GREMLIN Database
GerA - Bacillus/Clostridium GerA spore germination protein
PFAM: PF03323 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 460 (457)
Sequences: 7032 (5528)
Seq/√Len: 258.6
META: 0.514

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_E181_K6.0951.00
222_V232_A5.2771.00
400_L412_G4.4761.00
157_R188_D4.1841.00
89_T104_T4.1471.00
355_Q359_Q4.0971.00
172_A177_V3.3071.00
150_I166_A3.1671.00
203_E261_R3.1161.00
76_D79_E2.8391.00
165_I181_K2.8051.00
320_A367_M2.7551.00
150_I164_A2.7491.00
74_V101_I2.7111.00
73_E98_E2.6891.00
191_G227_L2.6791.00
287_V398_L2.6581.00
147_N170_G2.6521.00
90_V101_I2.6401.00
281_L413_L2.6301.00
149_K169_E2.5991.00
213_V244_V2.5721.00
155_V184_L2.5611.00
80_I90_V2.5411.00
397_L412_G2.5141.00
153_L185_K2.4971.00
168_I171_I2.4751.00
126_E142_R2.4751.00
84_I90_V2.3751.00
139_I166_A2.3421.00
133_R136_T2.3011.00
74_V79_E2.3011.00
234_L241_V2.2341.00
139_I234_L2.2301.00
401_A409_I2.1731.00
397_L416_L2.1631.00
145_D158_R2.1441.00
252_F276_F2.1311.00
13_L30_I2.1281.00
216_T222_V2.1051.00
178_E182_K2.0721.00
88_D105_R2.0621.00
194_D238_S2.0251.00
179_E182_K2.0241.00
169_E174_P2.0151.00
158_R170_G2.0121.00
83_A101_I1.9961.00
317_F402_A1.9541.00
180_V231_V1.9481.00
17_E24_K1.9451.00
132_L164_A1.9311.00
174_P178_E1.9111.00
195_S235_V1.9031.00
177_V231_V1.8981.00
37_E41_E1.8631.00
82_D160_K1.8561.00
83_A88_D1.8481.00
284_A401_A1.8471.00
91_L102_I1.8431.00
182_K186_K1.8431.00
324_E394_R1.8381.00
147_N169_E1.8361.00
266_S270_L1.8171.00
10_S149_K1.8171.00
179_E183_R1.8081.00
8_G149_K1.8071.00
320_A398_L1.7981.00
233_I244_V1.7821.00
19_K24_K1.7691.00
421_A431_L1.7691.00
155_V163_V1.7681.00
225_A243_I1.7671.00
153_L181_K1.7651.00
180_V244_V1.7381.00
92_L99_A1.7331.00
189_I201_L1.7231.00
246_A251_F1.7211.00
75_D98_E1.7181.00
13_L28_V1.6901.00
9_N151_E1.6821.00
115_P127_G1.6811.00
15_I26_A1.6601.00
124_P259_Y1.6571.00
154_T162_D1.6531.00
163_V235_V1.6451.00
437_F442_L1.6431.00
152_S162_D1.6351.00
183_R204_D1.6241.00
143_I223_A1.6111.00
159_S191_G1.6031.00
152_S164_A1.6021.00
35_D106_G1.5941.00
41_E45_K1.5791.00
31_D133_R1.5741.00
168_I226_L1.5711.00
275_A329_L1.5291.00
114_E127_G1.5251.00
284_A397_L1.5161.00
4_K15_I1.5111.00
88_D103_D1.5061.00
15_I28_V1.4961.00
407_Y411_L1.4961.00
315_P318_V1.4931.00
90_V99_A1.4851.00
153_L165_I1.4681.00
172_A231_V1.4681.00
34_V39_I1.4531.00
258_Y444_D1.4451.00
86_S144_R1.4391.00
70_E103_D1.4371.00
154_T160_K1.4331.00
114_E125_R1.4271.00
396_P400_L1.4271.00
139_I148_L1.4141.00
419_H423_L1.4021.00
107_W141_R1.3951.00
109_K134_T1.3831.00
136_T150_I1.3831.00
275_A380_A1.3671.00
80_I99_A1.3651.00
287_V320_A1.3611.00
283_P374_T1.3611.00
88_D101_I1.3591.00
267_F392_L1.3561.00
420_L431_L1.3541.00
59_E63_E1.3531.00
82_D154_T1.3511.00
328_E395_F1.3491.00
393_L416_L1.3451.00
72_K83_A1.3431.00
230_R250_E1.3371.00
9_N169_E1.3251.00
276_F390_I1.3241.00
143_I227_L1.3231.00
158_R171_I1.3141.00
33_L137_A1.3081.00
132_L234_L1.3051.00
208_S212_Q1.2941.00
32_G137_A1.2861.00
180_V233_I1.2831.00
166_A234_L1.2731.00
74_V80_I1.2681.00
116_E125_R1.2671.00
68_V102_I1.2651.00
213_V242_L1.2581.00
20_I25_A1.2551.00
176_L231_V1.2461.00
62_L73_E1.2411.00
178_E181_K1.2361.00
208_S419_H1.2301.00
327_F375_A1.2291.00
113_E116_E1.2251.00
247_T428_V1.2251.00
210_F430_Y1.2131.00
16_R71_V1.2081.00
438_N441_D1.2011.00
251_F386_L1.1881.00
324_E395_F1.1821.00
25_A93_I1.1811.00
26_A92_L1.1751.00
433_P436_P1.1721.00
210_F393_L1.1721.00
317_F399_I1.1711.00
7_F85_L1.1701.00
112_V126_E1.1631.00
39_I89_T1.1581.00
326_T352_V1.1551.00
119_K339_K1.1521.00
187_I198_I1.1501.00
324_E398_L1.1501.00
109_K131_T1.1491.00
126_E141_R1.1491.00
128_F222_V1.1481.00
222_V241_V1.1481.00
317_F398_L1.1451.00
17_E26_A1.1401.00
139_I222_V1.1361.00
247_T250_E1.1351.00
288_A409_I1.1341.00
314_F318_V1.1291.00
434_L445_T1.1261.00
181_K185_K1.1211.00
193_L197_Y1.1141.00
194_D259_Y1.1111.00
165_I231_V1.1101.00
270_L274_L1.0991.00
147_N158_R1.0961.00
107_W131_T1.0951.00
232_A243_I1.0921.00
122_R199_E1.0911.00
214_L243_I1.0871.00
449_A454_M1.0841.00
231_V244_V1.0831.00
200_E448_R1.0821.00
39_I104_T1.0771.00
12_D140_R1.0761.00
43_I102_I1.0741.00
249_F434_L1.0671.00
214_L246_A1.0551.00
175_E178_E1.0521.00
285_L409_I1.0511.00
290_T316_A1.0451.00
136_T166_A1.0441.00
281_L397_L1.0371.00
129_T135_N1.0361.00
159_S227_L1.0351.00
280_L393_L1.0351.00
7_F81_I1.0241.00
108_P134_T1.0241.00
173_N428_V1.0201.00
9_N149_K1.0161.00
243_I250_E1.0151.00
316_A367_M1.0121.00
79_E82_D1.0111.00
182_K185_K1.0101.00
27_L91_L1.0101.00
32_G133_R1.0051.00
442_L445_T0.9991.00
165_I180_V0.9971.00
443_K449_A0.9921.00
166_A226_L0.9911.00
232_A241_V0.9861.00
171_I457_R0.9841.00
190_D457_R0.9821.00
59_E73_E0.9751.00
210_F420_L0.9711.00
321_L398_L0.9691.00
279_S390_I0.9681.00
3_L28_V0.9681.00
171_I190_D0.9671.00
143_I168_I0.9661.00
34_V104_T0.9661.00
144_R236_D0.9641.00
6_I81_I0.9621.00
170_G174_P0.9611.00
10_S13_L0.9591.00
176_L426_F0.9591.00
72_K79_E0.9581.00
137_A141_R0.9541.00
248_F431_L0.9531.00
11_S151_E0.9531.00
28_V92_L0.9501.00
32_G136_T0.9481.00
252_F273_F0.9471.00
144_R162_D0.9471.00
125_R240_F0.9461.00
158_R190_D0.9431.00
277_F281_L0.9391.00
214_L221_V0.9381.00
399_I402_A0.9341.00
308_S366_I0.9341.00
120_V256_E0.9331.00
30_I33_L0.9321.00
440_K456_K0.9271.00
80_I92_L0.9231.00
281_L409_I0.9191.00
279_S381_I0.9191.00
224_A228_E0.9171.00
225_A250_E0.9161.00
109_K129_T0.9131.00
117_T240_F0.9131.00
111_S129_T0.9121.00
377_A380_A0.9111.00
77_L80_I0.9101.00
166_A241_V0.9081.00
35_D38_L0.9071.00
214_L250_E0.9001.00
221_V255_P0.8991.00
448_R451_L0.8871.00
14_V31_D0.8861.00
200_E451_L0.8851.00
189_I192_I0.8851.00
128_F139_I0.8801.00
209_P419_H0.8801.00
222_V243_I0.8791.00
308_S365_P0.8771.00
317_F321_L0.8751.00
77_L92_L0.8751.00
129_T134_T0.8741.00
24_K94_D0.8721.00
120_V255_P0.8701.00
275_A377_A0.8681.00
126_E138_L0.8681.00
19_K64_N0.8671.00
187_I201_L0.8651.00
131_T134_T0.8621.00
274_L325_I0.8611.00
11_S152_S0.8611.00
44_L48_M0.8571.00
120_V254_S0.8571.00
62_L100_L0.8551.00
395_F399_I0.8530.99
384_Y388_I0.8520.99
324_E371_V0.8510.99
291_T316_A0.8510.99
210_F416_L0.8500.99
27_L89_T0.8480.99
126_E237_G0.8480.99
203_E212_Q0.8440.99
389_A393_L0.8440.99
139_I223_A0.8390.99
396_P415_L0.8340.99
214_L225_A0.8320.99
440_K443_K0.8320.99
248_F386_L0.8310.99
196_G200_E0.8290.99
287_V402_A0.8280.99
346_S351_L0.8280.99
177_V180_V0.8260.99
212_Q261_R0.8250.99
270_L446_L0.8240.99
417_L421_A0.8240.99
134_T137_A0.8230.99
209_P263_I0.8230.99
328_E331_R0.8190.99
184_L233_I0.8180.99
215_Y242_L0.8180.99
25_A91_L0.8180.99
18_F27_L0.8160.99
28_V84_I0.8160.99
359_Q365_P0.8130.99
225_A230_R0.8120.99
305_I366_I0.8110.99
280_L390_I0.8070.99
145_D160_K0.8050.99
329_L380_A0.8050.99
215_Y240_F0.8050.99
121_V256_E0.8040.99
206_P452_W0.8040.99
158_R168_I0.8030.99
73_E100_L0.8030.99
180_V426_F0.8020.99
176_L180_V0.8010.99
174_P177_V0.7990.99
267_F328_E0.7980.99
293_H405_G0.7960.99
59_E62_L0.7940.99
253_Q258_Y0.7930.99
166_A232_A0.7920.99
6_I146_P0.7870.99
159_S193_L0.7870.99
14_V29_Y0.7860.99
409_I412_G0.7840.99
183_R202_I0.7840.99
249_F445_T0.7820.99
60_E64_N0.7820.99
244_V426_F0.7810.99
411_L415_L0.7810.99
122_R215_Y0.7810.99
439_L443_K0.7810.99
133_R162_D0.7780.99
142_R237_G0.7750.99
112_V138_L0.7750.99
269_R444_D0.7740.99
62_L65_L0.7740.99
324_E331_R0.7740.99
438_N459_S0.7740.99
400_L403_L0.7740.99
38_L104_T0.7740.99
86_S162_D0.7730.99
432_S438_N0.7710.99
19_K63_E0.7690.99
443_K454_M0.7670.99
162_D236_D0.7640.99
260_Q388_I0.7630.99
109_K141_R0.7630.99
348_V375_A0.7610.99
108_P137_A0.7600.99
414_I417_L0.7600.99
161_T235_V0.7590.99
7_F10_S0.7580.99
202_I213_V0.7570.99
282_L373_L0.7570.99
3_L15_I0.7570.99
158_R457_R0.7540.99
5_E8_G0.7530.99
266_S447_I0.7530.99
203_E206_P0.7530.99
205_N212_Q0.7510.99
213_V426_F0.7490.99
145_D168_I0.7470.99
79_E83_A0.7460.99
142_R223_A0.7420.99
432_S441_D0.7410.99
74_V99_A0.7400.99
248_F276_F0.7400.99
278_I282_L0.7390.99
211_P251_F0.7370.99
212_Q423_L0.7360.98
172_A176_L0.7350.98
187_I190_D0.7340.98
304_S361_G0.7330.98
267_F325_I0.7290.98
214_L251_F0.7280.98
136_T164_A0.7260.98
46_P67_P0.7250.98
199_E215_Y0.7240.98
45_K49_E0.7220.98
247_T251_F0.7180.98
397_L401_A0.7180.98
434_L446_L0.7170.98
321_L325_I0.7160.98
246_A249_F0.7150.98
17_E63_E0.7140.98
228_E258_Y0.7140.98
197_Y451_L0.7140.98
198_I202_I0.7120.98
449_A453_K0.7110.98
283_P398_L0.7100.98
115_P217_E0.7080.98
78_D82_D0.7080.98
18_F44_L0.7070.98
358_V365_P0.7060.98
396_P416_L0.7060.98
194_D197_Y0.7050.98
31_D36_K0.7040.98
281_L285_L0.7000.98
356_A360_A0.6990.98
249_F273_F0.6990.98
197_Y224_A0.6960.98
113_E127_G0.6960.98
122_R195_S0.6950.98
153_L184_L0.6920.98
14_V70_E0.6920.98
72_K88_D0.6910.98
82_D86_S0.6910.98
398_L402_A0.6910.98
278_I373_L0.6900.98
75_D97_D0.6880.98
19_K22_G0.6880.98
448_R454_M0.6870.98
323_M363_V0.6870.98
110_R130_E0.6870.98
334_G342_G0.6860.98
355_Q372_A0.6850.98
192_I197_Y0.6840.98
148_L166_A0.6840.98
358_V369_I0.6830.98
157_R190_D0.6800.97
176_L428_V0.6800.97
71_V102_I0.6770.97
195_S242_L0.6770.97
131_T162_D0.6750.97
450_P453_K0.6740.97
443_K456_K0.6730.97
260_Q385_E0.6700.97
132_L152_S0.6690.97
324_E391_R0.6680.97
169_E172_A0.6670.97
23_I94_D0.6670.97
31_D70_E0.6640.97
18_F25_A0.6630.97
74_V90_V0.6620.97
391_R395_F0.6610.97
224_A253_Q0.6610.97
93_I96_E0.6590.97
142_R161_T0.6590.97
23_I96_E0.6590.97
131_T141_R0.6590.97
253_Q444_D0.6580.97
3_L13_L0.6580.97
193_L227_L0.6580.97
270_L447_I0.6560.97
399_I403_L0.6550.97
262_P266_S0.6540.97
75_D79_E0.6530.97
38_L42_F0.6520.97
151_E169_E0.6520.97
81_I146_P0.6520.97
34_V89_T0.6510.97
148_L226_L0.6510.97
155_V187_I0.6500.97
309_R312_V0.6490.97
125_R217_E0.6490.97
314_F362_L0.6460.97
406_L409_I0.6450.97
293_H406_L0.6440.97
201_L451_L0.6440.97
246_A250_E0.6440.97
167_Y172_A0.6430.96
334_G340_P0.6420.96
279_S378_S0.6400.96
47_L91_L0.6390.96
118_E221_V0.6380.96
86_S105_R0.6380.96
4_K17_E0.6340.96
155_V198_I0.6330.96
138_L141_R0.6320.96
351_L372_A0.6320.96
207_Y453_K0.6300.96
151_E165_I0.6280.96
198_I235_V0.6280.96
262_P450_P0.6270.96
444_D454_M0.6240.96
128_F241_V0.6230.96
3_L92_L0.6230.96
282_L370_V0.6220.96
143_I226_L0.6220.96
192_I198_I0.6210.96
339_K345_I0.6210.96
251_F383_S0.6190.96
292_F403_L0.6170.96
105_R133_R0.6170.96
179_E204_D0.6170.96
337_L379_F0.6160.96
384_Y387_S0.6150.96
18_F48_M0.6150.96
253_Q269_R0.6140.95
49_E52_E0.6120.95
179_E186_K0.6100.95
178_E185_K0.6090.95
122_R194_D0.6080.95
289_L406_L0.6070.95
201_L452_W0.6050.95
381_I390_I0.6040.95
283_P324_E0.6020.95
248_F420_L0.6020.95
173_N177_V0.6010.95
127_G217_E0.6000.95
378_S387_S0.5990.95
334_G344_A0.5990.95
119_K340_P0.5990.95
31_D136_T0.5980.95
132_L236_D0.5970.95
163_V198_I0.5960.95
142_R193_L0.5950.95
322_L326_T0.5950.95
59_E98_E0.5950.95
328_E391_R0.5950.95
206_P261_R0.5940.95
27_L44_L0.5930.95
117_T127_G0.5930.95
165_I233_I0.5910.94
131_T236_D0.5910.94
258_Y269_R0.5900.94
163_V195_S0.5900.94
265_G268_L0.5900.94
255_P259_Y0.5870.94
287_V291_T0.5860.94
122_R196_G0.5860.94
206_P209_P0.5860.94
186_K424_R0.5850.94
285_L289_L0.5850.94
143_I159_S0.5840.94
74_V83_A0.5830.94
210_F419_H0.5820.94
337_L345_I0.5810.94
122_R242_L0.5810.94
215_Y383_S0.5800.94
11_S150_I0.5790.94
396_P412_G0.5790.94
344_A350_A0.5780.94
32_G107_W0.5770.94
66_L102_I0.5770.94
189_I451_L0.5760.94
33_L141_R0.5740.94
386_L389_A0.5730.93
106_G109_K0.5730.93
6_I147_N0.5720.93
307_A311_G0.5720.93
397_L413_L0.5720.93
205_N208_S0.5700.93
96_E100_L0.5700.93
323_M367_M0.5690.93
200_E203_E0.5690.93
288_A401_A0.5680.93
16_R48_M0.5680.93
451_L454_M0.5670.93
46_P49_E0.5670.93
204_D425_S0.5660.93
71_V100_L0.5660.93
263_I266_S0.5660.93
187_I192_I0.5650.93
77_L81_I0.5650.93
6_I77_L0.5640.93
360_A369_I0.5620.93
40_N69_S0.5620.93
304_S308_S0.5620.93
301_L313_P0.5620.93
8_G169_E0.5610.93
309_R316_A0.5600.93
211_P430_Y0.5590.93
78_D160_K0.5580.93
238_S259_Y0.5560.92
158_R227_L0.5560.92
228_E253_Q0.5540.92
179_E424_R0.5540.92
334_G343_Q0.5540.92
432_S436_P0.5530.92
393_L396_P0.5520.92
331_R395_F0.5520.92
327_F346_S0.5520.92
208_S423_L0.5500.92
326_T373_L0.5490.92
264_I392_L0.5480.92
329_L373_L0.5460.92
300_E303_L0.5460.92
348_V372_A0.5440.92
18_F26_A0.5430.92
42_F67_P0.5430.92
439_L442_L0.5410.91
173_N178_E0.5400.91
452_W455_K0.5400.91
204_D424_R0.5400.91
453_K456_K0.5390.91
214_L383_S0.5390.91
25_A44_L0.5380.91
417_L431_L0.5360.91
287_V401_A0.5360.91
289_L296_M0.5350.91
308_S364_S0.5350.91
421_A435_A0.5340.91
83_A90_V0.5340.91
135_N138_L0.5340.91
120_V124_P0.5320.91
279_S377_A0.5320.91
118_E275_A0.5320.91
176_L179_E0.5320.91
133_R152_S0.5300.91
401_A405_G0.5290.90
332_E336_R0.5280.90
456_K459_S0.5280.90
61_L65_L0.5270.90
11_S136_T0.5270.90
409_I413_L0.5270.90
179_E202_I0.5270.90
362_L369_I0.5270.90
340_P344_A0.5260.90
48_M51_S0.5250.90
212_Q425_S0.5230.90
299_T303_L0.5230.90
304_S366_I0.5230.90
444_D447_I0.5230.90
50_L53_E0.5200.90
45_K67_P0.5200.90
411_L418_I0.5170.89
4_K9_N0.5170.89
105_R162_D0.5170.89
81_I84_I0.5170.89
260_Q268_L0.5160.89
345_I375_A0.5160.89
34_V106_G0.5160.89
289_L297_I0.5160.89
43_I46_P0.5150.89
339_K344_A0.5150.89
305_I308_S0.5150.89
80_I84_I0.5150.89
39_I43_I0.5150.89
280_L284_A0.5150.89
340_P346_S0.5140.89
424_R429_P0.5130.89
286_Y316_A0.5130.89
3_L81_I0.5120.89
196_G199_E0.5100.89
418_I422_S0.5100.89
150_I234_L0.5090.89
327_F379_F0.5090.89
431_L435_A0.5090.89
43_I89_T0.5090.89
297_I300_E0.5090.89
60_E63_E0.5090.89
193_L223_A0.5080.89
374_T394_R0.5080.89
442_L449_A0.5080.89
337_L341_I0.5070.89
11_S164_A0.5070.89
364_S367_M0.5070.89
440_K459_S0.5060.88
220_D259_Y0.5060.88
400_L411_L0.5060.88
112_V129_T0.5060.88
44_L67_P0.5060.88
358_V363_V0.5050.88
432_S435_A0.5050.88
48_M67_P0.5050.88
63_E73_E0.5040.88
252_F386_L0.5040.88
70_E88_D0.5020.88
171_I177_V0.5020.88
221_V225_A0.5020.88
194_D235_V0.5010.88
7_F13_L0.5010.88
303_L306_A0.5010.88
222_V226_L0.5010.88
209_P392_L0.5000.88
444_D448_R0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hh1A 2 0.2261 20.5 0.98 Contact Map
4g3oA 1 0.0957 17.1 0.981 Contact Map
3kpeA 3 0.1065 16.4 0.981 Contact Map
2qx0A 2 0.1587 12.8 0.982 Contact Map
1rybA 1 0.1522 11.9 0.982 Contact Map
1xtiA 1 0.35 11.5 0.982 Contact Map
1t5iA 1 0.3326 8.8 0.983 Contact Map
2k8yA 1 0.3109 8.5 0.983 Contact Map
1cbkA 2 0.163 8.5 0.983 Contact Map
4bemA 3 0.1761 8.4 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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