GREMLIN Database
Cornichon - Cornichon protein
PFAM: PF03311 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 122 (121)
Sequences: 627 (412)
Seq/√Len: 37.5
META: 0.212

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_L62_L3.5341.00
72_N120_Y2.9711.00
28_L31_D2.6921.00
81_Y85_S2.6811.00
82_K105_E2.6111.00
31_D34_N2.5101.00
19_V118_F2.4971.00
14_L18_A2.3621.00
49_E109_K2.1630.99
117_F122_Y2.1500.99
27_D38_L2.1060.99
39_C90_Y2.0510.99
96_F103_K2.0480.99
35_P96_F1.9760.98
43_N93_T1.9550.98
14_L25_L1.8660.98
79_N113_Y1.8620.98
29_E103_K1.8230.97
15_L19_V1.7360.97
51_I54_G1.7180.96
54_G76_L1.6850.96
7_A60_F1.6370.95
31_D35_P1.6170.95
53_H72_N1.6100.95
105_E109_K1.5920.94
94_E97_N1.5830.94
73_L77_A1.5800.94
16_F19_V1.5700.94
32_Y99_L1.4860.92
29_E94_E1.4750.92
24_C38_L1.4610.91
55_F58_L1.4550.91
46_V90_Y1.4420.91
75_L79_N1.4310.90
28_L34_N1.3280.87
79_N109_K1.3130.86
48_P74_P1.3120.86
67_F115_L1.3060.86
92_P96_F1.3010.86
23_I52_L1.2990.85
27_D33_I1.2700.84
5_L9_L1.2510.83
46_V75_L1.2480.83
26_S29_E1.2400.83
47_L53_H1.2170.81
12_A122_Y1.2170.81
8_L22_L1.1810.79
114_L121_L1.1700.79
62_L114_L1.1490.78
31_D37_D1.1370.77
80_V84_M1.1370.77
34_N43_N1.1140.75
13_A66_W1.1010.74
14_L22_L1.0880.74
7_A13_A1.0740.73
57_T69_F1.0710.72
49_E82_K1.0670.72
17_L52_L1.0650.72
51_I55_F1.0390.70
25_L38_L1.0340.70
53_H63_T1.0010.67
77_A81_Y0.9920.66
105_E108_I0.9890.66
31_D96_F0.9740.65
105_E112_F0.9550.63
68_M119_Y0.9540.63
117_F121_L0.9520.63
22_L115_L0.9480.63
78_Y81_Y0.9460.63
104_K108_I0.9430.62
31_D66_W0.9230.61
72_N75_L0.9220.61
54_G77_A0.9200.60
72_N112_F0.9130.60
95_I99_L0.8950.58
7_A17_L0.8910.58
78_Y89_L0.8880.58
16_F21_F0.8790.57
86_K100_N0.8710.56
21_F92_P0.8700.56
48_P66_W0.8670.56
5_L37_D0.8630.56
5_L11_N0.8340.53
6_L13_A0.8290.53
104_K111_G0.8180.52
65_H68_M0.8130.51
70_L81_Y0.8060.51
117_F120_Y0.8010.50
42_L90_Y0.7760.48
79_N112_F0.7710.47
69_F112_F0.7690.47
40_N44_P0.7690.47
16_F86_K0.7690.47
11_N18_A0.7680.47
4_W119_Y0.7650.47
26_S91_D0.7630.47
64_G67_F0.7600.46
19_V23_I0.7550.46
79_N105_E0.7530.46
105_E114_L0.7490.45
49_E78_Y0.7470.45
114_L118_F0.7420.45
37_D103_K0.7410.45
67_F75_L0.7380.45
37_D40_N0.7380.45
39_C92_P0.7350.44
4_W8_L0.7350.44
24_C45_L0.7330.44
61_L77_A0.7320.44
33_I41_R0.7320.44
35_P100_N0.7280.44
28_L48_P0.7210.43
97_N112_F0.7170.43
51_I80_V0.7170.43
11_N14_L0.7140.42
50_Y78_Y0.6930.41
34_N99_L0.6870.40
2_F12_A0.6830.40
22_L63_T0.6720.39
21_F27_D0.6700.39
12_A20_Y0.6690.39
102_H106_R0.6560.37
67_F116_L0.6540.37
111_G116_L0.6500.37
16_F23_I0.6490.37
71_L121_L0.6440.36
11_N52_L0.6410.36
60_F76_L0.6380.36
5_L50_Y0.6380.36
118_F121_L0.6310.35
84_M87_Q0.6250.35
23_I113_Y0.6250.35
103_K107_F0.6190.34
88_H103_K0.6150.34
8_L12_A0.6100.34
51_I70_L0.6080.34
32_Y95_I0.6050.33
3_L7_A0.6050.33
4_W88_H0.6020.33
17_L39_C0.5930.32
59_L65_H0.5930.32
11_N97_N0.5880.32
52_L78_Y0.5860.32
2_F58_L0.5810.31
94_E103_K0.5810.31
58_L67_F0.5720.31
10_L13_A0.5710.31
34_N94_E0.5680.30
97_N103_K0.5670.30
54_G57_T0.5660.30
54_G106_R0.5660.30
69_F116_L0.5610.30
116_L119_Y0.5610.30
76_L81_Y0.5600.30
100_N104_K0.5570.30
2_F9_L0.5560.30
3_L11_N0.5540.29
6_L12_A0.5530.29
5_L75_L0.5500.29
81_Y114_L0.5490.29
73_L116_L0.5480.29
73_L76_L0.5470.29
114_L122_Y0.5460.29
28_L91_D0.5440.29
18_A58_L0.5420.29
70_L108_I0.5410.28
20_Y26_S0.5400.28
61_L67_F0.5360.28
61_L64_G0.5360.28
51_I115_L0.5320.28
2_F10_L0.5270.27
32_Y40_N0.5260.27
11_N92_P0.5240.27
96_F100_N0.5240.27
16_F121_L0.5180.27
52_L73_L0.5180.27
37_D49_E0.5170.27
51_I58_L0.5160.27
56_L60_F0.5150.27
71_L80_V0.5140.27
99_L104_K0.5080.26
45_L108_I0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z73A 2 0.8934 5.2 0.927 Contact Map
4mbsA 1 0.9016 4.4 0.929 Contact Map
4eiyA 1 0.9098 3.7 0.932 Contact Map
2ks9A 1 0.8689 3.5 0.933 Contact Map
4xnvA 1 0.8852 3.5 0.933 Contact Map
4yayA 1 0.7049 3.3 0.934 Contact Map
4pxzA 1 0.8852 3 0.935 Contact Map
4tq3A 1 0.9426 2.8 0.936 Contact Map
4ea3A 2 0.8607 2.5 0.938 Contact Map
1v96A 2 0.418 2.5 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0057 seconds.