GREMLIN Database
PhaG_MnhG_YufB - Na+/H+ antiporter subunit
PFAM: PF03334 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 79 (78)
Sequences: 19729 (11569)
Seq/√Len: 1309.9
META: 0.872

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_A53_S2.6121.00
7_F11_V2.5901.00
19_L28_A2.4881.00
26_L75_A2.3121.00
4_L39_L2.3101.00
22_F78_A2.0641.00
49_F53_S2.0471.00
9_A32_A1.8721.00
9_A36_G1.8651.00
41_L56_L1.8251.00
44_L56_L1.7731.00
30_T71_A1.7681.00
21_D24_T1.7451.00
38_G60_I1.7321.00
20_P24_T1.6901.00
2_L43_G1.6771.00
15_G28_A1.6191.00
1_L39_L1.6061.00
5_G40_I1.6011.00
10_L14_I1.5941.00
1_L42_L1.5571.00
37_A63_L1.5451.00
44_L48_F1.4351.00
72_H76_R1.3791.00
3_L6_A1.3691.00
49_F52_V1.3621.00
14_I18_R1.3281.00
51_L55_K1.3181.00
48_F52_V1.3061.00
60_I64_L1.2781.00
62_F66_T1.2701.00
45_A56_L1.2591.00
8_F35_L1.2241.00
12_G32_A1.1971.00
38_G64_L1.1401.00
23_Y78_A1.1011.00
6_A10_L1.1011.00
50_S53_S1.0891.00
42_L46_L1.0531.00
41_L60_I1.0231.00
3_L7_F0.9861.00
8_F31_K0.9831.00
48_F53_S0.9551.00
40_I44_L0.9471.00
45_A57_L0.9471.00
16_L29_A0.8941.00
1_L46_L0.8701.00
34_T68_P0.8681.00
34_T64_L0.8681.00
5_G43_G0.8531.00
73_A77_A0.8501.00
42_L45_A0.8431.00
63_L67_A0.8271.00
17_L20_P0.8191.00
6_A13_A0.8191.00
9_A13_A0.8051.00
5_G36_G0.8031.00
31_K35_L0.7951.00
51_L54_L0.7941.00
12_G31_K0.7921.00
54_L57_L0.7861.00
35_L39_L0.7851.00
38_G42_L0.7821.00
66_T70_A0.7651.00
67_A71_A0.7601.00
70_A74_L0.7521.00
9_A40_I0.7461.00
6_A9_A0.7141.00
45_A49_F0.7121.00
53_S57_L0.6971.00
65_L69_V0.6951.00
30_T33_D0.6891.00
27_H58_L0.6831.00
50_S54_L0.6791.00
21_D25_R0.6791.00
40_I47_Y0.6721.00
9_A12_G0.6721.00
2_L6_A0.6691.00
34_T37_A0.6681.00
41_L59_I0.6661.00
4_L8_F0.6631.00
33_D44_L0.6481.00
48_F51_L0.6451.00
11_V14_I0.6441.00
59_I63_L0.6381.00
33_D56_L0.6351.00
22_F26_L0.6291.00
55_K59_I0.6251.00
54_L58_L0.6231.00
43_G47_Y0.6201.00
62_F65_L0.6201.00
10_L13_A0.6151.00
8_F36_G0.6131.00
57_L61_L0.6061.00
70_A76_R0.5981.00
33_D67_A0.5971.00
37_A59_I0.5811.00
45_A48_F0.5771.00
38_G41_L0.5691.00
2_L5_G0.5601.00
34_T67_A0.5581.00
24_T27_H0.5571.00
32_A37_A0.5511.00
29_A33_D0.5481.00
56_L59_I0.5471.00
13_A32_A0.5451.00
11_V31_K0.5441.00
62_F68_P0.5371.00
26_L71_A0.5241.00
18_R28_A0.5241.00
31_K38_G0.5191.00
39_L42_L0.5121.00
49_F54_L0.5101.00
49_F55_K0.5031.00
9_A37_A0.5021.00
61_L68_P0.5001.00
14_I17_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoM 1 0.9873 3.7 0.885 Contact Map
3rkoL 1 0.9241 3.2 0.889 Contact Map
4he8L 1 0.7975 2.1 0.9 Contact Map
3rkoN 1 0.9747 1.7 0.904 Contact Map
4p02B 1 0.2911 1.7 0.905 Contact Map
4he8M 1 0.8354 1.5 0.907 Contact Map
2i68A 2 0.7215 1.3 0.91 Contact Map
4hkrA 3 0.7595 1.2 0.912 Contact Map
2bg9E 1 0.3418 1.2 0.912 Contact Map
1oedA 1 0.3544 1.1 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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