GREMLIN Database
DUF262 - Protein of unknown function DUF262
PFAM: PF03235 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 221 (214)
Sequences: 29610 (25712)
Seq/√Len: 1757.7
META: 0.849

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_Q208_K3.7701.00
24_D27_Q3.5901.00
21_Y70_T3.1711.00
13_V58_K2.8621.00
30_D206_R2.6681.00
61_V68_L2.5351.00
13_V60_L2.4461.00
86_I93_I2.3521.00
22_V208_K2.0711.00
163_F167_K2.0331.00
86_I89_L1.9911.00
48_L61_V1.9781.00
90_L93_I1.9011.00
17_Y62_I1.8851.00
156_R160_A1.8481.00
48_L184_V1.8401.00
181_K184_V1.8371.00
201_E218_A1.8171.00
117_F120_L1.7841.00
116_F119_K1.7541.00
153_S157_I1.7521.00
180_L183_V1.7331.00
202_R206_R1.7161.00
3_E6_S1.7051.00
192_D195_D1.6931.00
139_S142_F1.6741.00
87_K91_Y1.6281.00
160_A163_F1.6241.00
89_L93_I1.6161.00
113_D116_F1.6131.00
157_I160_A1.6041.00
31_L71_L1.5911.00
182_I188_E1.5831.00
114_R117_F1.5821.00
172_L175_A1.5631.00
183_V187_L1.5601.00
133_L136_E1.5281.00
114_R118_E1.5101.00
106_K109_P1.4931.00
113_D117_F1.4901.00
91_Y95_D1.4881.00
119_K122_D1.4861.00
91_Y94_E1.4811.00
164_F167_K1.4641.00
115_D119_K1.4621.00
133_L137_L1.4321.00
25_E29_E1.4231.00
173_L177_L1.4131.00
47_V203_L1.4091.00
117_F121_I1.3981.00
85_D89_L1.3971.00
134_L137_L1.3901.00
167_K171_L1.3901.00
87_K90_L1.3741.00
153_S160_A1.3611.00
131_K134_L1.3531.00
118_E121_I1.3451.00
132_L136_E1.3391.00
32_L74_L1.3371.00
183_V186_E1.3301.00
48_L59_Y1.3181.00
115_D118_E1.3121.00
86_I90_L1.3091.00
131_K136_E1.3061.00
153_S156_R1.2931.00
212_Q215_L1.2821.00
28_V160_A1.2801.00
198_E202_R1.2791.00
118_E122_D1.2781.00
90_L94_E1.2761.00
151_D154_E1.2751.00
28_V70_T1.2661.00
161_Y165_K1.2561.00
198_E201_E1.2491.00
138_N141_K1.2411.00
134_L138_N1.2251.00
85_D90_L1.2231.00
156_R159_E1.2221.00
154_E157_I1.2201.00
82_L90_L1.2071.00
36_L171_L1.2021.00
137_L141_K1.1941.00
149_E153_S1.1851.00
43_L182_I1.1791.00
180_L184_V1.1761.00
133_L138_N1.1681.00
29_E33_D1.1571.00
44_G47_V1.1571.00
197_Q201_E1.1501.00
109_P113_D1.1471.00
82_L89_L1.1381.00
119_K123_D1.1361.00
141_K144_D1.1331.00
83_E91_Y1.1311.00
187_L190_D1.1301.00
110_R113_D1.1071.00
132_L135_S1.0971.00
135_S139_S1.0951.00
138_N142_F1.0911.00
29_E163_F1.0901.00
41_Y47_V1.0871.00
157_I161_Y1.0711.00
31_L35_I1.0581.00
160_A164_F1.0541.00
3_E7_D1.0531.00
116_F121_I1.0451.00
83_E90_L1.0441.00
72_Y76_K1.0431.00
116_F120_L1.0401.00
107_L110_R1.0361.00
185_I188_E1.0341.00
135_S138_N1.0341.00
82_L85_D1.0331.00
87_K92_E1.0321.00
109_P116_F1.0321.00
215_L218_A1.0221.00
83_E86_I1.0221.00
137_L142_F1.0161.00
92_E95_D1.0131.00
124_D127_E1.0131.00
180_L187_L1.0111.00
85_D88_D1.0081.00
184_V187_L1.0021.00
167_K170_E0.9921.00
110_R116_F0.9891.00
123_D127_E0.9881.00
34_D41_Y0.9851.00
109_P114_R0.9781.00
89_L95_D0.9781.00
168_L171_L0.9731.00
86_I92_E0.9711.00
87_K93_I0.9681.00
152_E156_R0.9661.00
100_E104_R0.9631.00
136_E141_K0.9621.00
131_K137_L0.9591.00
88_D93_I0.9591.00
86_I91_Y0.9571.00
133_L139_S0.9531.00
132_L138_N0.9511.00
140_L144_D0.9491.00
21_Y28_V0.9441.00
89_L94_E0.9401.00
160_A165_K0.9401.00
90_L95_D0.9381.00
28_V31_L0.9341.00
156_R163_F0.9341.00
157_I164_F0.9331.00
7_D10_Q0.9331.00
111_E114_R0.9251.00
83_E89_L0.9241.00
182_I185_I0.9161.00
103_E106_K0.9111.00
59_Y186_E0.9081.00
120_L127_E0.9061.00
142_F145_L0.9041.00
29_E167_K0.9021.00
113_D118_E0.8931.00
85_D93_I0.8831.00
111_E117_F0.8831.00
84_K89_L0.8821.00
197_Q216_L0.8781.00
183_V188_E0.8761.00
117_F122_D0.8751.00
125_K128_L0.8731.00
8_I11_G0.8681.00
43_L71_L0.8681.00
88_D95_D0.8591.00
89_L92_E0.8541.00
40_G181_K0.8501.00
26_E30_D0.8471.00
85_D92_E0.8471.00
124_D128_L0.8471.00
153_S161_Y0.8461.00
141_K145_L0.8421.00
85_D94_E0.8391.00
201_E219_Y0.8361.00
187_L199_I0.8351.00
158_L162_E0.8341.00
82_L86_I0.8281.00
30_D33_D0.8211.00
161_Y164_F0.8201.00
114_R121_I0.8191.00
108_E111_E0.8151.00
86_I94_E0.8111.00
97_K102_E0.8051.00
136_E140_L0.8041.00
216_L220_L0.8011.00
110_R114_R0.7981.00
96_N99_E0.7971.00
140_L145_L0.7871.00
73_L77_A0.7821.00
21_Y69_T0.7801.00
159_E163_F0.7781.00
136_E139_S0.7761.00
60_L196_A0.7731.00
165_K169_K0.7731.00
174_D178_N0.7621.00
49_W196_A0.7591.00
112_S115_D0.7521.00
97_K101_D0.7511.00
182_I186_E0.7511.00
113_D122_D0.7501.00
109_P117_F0.7491.00
172_L176_L0.7431.00
163_F166_E0.7431.00
107_L113_D0.7401.00
139_S144_D0.7401.00
139_S143_K0.7381.00
45_S185_I0.7371.00
122_D125_K0.7331.00
83_E88_D0.7291.00
28_V164_F0.7281.00
111_E116_F0.7211.00
101_D106_K0.7191.00
134_L141_K0.7151.00
82_L93_I0.7131.00
178_N181_K0.7111.00
82_L87_K0.7081.00
173_L176_L0.7041.00
49_W60_L0.7031.00
103_E107_L0.6971.00
17_Y201_E0.6971.00
117_F124_D0.6931.00
36_L167_K0.6901.00
120_L128_L0.6891.00
103_E108_E0.6891.00
101_D104_R0.6871.00
82_L92_E0.6771.00
117_F126_L0.6731.00
51_D54_D0.6701.00
83_E93_I0.6701.00
85_D95_D0.6691.00
214_D217_K0.6671.00
150_K153_S0.6661.00
101_D105_F0.6661.00
115_D120_L0.6641.00
131_K138_N0.6641.00
100_E103_E0.6631.00
42_F45_S0.6611.00
182_I190_D0.6591.00
34_D206_R0.6581.00
122_D126_L0.6501.00
121_I125_K0.6501.00
77_A168_L0.6501.00
9_K76_K0.6491.00
87_K94_E0.6471.00
105_F108_E0.6431.00
126_L130_D0.6421.00
32_L167_K0.6361.00
97_K100_E0.6351.00
180_L185_I0.6341.00
120_L123_D0.6321.00
112_S116_F0.6291.00
118_E123_D0.6271.00
197_Q218_A0.6271.00
22_V214_D0.6231.00
121_I124_D0.6221.00
110_R117_F0.6221.00
132_L137_L0.6191.00
88_D91_Y0.6171.00
127_E130_D0.6151.00
114_R119_K0.6131.00
42_F47_V0.6091.00
82_L91_Y0.6091.00
83_E94_E0.6091.00
14_I65_Q0.6071.00
84_K87_K0.6061.00
24_D208_K0.6021.00
154_E160_A0.6001.00
118_E125_K0.5961.00
17_Y60_L0.5941.00
28_V32_L0.5891.00
123_D126_L0.5831.00
85_D91_Y0.5811.00
82_L94_E0.5781.00
137_L145_L0.5761.00
6_S10_Q0.5731.00
112_S119_K0.5731.00
84_K94_E0.5731.00
205_S215_L0.5731.00
102_E106_K0.5701.00
16_D197_Q0.5681.00
123_D128_L0.5661.00
153_S158_L0.5631.00
120_L129_L0.5631.00
155_K160_A0.5571.00
97_K106_K0.5551.00
102_E107_L0.5541.00
120_L126_L0.5521.00
152_E157_I0.5511.00
27_Q206_R0.5501.00
133_L141_K0.5491.00
122_D128_L0.5431.00
184_V188_E0.5421.00
131_K135_S0.5411.00
130_D133_L0.5411.00
126_L129_L0.5381.00
154_E164_F0.5371.00
99_E102_E0.5371.00
30_D202_R0.5351.00
151_D156_R0.5351.00
135_S140_L0.5331.00
161_Y168_L0.5321.00
162_E165_K0.5321.00
182_I187_L0.5281.00
211_S214_D0.5251.00
119_K126_L0.5251.00
160_A168_L0.5231.00
96_N103_E0.5231.00
213_A216_L0.5201.00
84_K88_D0.5171.00
99_E103_E0.5161.00
139_S145_L0.5101.00
140_L143_K0.5061.00
121_I126_L0.5041.00
123_D129_L0.5021.00
96_N101_D0.5011.00
113_D120_L0.5011.00
179_K182_I0.5001.00
100_E105_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xw3A 1 0.4434 88.8 0.865 Contact Map
1yzsA 1 0.4434 86.3 0.87 Contact Map
1vz0A 3 0.8371 48.8 0.903 Contact Map
4umkA 2 0.8281 34.5 0.911 Contact Map
1vk1A 1 0.5928 5.9 0.937 Contact Map
1w2lA 1 0.1629 2.1 0.95 Contact Map
3skqA 1 0.276 2 0.951 Contact Map
1k6oB 2 0.2127 1.9 0.951 Contact Map
2l02A 2 0.1538 1.8 0.952 Contact Map
1cchA 1 0.1584 1.7 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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