GREMLIN Database
FTR1 - Iron permease FTR1 family
PFAM: PF03239 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 306 (253)
Sequences: 5711 (3498)
Seq/√Len: 219.9
META: 0.756

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_F178_A4.9791.00
102_K106_E4.8301.00
81_L217_G3.6091.00
265_T268_Q3.2421.00
16_A183_G2.9211.00
222_Q226_L2.6031.00
219_H223_E2.5071.00
268_Q271_G2.3021.00
19_V42_V2.3021.00
221_L225_G2.2881.00
23_L38_V2.2541.00
32_R35_L2.1971.00
197_R200_R2.1961.00
218_V271_G2.1101.00
31_R34_R2.1061.00
184_W188_R2.0731.00
5_F174_L2.0651.00
221_L226_L2.0231.00
8_V150_T1.9941.00
219_H222_Q1.9351.00
222_Q227_L1.8831.00
104_E108_K1.8491.00
87_L206_L1.8211.00
268_Q275_Y1.8151.00
229_P232_G1.8071.00
214_L271_G1.7941.00
221_L224_A1.7891.00
84_V214_L1.7841.00
220_E223_E1.7721.00
88_T92_F1.7611.00
100_E104_E1.7481.00
268_Q272_Y1.7401.00
23_L35_L1.7291.00
27_R32_R1.7281.00
174_L178_A1.7241.00
74_L78_V1.7201.00
222_Q225_G1.7131.00
194_N197_R1.6961.00
219_H226_L1.6701.00
218_V222_Q1.6671.00
196_R200_R1.6651.00
136_A140_F1.6631.00
9_L182_L1.6591.00
98_A102_K1.6541.00
106_E110_D1.6451.00
48_L144_L1.6411.00
44_A136_A1.6361.00
81_L85_A1.6231.00
220_E224_A1.6051.00
219_H224_A1.5841.00
77_G221_L1.5841.00
265_T269_L1.5431.00
131_S134_A1.5421.00
26_L38_V1.5321.00
100_E103_G1.5171.00
80_L216_Y1.5141.00
25_Y110_D1.5131.00
244_D260_A1.5101.00
235_A269_L1.5071.00
47_A51_A1.4961.00
188_R192_R1.4831.00
249_G258_Y1.4721.00
134_A138_L1.4681.00
28_K106_E1.4671.00
252_L256_F1.4581.00
223_E226_L1.4581.00
258_Y262_P1.4511.00
54_A58_A1.4451.00
154_L172_A1.4391.00
177_A181_A1.4281.00
78_V82_V1.4121.00
266_L269_L1.4031.00
220_E225_G1.4021.00
75_F79_V1.3951.00
109_V112_A1.3861.00
266_L270_L1.3821.00
112_A134_A1.3811.00
12_G179_A1.3801.00
235_A266_L1.3651.00
271_G275_Y1.3541.00
74_L226_L1.3411.00
137_L141_L1.3331.00
25_Y29_T1.3231.00
262_P269_L1.3111.00
204_V208_L1.3061.00
252_L258_Y1.3041.00
231_L270_L1.3031.00
183_G187_Y1.3031.00
108_K111_A1.2991.00
20_G186_L1.2871.00
239_S260_A1.2831.00
238_T241_L1.2781.00
27_R35_L1.2771.00
272_Y275_Y1.2571.00
97_H100_E1.2511.00
257_G262_P1.2351.00
52_V148_L1.2341.00
80_L217_G1.2061.00
200_R204_V1.2011.00
259_T268_Q1.1971.00
91_V203_G1.1911.00
218_V221_L1.1831.00
270_L273_L1.1791.00
246_S249_G1.1701.00
218_V225_G1.1591.00
44_A140_F1.1501.00
116_G130_G1.1471.00
232_G235_A1.1381.00
132_L136_A1.1351.00
249_G252_L1.1311.00
158_A168_P1.1221.00
109_V135_L1.1121.00
4_T154_L1.1111.00
15_A19_V1.1081.00
218_V226_L1.1061.00
269_L275_Y1.1021.00
38_V135_L1.0861.00
22_L139_A1.0811.00
133_W137_L1.0771.00
220_E226_L1.0761.00
137_L140_F1.0711.00
55_A59_I1.0611.00
13_L182_L1.0511.00
266_L271_G1.0481.00
40_L136_A1.0341.00
265_T271_G1.0231.00
7_I150_T1.0211.00
4_T168_P1.0121.00
109_V113_L0.9871.00
53_G57_T0.9791.00
9_L12_G0.9741.00
266_L272_Y0.9741.00
36_R40_L0.9691.00
234_P237_D0.9681.00
267_L271_G0.9671.00
53_G56_L0.9651.00
34_R113_L0.9591.00
269_L272_Y0.9581.00
165_A169_L0.9531.00
72_Q76_E0.9491.00
30_G33_D0.9481.00
51_A55_A0.9451.00
135_L140_F0.9441.00
13_L195_L0.9361.00
77_G220_E0.9361.00
269_L273_L0.9351.00
231_L235_A0.9250.99
259_T262_P0.9210.99
132_L140_F0.9150.99
46_V50_L0.9110.99
197_R201_V0.9060.99
52_V55_A0.9050.99
134_A140_F0.9030.99
29_T33_D0.9030.99
11_E14_E0.9020.99
7_I157_I0.9020.99
178_A181_A0.8940.99
90_M94_M0.8920.99
104_E107_A0.8870.99
60_S75_F0.8860.99
31_R35_L0.8850.99
219_H225_G0.8810.99
208_L256_F0.8800.99
238_T258_Y0.8790.99
22_L109_V0.8780.99
232_G265_T0.8760.99
218_V223_E0.8750.99
77_G217_G0.8750.99
110_D113_L0.8720.99
132_L138_L0.8690.99
20_G187_Y0.8690.99
222_Q230_G0.8650.99
59_I75_F0.8640.99
22_L38_V0.8630.99
107_A111_A0.8610.99
181_A185_L0.8600.99
258_Y261_R0.8560.99
12_G150_T0.8550.99
249_G262_P0.8500.99
91_V207_L0.8480.99
265_T270_L0.8400.99
9_L178_A0.8380.99
206_L209_V0.8340.99
257_G260_A0.8310.99
247_W251_L0.8300.99
83_A94_M0.8290.99
65_G71_G0.8250.99
255_L262_P0.8250.99
265_T275_Y0.8210.99
59_I63_L0.8190.99
173_L177_A0.8150.99
133_W136_A0.8150.99
97_H101_L0.8120.99
262_P273_L0.8120.99
158_A169_L0.8120.99
203_G207_L0.8070.99
227_L267_L0.7980.98
265_T272_Y0.7960.98
103_G106_E0.7950.98
70_R74_L0.7910.98
106_E109_V0.7900.98
166_A170_L0.7840.98
221_L227_L0.7820.98
130_G134_A0.7810.98
45_A140_F0.7800.98
25_Y109_V0.7750.98
5_F9_L0.7740.98
218_V224_A0.7730.98
224_A227_L0.7710.98
39_W43_A0.7620.98
268_Q273_L0.7600.98
92_F95_R0.7560.98
70_R73_E0.7550.98
103_G107_A0.7500.98
54_A57_T0.7430.98
233_A266_L0.7390.97
42_V139_A0.7370.97
77_G81_L0.7320.97
56_L151_V0.7300.97
185_L191_V0.7300.97
105_L108_K0.7290.97
40_L43_A0.7270.97
243_S249_G0.7270.97
247_W250_T0.7250.97
74_L77_G0.7220.97
13_L186_L0.7200.97
223_E227_L0.7200.97
205_L256_F0.7200.97
267_L275_Y0.7190.97
86_M101_L0.7180.97
255_L258_Y0.7090.97
252_L262_P0.7080.97
40_L44_A0.7070.97
219_H227_L0.7070.97
49_S147_G0.7060.97
271_G274_A0.7060.97
230_G233_A0.7050.97
249_G260_A0.7040.97
244_D259_T0.6980.96
215_A259_T0.6980.96
16_A180_V0.6960.96
57_T60_S0.6950.96
249_G257_G0.6930.96
244_D247_W0.6910.96
195_L198_F0.6890.96
9_L13_L0.6880.96
229_P233_A0.6880.96
249_G253_H0.6870.96
253_H259_T0.6850.96
267_L273_L0.6800.96
131_S140_F0.6790.96
244_D253_H0.6780.96
240_A243_S0.6760.96
10_R14_E0.6740.96
265_T273_L0.6730.96
222_Q229_P0.6680.95
49_S53_G0.6670.95
261_R265_T0.6660.95
164_S167_A0.6660.95
259_T269_L0.6630.95
231_L234_P0.6610.95
131_S139_A0.6590.95
131_S138_L0.6590.95
252_L257_G0.6590.95
83_A153_F0.6580.95
262_P275_Y0.6540.95
155_Y159_A0.6470.95
33_D36_R0.6460.95
270_L274_A0.6450.95
209_V212_G0.6450.95
244_D250_T0.6410.94
16_A20_G0.6390.94
56_L60_S0.6360.94
144_L148_L0.6350.94
242_L248_L0.6320.94
37_W132_L0.6320.94
91_V206_L0.6320.94
234_P262_P0.6310.94
94_M203_G0.6300.94
229_P234_P0.6290.94
29_T32_R0.6270.94
253_H260_A0.6260.94
262_P265_T0.6240.94
161_G168_P0.6240.94
43_A47_A0.6210.93
37_W40_L0.6200.93
157_I168_P0.6200.93
60_S65_G0.6200.93
170_L173_L0.6180.93
46_V176_L0.6160.93
236_W239_S0.6150.93
186_L191_V0.6150.93
58_A62_A0.6140.93
169_L172_A0.6120.93
12_G176_L0.6110.93
239_S243_S0.6100.93
156_G159_A0.6090.93
57_T155_Y0.6090.93
20_G24_A0.6040.92
253_H268_Q0.6030.92
146_E149_E0.6010.92
244_D249_G0.6010.92
239_S261_R0.5990.92
46_V150_T0.5960.92
262_P267_L0.5940.92
171_G174_L0.5940.92
270_L275_Y0.5920.92
179_A183_G0.5890.91
243_S248_L0.5880.91
94_M199_F0.5870.91
249_G275_Y0.5830.91
91_V95_R0.5830.91
178_A182_L0.5820.91
75_F205_L0.5790.91
79_V144_L0.5760.91
136_A139_A0.5740.90
73_E224_A0.5730.90
248_L257_G0.5730.90
242_L258_Y0.5700.90
111_A114_A0.5680.90
135_L139_A0.5680.90
152_L156_G0.5660.90
57_T61_G0.5660.90
85_A89_W0.5650.90
257_G273_L0.5650.90
79_V189_G0.5620.89
12_G16_A0.5620.89
211_A215_A0.5620.89
56_L59_I0.5610.89
267_L270_L0.5600.89
244_D258_Y0.5590.89
110_D114_A0.5570.89
91_V209_V0.5570.89
45_A148_L0.5550.89
4_T8_V0.5540.89
56_L61_G0.5540.89
86_M152_L0.5530.89
222_Q267_L0.5510.89
19_V180_V0.5500.88
188_R191_V0.5500.88
130_G138_L0.5490.88
86_M89_W0.5490.88
6_L256_F0.5480.88
91_V202_T0.5460.88
201_V204_V0.5460.88
241_L262_P0.5440.88
6_L205_L0.5440.88
56_L65_G0.5430.88
205_L208_L0.5430.88
7_I10_R0.5430.88
213_L216_Y0.5380.87
7_I203_G0.5340.87
227_L231_L0.5340.87
245_G249_G0.5330.87
218_V227_L0.5330.87
87_L91_V0.5330.87
253_H258_Y0.5330.87
229_P236_W0.5320.87
250_T260_A0.5300.87
17_L20_G0.5290.86
226_L229_P0.5280.86
201_V205_L0.5250.86
219_H268_Q0.5220.86
230_G234_P0.5220.86
250_T254_G0.5210.86
56_L63_L0.5200.86
7_I79_V0.5200.86
88_T210_A0.5170.85
134_A139_A0.5150.85
7_I20_G0.5140.85
244_D261_R0.5110.85
99_R102_K0.5070.84
140_F144_L0.5060.84
63_L74_L0.5040.84
15_A143_V0.5040.84
186_L190_G0.5030.84
171_G175_G0.5020.84
22_L105_L0.5020.84
21_I102_K0.5010.83
183_G186_L0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k1kA 2 0.1242 4.2 0.968 Contact Map
4c7rA 3 0.3497 3.2 0.97 Contact Map
1iijA 1 0.1144 2.8 0.971 Contact Map
2xq2A 2 0.281 2.7 0.971 Contact Map
4oh3A 2 0.3431 2.6 0.972 Contact Map
2m20A 2 0.1895 2.6 0.972 Contact Map
1pw4A 1 0.8922 2.5 0.972 Contact Map
2kx2A 1 0.1961 2.3 0.972 Contact Map
2l2tA 2 0.1438 2.1 0.973 Contact Map
4tphA 2 0.3007 2 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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