GREMLIN Database
PRA1 - PRA1 family protein
PFAM: PF03208 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 142 (139)
Sequences: 1489 (1029)
Seq/√Len: 87.2
META: 0.233

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_V130_A2.8591.00
36_Y40_N2.7101.00
26_A130_A2.5791.00
37_F133_D2.5431.00
82_V85_G2.3531.00
48_L124_L2.3461.00
41_Y128_H2.3251.00
121_S125_V2.2951.00
100_V103_V2.2871.00
137_L140_D2.2761.00
127_L131_F2.2571.00
6_R36_Y2.1231.00
11_F14_R2.1031.00
45_F121_S1.9141.00
40_N132_R1.8891.00
5_L43_L1.8491.00
46_L113_T1.8401.00
7_P10_E1.7501.00
17_F132_R1.7141.00
23_F119_G1.6851.00
40_N57_P1.6541.00
37_F132_R1.6121.00
51_L116_W1.6081.00
49_L117_A1.5621.00
70_W97_L1.5191.00
109_S112_S1.5101.00
10_E23_F1.4720.99
36_Y132_R1.4660.99
92_Q104_L1.4620.99
135_E140_D1.4610.99
37_F136_D1.4340.99
95_T98_L1.4280.99
60_L117_A1.4050.99
70_W73_L1.3850.99
112_S119_G1.3820.99
49_L55_T1.3710.99
60_L68_A1.3580.99
17_F131_F1.3580.99
60_L70_W1.3250.99
34_L129_A1.3160.99
112_S116_W1.3050.99
34_L46_L1.2950.99
45_F125_V1.2930.99
6_R10_E1.2900.99
61_I95_T1.2760.98
13_D16_R1.2650.98
95_T105_L1.2610.98
66_L104_L1.2340.98
88_F91_R1.2330.98
23_F27_T1.2330.98
85_G88_F1.2320.98
61_I81_L1.2140.98
43_L79_E1.2100.98
9_S12_F1.1990.98
116_W120_A1.1920.98
110_V114_L1.1690.97
26_A37_F1.1680.97
99_V103_V1.1600.97
57_P60_L1.1460.97
67_V71_L1.1420.97
14_R30_V1.1410.97
13_D17_F1.1210.96
26_A30_V1.1150.96
37_F137_L1.1130.96
19_K96_G1.1080.96
88_F105_L1.0990.96
106_F109_S1.0970.96
65_L109_S1.0960.96
27_T37_F1.0910.96
18_S133_D1.0770.96
30_V129_A1.0650.95
65_L100_V1.0600.95
105_L108_T1.0570.95
33_N41_Y1.0540.95
102_V123_V1.0480.95
59_S110_V1.0410.95
59_S62_V1.0350.94
74_Y90_D1.0230.94
51_L55_T1.0210.94
68_A71_L1.0180.94
65_L69_A1.0080.94
52_S120_A0.9970.93
82_V87_R0.9930.93
53_L117_A0.9870.93
60_L63_L0.9830.93
53_L93_V0.9770.93
33_N128_H0.9630.92
134_P137_L0.9580.92
135_E139_L0.9570.92
6_R82_V0.9500.92
94_L123_V0.9450.91
16_R25_E0.9280.91
91_R95_T0.9180.90
17_F36_Y0.9160.90
61_I68_A0.9160.90
43_L73_L0.9120.90
92_Q105_L0.9030.89
107_L110_V0.8790.88
16_R26_A0.8770.88
115_L119_G0.8690.87
54_L86_R0.8600.87
78_D81_L0.8590.87
98_L104_L0.8550.87
62_V106_F0.8510.86
72_F75_F0.8400.86
39_T129_A0.8290.85
76_L80_P0.8270.85
72_F76_L0.8250.85
46_L99_V0.8170.84
18_S28_S0.8150.84
93_V97_L0.8090.83
85_G90_D0.8070.83
70_W101_T0.8060.83
12_F16_R0.8030.83
103_V120_A0.7890.82
56_N59_S0.7850.82
49_L56_N0.7790.81
71_L105_L0.7780.81
133_D139_L0.7750.81
7_P24_S0.7740.81
57_P61_I0.7660.80
65_L116_W0.7590.79
34_L126_L0.7590.79
45_F117_A0.7580.79
43_L95_T0.7540.79
4_P92_Q0.7450.78
48_L108_T0.7370.77
64_L71_L0.7360.77
38_R129_A0.7270.76
101_T109_S0.7260.76
9_S13_D0.7140.75
81_L96_G0.7130.75
65_L118_L0.7100.75
4_P39_T0.7060.74
70_W77_R0.7050.74
66_L101_T0.6980.73
97_L108_T0.6960.73
96_G99_V0.6910.73
35_S38_R0.6840.72
43_L91_R0.6830.72
58_L107_L0.6800.71
43_L98_L0.6720.70
9_S119_G0.6670.70
52_S113_T0.6600.69
57_P70_W0.6540.68
132_R135_E0.6520.68
100_V107_L0.6520.68
61_I127_L0.6420.67
31_R97_L0.6410.67
123_V131_F0.6400.67
39_T98_L0.6400.67
88_F92_Q0.6380.67
6_R40_N0.6350.66
83_I88_F0.6330.66
96_G112_S0.6230.65
8_W44_V0.6210.64
9_S28_S0.6170.64
14_R17_F0.6150.64
26_A36_Y0.6140.64
15_S127_L0.6140.64
67_V98_L0.6090.63
101_T114_L0.6090.63
71_L122_L0.6020.62
12_F27_T0.5970.61
102_V116_W0.5960.61
58_L62_V0.5920.61
48_L52_S0.5920.61
122_L130_A0.5910.61
6_R16_R0.5900.61
34_L64_L0.5880.60
52_S56_N0.5880.60
110_V132_R0.5880.60
15_S104_L0.5880.60
3_A6_R0.5880.60
53_L76_L0.5880.60
38_R121_S0.5830.60
49_L122_L0.5800.59
67_V104_L0.5730.58
134_P138_F0.5710.58
119_G126_L0.5670.57
127_L130_A0.5660.57
56_N110_V0.5600.57
52_S121_S0.5590.56
59_S63_L0.5580.56
17_F85_G0.5580.56
64_L98_L0.5560.56
3_A39_T0.5540.56
22_S77_R0.5530.56
30_V35_S0.5490.55
50_A65_L0.5470.55
78_D99_V0.5450.55
17_F82_V0.5440.54
8_W12_F0.5420.54
4_P98_L0.5400.54
4_P9_S0.5390.54
42_A51_L0.5390.54
107_L115_L0.5390.54
28_S130_A0.5330.53
76_L99_V0.5320.53
73_L100_V0.5300.53
45_F95_T0.5280.52
45_F52_S0.5240.52
90_D137_L0.5180.51
83_I86_R0.5110.50
50_A68_A0.5110.50
10_E40_N0.5060.49
94_L98_L0.5040.49
64_L69_A0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5c4iC 2 0.3239 3.8 0.931 Contact Map
4qtnA 3 0.8028 3.6 0.932 Contact Map
4ognA 1 0.2535 3.5 0.932 Contact Map
4pj6A 2 0.338 3.4 0.933 Contact Map
4bpmA 3 0.9155 2.9 0.935 Contact Map
2m1mA 1 0.2535 2.8 0.935 Contact Map
4mndA 2 0.7535 2.3 0.938 Contact Map
2oyzA 2 0.2817 2 0.94 Contact Map
3j01B 1 0.4155 2 0.94 Contact Map
2lm1A 1 0.331 1.9 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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