GREMLIN Database
ANT - Phage antirepressor protein KilAC domain
PFAM: PF03374 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 107 (103)
Sequences: 7127 (5591)
Seq/√Len: 550.9
META: 0.799

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_L11_A3.5791.00
4_I7_L3.3901.00
43_W47_N2.8761.00
10_K15_D2.5491.00
3_Q7_L2.5081.00
45_R59_N2.3191.00
70_Y100_F2.1211.00
80_H86_K2.0961.00
26_I41_F2.0361.00
23_S92_K2.0291.00
23_S72_E1.9911.00
27_T37_A1.9171.00
36_G39_R1.7591.00
35_I39_R1.6881.00
29_I98_R1.6761.00
74_K92_K1.6201.00
25_L28_E1.5661.00
8_K12_E1.5501.00
65_Y70_Y1.4801.00
80_H84_S1.4611.00
78_I88_T1.4181.00
63_Q66_I1.4161.00
64_K68_K1.3781.00
42_K46_E1.3691.00
47_N105_L1.3691.00
49_I100_F1.3461.00
71_F91_T1.3001.00
28_E60_L1.2891.00
76_T88_T1.2751.00
3_Q8_K1.2681.00
25_L90_T1.2641.00
100_F104_L1.2521.00
62_Y65_Y1.2491.00
13_F17_V1.2451.00
5_E8_K1.2371.00
29_I93_V1.2311.00
78_I86_K1.2171.00
10_K14_A1.1981.00
37_A41_F1.1961.00
77_T85_T1.1791.00
71_F93_V1.1691.00
99_L103_N1.1671.00
24_I29_I1.1191.00
51_Y62_Y1.1111.00
49_I101_L1.0771.00
99_L102_Y1.0771.00
26_I93_V1.0721.00
48_G62_Y1.0631.00
26_I37_A1.0271.00
17_V95_G1.0231.00
31_K51_Y0.9941.00
30_A40_L0.9861.00
49_I65_Y0.9801.00
75_E87_I0.9751.00
31_K63_Q0.9721.00
61_P71_F0.9651.00
23_S94_T0.9601.00
41_F50_L0.9591.00
11_A15_D0.9551.00
3_Q6_E0.9511.00
32_D98_R0.9431.00
47_N104_L0.9391.00
75_E89_T0.9381.00
79_T85_T0.9381.00
50_L59_N0.9231.00
102_Y106_K0.9141.00
6_E11_A0.9041.00
43_W105_L0.9001.00
27_T31_K0.8961.00
51_Y60_L0.8901.00
50_L91_T0.8761.00
15_D18_L0.8711.00
31_K66_I0.8691.00
51_Y57_G0.8351.00
65_Y68_K0.8331.00
29_I40_L0.8271.00
11_A14_A0.8261.00
60_L73_V0.8141.00
41_F59_N0.8031.00
7_L10_K0.8021.00
76_T90_T0.8021.00
61_P73_V0.7981.00
29_I101_L0.7961.00
77_T87_I0.7931.00
52_K59_N0.7871.00
73_V89_T0.7861.00
44_L101_L0.7811.00
12_E16_A0.7761.00
49_I104_L0.7601.00
27_T51_Y0.7561.00
53_R60_L0.7541.00
25_L92_K0.7471.00
35_I43_W0.7451.00
2_Q5_E0.7411.00
38_N42_K0.7401.00
39_R42_K0.7351.00
13_F18_L0.7351.00
81_S84_S0.7311.00
14_A18_L0.7281.00
36_G63_Q0.7121.00
27_T60_L0.7101.00
24_I98_R0.7091.00
28_E89_T0.7061.00
41_F45_R0.7041.00
14_A99_L0.7011.00
22_G87_I0.6871.00
24_I32_D0.6781.00
39_R67_D0.6771.00
48_G64_K0.6751.00
32_D75_E0.6711.00
26_I50_L0.6691.00
20_S87_I0.6601.00
75_E98_R0.6591.00
76_T86_K0.6581.00
93_V101_L0.6571.00
53_R56_G0.6561.00
28_E58_R0.6551.00
4_I8_K0.6541.00
40_L101_L0.6491.00
43_W46_E0.6461.00
2_Q6_E0.6461.00
65_Y71_F0.6461.00
13_F99_L0.6251.00
24_I89_T0.6201.00
43_W104_L0.6191.00
16_A102_Y0.6121.00
18_L99_L0.6021.00
93_V100_F0.6011.00
26_I40_L0.6011.00
73_V91_T0.5961.00
56_G92_K0.5941.00
63_Q67_D0.5931.00
33_L102_Y0.5891.00
100_F103_N0.5841.00
35_I40_L0.5831.00
31_K60_L0.5800.99
23_S95_G0.5800.99
14_A17_V0.5750.99
8_K11_A0.5620.99
79_T82_D0.5520.99
42_K45_R0.5480.99
53_R58_R0.5480.99
16_A77_T0.5400.99
39_R43_W0.5390.99
12_E15_D0.5260.99
69_G96_K0.5230.99
45_R62_Y0.5230.99
45_R52_K0.5140.99
61_P66_I0.5110.99
25_L37_A0.5090.99
4_I11_A0.5090.99
35_I105_L0.5090.99
61_P93_V0.5080.99
13_F98_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l5eA 2 0.4299 67.3 0.826 Contact Map
3r4kA 2 0.9813 64.8 0.829 Contact Map
1y6uA 1 0.5421 61.7 0.833 Contact Map
4ou0A 1 0.5514 60.9 0.834 Contact Map
1on2A 2 0.8879 59.2 0.835 Contact Map
4j2nA 4 0.5234 58.9 0.835 Contact Map
3nqoA 2 0.9439 58.7 0.836 Contact Map
2nyxA 2 0.9346 58.4 0.836 Contact Map
2og0A 1 0.4299 57.8 0.836 Contact Map
2pg4A 3 0.729 57.8 0.836 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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