GREMLIN Database
Serinc - Serine incorporator (Serinc)
PFAM: PF03348 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 425 (423)
Sequences: 941 (539)
Seq/√Len: 26.2
META: 0.142

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
200_Y216_S6.5681.00
213_F217_I6.4691.00
161_W165_W5.7541.00
194_A198_L5.6481.00
58_C67_C4.5641.00
197_V201_V4.4461.00
208_C269_C4.0641.00
228_V412_L3.6451.00
217_I221_L3.6071.00
264_E397_V3.2201.00
165_W180_A3.1361.00
189_Y226_S3.0621.00
394_W397_V2.9751.00
225_V412_L2.9271.00
218_N404_S2.9231.00
190_A194_A2.8951.00
88_A362_F2.8381.00
78_F131_F2.5960.99
193_I197_V2.5560.99
211_N264_E2.5560.99
192_S250_S2.5300.99
210_L213_F2.5060.99
134_V138_I2.4980.99
222_C250_S2.4900.99
264_E394_W2.4660.99
195_G199_L2.4290.99
216_S220_I2.4200.99
142_G369_L2.4010.99
191_L251_L2.3220.98
214_F397_V2.3140.98
4_G12_C2.2800.98
81_A365_F2.2240.98
216_S219_L2.1970.97
417_A424_R2.1890.97
155_V297_Y2.1220.97
421_L424_R2.0880.97
1_C8_C2.0180.96
398_W405_W1.9750.95
229_S246_S1.9480.95
195_G254_T1.9080.94
414_T421_L1.8880.94
181_L185_T1.8840.94
203_Y211_N1.8760.94
4_G8_C1.8570.93
257_T401_I1.8470.93
95_K99_D1.8460.93
3_C17_S1.8350.93
10_L16_P1.8060.92
34_L410_L1.7830.92
5_S17_S1.7730.92
265_P400_K1.7710.92
355_Y361_H1.7620.91
198_L201_V1.7600.91
373_M378_W1.7560.91
109_W112_K1.7540.91
85_F365_F1.7470.91
241_S245_Q1.7450.91
105_Q394_W1.7390.91
105_Q162_N1.7110.90
164_S168_K1.6990.90
188_M251_L1.6980.90
81_A85_F1.6910.90
265_P394_W1.6740.89
256_L376_T1.6680.89
413_W417_A1.6680.89
299_T304_S1.6600.89
1_C4_G1.6540.89
413_W418_P1.6490.88
18_C23_S1.6470.88
180_A184_S1.6440.88
225_V408_L1.6230.88
218_N257_T1.6190.87
2_C9_S1.6150.87
50_K53_K1.6110.87
159_H240_R1.6040.87
188_M247_S1.6000.87
308_V312_R1.5980.87
31_I162_N1.5910.86
34_L287_G1.5670.86
196_T254_T1.5210.84
253_C408_L1.5060.83
21_S24_T1.4950.83
78_F123_A1.4890.83
242_G245_Q1.4770.82
369_L374_L1.4690.82
11_C14_C1.4640.81
102_A352_G1.4550.81
7_A11_C1.4450.81
40_W364_F1.4450.81
300_I303_S1.4410.80
220_I420_V1.4400.80
415_L418_P1.4050.79
413_W424_R1.4040.79
162_N166_V1.4030.79
318_V324_P1.4020.78
203_Y270_N1.3980.78
44_S47_V1.3900.78
192_S254_T1.3800.77
370_Y378_W1.3700.77
3_C6_A1.3580.76
200_Y219_L1.3560.76
211_N261_L1.3490.76
1_C16_P1.3240.74
12_C15_C1.3180.74
211_N357_Y1.3170.74
319_E323_L1.3130.74
185_T226_S1.3110.74
120_I285_I1.3090.73
335_E340_E1.3070.73
263_S400_K1.3050.73
136_N393_G1.2950.73
89_L92_I1.2940.73
38_V115_L1.2910.72
320_E326_S1.2900.72
85_F88_A1.2890.72
118_G122_G1.2860.72
1_C5_S1.2850.72
8_C11_C1.2710.71
309_N312_R1.2650.71
161_W177_W1.2640.71
97_S349_E1.2550.70
2_C14_C1.2480.70
321_G324_P1.2460.70
123_A126_I1.2440.70
321_G327_A1.2400.69
218_N239_P1.2370.69
159_H414_T1.2360.69
161_W188_M1.2340.69
31_I113_I1.2270.68
220_I224_I1.2250.68
369_L372_A1.2240.68
193_I220_I1.2210.68
83_F87_L1.2150.68
115_L201_V1.2130.68
1_C12_C1.2110.67
148_L402_V1.2080.67
261_L308_V1.2060.67
6_A12_C1.1880.66
237_A419_L1.1760.65
117_L223_I1.1700.65
414_T424_R1.1650.64
2_C11_C1.1630.64
135_W139_G1.1610.64
35_G80_L1.1530.63
298_S304_S1.1510.63
72_A124_F1.1480.63
27_A31_I1.1480.63
69_G414_T1.1430.63
86_L115_L1.1430.63
143_A376_T1.1390.63
79_A119_L1.1350.62
150_Q244_L1.1330.62
359_F373_M1.1320.62
256_L407_C1.1320.62
223_I348_D1.1250.62
25_R101_R1.1220.61
82_L123_A1.1200.61
139_G372_A1.1160.61
23_S27_A1.1130.61
173_N230_I1.1110.61
376_T403_S1.1080.60
6_A9_S1.1030.60
9_S15_C1.1030.60
384_A387_K1.1020.60
42_M72_A1.1010.60
4_G17_S1.0990.60
168_K199_L1.0980.60
49_E52_K1.0920.59
165_W178_Y1.0920.59
90_L186_L1.0870.59
256_L259_S1.0860.59
182_L341_D1.0850.59
127_P287_G1.0850.59
5_S8_C1.0790.58
250_S296_L1.0770.58
10_L17_S1.0750.58
77_C135_W1.0730.58
84_F257_T1.0730.58
215_I229_S1.0720.58
265_P397_V1.0700.58
30_L34_L1.0550.57
228_V231_H1.0530.56
39_A76_V1.0500.56
6_A10_L1.0500.56
124_F361_H1.0480.56
3_C7_A1.0460.56
144_F359_F1.0440.56
294_C374_L1.0410.56
225_V253_C1.0400.55
5_S10_L1.0380.55
41_I228_V1.0340.55
91_M105_Q1.0330.55
264_E365_F1.0300.55
199_L211_N1.0260.54
310_K322_S1.0220.54
7_A13_S1.0140.54
224_I416_V1.0140.54
94_V101_R1.0140.54
316_A320_E1.0120.53
335_E338_D1.0100.53
1_C14_C1.0090.53
161_W180_A1.0060.53
199_L261_L1.0010.53
145_L363_I0.9980.52
159_H247_S0.9930.52
317_A321_G0.9930.52
242_G260_A0.9920.52
55_I71_L0.9910.52
356_S420_V0.9840.51
257_T404_S0.9830.51
8_C28_Y0.9790.51
196_T219_L0.9780.51
123_A139_G0.9760.51
336_D339_D0.9750.51
14_C18_C0.9740.51
67_C75_R0.9690.50
241_S263_S0.9690.50
198_L202_F0.9650.50
301_R304_S0.9640.50
1_C6_A0.9620.50
391_G396_A0.9560.49
113_I287_G0.9550.49
403_S407_C0.9540.49
152_I311_L0.9540.49
360_F373_M0.9330.48
11_C17_S0.9320.47
422_P425_D0.9300.47
228_V234_V0.9300.47
1_C10_L0.9290.47
136_N258_W0.9290.47
34_L53_K0.9270.47
233_K362_F0.9260.47
122_G187_L0.9260.47
172_G206_S0.9240.47
293_L375_L0.9230.47
9_S12_C0.9230.47
162_N393_G0.9220.47
166_V193_I0.9200.47
312_R363_I0.9160.46
227_V231_H0.9160.46
266_D401_I0.9130.46
244_L258_W0.9120.46
211_N394_W0.9120.46
327_A333_D0.9090.46
159_H245_Q0.9090.46
186_L190_A0.9080.46
2_C6_A0.9080.46
114_L370_Y0.9050.45
147_I263_S0.9040.45
85_F89_L0.9020.45
87_L414_T0.9000.45
193_I216_S0.8910.44
7_A12_C0.8890.44
319_E322_S0.8850.44
32_L40_W0.8840.44
288_L302_A0.8830.44
417_A421_L0.8820.44
83_F142_G0.8810.44
31_I116_L0.8800.44
252_Y398_W0.8790.44
200_Y215_I0.8770.43
87_L344_R0.8730.43
308_V313_A0.8720.43
416_V420_V0.8720.43
143_A395_A0.8710.43
310_K313_A0.8700.43
29_A155_V0.8690.43
271_P403_S0.8680.43
389_T397_V0.8670.43
137_Y246_S0.8650.43
219_L224_I0.8640.42
48_E51_L0.8640.42
156_D297_Y0.8630.42
299_T303_S0.8620.42
157_F298_S0.8610.42
91_M94_V0.8590.42
375_L397_V0.8490.41
370_Y373_M0.8490.41
54_F400_K0.8480.41
212_K216_S0.8440.41
51_L121_V0.8430.41
214_F401_I0.8400.41
32_L364_F0.8390.41
121_V126_I0.8390.41
161_W184_S0.8390.41
381_P393_G0.8380.41
413_W421_L0.8370.40
88_A92_I0.8350.40
281_T285_I0.8340.40
109_W355_Y0.8310.40
313_A321_G0.8260.40
187_L409_L0.8260.40
307_Q310_K0.8230.39
155_V229_S0.8220.39
120_I190_A0.8210.39
360_F367_A0.8180.39
97_S348_D0.8170.39
215_I251_L0.8160.39
201_V209_S0.8100.39
219_L269_C0.8090.39
122_G125_F0.8090.39
82_L119_L0.8080.38
291_T390_I0.8070.38
6_A14_C0.8040.38
4_G15_C0.8040.38
151_L242_G0.8020.38
94_V353_V0.7970.38
224_I268_E0.7940.37
246_S256_L0.7930.37
288_L299_T0.7930.37
4_G9_S0.7900.37
184_S203_Y0.7900.37
6_A16_P0.7880.37
318_V328_L0.7870.37
238_Q425_D0.7860.37
255_Y259_S0.7830.37
115_L289_I0.7820.37
85_F194_A0.7800.36
361_H367_A0.7800.36
19_K22_T0.7790.36
318_V321_G0.7770.36
162_N169_A0.7770.36
338_D341_D0.7750.36
225_V261_L0.7750.36
236_E239_P0.7740.36
285_I289_I0.7740.36
21_S25_R0.7730.36
106_N407_C0.7720.36
172_G295_V0.7720.36
114_L117_L0.7710.36
32_L43_L0.7690.36
298_S370_Y0.7640.35
32_L156_D0.7630.35
92_I149_I0.7630.35
157_F161_W0.7620.35
185_T419_L0.7600.35
144_F399_V0.7600.35
75_R270_N0.7580.35
295_V364_F0.7550.35
179_A183_G0.7510.35
308_V368_S0.7410.34
184_S188_M0.7390.34
92_I95_K0.7360.34
211_N215_I0.7360.34
74_Y150_Q0.7350.33
265_P399_V0.7340.33
84_F130_F0.7280.33
81_A393_G0.7280.33
412_L416_V0.7280.33
397_V404_S0.7250.33
334_E337_G0.7240.33
85_F90_L0.7240.33
154_L297_Y0.7230.33
319_E327_A0.7230.33
189_Y246_S0.7220.33
121_V125_F0.7220.33
59_E199_L0.7220.33
195_G198_L0.7190.32
256_L295_V0.7180.32
230_I243_L0.7170.32
242_G252_Y0.7140.32
270_N303_S0.7140.32
39_A246_S0.7140.32
77_C373_M0.7140.32
115_L148_L0.7120.32
76_V384_A0.7110.32
332_D340_E0.7100.32
266_D270_N0.7090.32
70_Y407_C0.7090.32
261_L305_N0.7070.32
58_C75_R0.7070.32
236_E242_G0.7060.32
45_P49_E0.7060.32
185_T425_D0.7060.32
235_Q417_A0.7040.31
146_F189_Y0.7040.31
229_S242_G0.7030.31
166_V178_Y0.7000.31
29_A33_L0.6990.31
37_I152_I0.6970.31
24_T102_A0.6940.31
33_L86_L0.6940.31
151_L245_Q0.6930.31
153_L376_T0.6910.31
318_V323_L0.6910.31
119_L357_Y0.6910.31
140_L218_N0.6900.31
138_I191_L0.6900.31
260_A265_P0.6900.31
399_V405_W0.6890.30
384_A410_L0.6880.30
2_C13_S0.6870.30
159_H185_T0.6860.30
106_N245_Q0.6850.30
77_C371_V0.6840.30
213_F220_I0.6840.30
63_G79_A0.6830.30
254_T362_F0.6830.30
92_I385_D0.6810.30
165_W184_S0.6810.30
187_L190_A0.6790.30
382_D421_L0.6770.30
137_Y393_G0.6750.30
143_A213_F0.6750.30
99_D365_F0.6740.30
14_C17_S0.6740.30
82_L223_I0.6730.29
220_I227_V0.6720.29
320_E323_L0.6710.29
36_S123_A0.6710.29
230_I279_T0.6700.29
151_L159_H0.6670.29
150_Q378_W0.6650.29
244_L302_A0.6650.29
162_N291_T0.6630.29
191_L198_L0.6620.29
123_A127_P0.6590.29
146_F374_L0.6590.29
153_L288_L0.6590.29
414_T417_A0.6570.29
246_S419_L0.6560.28
151_L361_H0.6560.28
277_I414_T0.6560.28
88_A383_S0.6560.28
214_F261_L0.6550.28
317_A326_S0.6550.28
414_T422_P0.6540.28
416_V424_R0.6530.28
406_V412_L0.6530.28
180_A203_Y0.6530.28
154_L365_F0.6520.28
25_R245_Q0.6510.28
176_L180_A0.6500.28
2_C10_L0.6500.28
148_L152_I0.6500.28
139_G144_F0.6490.28
300_I305_N0.6490.28
308_V311_L0.6480.28
290_I410_L0.6470.28
11_C309_N0.6470.28
259_S376_T0.6450.28
49_E190_A0.6450.28
85_F256_L0.6450.28
51_L401_I0.6450.28
157_F263_S0.6430.28
195_G251_L0.6430.28
152_I214_F0.6430.28
8_C13_S0.6390.27
83_F225_V0.6390.27
203_Y244_L0.6380.27
111_F273_L0.6360.27
189_Y231_H0.6360.27
67_C112_K0.6350.27
281_T409_L0.6350.27
359_F378_W0.6350.27
31_I143_A0.6320.27
259_S400_K0.6320.27
353_V356_S0.6280.27
106_N242_G0.6280.27
156_D177_W0.6280.27
127_P398_W0.6270.27
227_V351_D0.6260.27
151_L218_N0.6250.27
46_G54_F0.6240.27
317_A327_A0.6210.26
306_S310_K0.6180.26
84_F238_Q0.6180.26
47_V76_V0.6180.26
156_D376_T0.6170.26
319_E324_P0.6140.26
247_S367_A0.6120.26
153_L403_S0.6120.26
124_F405_W0.6120.26
357_Y361_H0.6110.26
334_E342_G0.6110.26
334_E341_D0.6090.26
402_V409_L0.6090.26
98_K358_S0.6080.26
299_T397_V0.6070.26
143_A228_V0.6060.26
380_S383_S0.6050.25
277_I341_D0.6050.25
211_N256_L0.6050.25
139_G369_L0.6030.25
40_W44_S0.6030.25
77_C393_G0.6020.25
322_S327_A0.6010.25
221_L348_D0.6010.25
24_T216_S0.6000.25
150_Q165_W0.6000.25
181_L235_Q0.6000.25
94_V283_T0.5970.25
6_A17_S0.5970.25
125_F128_N0.5960.25
241_S403_S0.5960.25
39_A108_F0.5950.25
74_Y108_F0.5950.25
332_D335_E0.5940.25
124_F241_S0.5940.25
225_V270_N0.5930.25
357_Y400_K0.5900.25
23_S113_I0.5890.25
38_V87_L0.5890.25
43_L377_N0.5850.24
349_E353_V0.5850.24
78_F135_W0.5850.24
177_W287_G0.5850.24
138_I385_D0.5850.24
136_N143_A0.5840.24
171_E230_I0.5820.24
299_T393_G0.5820.24
4_G7_A0.5820.24
18_C27_A0.5800.24
189_Y374_L0.5800.24
210_L214_F0.5790.24
337_G340_E0.5780.24
303_S308_V0.5780.24
208_C211_N0.5770.24
126_I284_V0.5760.24
418_P424_R0.5740.24
373_M398_W0.5740.24
261_L277_I0.5720.24
245_Q357_Y0.5710.24
126_I270_N0.5710.24
264_E357_Y0.5710.24
46_G196_T0.5700.24
162_N368_S0.5680.23
38_V42_M0.5680.23
81_A230_I0.5670.23
78_F82_L0.5670.23
125_F132_I0.5630.23
58_C69_G0.5620.23
315_R318_V0.5600.23
52_K409_L0.5580.23
11_C22_T0.5570.23
11_C345_V0.5560.23
46_G396_A0.5560.23
138_I171_E0.5560.23
102_A247_S0.5550.23
81_A368_S0.5540.23
26_L419_L0.5520.23
154_L397_V0.5520.23
126_I153_L0.5520.23
138_I266_D0.5500.22
210_L217_I0.5500.22
254_T302_A0.5490.22
143_A369_L0.5490.22
128_N207_G0.5490.22
193_I337_G0.5490.22
247_S252_Y0.5480.22
153_L159_H0.5470.22
365_F369_L0.5460.22
162_N173_N0.5440.22
235_Q240_R0.5440.22
123_A131_F0.5420.22
25_R91_M0.5420.22
267_E367_A0.5400.22
246_S384_A0.5400.22
291_T391_G0.5400.22
366_L421_L0.5400.22
79_A234_V0.5400.22
207_G211_N0.5390.22
91_M99_D0.5380.22
45_P379_Y0.5370.22
393_G396_A0.5370.22
137_Y140_L0.5370.22
155_V158_A0.5360.22
212_K218_N0.5360.22
369_L379_Y0.5360.22
216_S223_I0.5360.22
152_I201_V0.5360.22
314_S319_E0.5360.22
290_I351_D0.5350.22
83_F369_L0.5330.22
65_G113_I0.5320.22
157_F170_E0.5320.22
70_Y87_L0.5310.22
30_L123_A0.5310.22
135_W407_C0.5300.21
96_S197_V0.5300.21
46_G51_L0.5290.21
159_H235_Q0.5290.21
364_F390_I0.5290.21
232_P245_Q0.5280.21
98_K120_I0.5270.21
291_T302_A0.5270.21
84_F87_L0.5270.21
138_I168_K0.5270.21
211_N364_F0.5260.21
74_Y116_L0.5250.21
203_Y272_L0.5250.21
139_G363_I0.5250.21
303_S363_I0.5240.21
63_G255_Y0.5240.21
373_M396_A0.5240.21
197_V364_F0.5230.21
17_S103_A0.5230.21
220_I289_I0.5230.21
264_E393_G0.5210.21
151_L260_A0.5210.21
48_E52_K0.5190.21
303_S310_K0.5190.21
25_R32_L0.5180.21
222_C408_L0.5170.21
262_S380_S0.5170.21
86_L227_V0.5170.21
305_N359_F0.5160.21
141_I203_Y0.5150.21
398_W401_I0.5140.21
154_L251_L0.5130.21
2_C254_T0.5130.21
219_L417_A0.5120.21
220_I343_G0.5120.21
405_W424_R0.5120.21
150_Q373_M0.5110.21
77_C368_S0.5100.20
11_C15_C0.5100.20
90_L219_L0.5090.20
263_S370_Y0.5060.20
203_Y258_W0.5060.20
188_M211_N0.5050.20
393_G408_L0.5040.20
278_G323_L0.5040.20
180_A290_I0.5030.20
29_A40_W0.5030.20
405_W415_L0.5030.20
26_L226_S0.5030.20
313_A325_A0.5020.20
106_N185_T0.5020.20
27_A48_E0.5020.20
59_E425_D0.5020.20
152_I344_R0.5010.20
28_Y361_H0.5000.20
149_I377_N0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pypA 1 0.6329 19.5 0.975 Contact Map
3dl8E 1 0.1482 9.3 0.979 Contact Map
4bgnA 3 0.4565 7.3 0.98 Contact Map
1yewC 1 0.1624 6.2 0.98 Contact Map
3j1rA 5 0.0612 4.8 0.981 Contact Map
4ymkA 1 0.1859 4.2 0.982 Contact Map
4zw9A 1 0.1718 4.2 0.982 Contact Map
5a63B 1 0.0635 4.1 0.982 Contact Map
1dl0A 1 0.08 2.8 0.983 Contact Map
2mf3A 1 0.0424 2.6 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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