GREMLIN Database
DUF260 - Protein of unknown function DUF260
PFAM: PF03195 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 99 (98)
Sequences: 1026 (487)
Seq/√Len: 49.2
META: 0.044

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_L57_A5.9991.00
33_V42_V5.6651.00
76_C80_I2.7891.00
40_S44_K2.6351.00
8_L39_A2.1241.00
6_K11_K2.0871.00
68_R73_V2.0151.00
61_L65_A1.9860.99
71_D78_G1.8990.99
93_E97_A1.8170.99
30_F39_A1.7630.99
41_N44_K1.7570.99
1_P39_A1.6460.98
32_N66_N1.5810.97
6_K9_R1.5760.97
83_L86_Q1.5210.97
18_F43_S1.5080.96
22_F30_F1.4760.96
74_Y77_V1.4700.96
2_C5_C1.4670.96
26_Q29_K1.3930.95
88_C92_A1.3730.94
80_I83_L1.3530.94
61_L66_N1.3510.94
3_A23_P1.3450.93
35_K65_A1.3230.93
38_G41_N1.2980.92
60_S78_G1.2680.91
10_R14_P1.2500.91
87_V90_L1.2410.90
95_A98_Q1.2370.90
29_K66_N1.2300.90
7_F18_F1.2130.89
55_A59_N1.1800.88
68_R76_C1.1660.87
19_A22_F1.1570.87
1_P8_L1.1520.87
56_D63_Y1.1410.86
90_L93_E1.1380.86
53_Q70_R1.1380.86
18_F39_A1.1250.85
66_N86_Q1.1060.84
30_F41_N1.1040.84
62_V67_A1.0900.83
7_F45_L1.0900.83
50_P53_Q1.0870.83
43_S62_V1.0760.83
22_F33_V1.0390.80
74_Y78_G1.0340.80
71_D80_I1.0240.79
4_A9_R1.0150.79
71_D91_Q1.0060.78
68_R72_P0.9780.76
33_V65_A0.9600.75
17_V46_L0.9560.74
34_H42_V0.9540.74
27_P31_A0.9460.74
14_P17_V0.9460.74
39_A43_S0.9220.72
77_V82_A0.9010.70
63_Y70_R0.8760.68
86_Q89_Q0.8660.67
92_A96_A0.8390.64
6_K10_R0.8280.63
2_C22_F0.8280.63
27_P61_L0.8070.61
36_V91_Q0.7980.61
6_K87_V0.7950.60
61_L81_S0.7950.60
32_N45_L0.7950.60
91_Q96_A0.7880.60
50_P84_Q0.7790.59
91_Q98_Q0.7790.59
61_L87_V0.7710.58
21_Y44_K0.7690.58
29_K58_V0.7560.56
12_C16_C0.7550.56
87_V98_Q0.7490.56
64_E76_C0.7480.56
50_P91_Q0.7430.55
89_Q93_E0.7420.55
8_L69_L0.7420.55
53_Q61_L0.7390.55
21_Y25_D0.7340.54
62_V66_N0.7290.54
21_Y55_A0.7270.53
5_C12_C0.7270.53
37_F81_S0.7210.53
87_V91_Q0.7160.52
92_A95_A0.7070.51
24_A89_Q0.7010.51
26_Q70_R0.6890.50
69_L74_Y0.6870.49
7_F59_N0.6810.49
28_Q55_A0.6790.49
38_G57_A0.6730.48
65_A90_L0.6730.48
2_C12_C0.6720.48
3_A33_V0.6720.48
32_N42_V0.6660.47
85_Q88_C0.6610.47
1_P18_F0.6540.46
75_G80_I0.6500.46
46_L68_R0.6350.44
31_A40_S0.6340.44
52_H70_R0.6310.44
4_A14_P0.6300.44
84_Q87_V0.6280.43
34_H38_G0.6270.43
34_H41_N0.6250.43
46_L57_A0.6240.43
20_P76_C0.6170.42
68_R74_Y0.6040.41
48_E59_N0.5990.41
45_L57_A0.5990.41
47_Q62_V0.5980.40
19_A36_V0.5980.40
24_A87_V0.5980.40
36_V79_L0.5930.40
23_P78_G0.5920.40
27_P53_Q0.5890.40
63_Y80_I0.5770.38
88_C97_A0.5750.38
69_L85_Q0.5750.38
91_Q95_A0.5710.38
29_K71_D0.5700.38
55_A98_Q0.5690.38
47_Q94_L0.5660.37
49_L97_A0.5590.37
26_Q90_L0.5590.37
55_A82_A0.5560.36
81_S85_Q0.5550.36
73_V94_L0.5420.35
29_K46_L0.5380.35
88_C95_A0.5370.35
82_A86_Q0.5230.33
76_C86_Q0.5220.33
17_V65_A0.5210.33
29_K97_A0.5200.33
65_A76_C0.5140.33
26_Q49_L0.5140.33
51_P62_V0.5120.32
12_C20_P0.5080.32
18_F45_L0.5040.32
36_V39_A0.5010.31
20_P40_S0.5000.31
21_Y58_V0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2er8A 1 0.6465 19.5 0.919 Contact Map
1zmeC 2 0.6364 19.5 0.919 Contact Map
3i00A 2 0.5253 16.7 0.922 Contact Map
4dznA 3 0.2222 14.8 0.924 Contact Map
2ic6A 1 0.2424 13.9 0.925 Contact Map
1hwtC 2 0.6465 11.7 0.927 Contact Map
4y66B 1 0.8889 10.7 0.929 Contact Map
1pyiA 2 0.6465 8.9 0.931 Contact Map
1am9A 2 0.6566 8.4 0.932 Contact Map
1z0jB 1 0.4848 8.1 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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