94_M130_V1.6041.00
43_E54_K1.6011.00
42_A57_L1.5461.00
145_S151_E1.5441.00
44_V171_P1.5261.00
144_E150_N1.5241.00
88_L166_A1.5231.00
38_I41_Q1.5121.00
34_Y108_K1.4981.00
65_N69_I1.4881.00
45_K51_V1.4831.00
99_W106_I1.4781.00
72_N96_T1.4691.00
41_Q44_V1.4521.00
115_P121_I1.4401.00
72_N94_M1.4051.00
113_D123_K1.3881.00
39_F109_A1.3751.00
63_R67_E1.3511.00
123_K127_E1.3271.00
33_L127_E1.3211.00
124_S127_E1.3201.00
113_D120_K1.3191.00
58_E62_K1.3181.00
109_A164_I1.3121.00
101_D104_N1.2931.00
65_N68_F1.2881.00
79_D87_N1.2551.00
41_Q172_G1.2301.00
96_T110_K1.2261.00
144_E147_G1.2221.00
67_E71_E1.2161.00
64_Y74_A1.2021.00
39_F107_G1.1951.00
53_P56_I1.1771.00
75_L91_V1.1731.00
142_L150_N1.1721.00
78_L122_V1.1611.00
65_N70_K1.1551.00
62_K66_K1.1401.00
64_Y161_A1.1301.00
76_G93_H1.1071.00
112_L128_S1.1021.00
61_V105_V1.1011.00
59_R154_D1.0961.00
38_I104_N1.0821.00
77_E90_R1.0771.00
124_S128_S1.0761.00
141_S153_Q1.0741.00
39_F95_I1.0501.00
65_N97_E1.0450.99
55_E58_E1.0190.99
90_R116_M1.0190.99
96_T108_K1.0010.99
72_N129_G0.9930.99
39_F98_L0.9820.99
46_N169_S0.9800.99
59_R62_K0.9420.99
134_V164_I0.9370.99
110_K128_S0.9330.99
145_S149_V0.9320.99
47_R167_D0.9250.99
40_Q105_V0.9220.99
113_D124_S0.9150.99
40_Q57_L0.9130.99
51_V151_E0.9050.99
61_V98_L0.8950.98
69_I74_A0.8920.98
39_F134_V0.8890.98
35_I109_A0.8890.98
112_L130_V0.8770.98
54_K105_V0.8760.98
44_V172_G0.8740.98
84_P139_M0.8650.98
53_P151_E0.8520.98
88_L132_L0.8500.98
143_K151_E0.8470.98
70_K97_E0.8380.98
42_A100_W0.8350.98
33_L123_K0.8330.97
41_Q170_A0.8120.97
75_L125_L0.8080.97
66_K69_I0.8060.97
35_I164_I0.8050.97
36_E99_W0.8030.97
26_D31_K0.8020.97
131_K176_N0.7970.97
81_P137_R0.7970.97
136_S162_F0.7900.97
120_K124_S0.7750.96
88_L91_V0.7740.96
75_L94_M0.7740.96
33_L126_L0.7730.96
59_R63_R0.7600.96
134_V162_F0.7570.96
40_Q162_F0.7510.95
77_E81_P0.7500.95
72_N110_K0.7470.95
40_Q170_A0.7440.95
57_L105_V0.7300.95
35_I126_L0.7260.94
43_E53_P0.7200.94
38_I106_I0.7190.94
99_W108_K0.7110.94
25_K30_K0.7090.94
83_G87_N0.7080.94
63_R157_E0.7070.94
92_S164_I0.7020.93
113_D127_E0.6940.93
66_K71_E0.6910.93
134_V175_V0.6830.93
43_E55_E0.6800.92
44_V103_N0.6790.92
114_T121_I0.6730.92
114_T128_S0.6690.92
26_D30_K0.6660.92
151_E154_D0.6580.91
25_K31_K0.6570.91
101_D106_I0.6560.91
68_F73_R0.6510.91
112_L124_S0.6500.91
77_E87_N0.6490.90
41_Q171_P0.6490.90
114_T120_K0.6490.90
49_G149_V0.6420.90
33_L111_I0.6360.90
104_N172_G0.6360.90
116_M121_I0.6340.89
116_M124_S0.6340.89
74_A161_A0.6320.89
94_M112_L0.6260.89
56_I60_E0.6240.89
162_F175_V0.6210.88
34_Y96_T0.6200.88
68_F71_E0.6200.88
114_T123_K0.6190.88
56_I59_R0.6170.88
150_N153_Q0.6140.88
111_I164_I0.6120.88
58_E105_V0.6100.88
97_E101_D0.6040.87
47_R171_P0.6020.87
62_K65_N0.6020.87
174_F177_G0.6010.87
86_I161_A0.5980.87
36_E97_E0.5920.86
34_Y110_K0.5910.86
95_I109_A0.5890.86
40_Q61_V0.5880.86
121_I124_S0.5840.85
115_P124_S0.5830.85
132_L164_I0.5790.85
95_I161_A0.5770.85
59_R155_D0.5690.84
109_A132_L0.5690.84
30_K127_E0.5690.84
24_G31_K0.5680.84
72_N131_K0.5610.83
63_R66_K0.5590.83
73_R131_K0.5580.83
55_E154_D0.5540.82
64_Y69_I0.5510.82
120_K128_S0.5510.82
78_L121_I0.5490.82
57_L100_W0.5490.82
91_V166_A0.5480.81
79_D88_L0.5470.81
121_I125_L0.5460.81
126_L132_L0.5450.81
58_E61_V0.5450.81
95_I162_F0.5440.81
37_G175_V0.5430.81
164_I175_V0.5420.81
133_G169_S0.5410.81
83_G89_D0.5380.80
51_V149_V0.5370.80
93_H164_I0.5370.80
73_R167_D0.5310.79
46_N50_R0.5260.79
24_G32_N0.5200.78
95_I134_V0.5170.78
42_A105_V0.5160.77
61_V136_S0.5160.77
56_I154_D0.5150.77
136_S170_A0.5150.77
116_M122_V0.5130.77
122_V132_L0.5110.77
24_G30_K0.5100.77
109_A134_V0.5080.76
134_V170_A0.5060.76
92_S122_V0.5030.76
162_F170_A0.5010.75
114_T124_S0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v2hA 4 0.427 5.2 0.96 Contact Map
2ek0A 3 0.4162 3.3 0.964 Contact Map
4bnwA 4 0.5027 3.3 0.964 Contact Map
3kojA 3 0.2486 3.1 0.964 Contact Map
1qx2A 2 0.373 2.8 0.965 Contact Map
3h38A 1 0.3189 2.7 0.966 Contact Map
4c31C 2 0.0811 2.5 0.966 Contact Map
2mhhA 1 0.5081 2.5 0.966 Contact Map
1wwhA 3 0.3243 2.4 0.966 Contact Map
2ns1B 3 0.4216 2.1 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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