GREMLIN Database
Mucin_bdg - Putative mucin or carbohydrate-binding module
PFAM: PF03272 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 115 (114)
Sequences: 587 (414)
Seq/√Len: 38.7
META: 0.235

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_F41_A3.7901.00
47_D51_K3.4671.00
32_H84_E3.3651.00
53_V76_D3.1301.00
2_F89_L3.0191.00
111_T114_G2.8041.00
5_L33_S2.3901.00
83_A104_K2.3051.00
5_L34_Y2.1740.99
16_D19_T2.1100.99
39_T57_E2.1060.99
22_L45_V1.9820.99
35_F84_E1.9560.99
40_Y84_E1.9330.98
44_T79_K1.9190.98
46_Y79_K1.8440.98
8_R29_G1.8130.98
93_N97_K1.7220.97
35_F83_A1.7080.97
20_K73_E1.6980.96
48_A73_E1.6640.96
47_D76_D1.6440.96
5_L8_R1.6020.95
6_G34_Y1.5900.95
74_Y112_K1.5450.94
35_F60_G1.5340.94
6_G32_H1.4290.91
79_K105_T1.3700.89
84_E88_R1.3480.88
95_N98_K1.3410.88
73_E76_D1.3390.88
21_K71_P1.3390.88
91_T97_K1.3070.87
34_Y60_G1.3000.86
17_L72_F1.2860.86
82_H89_L1.2780.86
39_T42_S1.2630.85
78_I115_L1.2360.84
32_H35_F1.2330.83
52_E55_N1.2270.83
23_T69_G1.2220.83
47_D50_G1.2060.82
41_A82_H1.1530.79
32_H40_Y1.1280.77
72_F110_V1.1240.77
11_A24_V1.0970.75
31_P58_I1.0960.75
9_E12_T1.0650.73
38_E83_A1.0610.73
21_K69_G1.0250.70
10_F82_H1.0170.70
40_Y82_H0.9960.68
32_H88_R0.9930.68
102_K112_K0.9790.67
77_V109_K0.9540.65
92_N95_N0.9530.65
10_F58_I0.9520.65
94_D108_Y0.9430.64
24_V115_L0.9350.63
61_N80_V0.9290.63
53_V73_E0.9280.63
13_V24_V0.9250.62
46_Y77_V0.9140.61
24_V70_V0.9110.61
24_V76_D0.8970.60
2_F13_V0.8950.60
93_N99_L0.8950.60
14_T25_T0.8950.60
17_L76_D0.8810.58
17_L89_L0.8790.58
26_V58_I0.8710.58
30_Q33_S0.8690.57
48_A76_D0.8680.57
41_A58_I0.8650.57
26_V54_Y0.8510.56
90_I108_Y0.8420.55
54_Y77_V0.8380.55
26_V71_P0.8340.54
6_G23_T0.8330.54
50_G77_V0.8310.54
94_D99_L0.8230.53
73_E112_K0.8170.53
78_I110_V0.8140.53
111_T115_L0.8060.52
46_Y52_E0.8060.52
72_F108_Y0.8030.52
99_L106_N0.7990.51
90_I94_D0.7940.51
15_L66_A0.7880.50
72_F79_K0.7860.50
10_F31_P0.7850.50
100_E106_N0.7850.50
31_P61_N0.7700.49
107_T115_L0.7570.47
29_G45_V0.7560.47
44_T52_E0.7440.46
90_I99_L0.7350.45
56_K75_G0.7230.44
63_K67_E0.7190.44
54_Y60_G0.7190.44
3_K9_E0.7050.43
107_T110_V0.6960.42
32_H36_G0.6940.42
24_V31_P0.6940.42
94_D98_K0.6900.41
57_E67_E0.6900.41
8_R27_T0.6890.41
103_G106_N0.6850.41
3_K90_I0.6780.40
6_G33_S0.6750.40
20_K47_D0.6740.40
44_T76_D0.6720.40
18_E21_K0.6700.40
93_N98_K0.6640.39
56_K80_V0.6620.39
4_G7_D0.6570.39
43_I93_N0.6530.38
63_K71_P0.6490.38
5_L9_E0.6390.37
3_K30_Q0.6350.37
106_N115_L0.6310.36
34_Y84_E0.6290.36
62_S70_V0.6250.36
15_L80_V0.6230.36
73_E95_N0.6230.36
106_N114_G0.6220.36
74_Y111_T0.6140.35
43_I101_K0.6130.35
4_G40_Y0.6040.34
20_K54_Y0.6010.34
105_T108_Y0.5960.33
31_P41_A0.5910.33
4_G32_H0.5910.33
12_T21_K0.5850.33
60_G83_A0.5840.33
16_D46_Y0.5780.32
11_A58_I0.5750.32
25_T28_A0.5700.31
22_L61_N0.5680.31
13_V43_I0.5670.31
7_D55_N0.5660.31
45_V54_Y0.5650.31
4_G35_F0.5640.31
6_G28_A0.5630.31
102_K107_T0.5620.31
37_N63_K0.5620.31
12_T115_L0.5590.31
86_D113_N0.5590.31
96_N99_L0.5530.30
53_V81_Y0.5490.30
49_N53_V0.5470.30
14_T49_N0.5470.30
86_D101_K0.5430.29
75_G111_T0.5350.29
3_K76_D0.5340.29
10_F88_R0.5310.28
53_V80_V0.5280.28
66_A98_K0.5260.28
42_S81_Y0.5260.28
34_Y88_R0.5220.28
68_N76_D0.5200.28
32_H41_A0.5190.28
78_I94_D0.5180.28
35_F38_E0.5130.27
42_S53_V0.5120.27
93_N100_E0.5090.27
60_G115_L0.5080.27
55_N70_V0.5070.27
19_T104_K0.5040.27
52_E77_V0.5020.26
52_E71_P0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1n4kA 1 0.313 39.7 0.882 Contact Map
3d33A 1 0.7217 24 0.894 Contact Map
3isyA 1 0.8783 20.2 0.898 Contact Map
3h63A 1 0.3565 13.2 0.906 Contact Map
4yx7A 1 0.4957 8.4 0.914 Contact Map
4exrA 2 0.7043 8.2 0.915 Contact Map
3sd2A 2 0.6957 7.4 0.916 Contact Map
1yfbA 2 0.4522 6.7 0.918 Contact Map
2l66A 2 0.4609 6.5 0.918 Contact Map
3malA 1 0.3913 6.3 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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