GREMLIN Database
Phage_lysis - Bacteriophage Rz lysis protein
PFAM: PF03245 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 126 (118)
Sequences: 1971 (1243)
Seq/√Len: 114.4
META: 0.438

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_I26_R3.0671.00
42_K46_D2.9031.00
37_D41_T2.5101.00
110_A114_L2.4271.00
16_L19_A2.2301.00
85_D116_A2.1971.00
119_A123_E2.1901.00
57_D63_L2.1831.00
114_L117_L2.0611.00
107_G111_L2.0591.00
110_A113_Q2.0401.00
16_L20_N1.9321.00
47_A50_E1.8671.00
12_A15_A1.8351.00
23_I27_Q1.8011.00
57_D62_D1.7961.00
91_R97_A1.7711.00
93_D107_G1.7431.00
8_Q12_A1.6821.00
9_R13_T1.6571.00
82_G116_A1.6051.00
11_K15_A1.6011.00
58_L61_G1.5841.00
15_A19_A1.5421.00
115_R118_Q1.5401.00
8_Q11_K1.5211.00
117_L121_I1.5191.00
107_G110_A1.4791.00
104_R107_G1.4721.00
95_A106_R1.4521.00
38_A42_K1.4501.00
9_R12_A1.4421.00
8_Q13_T1.4371.00
111_L114_L1.4371.00
7_D11_K1.4061.00
22_E26_R1.3921.00
39_K43_E1.3741.00
25_K29_R1.3631.00
49_A53_R1.3611.00
26_R29_R1.3251.00
111_L115_R1.3081.00
103_I106_R1.3071.00
53_R57_D1.2971.00
56_D60_T1.2840.99
57_D64_R1.2750.99
97_A100_Y1.2730.99
40_H44_L1.2720.99
48_K52_D1.2690.99
14_A17_A1.2180.99
100_Y103_I1.2130.99
24_D28_A1.1900.99
83_G86_D1.1800.99
26_R30_Q1.1340.99
58_L101_F1.1320.99
53_R56_D1.1180.99
106_R110_A1.1030.98
11_K14_A1.0840.98
50_E53_R1.0500.98
24_D27_Q1.0370.98
17_A21_A1.0360.98
120_Y124_Q1.0350.98
12_A16_L1.0100.97
118_Q121_I0.9950.97
99_D103_I0.9650.96
55_R59_A0.9600.96
13_T17_A0.9480.96
115_R119_A0.9460.96
10_D13_T0.9420.96
13_T20_N0.9380.96
65_L101_F0.9290.95
97_A101_F0.9240.95
41_T44_L0.9210.95
36_L40_H0.9200.95
52_D55_R0.9170.95
100_Y104_R0.9170.95
91_R94_P0.9100.95
63_L66_R0.9090.95
41_T45_A0.8900.94
7_D10_D0.8880.94
100_Y108_D0.8870.94
108_D111_L0.8810.94
17_A20_N0.8780.94
109_T112_I0.8640.93
12_A17_A0.8620.93
15_A18_Q0.8580.93
105_D109_T0.8430.92
21_A24_D0.8370.92
117_L120_Y0.8090.91
98_Q106_R0.8030.90
46_D50_E0.8020.90
34_A37_D0.8020.90
112_I115_R0.7910.90
95_A98_Q0.7910.90
51_I55_R0.7840.89
37_D44_L0.7800.89
93_D96_A0.7790.89
41_T87_A0.7760.89
106_R109_T0.7730.89
15_A20_N0.7690.88
34_A38_A0.7670.88
109_T113_Q0.7590.88
102_A106_R0.7520.87
9_R14_A0.7390.86
36_L41_T0.7380.86
12_A19_A0.7340.86
95_A107_G0.7310.86
7_D13_T0.7290.86
22_E25_K0.7280.85
14_A18_Q0.7270.85
13_T19_A0.7090.84
68_K71_C0.6980.83
7_D14_A0.6950.83
54_L58_L0.6950.83
114_L121_I0.6900.82
104_R108_D0.6890.82
21_A25_K0.6830.82
78_T84_V0.6760.81
113_Q116_A0.6720.81
94_P97_A0.6700.80
25_K28_A0.6690.80
62_D65_L0.6660.80
102_A105_D0.6650.80
44_L48_K0.6530.79
93_D111_L0.6510.78
92_L100_Y0.6480.78
110_A115_R0.6460.78
10_D15_A0.6460.78
19_A29_R0.6450.78
10_D14_A0.6410.77
20_N23_I0.6350.77
71_C74_G0.6330.76
96_A100_Y0.6310.76
90_A97_A0.6280.76
9_R15_A0.6250.76
23_I29_R0.6140.74
114_L118_Q0.6100.74
97_A106_R0.6070.73
48_K109_T0.6050.73
103_I107_G0.6010.73
119_A124_Q0.6010.73
45_A49_A0.5970.72
90_A110_A0.5860.71
70_T73_A0.5850.71
7_D12_A0.5750.69
95_A103_I0.5700.69
13_T16_L0.5670.68
7_D15_A0.5670.68
13_T28_A0.5650.68
95_A99_D0.5580.67
58_L102_A0.5580.67
118_Q122_R0.5560.67
103_I114_L0.5520.66
8_Q31_R0.5520.66
10_D19_A0.5510.66
32_D35_A0.5500.66
87_A113_Q0.5490.66
35_A38_A0.5490.66
100_Y113_Q0.5490.66
103_I110_A0.5460.65
8_Q20_N0.5440.65
49_A52_D0.5440.65
22_E27_Q0.5440.65
11_K17_A0.5420.65
40_H43_E0.5320.63
93_D97_A0.5310.63
106_R111_L0.5300.63
59_A98_Q0.5280.63
89_R115_R0.5280.63
51_I54_L0.5270.63
19_A22_E0.5230.62
85_D114_L0.5180.61
81_A120_Y0.5180.61
91_R96_A0.5170.61
59_A66_R0.5140.61
60_T78_T0.5040.59
43_E46_D0.5030.59
84_V87_A0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bnxA 2 0.0873 25.3 0.888 Contact Map
4cgkA 3 0.9762 19.6 0.894 Contact Map
4q4gX 1 0 19 0.894 Contact Map
4rsjA 2 0.4603 14.7 0.9 Contact Map
3sggA 1 0.2937 13.2 0.902 Contact Map
3mq7A 6 0.5238 7.8 0.912 Contact Map
2msvA 1 0.2619 7.7 0.912 Contact Map
3ojaB 1 0.4683 7.4 0.913 Contact Map
1gaxA 1 0.4921 7.3 0.913 Contact Map
1lwuA 2 0.3492 6.7 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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