MerC - PFAM28P - GREMLIN Contacts

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MerC - MerC mercury resistance protein

PFAM:	PF03203	Sequences: DRLGIGLSGLCAIHCLALPLLLALLPLLGLGFLANEAFHLVLLLLALPISLFALGLGYRRHRRLLPLLLGLLGLALLLLALFLGHEGYETLLGESLEEVLTVIGALLLAAAHLLNLR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	117 (111)
Sequences:	7729 (5574)
Seq/√Len:	529.0
META:	0.906

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
54_L	70_G	3.089	1.00
73_G	107_L	2.800	1.00
57_G	61_H	2.368	1.00
76_L	104_G	2.245	1.00
65_L	114_L	2.243	1.00
80_A	104_G	2.211	1.00
110_A	114_L	2.178	1.00
39_H	70_G	2.086	1.00
51_L	55_G	2.069	1.00
44_L	48_P	2.031	1.00
79_L	83_L	1.997	1.00
25_L	29_G	1.969	1.00
106_L	110_A	1.925	1.00
50_S	70_G	1.924	1.00
52_F	56_L	1.905	1.00
56_L	60_R	1.820	1.00
58_Y	64_L	1.738	1.00
11_C	14_H	1.733	1.00
47_L	74_L	1.726	1.00
37_A	41_V	1.609	1.00
73_G	104_G	1.578	1.00
41_V	45_L	1.561	1.00
6_G	9_G	1.479	1.00
56_L	59_R	1.477	1.00
58_Y	62_R	1.457	1.00
46_A	105_A	1.448	1.00
12_A	16_L	1.446	1.00
39_H	46_A	1.375	1.00
72_L	107_L	1.374	1.00
5_I	113_L	1.368	1.00
17_A	21_L	1.333	1.00
40_L	44_L	1.323	1.00
88_Y	91_L	1.319	1.00
23_A	27_L	1.298	1.00
102_V	106_L	1.288	1.00
58_Y	61_H	1.261	1.00
4_G	50_S	1.256	1.00
87_G	90_T	1.255	1.00
20_L	24_L	1.239	1.00
67_L	71_L	1.225	1.00
72_L	76_L	1.216	1.00
5_I	9_G	1.209	1.00
96_L	99_V	1.191	1.00
2_R	116_L	1.157	1.00
1_D	112_H	1.153	1.00
53_A	112_H	1.144	1.00
99_V	103_I	1.139	1.00
27_L	31_G	1.135	1.00
81_L	84_G	1.126	1.00
70_G	111_A	1.122	1.00
87_G	91_L	1.115	1.00
77_L	104_G	1.103	1.00
38_F	42_L	1.092	1.00
54_L	108_L	1.085	1.00
2_R	6_G	1.069	1.00
102_V	105_A	1.044	1.00
43_L	81_L	1.035	1.00
113_L	117_R	1.030	1.00
105_A	109_A	1.010	1.00
98_E	102_V	1.009	1.00
48_P	52_F	1.001	1.00
68_L	72_L	0.976	1.00
97_E	100_L	0.967	1.00
58_Y	67_L	0.959	1.00
63_R	114_L	0.957	1.00
76_L	103_I	0.935	1.00
65_L	68_L	0.931	1.00
18_L	22_L	0.922	1.00
23_A	26_P	0.922	1.00
43_L	77_L	0.914	1.00
25_L	28_L	0.907	1.00
28_L	31_G	0.903	1.00
113_L	116_L	0.895	1.00
73_G	108_L	0.892	1.00
6_G	10_L	0.891	1.00
77_L	108_L	0.876	1.00
9_G	13_I	0.868	1.00
42_L	46_A	0.867	1.00
110_A	113_L	0.858	1.00
34_A	37_A	0.847	1.00
75_A	79_L	0.846	1.00
55_G	67_L	0.837	1.00
31_G	34_A	0.836	1.00
114_L	117_R	0.827	1.00
76_L	80_A	0.820	1.00
64_L	68_L	0.817	1.00
91_L	103_I	0.817	1.00
80_A	100_L	0.817	1.00
79_L	84_G	0.817	1.00
68_L	71_L	0.816	1.00
66_P	115_N	0.809	1.00
40_L	82_F	0.808	1.00
76_L	100_L	0.796	1.00
47_L	78_L	0.796	1.00
1_D	4_G	0.792	1.00
2_R	5_I	0.785	1.00
111_A	114_L	0.783	1.00
5_I	109_A	0.769	1.00
101_T	104_G	0.759	1.00
59_R	62_R	0.758	1.00
14_H	112_H	0.757	1.00
71_L	75_A	0.749	1.00
45_L	49_I	0.749	1.00
43_L	46_A	0.746	1.00
39_H	43_L	0.744	1.00
76_L	107_L	0.727	1.00
69_L	107_L	0.718	1.00
41_V	44_L	0.716	1.00
101_T	105_A	0.711	1.00
43_L	78_L	0.706	1.00
18_L	21_L	0.697	1.00
61_H	66_P	0.691	1.00
69_L	111_A	0.688	1.00
55_G	58_Y	0.679	1.00
90_T	102_V	0.678	1.00
64_L	67_L	0.678	1.00
37_A	40_L	0.663	1.00
80_A	101_T	0.663	1.00
19_P	22_L	0.662	1.00
84_G	89_E	0.651	1.00
65_L	110_A	0.650	1.00
58_Y	71_L	0.644	1.00
51_L	71_L	0.639	1.00
69_L	110_A	0.638	1.00
52_F	55_G	0.623	1.00
77_L	81_L	0.622	1.00
66_P	111_A	0.618	1.00
12_A	102_V	0.614	1.00
107_L	111_A	0.611	1.00
112_H	115_N	0.610	1.00
24_L	28_L	0.607	1.00
3_L	49_I	0.602	1.00
96_L	103_I	0.602	1.00
13_I	16_L	0.599	1.00
40_L	52_F	0.597	1.00
4_G	112_H	0.591	0.99
39_H	48_P	0.588	0.99
17_A	20_L	0.587	0.99
70_G	73_G	0.585	0.99
49_I	52_F	0.582	0.99
39_H	80_A	0.581	0.99
50_S	53_A	0.579	0.99
55_G	64_L	0.578	0.99
55_G	59_R	0.576	0.99
53_A	57_G	0.574	0.99
10_L	13_I	0.572	0.99
7_L	16_L	0.565	0.99
43_L	74_L	0.558	0.99
45_L	48_P	0.558	0.99
40_L	83_L	0.556	0.99
11_C	15_C	0.555	0.99
103_I	107_L	0.544	0.99
40_L	43_L	0.544	0.99
57_G	67_L	0.543	0.99
39_H	81_L	0.542	0.99
61_H	115_N	0.541	0.99
22_L	34_A	0.533	0.99
14_H	17_A	0.521	0.99
108_L	112_H	0.521	0.99
27_L	32_F	0.520	0.99
32_F	35_N	0.519	0.99
101_T	108_L	0.513	0.99
30_L	33_L	0.510	0.98
11_C	17_A	0.502	0.98
78_L	82_F	0.501	0.98
40_L	81_L	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2m67A	1	0.6154	52.9	0.849	Contact Map
1wazA	1	0.3932	32.4	0.867	Contact Map
2h3oA	1	0.3761	20.3	0.879	Contact Map
3j1zP	8	0.9829	8.2	0.899	Contact Map
3wxwA	1	0.8632	7.5	0.9	Contact Map
3h90A	3	0.9829	5	0.908	Contact Map
4i0uA	4	0.5128	3.8	0.913	Contact Map
4ev6A	3	0.5299	3.8	0.913	Contact Map
1jdpH	1	0.094	3.3	0.916	Contact Map
3wajA	1	0.8803	2.9	0.918	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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