GREMLIN Database
Rer1 - Rer1 family
PFAM: PF03248 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 170 (164)
Sequences: 638 (377)
Seq/√Len: 29.4
META: 0.281

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_F48_T4.0901.00
27_T111_T4.0281.00
143_F147_M3.8911.00
124_S127_D3.8221.00
50_A120_C3.4421.00
9_Y108_Y2.9731.00
116_I120_C2.8891.00
54_Y58_L2.7511.00
4_K8_R2.7151.00
140_I144_V2.6911.00
11_Y15_K2.4950.99
148_K152_Q2.4790.99
25_I29_V2.3220.99
8_R12_Y2.2820.99
10_Q14_D2.1760.98
52_G136_L2.0590.97
123_F131_F2.0300.97
36_L40_L1.9850.97
13_L17_T1.8920.96
38_V41_L1.8910.96
34_F38_V1.7770.94
72_E163_S1.7340.93
21_L25_I1.6050.90
108_Y112_K1.6000.90
119_V123_F1.5450.88
60_I64_S1.5230.87
44_W127_D1.5120.87
38_V42_Q1.4630.85
109_S112_K1.4560.85
62_F106_F1.4560.85
27_T110_A1.4450.84
92_D158_K1.4270.84
27_T114_T1.4090.83
147_M150_Q1.4070.83
41_L44_W1.4020.82
62_F99_R1.3880.82
55_L110_A1.3880.82
118_F122_F1.3870.82
97_F161_P1.3610.81
34_F118_F1.3590.80
44_W124_S1.3510.80
145_L152_Q1.3380.79
34_F114_T1.3350.79
15_K137_M1.3340.79
123_F126_F1.3280.79
59_F106_F1.3110.78
120_C126_F1.2810.76
41_L122_F1.2760.76
146_T150_Q1.2430.74
34_F39_Y1.2280.73
118_F139_F1.2040.72
157_Y162_F1.2040.72
115_L119_V1.1920.71
103_E107_W1.1880.71
112_K163_S1.1790.70
35_F48_T1.1790.70
50_A134_I1.1760.70
18_P98_I1.1740.70
45_Y98_I1.1450.68
129_P132_W1.1380.67
34_F121_T1.1370.67
18_P101_L1.1280.67
89_K139_F1.1180.66
33_L115_L1.1160.66
56_L93_E1.1110.65
155_I162_F1.1080.65
54_Y62_F1.1070.65
81_E157_Y1.0830.63
55_L113_A1.0820.63
99_R102_P1.0630.62
58_L110_A1.0550.61
81_E162_F1.0520.61
57_N143_F1.0510.61
148_K165_G1.0440.60
30_L119_V1.0000.57
26_G29_V0.9930.57
129_P133_P0.9920.56
10_Q60_I0.9900.56
43_G132_W0.9850.56
61_A66_K0.9850.56
64_S98_I0.9830.56
93_E97_F0.9760.55
41_L148_K0.9760.55
34_F41_L0.9640.54
51_L104_F0.9590.54
154_M159_Y0.9560.54
12_Y145_L0.9550.54
31_L114_T0.9500.53
102_P134_I0.9480.53
120_C141_V0.9430.53
61_A101_L0.9390.52
15_K25_I0.9340.52
3_S136_L0.9150.50
56_L131_F0.9150.50
39_Y60_I0.9100.50
26_G83_G0.9080.50
160_V164_F0.9060.50
144_V167_K0.9030.50
127_D136_L0.8960.49
60_I67_F0.8950.49
143_F150_Q0.8910.49
22_Y26_G0.8840.48
70_E157_Y0.8820.48
120_C155_I0.8820.48
80_L160_V0.8800.48
18_P94_F0.8610.46
130_V138_Y0.8600.46
64_S67_F0.8600.46
39_Y118_F0.8550.46
55_L114_T0.8460.45
154_M161_P0.8410.45
46_I141_V0.8360.44
121_T148_K0.8340.44
79_E86_L0.8310.44
80_L84_P0.8300.44
54_Y110_A0.8290.44
55_L144_V0.8190.43
99_R146_T0.8180.43
66_K101_L0.8150.43
28_L32_L0.8150.43
19_H162_F0.8140.43
25_I157_Y0.8120.42
3_S6_S0.8080.42
26_G36_L0.8040.42
125_V128_V0.8020.42
30_L111_T0.8010.42
66_K98_I0.8010.42
42_Q59_F0.7970.41
21_L47_V0.7970.41
6_S52_G0.7950.41
60_I163_S0.7920.41
14_D128_V0.7890.41
40_L95_R0.7880.41
72_E80_L0.7840.40
18_P113_A0.7770.40
25_I28_L0.7640.39
105_K131_F0.7500.38
147_M151_I0.7500.38
158_K162_F0.7430.37
128_V149_R0.7380.37
13_L104_F0.7360.37
27_T131_F0.7340.37
5_L115_L0.7300.36
115_L124_S0.7250.36
34_F61_A0.7250.36
45_Y94_F0.7240.36
3_S33_L0.7230.36
14_D18_P0.7230.36
126_F145_L0.7220.36
12_Y16_S0.7170.35
35_F52_G0.7100.35
116_I125_V0.7070.35
73_D152_Q0.7070.35
5_L36_L0.7030.34
160_V163_S0.7020.34
59_F84_P0.6990.34
155_I158_K0.6980.34
12_Y15_K0.6930.34
104_F131_F0.6800.33
84_P152_Q0.6790.33
110_A114_T0.6740.32
85_S114_T0.6720.32
58_L98_I0.6710.32
31_L117_A0.6700.32
166_K169_Y0.6690.32
156_K159_Y0.6680.32
3_S7_R0.6640.32
61_A100_R0.6600.31
19_H71_L0.6560.31
119_V125_V0.6550.31
90_G168_R0.6500.31
164_F167_K0.6500.31
29_V127_D0.6470.30
22_Y168_R0.6460.30
52_G60_I0.6420.30
51_L113_A0.6400.30
30_L114_T0.6370.30
55_L91_D0.6340.30
41_L121_T0.6320.29
31_L52_G0.6320.29
48_T134_I0.6310.29
16_S64_S0.6270.29
135_L139_F0.6170.28
63_L143_F0.6110.28
151_I155_I0.6100.28
63_L99_R0.6090.28
102_P146_T0.6060.28
57_N62_F0.6060.28
27_T45_Y0.6030.28
101_L105_K0.6020.28
102_P106_F0.6000.27
98_I113_A0.6000.27
4_K7_R0.5970.27
62_F101_L0.5960.27
45_Y58_L0.5940.27
128_V141_V0.5940.27
134_I142_L0.5920.27
130_V133_P0.5890.27
93_E96_P0.5890.27
30_L36_L0.5860.27
39_Y116_I0.5840.26
17_T59_F0.5830.26
159_Y166_K0.5810.26
66_K137_M0.5780.26
2_T32_L0.5770.26
85_S98_I0.5760.26
7_R55_L0.5710.26
20_V64_S0.5690.26
135_L138_Y0.5680.25
38_V50_A0.5660.25
33_L36_L0.5630.25
60_I140_I0.5590.25
130_V135_L0.5550.25
33_L140_I0.5540.25
11_Y168_R0.5520.25
36_L39_Y0.5500.24
134_I139_F0.5460.24
61_A136_L0.5420.24
4_K29_V0.5410.24
161_P166_K0.5400.24
97_F134_I0.5380.24
42_Q45_Y0.5340.23
136_L142_L0.5340.23
46_I142_L0.5340.23
100_R157_Y0.5330.23
16_S145_L0.5330.23
54_Y146_T0.5320.23
73_D136_L0.5290.23
92_D118_F0.5230.23
133_P138_Y0.5200.23
149_R153_H0.5160.22
19_H22_Y0.5130.22
48_T121_T0.5110.22
30_L40_L0.5110.22
50_A101_L0.5100.22
64_S69_P0.5100.22
136_L167_K0.5090.22
22_Y124_S0.5090.22
141_V144_V0.5060.22
34_F42_Q0.5060.22
115_L122_F0.5060.22
89_K160_V0.5050.22
2_T139_F0.5050.22
115_L156_K0.5000.22
46_I53_I0.5000.22
51_L108_Y0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3owtC 1 0.0824 16.4 0.959 Contact Map
4bpmA 3 0.3882 5.3 0.967 Contact Map
1ji6A 1 0.3588 4.1 0.969 Contact Map
2zjsY 2 0.7765 2.7 0.972 Contact Map
3dl8G 1 0.8176 2.5 0.972 Contact Map
3j01A 1 0.8941 2.1 0.973 Contact Map
3dinC 1 0.8 1.8 0.974 Contact Map
4od4A 1 0.7353 1.6 0.975 Contact Map
3ibpA 2 0.2706 1.4 0.976 Contact Map
4ec6A 3 0.0706 1.4 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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