GREMLIN Database
UPF0114 - Uncharacterized protein family, UPF0114
PFAM: PF03350 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 118 (117)
Sequences: 8062 (4290)
Seq/√Len: 396.6
META: 0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_K28_V3.1411.00
31_V35_P2.9421.00
18_A50_V2.9351.00
14_G26_F2.8731.00
35_P38_F2.3961.00
113_H116_K2.3921.00
11_A57_F2.3881.00
61_N70_G2.3481.00
29_E32_H2.2601.00
24_V38_F2.2561.00
14_G30_L2.1771.00
21_A34_V2.0651.00
17_L30_L2.0571.00
24_V28_V2.0511.00
16_L67_I2.0361.00
33_L49_G2.0291.00
11_A23_F2.0031.00
32_H35_P2.0001.00
103_A108_A1.9571.00
36_H39_T1.9551.00
103_A111_A1.9531.00
21_A37_V1.7951.00
52_G116_K1.7271.00
42_L45_D1.7071.00
35_P39_T1.6721.00
59_I109_I1.6271.00
22_L56_L1.5451.00
32_H36_H1.5201.00
27_F57_F1.5091.00
113_H117_A1.4991.00
26_F53_L1.4971.00
54_I63_L1.4281.00
41_A44_E1.4271.00
27_F31_V1.4191.00
25_K29_E1.3561.00
62_L105_S1.3191.00
4_S16_L1.3091.00
80_L83_H1.3041.00
80_L86_R1.2781.00
1_L16_L1.2731.00
7_L20_L1.2661.00
64_L68_F1.2221.00
28_V32_H1.2201.00
23_F60_A1.2061.00
76_S79_D1.1961.00
8_L70_G1.1751.00
24_V37_V1.1741.00
30_L53_L1.1491.00
94_D97_D1.1331.00
81_A84_P1.1141.00
55_D99_K1.1091.00
17_L34_V1.1061.00
71_Y75_V1.0491.00
107_V111_A1.0481.00
22_L50_V1.0481.00
104_G108_A1.0201.00
80_L84_P1.0031.00
51_L115_L1.0011.00
50_V63_L0.9811.00
69_G92_I0.9781.00
61_N105_S0.9541.00
26_F57_F0.9341.00
111_A115_L0.9241.00
96_S104_G0.9151.00
10_P27_F0.9091.00
41_A46_L0.9051.00
62_L112_I0.8951.00
71_Y76_S0.8921.00
101_K104_G0.8871.00
72_E78_I0.8741.00
36_H41_A0.8491.00
109_I116_K0.8471.00
96_S103_A0.8461.00
28_V38_F0.8421.00
14_G27_F0.8391.00
25_K46_L0.8351.00
57_F72_E0.8331.00
86_R90_L0.8291.00
6_W10_P0.8271.00
4_S7_L0.8271.00
101_K107_V0.8251.00
48_L52_G0.8031.00
77_K82_E0.7951.00
28_V31_V0.7911.00
8_L11_A0.7871.00
7_L10_P0.7861.00
18_A53_L0.7561.00
21_A30_L0.7501.00
19_L23_F0.7441.00
57_F61_N0.7431.00
54_I112_I0.7411.00
87_P90_L0.7351.00
96_S100_L0.7291.00
100_L104_G0.7291.00
58_L102_L0.7241.00
17_L21_A0.7231.00
7_L19_L0.7231.00
20_L24_V0.7221.00
34_V38_F0.7211.00
69_G73_L0.7141.00
23_F27_F0.7131.00
9_A75_V0.7091.00
45_D49_G0.7061.00
39_T42_L0.7031.00
65_I95_L0.7021.00
64_L67_I0.7001.00
77_K85_D0.6981.00
111_A117_A0.6971.00
38_F83_H0.6911.00
39_T43_E0.6850.99
89_W94_D0.6740.99
18_A57_F0.6710.99
103_A109_I0.6600.99
18_A22_L0.6600.99
8_L61_N0.6590.99
15_L66_V0.6560.99
108_A111_A0.6470.99
3_A80_L0.6460.99
79_D82_E0.6420.99
87_P91_G0.6340.99
21_A50_V0.6310.99
95_L103_A0.6290.99
15_L54_I0.6280.99
17_L20_L0.6260.99
93_V97_D0.6250.99
38_F41_A0.6200.99
35_P43_E0.6180.99
83_H88_E0.6160.99
107_V110_S0.6110.99
15_L18_A0.6090.99
35_P49_G0.6090.99
102_L107_V0.6030.99
25_K37_V0.6020.99
97_D103_A0.5970.99
69_G90_L0.5960.99
8_L23_F0.5960.99
41_A45_D0.5940.99
110_S114_L0.5910.98
9_A23_F0.5900.98
53_L62_L0.5890.98
85_D88_E0.5760.98
104_G113_H0.5750.98
14_G57_F0.5750.98
14_G66_V0.5720.98
72_E101_K0.5710.98
29_E36_H0.5670.98
33_L36_H0.5450.97
100_L114_L0.5420.97
106_I111_A0.5400.97
35_P44_E0.5400.97
12_Y70_G0.5390.97
95_L111_A0.5380.97
40_H45_D0.5370.97
16_L20_L0.5350.97
34_V49_G0.5350.97
74_F106_I0.5350.97
39_T83_H0.5350.97
77_K91_G0.5330.97
22_L59_I0.5320.97
59_I62_L0.5320.97
82_E85_D0.5310.97
16_L88_E0.5310.97
36_H45_D0.5250.97
69_G98_L0.5220.97
51_L112_I0.5210.97
81_A88_E0.5170.97
9_A71_Y0.5120.96
55_D106_I0.5100.96
66_V102_L0.5050.96
33_L50_V0.5050.96
97_D106_I0.5040.96
12_Y19_L0.5020.96
99_K104_G0.5020.96
15_L53_L0.5010.96
63_L67_I0.5000.96
105_S110_S0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q2eA 2 0.178 9.2 0.902 Contact Map
4hfiA 3 0.9322 6.7 0.908 Contact Map
3rqwA 4 0.8814 3.9 0.918 Contact Map
4pirA 3 0.822 3.3 0.921 Contact Map
4p6vB 1 0.3051 2.6 0.925 Contact Map
1rh5A 1 0.3475 2.5 0.926 Contact Map
4aq5A 1 0.6949 2.4 0.927 Contact Map
4aq5B 1 0.6949 2.3 0.927 Contact Map
3qnqA 2 0.7627 2.3 0.927 Contact Map
4aq5C 1 0.6949 2.3 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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