GREMLIN Database
CcmB - CcmB protein
PFAM: PF03379 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 215 (205)
Sequences: 16775 (9725)
Seq/√Len: 679.2
META: 0.914

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_R10_R4.5531.00
5_L100_L2.9701.00
43_L46_R2.9431.00
53_W134_G2.8111.00
64_L142_G2.6721.00
130_V177_A2.6311.00
137_G170_V2.5551.00
5_L96_L2.5021.00
106_L135_T2.4851.00
60_A138_L2.4271.00
4_L93_G2.4061.00
137_G198_D2.3291.00
179_A183_A2.2071.00
188_G192_L2.1391.00
176_G179_A2.1041.00
81_L87_L2.1021.00
5_L93_G2.0641.00
29_V55_A2.0521.00
95_A140_A1.9981.00
145_G163_L1.9851.00
95_A143_T1.9541.00
99_W135_T1.9111.00
144_L205_A1.8921.00
125_P129_L1.8711.00
197_F201_F1.8301.00
68_F143_T1.6861.00
193_L196_A1.6811.00
26_F109_L1.6671.00
86_P89_A1.6551.00
198_D201_F1.6381.00
67_L98_H1.6231.00
75_G78_D1.6131.00
134_G174_G1.6091.00
56_A106_L1.5991.00
125_P128_L1.5931.00
91_V95_A1.5701.00
93_G97_A1.5581.00
192_L195_A1.5371.00
190_W193_L1.5221.00
193_L197_F1.5081.00
141_V166_L1.4961.00
22_M63_G1.4951.00
53_W178_T1.4921.00
138_L167_L1.4901.00
69_A73_E1.4881.00
61_L164_L1.4661.00
136_P198_D1.4641.00
195_A198_D1.4631.00
197_F200_L1.4531.00
99_W136_P1.4141.00
99_W103_G1.4031.00
68_F147_A1.4001.00
176_G190_W1.3941.00
79_Q82_L1.3931.00
173_F190_W1.3871.00
37_L47_I1.3691.00
40_D46_R1.3611.00
157_L160_P1.3591.00
10_R14_R1.3251.00
33_F51_V1.3241.00
201_F204_L1.3231.00
80_L90_I1.3201.00
101_L105_P1.3061.00
98_H139_S1.3031.00
102_L106_L1.3021.00
133_L195_A1.2911.00
176_G180_A1.2831.00
42_A45_R1.2821.00
137_G197_F1.2751.00
136_P202_L1.2581.00
13_L16_R1.2521.00
163_L167_L1.2491.00
72_R150_V1.2451.00
141_V167_L1.2421.00
78_D81_L1.2211.00
41_P45_R1.2131.00
28_L31_V1.2001.00
85_V88_E1.1931.00
189_G192_L1.1901.00
12_E101_L1.1821.00
132_L136_P1.1811.00
124_L128_L1.1501.00
140_A202_L1.1321.00
126_L187_A1.1241.00
88_E92_L1.1191.00
200_L204_L1.1161.00
91_V140_A1.1101.00
198_D205_A1.1101.00
79_Q83_A1.1021.00
53_W174_G1.1021.00
33_F54_V1.0891.00
130_V174_G1.0871.00
121_L124_L1.0851.00
65_D154_R1.0831.00
3_A6_R1.0781.00
93_G96_L1.0701.00
149_T152_L1.0601.00
42_A46_R1.0541.00
126_L130_V1.0521.00
196_A200_L1.0521.00
145_G166_L1.0461.00
108_L111_P1.0421.00
25_F29_V1.0351.00
201_F205_A1.0301.00
130_V181_A1.0231.00
175_V178_T1.0201.00
107_V111_P1.0171.00
5_L97_A1.0061.00
199_L203_A1.0061.00
103_G132_L1.0031.00
84_P87_L0.9981.00
49_P178_T0.9981.00
185_L189_G0.9851.00
98_H143_T0.9841.00
187_A190_W0.9721.00
65_D69_A0.9701.00
193_L201_F0.9641.00
31_V34_P0.9641.00
173_F193_L0.9631.00
192_L196_A0.9621.00
21_A24_L0.9451.00
191_L198_D0.9421.00
127_L130_V0.9421.00
179_A182_L0.9421.00
122_A125_P0.9411.00
191_L195_A0.9311.00
40_D43_L0.9271.00
103_G107_V0.9211.00
110_A131_L0.9091.00
203_A206_P0.9071.00
180_A190_W0.9071.00
91_V143_T0.8981.00
102_L139_S0.8951.00
123_A126_L0.8951.00
193_L200_L0.8911.00
185_L188_G0.8831.00
60_A102_L0.8831.00
65_D156_G0.8821.00
170_V194_L0.8721.00
51_V54_V0.8681.00
112_L115_L0.8671.00
186_P189_G0.8611.00
145_G159_L0.8581.00
70_A73_E0.8501.00
107_V128_L0.8471.00
10_R13_L0.8421.00
190_W198_D0.8371.00
43_L47_I0.8361.00
133_L198_D0.8331.00
103_G135_T0.8321.00
192_L199_L0.8301.00
15_S18_A0.8291.00
188_G191_L0.8271.00
46_R179_A0.8241.00
200_L203_A0.8231.00
81_L84_P0.8231.00
177_A180_A0.8231.00
196_A201_F0.8211.00
76_T79_Q0.8201.00
66_R69_A0.8181.00
95_A139_S0.8151.00
56_A135_T0.8111.00
203_A207_L0.8111.00
141_V163_L0.8101.00
190_W197_F0.8061.00
18_A21_A0.8051.00
102_L105_P0.8001.00
33_F37_L0.7981.00
156_G160_P0.7951.00
111_P114_A0.7931.00
127_L178_T0.7851.00
187_A191_L0.7821.00
191_L197_F0.7781.00
85_V89_A0.7761.00
57_L61_L0.7731.00
129_L132_L0.7691.00
29_V54_V0.7671.00
110_A114_A0.7661.00
106_L110_A0.7621.00
190_W200_L0.7611.00
16_R19_L0.7611.00
170_V174_G0.7541.00
72_R77_L0.7531.00
180_A185_L0.7521.00
32_L54_V0.7501.00
45_R118_N0.7501.00
142_G163_L0.7501.00
30_V113_F0.7501.00
92_L202_L0.7471.00
8_D94_K0.7421.00
48_A119_L0.7331.00
83_A90_I0.7301.00
174_G178_T0.7261.00
103_G106_L0.7261.00
114_A118_N0.7261.00
30_V117_L0.7221.00
5_L8_D0.7201.00
190_W201_F0.7161.00
126_L181_A0.7141.00
180_A187_A0.7131.00
85_V90_I0.7101.00
83_A86_P0.7031.00
129_L191_L0.6941.00
140_A205_A0.6941.00
195_A199_L0.6911.00
22_M26_F0.6891.00
149_T159_L0.6871.00
67_L143_T0.6841.00
189_G193_L0.6831.00
121_L125_P0.6811.00
111_P115_L0.6791.00
186_P190_W0.6781.00
123_A182_L0.6761.00
8_D93_G0.6691.00
114_A121_L0.6651.00
15_S20_L0.6571.00
196_A203_A0.6561.00
30_V55_A0.6551.00
31_V35_F0.6541.00
13_L19_L0.6531.00
80_L84_P0.6521.00
33_F36_A0.6481.00
27_L112_L0.6461.00
41_P118_N0.6461.00
105_P109_L0.6431.00
37_L51_V0.6421.00
104_L107_V0.6421.00
95_A136_P0.6381.00
140_A201_F0.6341.00
193_L198_D0.6331.00
60_A139_S0.6331.00
100_L103_G0.6321.00
99_W106_L0.6321.00
44_L48_A0.6311.00
106_L131_L0.6191.00
191_L194_L0.6181.00
90_I94_K0.6161.00
78_D82_L0.6161.00
87_L90_I0.6111.00
40_D44_L0.6101.00
9_L97_A0.6101.00
200_L205_A0.6091.00
107_V110_A0.6061.00
17_E20_L0.6061.00
187_A192_L0.6061.00
99_W139_S0.6011.00
194_L198_D0.5931.00
12_E17_E0.5881.00
130_V178_T0.5881.00
30_V36_A0.5871.00
9_L100_L0.5871.00
25_F28_L0.5851.00
61_L65_D0.5811.00
126_L129_L0.5771.00
9_L13_L0.5771.00
7_K94_K0.5751.00
106_L111_P0.5721.00
195_A201_F0.5721.00
21_A157_L0.5721.00
52_L113_F0.5701.00
46_R49_P0.5681.00
57_L171_L0.5651.00
178_T181_A0.5641.00
38_G41_P0.5631.00
18_A28_L0.5611.00
134_G170_V0.5561.00
198_D204_L0.5551.00
119_L127_L0.5551.00
88_E207_L0.5551.00
198_D202_L0.5551.00
192_L198_D0.5521.00
204_L207_L0.5521.00
190_W194_L0.5521.00
26_F59_A0.5511.00
107_V136_P0.5501.00
96_L99_W0.5491.00
89_A93_G0.5461.00
110_A128_L0.5441.00
92_L96_L0.5421.00
35_F168_V0.5421.00
194_L197_F0.5391.00
184_G188_G0.5381.00
12_E16_R0.5381.00
60_A167_L0.5351.00
196_A199_L0.5341.00
28_L33_F0.5321.00
189_G196_A0.5311.00
122_A126_L0.5311.00
64_L98_H0.5311.00
34_P39_P0.5311.00
36_A54_V0.5301.00
66_R70_A0.5291.00
60_A63_G0.5291.00
189_G195_A0.5241.00
15_S19_L0.5231.00
112_L116_L0.5200.99
5_L9_L0.5190.99
71_E94_K0.5160.99
65_D117_L0.5140.99
12_E66_R0.5140.99
120_P123_A0.5130.99
177_A190_W0.5130.99
45_R48_A0.5130.99
56_A131_L0.5120.99
95_A99_W0.5050.99
34_P37_L0.5020.99
190_W195_A0.5010.99
4_L80_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.586 9.3 0.935 Contact Map
2ksfA 1 0.4977 4.4 0.944 Contact Map
2wswA 3 0.3256 3 0.949 Contact Map
4c5sA 4 0.2326 2.9 0.949 Contact Map
3d31C 2 0.5721 2.9 0.949 Contact Map
2a65A 2 0.6698 2.5 0.951 Contact Map
4us3A 1 0.4837 1.5 0.957 Contact Map
3zuxA 1 0.7953 1.4 0.957 Contact Map
4c7rA 3 0.2047 1.3 0.958 Contact Map
3tx3A 2 0.2884 1.3 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0067 seconds.