DNase_II - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DNase_II - Deoxyribonuclease II

PFAM:	PF03265	Sequences: SCRNENGKPVDWFFVYKLPSGPSSATGLEYVYADSTSPWQLSKGLINDTTGALGATLDQLYKASNNSSTAYVLYNDQPPSGSCSSSWGHSKGVLAWDSDQGFWLVHSVPKFPPRPEDGYSYPDNGVKYGQTFLCLSLSKDQLEKIAKQLLYAEPNVYDSNLPDTFAGGLPDLQKLVNGLGVKSSSTTLTSAGGTGFTSFAKSSKFNVDLYQDVVAPLLKTDLLVETWQRGPGKLPSDCSGPYKVYNVKTIKLGLGGTFSSTKDHSKWAVSTSGSGPWVCFGDINRQSSQNKRGGGTVCFQNPALWKAFRKLVKEYEPC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	318 (315)
Sequences:	916 (712)
Seq/√Len:	40.1
META:	0.412

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
135_L	190_S	4.555	1.00
74_Y	103_W	3.693	1.00
222_L	268_A	3.584	1.00
3_R	9_P	3.557	1.00
214_V	296_T	3.500	1.00
137_L	145_I	3.491	1.00
53_L	104_L	3.392	1.00
162_P	165_F	2.892	1.00
264_H	284_N	2.783	1.00
154_P	157_Y	2.748	1.00
108_V	132_F	2.661	1.00
289_Q	292_R	2.633	1.00
234_L	238_C	2.536	1.00
77_Q	110_K	2.503	1.00
279_C	298_C	2.488	1.00
4_N	8_K	2.359	1.00
14_F	304_L	2.355	1.00
143_E	171_D	2.234	1.00
269_V	305_W	2.164	0.99
89_H	264_H	2.150	0.99
161_L	165_F	2.125	0.99
60_L	102_F	2.125	0.99
266_K	284_N	2.087	0.99
234_L	237_D	2.084	0.99
148_Q	198_S	2.058	0.99
21_G	24_S	2.058	0.99
259_S	262_K	2.042	0.99
121_Y	125_G	2.035	0.99
89_H	284_N	2.023	0.99
130_Q	264_H	2.019	0.99
56_T	59_Q	1.993	0.99
89_H	130_Q	1.966	0.99
110_K	124_N	1.944	0.99
134_C	279_C	1.924	0.99
284_N	292_R	1.920	0.99
15_V	53_L	1.910	0.98
233_K	236_S	1.900	0.98
76_D	266_K	1.892	0.98
89_H	266_K	1.878	0.98
236_S	239_S	1.864	0.98
284_N	289_Q	1.864	0.98
210_Y	268_A	1.863	0.98
244_V	247_V	1.849	0.98
266_K	292_R	1.839	0.98
305_W	309_R	1.776	0.98
105_V	297_V	1.774	0.98
207_V	212_D	1.767	0.97
302_P	306_K	1.757	0.97
74_Y	88_G	1.756	0.97
231_P	236_S	1.747	0.97
77_Q	225_E	1.738	0.97
209_L	296_T	1.735	0.97
134_C	298_C	1.733	0.97
131_T	281_G	1.733	0.97
90_S	152_A	1.716	0.97
264_H	292_R	1.713	0.97
130_Q	284_N	1.699	0.97
231_P	234_L	1.698	0.97
79_P	267_W	1.683	0.97
231_P	238_C	1.655	0.96
34_D	52_A	1.652	0.96
220_T	270_S	1.634	0.96
10_V	13_F	1.633	0.96
162_P	166_A	1.614	0.96
281_G	296_T	1.565	0.95
185_S	192_G	1.564	0.95
59_Q	102_F	1.563	0.95
229_R	286_Q	1.558	0.95
89_H	292_R	1.551	0.95
201_K	227_W	1.550	0.95
76_D	89_H	1.544	0.94
94_L	142_L	1.536	0.94
146_A	175_L	1.533	0.94
210_Y	296_T	1.516	0.94
234_L	239_S	1.515	0.94
19_P	129_G	1.515	0.94
5_E	42_S	1.500	0.94
76_D	284_N	1.492	0.93
93_V	104_L	1.482	0.93
154_P	158_D	1.477	0.93
22_P	25_A	1.466	0.93
241_P	247_V	1.453	0.92
153_E	157_Y	1.429	0.92
275_G	300_Q	1.409	0.91
244_V	248_K	1.404	0.91
209_L	283_I	1.382	0.90
20_S	23_S	1.360	0.90
264_H	289_Q	1.350	0.89
293_G	304_L	1.350	0.89
76_D	264_H	1.346	0.89
242_Y	245_Y	1.339	0.89
232_G	236_S	1.335	0.89
228_Q	260_S	1.335	0.89
233_K	238_C	1.332	0.89
242_Y	248_K	1.328	0.89
130_Q	292_R	1.318	0.88
266_K	294_G	1.317	0.88
187_T	192_G	1.314	0.88
152_A	282_D	1.297	0.87
161_L	164_T	1.291	0.87
219_K	242_Y	1.283	0.87
242_Y	247_V	1.275	0.86
218_L	277_W	1.268	0.86
247_V	267_W	1.266	0.86
74_Y	105_V	1.245	0.85
282_D	295_G	1.232	0.84
243_K	247_V	1.232	0.84
189_T	192_G	1.232	0.84
266_K	289_Q	1.227	0.84
215_A	222_L	1.224	0.84
130_Q	266_K	1.221	0.84
245_Y	248_K	1.216	0.84
242_Y	246_N	1.216	0.84
131_T	280_F	1.210	0.83
190_S	196_F	1.195	0.83
5_E	30_Y	1.194	0.83
10_V	32_Y	1.191	0.82
185_S	189_T	1.189	0.82
109_P	292_R	1.173	0.81
218_L	222_L	1.173	0.81
224_V	244_V	1.173	0.81
231_P	239_S	1.157	0.80
89_H	227_W	1.149	0.80
194_T	301_N	1.135	0.79
16_Y	258_F	1.125	0.79
88_G	130_Q	1.119	0.78
76_D	292_R	1.114	0.78
89_H	109_P	1.110	0.78
266_K	282_D	1.107	0.77
73_L	94_L	1.104	0.77
17_K	56_T	1.102	0.77
168_G	179_L	1.101	0.77
243_K	248_K	1.097	0.77
209_L	214_V	1.097	0.77
151_Y	154_P	1.096	0.77
264_H	294_G	1.088	0.76
107_S	130_Q	1.082	0.76
185_S	190_S	1.078	0.75
76_D	294_G	1.077	0.75
283_I	296_T	1.072	0.75
278_V	305_W	1.070	0.75
240_G	244_V	1.068	0.75
135_L	297_V	1.057	0.74
70_A	97_D	1.055	0.74
89_H	289_Q	1.051	0.74
152_A	156_V	1.050	0.74
221_D	272_S	1.047	0.73
108_V	119_Y	1.039	0.73
118_G	121_Y	1.039	0.73
176_V	179_L	1.036	0.73
233_K	239_S	1.032	0.72
235_P	238_C	1.032	0.72
288_S	292_R	1.026	0.72
72_V	156_V	1.016	0.71
108_V	125_G	1.009	0.71
153_E	158_D	1.007	0.70
83_C	87_W	1.004	0.70
261_T	288_S	0.997	0.70
172_L	176_V	0.995	0.69
88_G	266_K	0.991	0.69
229_R	232_G	0.988	0.69
76_D	91_K	0.982	0.68
121_Y	124_N	0.978	0.68
26_T	29_E	0.972	0.68
160_N	163_D	0.964	0.67
109_P	266_K	0.964	0.67
232_G	235_P	0.962	0.67
88_G	284_N	0.958	0.66
16_Y	39_W	0.955	0.66
109_P	264_H	0.952	0.66
16_Y	88_G	0.949	0.66
138_S	141_Q	0.941	0.65
263_D	279_C	0.939	0.65
100_Q	136_S	0.936	0.65
109_P	289_Q	0.935	0.65
88_G	292_R	0.935	0.65
122_P	134_C	0.931	0.64
281_G	284_N	0.925	0.64
169_L	179_L	0.924	0.64
282_D	292_R	0.923	0.64
306_K	310_K	0.920	0.63
289_Q	294_G	0.920	0.63
112_P	282_D	0.920	0.63
167_G	170_P	0.914	0.63
249_T	252_L	0.911	0.63
284_N	294_G	0.896	0.61
33_A	304_L	0.892	0.61
39_W	74_Y	0.888	0.61
109_P	227_W	0.887	0.60
282_D	289_Q	0.887	0.60
286_Q	289_Q	0.884	0.60
53_L	56_T	0.883	0.60
214_V	218_L	0.881	0.60
227_W	284_N	0.880	0.60
241_P	246_N	0.877	0.60
227_W	289_Q	0.877	0.60
34_D	111_F	0.874	0.59
109_P	284_N	0.873	0.59
107_S	125_G	0.872	0.59
109_P	130_Q	0.871	0.59
241_P	245_Y	0.869	0.59
287_S	290_N	0.869	0.59
52_A	59_Q	0.869	0.59
6_N	36_T	0.868	0.59
88_G	264_H	0.867	0.59
172_L	180_G	0.867	0.59
248_K	251_K	0.867	0.59
153_E	156_V	0.856	0.58
242_Y	250_I	0.854	0.57
241_P	244_V	0.851	0.57
4_N	36_T	0.850	0.57
7_G	55_A	0.847	0.57
60_L	95_A	0.846	0.57
238_C	298_C	0.845	0.57
227_W	266_K	0.844	0.57
136_S	304_L	0.840	0.56
187_T	191_A	0.836	0.56
17_K	27_G	0.833	0.56
205_F	213_V	0.833	0.56
307_A	311_L	0.831	0.55
264_H	281_G	0.830	0.55
89_H	107_S	0.825	0.55
235_P	246_N	0.822	0.55
307_A	310_K	0.822	0.55
151_Y	156_V	0.820	0.54
256_G	260_S	0.820	0.54
128_Y	225_E	0.819	0.54
167_G	176_V	0.819	0.54
289_Q	293_G	0.815	0.54
103_W	208_D	0.808	0.53
90_S	135_L	0.804	0.53
169_L	172_L	0.801	0.53
130_Q	289_Q	0.800	0.53
167_G	179_L	0.799	0.52
157_Y	166_A	0.798	0.52
143_E	170_P	0.797	0.52
195_G	217_L	0.792	0.52
226_T	289_Q	0.791	0.52
114_R	117_D	0.786	0.51
74_Y	208_D	0.785	0.51
56_T	60_L	0.783	0.51
173_Q	180_G	0.782	0.51
122_P	125_G	0.780	0.51
79_P	157_Y	0.780	0.51
278_V	308_F	0.776	0.50
87_W	220_T	0.775	0.50
205_F	258_F	0.772	0.50
77_Q	89_H	0.767	0.50
16_Y	129_G	0.766	0.49
168_G	172_L	0.760	0.49
43_K	66_N	0.759	0.49
14_F	308_F	0.759	0.49
103_W	308_F	0.758	0.49
30_Y	75_N	0.758	0.49
210_Y	214_V	0.757	0.49
14_F	265_S	0.754	0.48
152_A	209_L	0.749	0.48
171_D	179_L	0.746	0.48
31_V	43_K	0.746	0.48
173_Q	177_N	0.744	0.47
77_Q	299_F	0.737	0.47
188_L	308_F	0.733	0.46
76_D	88_G	0.733	0.46
157_Y	163_D	0.727	0.46
279_C	285_R	0.726	0.46
10_V	35_S	0.725	0.46
157_Y	162_P	0.725	0.46
75_N	282_D	0.723	0.46
76_D	109_P	0.722	0.45
111_F	157_Y	0.721	0.45
14_F	108_V	0.719	0.45
232_G	238_C	0.716	0.45
199_F	217_L	0.715	0.45
90_S	154_P	0.712	0.45
75_N	109_P	0.711	0.44
130_Q	227_W	0.710	0.44
107_S	294_G	0.708	0.44
304_L	308_F	0.706	0.44
82_S	127_K	0.699	0.43
299_F	308_F	0.699	0.43
56_T	265_S	0.698	0.43
215_A	220_T	0.696	0.43
272_S	276_P	0.694	0.43
160_N	166_A	0.691	0.43
147_K	175_L	0.691	0.43
148_Q	200_A	0.691	0.43
105_V	131_T	0.687	0.42
42_S	52_A	0.687	0.42
158_D	165_F	0.686	0.42
91_K	266_K	0.685	0.42
175_L	180_G	0.684	0.42
135_L	196_F	0.684	0.42
88_G	151_Y	0.682	0.42
109_P	201_K	0.681	0.42
129_G	229_R	0.676	0.41
57_L	111_F	0.676	0.41
264_H	282_D	0.676	0.41
123_D	126_V	0.675	0.41
16_Y	128_Y	0.673	0.41
129_G	263_D	0.671	0.41
108_V	124_N	0.671	0.41
69_T	142_L	0.669	0.41
142_L	172_L	0.667	0.40
89_H	201_K	0.663	0.40
2_C	298_C	0.660	0.40
166_A	170_P	0.657	0.40
201_K	266_K	0.656	0.40
36_T	142_L	0.656	0.40
198_S	210_Y	0.655	0.39
144_K	191_A	0.655	0.39
75_N	136_S	0.655	0.39
77_Q	284_N	0.654	0.39
32_Y	41_L	0.653	0.39
233_K	237_D	0.651	0.39
2_C	12_W	0.649	0.39
187_T	197_T	0.647	0.39
306_K	309_R	0.646	0.39
173_Q	176_V	0.646	0.39
103_W	267_W	0.645	0.39
66_N	272_S	0.644	0.38
106_H	279_C	0.643	0.38
255_G	272_S	0.642	0.38
19_P	267_W	0.640	0.38
208_D	295_G	0.640	0.38
160_N	164_T	0.639	0.38
167_G	174_K	0.638	0.38
58_D	99_D	0.636	0.38
175_L	178_G	0.636	0.38
7_G	11_D	0.635	0.38
132_F	213_V	0.634	0.38
95_A	102_F	0.634	0.38
72_V	214_V	0.634	0.38
25_A	147_K	0.632	0.37
70_A	258_F	0.631	0.37
263_D	267_W	0.629	0.37
106_H	263_D	0.629	0.37
298_C	308_F	0.629	0.37
162_P	174_K	0.628	0.37
79_P	103_W	0.628	0.37
221_D	271_T	0.627	0.37
253_G	260_S	0.625	0.37
125_G	128_Y	0.622	0.37
122_P	190_S	0.619	0.36
30_Y	226_T	0.618	0.36
303_A	309_R	0.618	0.36
235_P	251_K	0.617	0.36
281_G	294_G	0.617	0.36
233_K	286_Q	0.617	0.36
175_L	179_L	0.616	0.36
210_Y	222_L	0.615	0.36
23_S	26_T	0.614	0.36
90_S	288_S	0.612	0.36
185_S	197_T	0.611	0.36
77_Q	130_Q	0.607	0.35
159_S	176_V	0.606	0.35
247_V	250_I	0.605	0.35
77_Q	264_H	0.604	0.35
190_S	193_G	0.604	0.35
151_Y	157_Y	0.604	0.35
180_G	183_S	0.603	0.35
20_S	24_S	0.601	0.35
106_H	285_R	0.601	0.35
106_H	298_C	0.601	0.35
14_F	18_L	0.601	0.35
275_G	306_K	0.601	0.35
30_Y	34_D	0.598	0.35
109_P	294_G	0.597	0.34
95_A	277_W	0.597	0.34
28_L	47_N	0.596	0.34
108_V	121_Y	0.594	0.34
101_G	142_L	0.594	0.34
6_N	306_K	0.592	0.34
60_L	93_V	0.591	0.34
80_S	83_C	0.591	0.34
241_P	248_K	0.589	0.34
200_A	244_V	0.587	0.34
285_R	295_G	0.585	0.33
269_V	309_R	0.583	0.33
208_D	285_R	0.583	0.33
106_H	267_W	0.582	0.33
70_A	100_Q	0.581	0.33
8_K	36_T	0.581	0.33
282_D	294_G	0.580	0.33
178_G	181_V	0.580	0.33
31_V	39_W	0.572	0.32
76_D	130_Q	0.571	0.32
128_Y	254_L	0.571	0.32
46_I	147_K	0.571	0.32
70_A	162_P	0.571	0.32
231_P	235_P	0.571	0.32
228_Q	261_T	0.570	0.32
14_F	39_W	0.570	0.32
100_Q	161_L	0.568	0.32
107_S	264_H	0.568	0.32
66_N	182_K	0.568	0.32
89_H	294_G	0.567	0.32
20_S	25_A	0.567	0.32
114_R	118_G	0.567	0.32
227_W	264_H	0.566	0.32
287_S	297_V	0.566	0.32
102_F	136_S	0.566	0.32
58_D	66_N	0.566	0.32
88_G	148_Q	0.566	0.32
16_Y	107_S	0.565	0.32
14_F	19_P	0.565	0.32
25_A	29_E	0.563	0.32
91_K	284_N	0.562	0.32
89_H	225_E	0.562	0.32
2_C	279_C	0.561	0.32
107_S	292_R	0.561	0.32
209_L	295_G	0.561	0.32
229_R	260_S	0.561	0.32
201_K	264_H	0.561	0.32
105_V	108_V	0.558	0.31
177_N	182_K	0.557	0.31
68_S	71_Y	0.556	0.31
112_P	222_L	0.556	0.31
36_T	40_Q	0.556	0.31
258_F	308_F	0.555	0.31
19_P	111_F	0.554	0.31
210_Y	224_V	0.554	0.31
89_H	282_D	0.553	0.31
152_A	157_Y	0.553	0.31
156_V	218_L	0.553	0.31
106_H	134_C	0.553	0.31
254_L	260_S	0.551	0.31
89_H	226_T	0.551	0.31
269_V	288_S	0.551	0.31
101_G	188_L	0.550	0.31
110_K	228_Q	0.548	0.31
177_N	181_V	0.547	0.30
253_G	256_G	0.546	0.30
53_L	60_L	0.546	0.30
157_Y	164_T	0.543	0.30
207_V	213_V	0.541	0.30
266_K	281_G	0.539	0.30
37_S	194_T	0.538	0.30
30_Y	53_L	0.537	0.30
167_G	172_L	0.533	0.29
54_G	112_P	0.532	0.29
6_N	15_V	0.532	0.29
170_P	174_K	0.531	0.29
76_D	289_Q	0.529	0.29
276_P	300_Q	0.528	0.29
63_A	66_N	0.528	0.29
32_Y	107_S	0.528	0.29
209_L	282_D	0.528	0.29
78_P	155_N	0.526	0.29
169_L	175_L	0.523	0.29
178_G	182_K	0.522	0.29
110_K	122_P	0.522	0.29
129_G	134_C	0.521	0.28
91_K	294_G	0.521	0.28
53_L	142_L	0.521	0.28
87_W	155_N	0.521	0.28
227_W	292_R	0.519	0.28
214_V	222_L	0.519	0.28
101_G	112_P	0.519	0.28
124_N	210_Y	0.518	0.28
168_G	173_Q	0.516	0.28
142_L	161_L	0.515	0.28
16_Y	131_T	0.515	0.28
30_Y	51_G	0.510	0.28
8_K	80_S	0.510	0.28
183_S	213_V	0.509	0.28
135_L	211_Q	0.509	0.28
306_K	312_V	0.509	0.28
142_L	145_I	0.508	0.28
76_D	107_S	0.508	0.28
50_T	104_L	0.506	0.27
138_S	192_G	0.505	0.27
79_P	263_D	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2cxyA	1	0.2453	19.8	0.967	Contact Map
1ig6A	1	0.2579	4.9	0.975	Contact Map
2bsjA	2	0.2956	3.7	0.976	Contact Map
3m95A	1	0.195	3.7	0.977	Contact Map
2rklA	2	0.1667	3.3	0.977	Contact Map
3w1yA	2	0.1918	2.9	0.978	Contact Map
1whvA	1	0.283	2.7	0.978	Contact Map
3h9dA	2	0.1981	2.7	0.978	Contact Map
2li6A	1	0.2421	2.4	0.979	Contact Map
1x9uA	1	0.1698	2.2	0.979	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.