GREMLIN Database
DNase_II - Deoxyribonuclease II
PFAM: PF03265 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 318 (315)
Sequences: 916 (712)
Seq/√Len: 40.1
META: 0.412

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_L190_S4.5551.00
74_Y103_W3.6931.00
222_L268_A3.5841.00
3_R9_P3.5571.00
214_V296_T3.5001.00
137_L145_I3.4911.00
53_L104_L3.3921.00
162_P165_F2.8921.00
264_H284_N2.7831.00
154_P157_Y2.7481.00
108_V132_F2.6611.00
289_Q292_R2.6331.00
234_L238_C2.5361.00
77_Q110_K2.5031.00
279_C298_C2.4881.00
4_N8_K2.3591.00
14_F304_L2.3551.00
143_E171_D2.2341.00
269_V305_W2.1640.99
89_H264_H2.1500.99
161_L165_F2.1250.99
60_L102_F2.1250.99
266_K284_N2.0870.99
234_L237_D2.0840.99
148_Q198_S2.0580.99
21_G24_S2.0580.99
259_S262_K2.0420.99
121_Y125_G2.0350.99
89_H284_N2.0230.99
130_Q264_H2.0190.99
56_T59_Q1.9930.99
89_H130_Q1.9660.99
110_K124_N1.9440.99
134_C279_C1.9240.99
284_N292_R1.9200.99
15_V53_L1.9100.98
233_K236_S1.9000.98
76_D266_K1.8920.98
89_H266_K1.8780.98
236_S239_S1.8640.98
284_N289_Q1.8640.98
210_Y268_A1.8630.98
244_V247_V1.8490.98
266_K292_R1.8390.98
305_W309_R1.7760.98
105_V297_V1.7740.98
207_V212_D1.7670.97
302_P306_K1.7570.97
74_Y88_G1.7560.97
231_P236_S1.7470.97
77_Q225_E1.7380.97
209_L296_T1.7350.97
134_C298_C1.7330.97
131_T281_G1.7330.97
90_S152_A1.7160.97
264_H292_R1.7130.97
130_Q284_N1.6990.97
231_P234_L1.6980.97
79_P267_W1.6830.97
231_P238_C1.6550.96
34_D52_A1.6520.96
220_T270_S1.6340.96
10_V13_F1.6330.96
162_P166_A1.6140.96
281_G296_T1.5650.95
185_S192_G1.5640.95
59_Q102_F1.5630.95
229_R286_Q1.5580.95
89_H292_R1.5510.95
201_K227_W1.5500.95
76_D89_H1.5440.94
94_L142_L1.5360.94
146_A175_L1.5330.94
210_Y296_T1.5160.94
234_L239_S1.5150.94
19_P129_G1.5150.94
5_E42_S1.5000.94
76_D284_N1.4920.93
93_V104_L1.4820.93
154_P158_D1.4770.93
22_P25_A1.4660.93
241_P247_V1.4530.92
153_E157_Y1.4290.92
275_G300_Q1.4090.91
244_V248_K1.4040.91
209_L283_I1.3820.90
20_S23_S1.3600.90
264_H289_Q1.3500.89
293_G304_L1.3500.89
76_D264_H1.3460.89
242_Y245_Y1.3390.89
232_G236_S1.3350.89
228_Q260_S1.3350.89
233_K238_C1.3320.89
242_Y248_K1.3280.89
130_Q292_R1.3180.88
266_K294_G1.3170.88
187_T192_G1.3140.88
152_A282_D1.2970.87
161_L164_T1.2910.87
219_K242_Y1.2830.87
242_Y247_V1.2750.86
218_L277_W1.2680.86
247_V267_W1.2660.86
74_Y105_V1.2450.85
282_D295_G1.2320.84
243_K247_V1.2320.84
189_T192_G1.2320.84
266_K289_Q1.2270.84
215_A222_L1.2240.84
130_Q266_K1.2210.84
245_Y248_K1.2160.84
242_Y246_N1.2160.84
131_T280_F1.2100.83
190_S196_F1.1950.83
5_E30_Y1.1940.83
10_V32_Y1.1910.82
185_S189_T1.1890.82
109_P292_R1.1730.81
218_L222_L1.1730.81
224_V244_V1.1730.81
231_P239_S1.1570.80
89_H227_W1.1490.80
194_T301_N1.1350.79
16_Y258_F1.1250.79
88_G130_Q1.1190.78
76_D292_R1.1140.78
89_H109_P1.1100.78
266_K282_D1.1070.77
73_L94_L1.1040.77
17_K56_T1.1020.77
168_G179_L1.1010.77
243_K248_K1.0970.77
209_L214_V1.0970.77
151_Y154_P1.0960.77
264_H294_G1.0880.76
107_S130_Q1.0820.76
185_S190_S1.0780.75
76_D294_G1.0770.75
283_I296_T1.0720.75
278_V305_W1.0700.75
240_G244_V1.0680.75
135_L297_V1.0570.74
70_A97_D1.0550.74
89_H289_Q1.0510.74
152_A156_V1.0500.74
221_D272_S1.0470.73
108_V119_Y1.0390.73
118_G121_Y1.0390.73
176_V179_L1.0360.73
233_K239_S1.0320.72
235_P238_C1.0320.72
288_S292_R1.0260.72
72_V156_V1.0160.71
108_V125_G1.0090.71
153_E158_D1.0070.70
83_C87_W1.0040.70
261_T288_S0.9970.70
172_L176_V0.9950.69
88_G266_K0.9910.69
229_R232_G0.9880.69
76_D91_K0.9820.68
121_Y124_N0.9780.68
26_T29_E0.9720.68
160_N163_D0.9640.67
109_P266_K0.9640.67
232_G235_P0.9620.67
88_G284_N0.9580.66
16_Y39_W0.9550.66
109_P264_H0.9520.66
16_Y88_G0.9490.66
138_S141_Q0.9410.65
263_D279_C0.9390.65
100_Q136_S0.9360.65
109_P289_Q0.9350.65
88_G292_R0.9350.65
122_P134_C0.9310.64
281_G284_N0.9250.64
169_L179_L0.9240.64
282_D292_R0.9230.64
306_K310_K0.9200.63
289_Q294_G0.9200.63
112_P282_D0.9200.63
167_G170_P0.9140.63
249_T252_L0.9110.63
284_N294_G0.8960.61
33_A304_L0.8920.61
39_W74_Y0.8880.61
109_P227_W0.8870.60
282_D289_Q0.8870.60
286_Q289_Q0.8840.60
53_L56_T0.8830.60
214_V218_L0.8810.60
227_W284_N0.8800.60
241_P246_N0.8770.60
227_W289_Q0.8770.60
34_D111_F0.8740.59
109_P284_N0.8730.59
107_S125_G0.8720.59
109_P130_Q0.8710.59
241_P245_Y0.8690.59
287_S290_N0.8690.59
52_A59_Q0.8690.59
6_N36_T0.8680.59
88_G264_H0.8670.59
172_L180_G0.8670.59
248_K251_K0.8670.59
153_E156_V0.8560.58
242_Y250_I0.8540.57
241_P244_V0.8510.57
4_N36_T0.8500.57
7_G55_A0.8470.57
60_L95_A0.8460.57
238_C298_C0.8450.57
227_W266_K0.8440.57
136_S304_L0.8400.56
187_T191_A0.8360.56
17_K27_G0.8330.56
205_F213_V0.8330.56
307_A311_L0.8310.55
264_H281_G0.8300.55
89_H107_S0.8250.55
235_P246_N0.8220.55
307_A310_K0.8220.55
151_Y156_V0.8200.54
256_G260_S0.8200.54
128_Y225_E0.8190.54
167_G176_V0.8190.54
289_Q293_G0.8150.54
103_W208_D0.8080.53
90_S135_L0.8040.53
169_L172_L0.8010.53
130_Q289_Q0.8000.53
167_G179_L0.7990.52
157_Y166_A0.7980.52
143_E170_P0.7970.52
195_G217_L0.7920.52
226_T289_Q0.7910.52
114_R117_D0.7860.51
74_Y208_D0.7850.51
56_T60_L0.7830.51
173_Q180_G0.7820.51
122_P125_G0.7800.51
79_P157_Y0.7800.51
278_V308_F0.7760.50
87_W220_T0.7750.50
205_F258_F0.7720.50
77_Q89_H0.7670.50
16_Y129_G0.7660.49
168_G172_L0.7600.49
43_K66_N0.7590.49
14_F308_F0.7590.49
103_W308_F0.7580.49
30_Y75_N0.7580.49
210_Y214_V0.7570.49
14_F265_S0.7540.48
152_A209_L0.7490.48
171_D179_L0.7460.48
31_V43_K0.7460.48
173_Q177_N0.7440.47
77_Q299_F0.7370.47
188_L308_F0.7330.46
76_D88_G0.7330.46
157_Y163_D0.7270.46
279_C285_R0.7260.46
10_V35_S0.7250.46
157_Y162_P0.7250.46
75_N282_D0.7230.46
76_D109_P0.7220.45
111_F157_Y0.7210.45
14_F108_V0.7190.45
232_G238_C0.7160.45
199_F217_L0.7150.45
90_S154_P0.7120.45
75_N109_P0.7110.44
130_Q227_W0.7100.44
107_S294_G0.7080.44
304_L308_F0.7060.44
82_S127_K0.6990.43
299_F308_F0.6990.43
56_T265_S0.6980.43
215_A220_T0.6960.43
272_S276_P0.6940.43
160_N166_A0.6910.43
147_K175_L0.6910.43
148_Q200_A0.6910.43
105_V131_T0.6870.42
42_S52_A0.6870.42
158_D165_F0.6860.42
91_K266_K0.6850.42
175_L180_G0.6840.42
135_L196_F0.6840.42
88_G151_Y0.6820.42
109_P201_K0.6810.42
129_G229_R0.6760.41
57_L111_F0.6760.41
264_H282_D0.6760.41
123_D126_V0.6750.41
16_Y128_Y0.6730.41
129_G263_D0.6710.41
108_V124_N0.6710.41
69_T142_L0.6690.41
142_L172_L0.6670.40
89_H201_K0.6630.40
2_C298_C0.6600.40
166_A170_P0.6570.40
201_K266_K0.6560.40
36_T142_L0.6560.40
198_S210_Y0.6550.39
144_K191_A0.6550.39
75_N136_S0.6550.39
77_Q284_N0.6540.39
32_Y41_L0.6530.39
233_K237_D0.6510.39
2_C12_W0.6490.39
187_T197_T0.6470.39
306_K309_R0.6460.39
173_Q176_V0.6460.39
103_W267_W0.6450.39
66_N272_S0.6440.38
106_H279_C0.6430.38
255_G272_S0.6420.38
19_P267_W0.6400.38
208_D295_G0.6400.38
160_N164_T0.6390.38
167_G174_K0.6380.38
58_D99_D0.6360.38
175_L178_G0.6360.38
7_G11_D0.6350.38
132_F213_V0.6340.38
95_A102_F0.6340.38
72_V214_V0.6340.38
25_A147_K0.6320.37
70_A258_F0.6310.37
263_D267_W0.6290.37
106_H263_D0.6290.37
298_C308_F0.6290.37
162_P174_K0.6280.37
79_P103_W0.6280.37
221_D271_T0.6270.37
253_G260_S0.6250.37
125_G128_Y0.6220.37
122_P190_S0.6190.36
30_Y226_T0.6180.36
303_A309_R0.6180.36
235_P251_K0.6170.36
281_G294_G0.6170.36
233_K286_Q0.6170.36
175_L179_L0.6160.36
210_Y222_L0.6150.36
23_S26_T0.6140.36
90_S288_S0.6120.36
185_S197_T0.6110.36
77_Q130_Q0.6070.35
159_S176_V0.6060.35
247_V250_I0.6050.35
77_Q264_H0.6040.35
190_S193_G0.6040.35
151_Y157_Y0.6040.35
180_G183_S0.6030.35
20_S24_S0.6010.35
106_H285_R0.6010.35
106_H298_C0.6010.35
14_F18_L0.6010.35
275_G306_K0.6010.35
30_Y34_D0.5980.35
109_P294_G0.5970.34
95_A277_W0.5970.34
28_L47_N0.5960.34
108_V121_Y0.5940.34
101_G142_L0.5940.34
6_N306_K0.5920.34
60_L93_V0.5910.34
80_S83_C0.5910.34
241_P248_K0.5890.34
200_A244_V0.5870.34
285_R295_G0.5850.33
269_V309_R0.5830.33
208_D285_R0.5830.33
106_H267_W0.5820.33
70_A100_Q0.5810.33
8_K36_T0.5810.33
282_D294_G0.5800.33
178_G181_V0.5800.33
31_V39_W0.5720.32
76_D130_Q0.5710.32
128_Y254_L0.5710.32
46_I147_K0.5710.32
70_A162_P0.5710.32
231_P235_P0.5710.32
228_Q261_T0.5700.32
14_F39_W0.5700.32
100_Q161_L0.5680.32
107_S264_H0.5680.32
66_N182_K0.5680.32
89_H294_G0.5670.32
20_S25_A0.5670.32
114_R118_G0.5670.32
227_W264_H0.5660.32
287_S297_V0.5660.32
102_F136_S0.5660.32
58_D66_N0.5660.32
88_G148_Q0.5660.32
16_Y107_S0.5650.32
14_F19_P0.5650.32
25_A29_E0.5630.32
91_K284_N0.5620.32
89_H225_E0.5620.32
2_C279_C0.5610.32
107_S292_R0.5610.32
209_L295_G0.5610.32
229_R260_S0.5610.32
201_K264_H0.5610.32
105_V108_V0.5580.31
177_N182_K0.5570.31
68_S71_Y0.5560.31
112_P222_L0.5560.31
36_T40_Q0.5560.31
258_F308_F0.5550.31
19_P111_F0.5540.31
210_Y224_V0.5540.31
89_H282_D0.5530.31
152_A157_Y0.5530.31
156_V218_L0.5530.31
106_H134_C0.5530.31
254_L260_S0.5510.31
89_H226_T0.5510.31
269_V288_S0.5510.31
101_G188_L0.5500.31
110_K228_Q0.5480.31
177_N181_V0.5470.30
253_G256_G0.5460.30
53_L60_L0.5460.30
157_Y164_T0.5430.30
207_V213_V0.5410.30
266_K281_G0.5390.30
37_S194_T0.5380.30
30_Y53_L0.5370.30
167_G172_L0.5330.29
54_G112_P0.5320.29
6_N15_V0.5320.29
170_P174_K0.5310.29
76_D289_Q0.5290.29
276_P300_Q0.5280.29
63_A66_N0.5280.29
32_Y107_S0.5280.29
209_L282_D0.5280.29
78_P155_N0.5260.29
169_L175_L0.5230.29
178_G182_K0.5220.29
110_K122_P0.5220.29
129_G134_C0.5210.28
91_K294_G0.5210.28
53_L142_L0.5210.28
87_W155_N0.5210.28
227_W292_R0.5190.28
214_V222_L0.5190.28
101_G112_P0.5190.28
124_N210_Y0.5180.28
168_G173_Q0.5160.28
142_L161_L0.5150.28
16_Y131_T0.5150.28
30_Y51_G0.5100.28
8_K80_S0.5100.28
183_S213_V0.5090.28
135_L211_Q0.5090.28
306_K312_V0.5090.28
142_L145_I0.5080.28
76_D107_S0.5080.28
50_T104_L0.5060.27
138_S192_G0.5050.27
79_P263_D0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cxyA 1 0.2453 19.8 0.967 Contact Map
1ig6A 1 0.2579 4.9 0.975 Contact Map
2bsjA 2 0.2956 3.7 0.976 Contact Map
3m95A 1 0.195 3.7 0.977 Contact Map
2rklA 2 0.1667 3.3 0.977 Contact Map
3w1yA 2 0.1918 2.9 0.978 Contact Map
1whvA 1 0.283 2.7 0.978 Contact Map
3h9dA 2 0.1981 2.7 0.978 Contact Map
2li6A 1 0.2421 2.4 0.979 Contact Map
1x9uA 1 0.1698 2.2 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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