GREMLIN Database
CDC50 - LEM3 (ligand-effect modulator 3) family / CDC50 family
PFAM: PF03381 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 260 (254)
Sequences: 1297 (933)
Seq/√Len: 58.5
META: 0.221

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_K166_D5.7191.00
46_T212_T4.5981.00
166_D184_G4.2991.00
37_G190_D3.8741.00
34_D192_P3.4151.00
129_A134_K3.1451.00
198_V215_I3.1011.00
11_V44_Q2.8121.00
28_T197_T2.7921.00
133_D172_R2.4601.00
42_Y182_L2.4281.00
60_D69_V2.4071.00
34_D193_A2.3901.00
45_L48_F2.3791.00
31_I35_M2.3211.00
123_L184_G2.3011.00
206_V209_F2.2831.00
45_L204_Y2.2161.00
48_F204_Y2.2091.00
55_Y98_I2.1601.00
128_I165_E2.1561.00
12_I29_F2.1511.00
26_T199_T2.1231.00
166_D183_Y2.0921.00
30_T195_T2.0671.00
160_N163_E2.0061.00
41_V107_F1.9701.00
40_Y185_R1.9671.00
250_I254_I1.9511.00
149_W196_Y1.9411.00
126_K165_E1.9381.00
110_S191_L1.9361.00
124_N127_G1.9051.00
229_F234_Y1.9011.00
127_G165_E1.8991.00
26_T197_T1.8881.00
62_D67_K1.8811.00
50_Q174_A1.7920.99
8_V33_E1.7360.99
104_N203_N1.7350.99
249_L253_L1.7310.99
138_F168_I1.7060.99
13_D212_T1.7020.99
140_N162_S1.6920.99
56_V173_T1.6920.99
80_L97_L1.6860.99
232_I236_V1.6770.99
174_A179_F1.6750.99
35_M39_V1.6710.99
107_F183_Y1.6670.99
8_V35_M1.6520.99
77_C95_C1.6520.99
12_I27_I1.6230.99
106_T205_P1.6000.99
2_Y6_S1.5490.98
129_A165_E1.5340.98
84_G89_G1.5230.98
13_D17_C1.5070.98
204_Y209_F1.5020.98
3_A6_S1.4980.98
49_Y177_P1.4910.98
24_T201_T1.4910.98
41_V184_G1.4810.98
51_N55_Y1.4800.98
18_C202_N1.4540.97
104_N205_P1.4480.97
134_K168_I1.4450.97
80_L100_N1.4450.97
36_K190_D1.3960.97
112_L115_N1.3910.97
44_Q216_V1.3730.96
41_V198_V1.3710.96
55_Y101_S1.3680.96
130_W172_R1.3650.96
71_A91_P1.3460.96
35_M219_T1.3450.96
44_Q180_R1.3310.96
152_R155_Y1.3270.96
124_N187_D1.3160.95
102_L164_N1.3130.95
126_K185_R1.2970.95
93_Y162_S1.2960.95
10_I31_I1.2740.95
78_D81_A1.2720.94
206_V211_G1.2610.94
107_F198_V1.2540.94
92_I184_G1.2480.94
161_L164_N1.2300.93
30_T193_A1.2190.93
152_R164_N1.2110.93
83_N92_I1.2080.93
125_K184_G1.2040.93
140_N161_L1.1990.93
38_P186_I1.1960.92
69_V73_D1.1960.92
128_I169_V1.1940.92
47_N179_F1.1900.92
41_V123_L1.1840.92
92_I162_S1.1730.92
34_D190_D1.1690.92
23_C202_N1.1660.91
167_F171_M1.1550.91
50_Q216_V1.1540.91
24_T199_T1.1460.91
58_S79_P1.1330.90
162_S167_F1.1330.90
102_L167_F1.1320.90
46_T178_T1.1270.90
232_I239_G1.1130.89
230_L234_Y1.1040.89
29_F194_G1.1010.89
241_C248_F1.0730.88
169_V172_R1.0690.87
9_E180_R1.0580.87
237_V248_F1.0510.87
10_I29_F1.0270.85
113_N116_S1.0270.85
68_A141_P1.0240.85
56_V98_I1.0220.85
108_S199_T1.0160.85
129_A133_D1.0070.84
229_F233_A1.0060.84
13_D16_D1.0000.84
124_N184_G0.9770.82
123_L183_Y0.9700.82
50_Q55_Y0.9690.82
151_K157_E0.9680.82
2_Y5_N0.9680.82
141_P164_N0.9610.81
191_L196_Y0.9580.81
53_R227_N0.9490.80
127_G134_K0.9460.80
218_S225_G0.9430.80
117_G120_N0.9400.80
132_S137_K0.9390.80
235_I239_G0.9290.79
143_T158_I0.9290.79
141_P161_L0.9280.79
83_N89_G0.9260.79
251_I255_K0.9240.79
27_I200_I0.9200.78
71_A74_L0.9130.78
133_D169_V0.9110.78
165_E185_R0.9100.77
44_Q178_T0.9070.77
134_K165_E0.9030.77
11_V214_S0.9010.77
144_V217_L0.8990.77
67_K139_K0.8930.76
70_S73_D0.8910.76
178_T223_L0.8890.76
134_K163_E0.8870.76
82_T89_G0.8860.76
10_I217_L0.8840.75
131_K135_E0.8780.75
139_K163_E0.8730.74
176_L206_V0.8690.74
124_N166_D0.8680.74
46_T214_S0.8660.74
40_Y221_S0.8630.74
100_N146_P0.8620.74
237_V241_C0.8610.73
12_I15_T0.8560.73
92_I100_N0.8540.73
39_V217_L0.8530.73
180_R216_V0.8530.73
31_I191_L0.8520.73
174_A219_T0.8410.72
41_V217_L0.8360.71
137_K216_V0.8350.71
102_L162_S0.8330.71
4_S231_G0.8320.71
105_D213_K0.8290.71
180_R221_S0.8220.70
12_I17_C0.8170.69
127_G185_R0.8130.69
5_N228_P0.8060.68
15_T212_T0.8050.68
140_N160_N0.8020.68
114_N117_G0.7980.68
13_D214_S0.7920.67
99_A103_F0.7830.66
47_N210_G0.7830.66
29_F196_Y0.7800.66
131_K134_K0.7800.66
60_D74_L0.7790.66
3_A222_W0.7730.65
145_P152_R0.7710.65
172_R182_L0.7680.65
54_R173_T0.7660.64
216_V243_L0.7640.64
231_G235_I0.7630.64
39_V219_T0.7630.64
6_S210_G0.7630.64
67_K70_S0.7570.64
100_N161_L0.7540.63
54_R79_P0.7530.63
34_D200_I0.7510.63
228_P252_H0.7460.62
240_L244_L0.7420.62
66_G69_V0.7380.62
174_A237_V0.7330.61
50_Q204_Y0.7330.61
70_S210_G0.7250.60
140_N163_E0.7240.60
102_L166_D0.7210.60
92_I146_P0.7110.59
99_A171_M0.7080.58
169_V237_V0.7080.58
249_L258_K0.7070.58
41_V109_L0.7050.58
84_G90_K0.7050.58
64_L171_M0.7050.58
141_P162_S0.7040.58
236_V240_L0.7000.58
69_V91_P0.7000.58
184_G198_V0.6980.57
52_H56_V0.6980.57
180_R204_Y0.6940.57
226_K229_F0.6930.57
116_S119_K0.6910.57
58_S211_G0.6850.56
186_I190_D0.6840.56
35_M217_L0.6830.56
54_R225_G0.6800.55
50_Q58_S0.6760.55
202_N205_P0.6730.55
92_I148_N0.6690.54
122_P189_D0.6690.54
16_D200_I0.6670.54
53_R224_G0.6580.53
63_Q77_C0.6540.52
55_Y176_L0.6510.52
98_I101_S0.6490.52
10_I32_P0.6490.52
49_Y52_H0.6480.52
102_L125_K0.6460.52
145_P149_W0.6450.51
29_F155_Y0.6450.51
82_T92_I0.6440.51
43_Y103_F0.6440.51
50_Q181_K0.6380.51
59_R173_T0.6380.51
26_T72_S0.6380.51
224_G227_N0.6380.51
139_K207_T0.6370.51
130_W171_M0.6350.50
173_T244_L0.6340.50
50_Q172_R0.6340.50
5_N246_I0.6340.50
128_I133_D0.6330.50
232_I235_I0.6310.50
172_R245_G0.6310.50
106_T147_P0.6290.50
110_S113_N0.6270.49
121_V186_I0.6240.49
129_A168_I0.6210.49
133_D181_K0.6170.48
100_N149_W0.6160.48
10_I89_G0.6160.48
51_N101_S0.6140.48
137_K176_L0.6130.48
4_S9_E0.6120.48
11_V33_E0.6110.48
4_S226_K0.6110.48
41_V215_I0.6100.48
164_N168_I0.6080.47
164_N203_N0.6070.47
251_I254_I0.6070.47
125_K164_N0.6050.47
36_K39_V0.6040.47
30_T84_G0.6030.47
54_R58_S0.6020.47
64_L167_F0.5980.46
68_A102_L0.5970.46
96_G170_W0.5950.46
48_F123_L0.5930.46
111_Y114_N0.5920.46
249_L252_H0.5910.45
134_K160_N0.5890.45
101_S219_T0.5880.45
65_R173_T0.5880.45
250_I258_K0.5870.45
174_A209_F0.5860.45
60_D129_A0.5840.45
239_G243_L0.5840.45
130_W176_L0.5830.45
25_C171_M0.5810.44
38_P190_D0.5800.44
150_Q203_N0.5800.44
139_K240_L0.5790.44
148_N248_F0.5780.44
82_T246_I0.5780.44
76_D81_A0.5770.44
130_W137_K0.5760.44
16_D212_T0.5750.44
93_Y145_P0.5740.44
127_G194_G0.5700.43
53_R234_Y0.5690.43
110_S120_N0.5690.43
186_I189_D0.5680.43
42_Y172_R0.5640.43
79_P211_G0.5640.43
44_Q214_S0.5640.43
16_D20_S0.5630.42
42_Y234_Y0.5600.42
54_R172_R0.5600.42
101_S209_F0.5600.42
7_V218_S0.5600.42
130_W174_A0.5590.42
15_T44_Q0.5580.42
61_D138_F0.5580.42
4_S228_P0.5560.42
39_V125_K0.5560.42
205_P222_W0.5550.42
55_Y133_D0.5540.41
62_D69_V0.5530.41
16_D167_F0.5520.41
250_I256_P0.5500.41
206_V213_K0.5500.41
54_R234_Y0.5500.41
34_D235_I0.5490.41
165_E169_V0.5490.41
61_D137_K0.5480.41
92_I144_V0.5460.41
182_L225_G0.5450.40
180_R208_S0.5440.40
18_C187_D0.5440.40
137_K174_A0.5410.40
134_K185_R0.5400.40
18_C23_C0.5400.40
141_P209_F0.5390.40
39_V122_P0.5380.40
12_I210_G0.5370.40
201_T204_Y0.5360.40
79_P103_F0.5350.39
114_N191_L0.5340.39
81_A131_K0.5320.39
55_Y58_S0.5310.39
41_V110_S0.5310.39
92_I161_L0.5290.39
195_T248_F0.5280.39
26_T30_T0.5260.38
169_V177_P0.5260.38
74_L81_A0.5260.38
101_S104_N0.5250.38
175_A234_Y0.5250.38
90_K236_V0.5250.38
14_Y103_F0.5250.38
40_Y133_D0.5250.38
109_L184_G0.5230.38
6_S76_D0.5220.38
114_N118_S0.5220.38
51_N176_L0.5220.38
112_L117_G0.5210.38
7_V225_G0.5210.38
102_L183_Y0.5210.38
177_P206_V0.5210.38
216_V251_I0.5210.38
99_A238_G0.5180.38
152_R157_E0.5170.38
33_E36_K0.5170.38
105_D170_W0.5170.38
155_Y159_P0.5160.37
139_K144_V0.5160.37
46_T60_D0.5130.37
12_I20_S0.5130.37
10_I62_D0.5120.37
98_I173_T0.5110.37
70_S75_S0.5110.37
115_N119_K0.5090.37
174_A177_P0.5090.37
7_V221_S0.5080.37
57_K180_R0.5080.37
31_I202_N0.5070.37
9_E219_T0.5070.37
58_S98_I0.5060.36
15_T202_N0.5040.36
218_S231_G0.5030.36
72_S208_S0.5010.36
196_Y215_I0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.1269 29 0.96 Contact Map
2kluA 1 0.1423 19.7 0.963 Contact Map
2l2tA 2 0.1538 17.6 0.964 Contact Map
2mfrA 1 0.1808 12.3 0.966 Contact Map
1iijA 1 0.1346 9.2 0.968 Contact Map
2k9yA 2 0.1577 7.5 0.969 Contact Map
2ks1B 1 0.1577 7.1 0.97 Contact Map
2l9uA 2 0.1385 6.4 0.97 Contact Map
2k1kA 2 0.1462 6.1 0.971 Contact Map
2lzlA 2 0.1654 5.2 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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