GREMLIN Database
MerC - MerC mercury resistance protein
PFAM: PF03203 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 117 (111)
Sequences: 7729 (5574)
Seq/√Len: 529.0
META: 0.906

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_L70_G3.0891.00
73_G107_L2.8001.00
57_G61_H2.3681.00
76_L104_G2.2451.00
65_L114_L2.2431.00
80_A104_G2.2111.00
110_A114_L2.1781.00
39_H70_G2.0861.00
51_L55_G2.0691.00
44_L48_P2.0311.00
79_L83_L1.9971.00
25_L29_G1.9691.00
106_L110_A1.9251.00
50_S70_G1.9241.00
52_F56_L1.9051.00
56_L60_R1.8201.00
58_Y64_L1.7381.00
11_C14_H1.7331.00
47_L74_L1.7261.00
37_A41_V1.6091.00
73_G104_G1.5781.00
41_V45_L1.5611.00
6_G9_G1.4791.00
56_L59_R1.4771.00
58_Y62_R1.4571.00
46_A105_A1.4481.00
12_A16_L1.4461.00
39_H46_A1.3751.00
72_L107_L1.3741.00
5_I113_L1.3681.00
17_A21_L1.3331.00
40_L44_L1.3231.00
88_Y91_L1.3191.00
23_A27_L1.2981.00
102_V106_L1.2881.00
58_Y61_H1.2611.00
4_G50_S1.2561.00
87_G90_T1.2551.00
20_L24_L1.2391.00
67_L71_L1.2251.00
72_L76_L1.2161.00
5_I9_G1.2091.00
96_L99_V1.1911.00
2_R116_L1.1571.00
1_D112_H1.1531.00
53_A112_H1.1441.00
99_V103_I1.1391.00
27_L31_G1.1351.00
81_L84_G1.1261.00
70_G111_A1.1221.00
87_G91_L1.1151.00
77_L104_G1.1031.00
38_F42_L1.0921.00
54_L108_L1.0851.00
2_R6_G1.0691.00
102_V105_A1.0441.00
43_L81_L1.0351.00
113_L117_R1.0301.00
105_A109_A1.0101.00
98_E102_V1.0091.00
48_P52_F1.0011.00
68_L72_L0.9761.00
97_E100_L0.9671.00
58_Y67_L0.9591.00
63_R114_L0.9571.00
76_L103_I0.9351.00
65_L68_L0.9311.00
18_L22_L0.9221.00
23_A26_P0.9221.00
43_L77_L0.9141.00
25_L28_L0.9071.00
28_L31_G0.9031.00
113_L116_L0.8951.00
73_G108_L0.8921.00
6_G10_L0.8911.00
77_L108_L0.8761.00
9_G13_I0.8681.00
42_L46_A0.8671.00
110_A113_L0.8581.00
34_A37_A0.8471.00
75_A79_L0.8461.00
55_G67_L0.8371.00
31_G34_A0.8361.00
114_L117_R0.8271.00
76_L80_A0.8201.00
64_L68_L0.8171.00
91_L103_I0.8171.00
80_A100_L0.8171.00
79_L84_G0.8171.00
68_L71_L0.8161.00
66_P115_N0.8091.00
40_L82_F0.8081.00
76_L100_L0.7961.00
47_L78_L0.7961.00
1_D4_G0.7921.00
2_R5_I0.7851.00
111_A114_L0.7831.00
5_I109_A0.7691.00
101_T104_G0.7591.00
59_R62_R0.7581.00
14_H112_H0.7571.00
71_L75_A0.7491.00
45_L49_I0.7491.00
43_L46_A0.7461.00
39_H43_L0.7441.00
76_L107_L0.7271.00
69_L107_L0.7181.00
41_V44_L0.7161.00
101_T105_A0.7111.00
43_L78_L0.7061.00
18_L21_L0.6971.00
61_H66_P0.6911.00
69_L111_A0.6881.00
55_G58_Y0.6791.00
90_T102_V0.6781.00
64_L67_L0.6781.00
37_A40_L0.6631.00
80_A101_T0.6631.00
19_P22_L0.6621.00
84_G89_E0.6511.00
65_L110_A0.6501.00
58_Y71_L0.6441.00
51_L71_L0.6391.00
69_L110_A0.6381.00
52_F55_G0.6231.00
77_L81_L0.6221.00
66_P111_A0.6181.00
12_A102_V0.6141.00
107_L111_A0.6111.00
112_H115_N0.6101.00
24_L28_L0.6071.00
3_L49_I0.6021.00
96_L103_I0.6021.00
13_I16_L0.5991.00
40_L52_F0.5971.00
4_G112_H0.5910.99
39_H48_P0.5880.99
17_A20_L0.5870.99
70_G73_G0.5850.99
49_I52_F0.5820.99
39_H80_A0.5810.99
50_S53_A0.5790.99
55_G64_L0.5780.99
55_G59_R0.5760.99
53_A57_G0.5740.99
10_L13_I0.5720.99
7_L16_L0.5650.99
43_L74_L0.5580.99
45_L48_P0.5580.99
40_L83_L0.5560.99
11_C15_C0.5550.99
103_I107_L0.5440.99
40_L43_L0.5440.99
57_G67_L0.5430.99
39_H81_L0.5420.99
61_H115_N0.5410.99
22_L34_A0.5330.99
14_H17_A0.5210.99
108_L112_H0.5210.99
27_L32_F0.5200.99
32_F35_N0.5190.99
101_T108_L0.5130.99
30_L33_L0.5100.98
11_C17_A0.5020.98
78_L82_F0.5010.98
40_L81_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m67A 1 0.6154 52.9 0.849 Contact Map
1wazA 1 0.3932 32.4 0.867 Contact Map
2h3oA 1 0.3761 20.3 0.879 Contact Map
3j1zP 8 0.9829 8.2 0.899 Contact Map
3wxwA 1 0.8632 7.5 0.9 Contact Map
3h90A 3 0.9829 5 0.908 Contact Map
4i0uA 4 0.5128 3.8 0.913 Contact Map
4ev6A 3 0.5299 3.8 0.913 Contact Map
1jdpH 1 0.094 3.3 0.916 Contact Map
3wajA 1 0.8803 2.9 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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