GREMLIN Database
PRP38 - PRP38 family
PFAM: PF03371 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 174 (163)
Sequences: 683 (454)
Seq/√Len: 35.6
META: 0.329

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_L97_G5.4271.00
95_A124_L4.8271.00
107_P165_P4.3911.00
95_A143_M4.0351.00
68_L99_F3.7441.00
142_T145_E2.9951.00
101_L105_G2.9451.00
14_K18_E2.7511.00
40_V84_Y2.7401.00
101_L110_V2.4901.00
95_A146_F2.3991.00
149_D153_K2.3861.00
124_L143_M2.3751.00
44_V93_L2.3090.99
82_L113_W2.2930.99
16_L65_L2.2360.99
97_G101_L2.1670.99
43_A47_L2.1270.99
98_A117_L2.0390.99
29_Q42_K1.8880.98
98_A114_L1.8520.97
64_F96_L1.7680.96
19_R63_P1.7550.96
37_E83_E1.7510.96
114_L147_V1.7460.96
68_L96_L1.7300.96
113_W119_N1.5490.93
50_I95_A1.5270.92
124_L146_F1.5220.92
98_A147_V1.5110.92
44_V89_D1.4870.91
33_L39_L1.4420.90
128_N139_E1.4410.89
167_R170_L1.4320.89
9_Q21_Y1.4110.88
31_F70_K1.3960.88
34_T37_E1.3640.87
43_A96_L1.3520.86
71_L81_V1.3440.86
5_G8_P1.3300.85
20_I69_L1.3160.85
130_D137_G1.3070.84
83_E86_K1.3050.84
56_G59_R1.3020.84
99_F103_L1.2790.83
126_R129_R1.2590.82
150_L161_L1.2440.81
17_R64_F1.2180.80
71_L84_Y1.2170.80
6_T10_F1.2080.79
85_L101_L1.2070.79
85_L105_G1.2060.79
94_R120_D1.1960.78
87_N93_L1.1860.78
25_Y42_K1.1760.77
64_F148_D1.1750.77
87_N97_G1.1570.76
50_I140_L1.1560.76
126_R149_D1.1230.74
71_L74_L1.1230.74
106_P165_P1.1190.74
84_Y93_L1.1090.73
22_D155_R1.0800.71
57_G60_K1.0790.71
155_R160_I1.0680.70
141_T149_D1.0330.67
97_G105_G0.9910.64
82_L86_K0.9600.62
39_L71_L0.9580.62
82_L101_L0.9560.61
30_C33_L0.9510.61
42_K172_E0.9430.60
89_D97_G0.9420.60
40_V93_L0.9390.60
140_L145_E0.9390.60
3_I104_T0.9300.59
6_T9_Q0.9270.59
65_L80_I0.9260.59
55_Y146_F0.9240.59
54_T59_R0.9220.59
117_L143_M0.9110.58
90_F93_L0.8970.56
16_L164_L0.8950.56
68_L163_R0.8900.56
110_V165_P0.8870.56
21_Y69_L0.8840.55
115_E118_L0.8810.55
74_L137_G0.8790.55
89_D93_L0.8790.55
6_T11_L0.8700.54
109_D152_T0.8650.54
19_R22_D0.8550.53
166_K170_L0.8520.53
107_P169_V0.8500.52
7_N10_F0.8500.52
91_K122_R0.8460.52
125_R128_N0.8450.52
76_P84_Y0.8300.51
55_Y127_R0.8230.50
78_K82_L0.8170.50
42_K45_E0.8160.49
13_E160_I0.8140.49
108_V168_I0.8140.49
33_L42_K0.8140.49
77_E80_I0.8090.49
20_I79_E0.8080.49
13_E155_R0.8070.49
15_I158_D0.8050.49
51_G62_S0.8050.49
32_G70_K0.8020.48
58_N149_D0.8000.48
26_W73_Q0.7980.48
150_L157_C0.7960.48
54_T58_N0.7950.48
31_F37_E0.7950.48
164_L167_R0.7940.48
111_Y167_R0.7930.47
146_F157_C0.7920.47
93_L97_G0.7840.47
13_E157_C0.7800.46
25_Y67_L0.7710.46
68_L126_R0.7690.45
100_Y109_D0.7680.45
160_I163_R0.7680.45
35_A70_K0.7660.45
27_K31_F0.7600.45
10_F24_P0.7580.44
3_I143_M0.7550.44
55_Y60_K0.7540.44
126_R156_V0.7540.44
71_L93_L0.7530.44
150_L156_V0.7520.44
2_S68_L0.7520.44
146_F156_V0.7510.44
23_S95_A0.7340.42
20_I103_L0.7340.42
64_F67_L0.7340.42
48_K159_T0.7330.42
23_S66_C0.7330.42
92_Y117_L0.7270.42
94_R97_G0.7250.42
16_L54_T0.7240.42
150_L160_I0.7200.41
26_W43_A0.7150.41
30_C114_L0.7110.40
143_M146_F0.7080.40
41_D44_V0.7000.40
30_C67_L0.6990.39
123_K142_T0.6950.39
16_L99_F0.6950.39
124_L127_R0.6940.39
41_D90_F0.6870.39
107_P130_D0.6850.38
124_L130_D0.6830.38
155_R161_L0.6790.38
17_R21_Y0.6790.38
39_L129_R0.6780.38
90_F111_Y0.6750.38
25_Y33_L0.6740.37
50_I64_F0.6690.37
127_R130_D0.6660.37
39_L43_A0.6640.37
163_R172_E0.6550.36
47_L51_G0.6500.36
8_P171_E0.6500.36
86_K113_W0.6470.35
165_P169_V0.6430.35
91_K144_D0.6410.35
91_K140_L0.6340.34
26_W69_L0.6300.34
68_L159_T0.6290.34
109_D113_W0.6270.34
44_V90_F0.6230.33
99_F159_T0.6220.33
33_L70_K0.6210.33
96_L109_D0.6200.33
26_W34_T0.6200.33
99_F146_F0.6200.33
23_S172_E0.6160.33
34_T139_E0.6150.33
35_A41_D0.6140.33
34_T70_K0.6140.33
12_I18_E0.6140.33
18_E22_D0.6130.33
12_I16_L0.6110.32
48_K109_D0.6080.32
20_I48_K0.6060.32
63_P129_R0.6000.32
39_L70_K0.5950.31
40_V44_V0.5950.31
98_A150_L0.5920.31
123_K144_D0.5920.31
149_D152_T0.5920.31
15_I57_G0.5910.31
130_D138_F0.5910.31
104_T112_K0.5900.31
81_V101_L0.5900.31
114_L151_L0.5890.31
19_R59_R0.5890.31
101_L113_W0.5880.31
13_E49_Y0.5840.30
24_P163_R0.5840.30
98_A115_E0.5800.30
26_W76_P0.5800.30
57_G118_L0.5790.30
43_A93_L0.5760.30
98_A157_C0.5740.30
49_Y81_V0.5740.30
65_L103_L0.5710.30
17_R92_Y0.5690.29
91_K123_K0.5630.29
47_L67_L0.5630.29
62_S65_L0.5620.29
106_P129_R0.5520.28
94_R165_P0.5520.28
54_T57_G0.5510.28
43_A50_I0.5480.28
47_L96_L0.5440.28
12_I24_P0.5430.28
118_L151_L0.5420.27
165_P168_I0.5380.27
20_I143_M0.5350.27
169_V172_E0.5350.27
39_L68_L0.5320.27
30_C66_C0.5310.27
7_N27_K0.5270.26
10_F13_E0.5250.26
12_I49_Y0.5240.26
41_D93_L0.5240.26
31_F84_Y0.5240.26
40_V140_L0.5230.26
85_L104_T0.5210.26
5_G67_L0.5200.26
10_F106_P0.5180.26
40_V48_K0.5180.26
81_V84_Y0.5160.26
22_D27_K0.5160.26
77_E88_E0.5160.26
12_I165_P0.5150.26
35_A39_L0.5130.26
13_E137_G0.5030.25
30_C84_Y0.5010.25
37_E79_E0.5000.25
42_K97_G0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l8tA 1 0.908 27 0.946 Contact Map
3gmiA 1 0.4885 15.6 0.951 Contact Map
3l9tA 1 0.9195 8.9 0.956 Contact Map
4lx2A 1 0.908 8.6 0.956 Contact Map
4lc2A 1 0.2471 7.3 0.958 Contact Map
4x8qA 1 0.8621 5.2 0.961 Contact Map
3d19A 5 0.908 4 0.963 Contact Map
2khzA 2 0.3391 3.8 0.963 Contact Map
3ee4A 2 0.4655 3.3 0.964 Contact Map
3j8bL 1 0 3.1 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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