GREMLIN Database
Otopetrin - Otopetrin
PFAM: PF03189 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 407 (391)
Sequences: 547 (350)
Seq/√Len: 17.7
META: 0.179

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
292_F326_T4.1301.00
209_G213_G4.0771.00
400_P406_R3.4541.00
355_V358_L3.2730.99
329_N405_Y3.1080.99
52_Q56_L3.0920.99
334_E338_R2.8880.98
55_F82_N2.7910.98
33_C144_C2.7860.98
73_F77_H2.7130.98
164_F333_I2.6470.97
358_L362_N2.6190.97
109_T112_T2.6170.97
400_P407_F2.5040.96
225_I228_F2.5010.96
400_P404_F2.4890.96
391_W400_P2.4540.96
5_G93_E2.4360.95
52_Q55_F2.3800.95
239_Q300_V2.3670.95
366_W391_W2.3420.94
40_V47_V2.3170.94
76_M80_A2.3120.94
171_I174_A2.3050.94
366_W371_F2.3040.94
163_P366_W2.3020.94
262_G331_F2.2640.93
400_P405_Y2.2590.93
157_G297_F2.2030.92
366_W400_P2.2010.92
17_D20_K2.2000.92
214_L363_F2.1760.92
362_N400_P2.1420.91
108_T112_T2.1080.90
267_R271_Y2.1010.90
71_T76_M2.0770.90
115_S118_L2.0680.89
197_H261_I2.0580.89
144_C162_Y2.0570.89
82_N290_G2.0310.89
301_A331_F1.9610.87
22_G176_L1.9230.86
191_H194_H1.9200.86
274_N287_A1.8700.84
281_V337_H1.8570.84
362_N406_R1.8440.83
3_R7_V1.8110.82
76_M282_I1.7590.80
259_C262_G1.7360.79
215_L219_A1.7260.79
162_Y301_A1.7050.78
287_A290_G1.7000.78
82_N93_E1.6860.77
163_P287_A1.6770.77
223_V227_Y1.6700.76
75_L170_L1.6660.76
81_T279_L1.6640.76
158_S183_V1.6600.76
363_F379_N1.6570.76
362_N366_W1.6500.75
52_Q82_N1.6440.75
331_F388_F1.6440.75
15_I204_S1.6280.74
182_N185_R1.6260.74
369_N372_E1.5810.72
186_R330_L1.5790.72
57_W60_S1.5770.72
40_V219_A1.5630.71
173_S178_V1.5350.70
96_H397_I1.5340.70
93_E144_C1.5110.69
111_L116_F1.5050.68
391_W406_R1.5020.68
52_Q59_H1.5010.68
294_Y399_L1.4970.68
353_Q357_F1.4910.68
82_N168_Y1.4750.67
91_V339_R1.4690.66
48_F85_L1.4590.66
18_G57_W1.4550.66
308_R323_L1.4530.65
316_A323_L1.4460.65
49_T59_H1.4450.65
363_F382_Q1.4450.65
60_S180_W1.4410.65
76_M279_L1.4380.65
332_I338_R1.4310.64
235_E250_V1.4290.64
361_C373_T1.4230.64
255_M363_F1.4110.63
217_L401_L1.4070.63
14_L46_A1.4050.63
5_G14_L1.4020.63
144_C163_P1.4000.63
363_F404_F1.3970.62
224_L232_S1.3970.62
291_Q325_V1.3810.61
161_L167_E1.3680.61
185_R299_I1.3650.60
48_F52_Q1.3550.60
10_G49_T1.3400.59
401_L406_R1.3340.59
10_G14_L1.3340.59
287_A324_Q1.3320.59
224_L230_L1.3290.58
108_T111_L1.3250.58
169_S385_F1.3240.58
255_M262_G1.3210.58
208_K211_F1.3090.57
164_F359_L1.2840.56
84_L352_R1.2810.56
209_G283_L1.2780.55
56_L60_S1.2780.55
110_S113_N1.2680.55
2_L9_F1.2600.54
41_F56_L1.2590.54
117_S122_S1.2590.54
203_C211_F1.2580.54
22_G298_S1.2580.54
155_Q162_Y1.2570.54
5_G9_F1.2520.54
261_I323_L1.2510.54
168_Y180_W1.2430.53
297_F394_I1.2400.53
202_D206_A1.2400.53
43_V47_V1.2360.53
89_A301_A1.2310.52
281_V336_L1.2260.52
215_L293_L1.2220.52
19_F53_T1.2180.52
118_L122_S1.2140.51
113_N116_F1.2120.51
332_I336_L1.2120.51
52_Q61_K1.2110.51
274_N277_R1.2090.51
18_G39_I1.2050.51
357_F362_N1.2020.51
152_S226_L1.2000.51
82_N169_S1.1980.50
335_G338_R1.1970.50
80_A330_L1.1890.50
112_T117_S1.1860.50
342_T367_I1.1830.50
164_F399_L1.1790.49
209_G280_D1.1770.49
366_W405_Y1.1700.49
42_P81_T1.1700.49
3_R82_N1.1700.49
351_G355_V1.1690.49
382_Q394_I1.1560.48
166_I331_F1.1540.48
351_G356_T1.1530.48
227_Y339_R1.1490.47
220_G364_A1.1470.47
77_H209_G1.1390.47
3_R10_G1.1380.47
353_Q365_L1.1300.46
59_H269_L1.1250.46
209_G338_R1.1170.46
148_T322_I1.1170.46
351_G359_L1.1160.45
136_G386_Y1.1120.45
262_G354_I1.1110.45
74_G290_G1.1050.45
251_L334_E1.1050.45
54_Y177_Y1.1030.45
190_S193_H1.1020.45
84_L159_P1.1000.45
366_W406_R1.0970.44
47_V260_L1.0970.44
137_N226_L1.0970.44
5_G17_D1.0960.44
260_L264_I1.0870.44
380_P383_L1.0840.44
54_Y60_S1.0820.43
13_S21_I1.0820.43
361_C379_N1.0800.43
52_Q180_W1.0710.43
166_I403_I1.0680.43
13_S17_D1.0650.42
52_Q60_S1.0620.42
87_L394_I1.0550.42
40_V44_I1.0540.42
368_I386_Y1.0520.42
320_L404_F1.0510.42
34_K40_V1.0500.42
77_H351_G1.0470.41
161_L184_G1.0450.41
2_L5_G1.0450.41
40_V321_M1.0440.41
374_Q396_H1.0420.41
203_C207_S1.0400.41
31_S44_I1.0400.41
99_I183_V1.0380.41
66_R177_Y1.0360.41
332_I370_T1.0350.41
282_I366_W1.0330.41
42_P45_Q1.0320.40
41_F59_H1.0290.40
280_D284_L1.0280.40
163_P291_Q1.0240.40
287_A404_F1.0220.40
13_S22_G1.0210.40
56_L59_H1.0190.40
373_T402_A1.0180.40
176_L298_S1.0170.40
217_L220_G1.0160.40
299_I348_K1.0130.39
237_K242_V1.0090.39
102_E106_N1.0080.39
389_W392_T1.0080.39
12_G19_F1.0070.39
300_V319_L1.0070.39
298_S318_S1.0030.39
392_T395_T0.9970.38
6_L12_G0.9960.38
84_L176_L0.9900.38
292_F299_I0.9900.38
94_S253_L0.9880.38
120_P123_E0.9880.38
20_K97_Q0.9820.38
168_Y326_T0.9810.37
300_V303_V0.9740.37
215_L241_L0.9720.37
182_N295_S0.9680.37
43_V140_T0.9680.37
172_A176_L0.9670.37
353_Q359_L0.9660.37
281_V370_T0.9630.36
177_Y283_L0.9620.36
315_L331_F0.9620.36
167_E328_Q0.9580.36
165_N175_V0.9560.36
40_V322_I0.9520.36
223_V252_L0.9450.35
342_T345_Q0.9450.35
144_C391_W0.9410.35
162_Y315_L0.9360.35
144_C366_W0.9340.35
203_C210_L0.9340.35
350_P356_T0.9340.35
52_Q209_G0.9330.35
352_R358_L0.9320.35
16_L20_K0.9320.35
109_T113_N0.9260.34
102_E105_L0.9220.34
263_L266_M0.9200.34
347_R359_L0.9160.34
361_C374_Q0.9160.34
135_L138_S0.9160.34
313_L379_N0.9150.34
68_K251_L0.9080.33
392_T396_H0.9040.33
74_G147_T0.9040.33
70_L254_L0.9030.33
369_N376_A0.8990.33
63_C170_L0.8990.33
2_L269_L0.8970.33
93_E166_I0.8920.33
257_L303_V0.8910.33
168_Y177_Y0.8880.32
93_E98_I0.8850.32
254_L324_Q0.8850.32
83_L260_L0.8810.32
7_V59_H0.8790.32
211_F324_Q0.8760.32
177_Y184_G0.8750.32
213_G351_G0.8740.32
154_F284_L0.8730.32
53_T56_L0.8730.32
166_I173_S0.8720.31
352_R355_V0.8700.31
212_L223_V0.8670.31
359_L386_Y0.8670.31
165_N329_N0.8660.31
217_L250_V0.8650.31
62_D65_Q0.8640.31
220_G224_L0.8640.31
91_V329_N0.8630.31
115_S123_E0.8630.31
25_F37_L0.8610.31
178_V182_N0.8610.31
172_A177_Y0.8600.31
52_Q213_G0.8560.31
287_A363_F0.8540.31
238_E293_L0.8540.31
45_Q169_S0.8520.30
279_L329_N0.8520.30
217_L231_V0.8500.30
183_V296_Y0.8500.30
53_T58_V0.8490.30
237_K322_I0.8480.30
353_Q396_H0.8480.30
114_L118_L0.8480.30
21_I234_P0.8470.30
43_V268_E0.8400.30
386_Y391_W0.8390.30
366_W370_T0.8380.30
152_S253_L0.8370.30
182_N315_L0.8370.30
84_L163_P0.8360.30
15_I21_I0.8360.30
15_I319_L0.8350.30
224_L300_V0.8340.30
3_R287_A0.8300.29
23_Y27_F0.8290.29
58_V287_A0.8280.29
183_V315_L0.8250.29
111_L268_E0.8250.29
6_L30_W0.8230.29
336_L340_P0.8230.29
118_L121_L0.8230.29
160_Y171_I0.8180.29
46_A50_F0.8170.29
153_I323_L0.8150.29
94_S176_L0.8130.28
54_Y174_A0.8040.28
10_G21_I0.8040.28
290_G363_F0.8040.28
95_K162_Y0.8020.28
363_F373_T0.7980.28
224_L231_V0.7940.28
56_L332_I0.7940.28
385_F394_I0.7930.27
45_Q56_L0.7920.27
87_L376_A0.7910.27
206_A227_Y0.7890.27
37_L233_G0.7870.27
238_E246_I0.7830.27
345_Q350_P0.7800.27
17_D93_E0.7800.27
36_A43_V0.7780.27
177_Y313_L0.7760.27
90_V292_F0.7760.27
154_F396_H0.7750.27
89_A95_K0.7730.27
279_L405_Y0.7710.26
168_Y386_Y0.7680.26
47_V134_N0.7670.26
11_I16_L0.7660.26
400_P403_I0.7650.26
245_Y318_S0.7600.26
207_S324_Q0.7590.26
15_I238_E0.7550.26
235_E238_E0.7550.26
169_S213_G0.7510.25
331_F378_S0.7510.25
186_R191_H0.7500.25
11_I93_E0.7490.25
255_M259_C0.7470.25
369_N377_E0.7450.25
42_P87_L0.7440.25
44_I51_V0.7430.25
196_H212_L0.7430.25
209_G352_R0.7420.25
325_V403_I0.7400.25
48_F290_G0.7390.25
79_L334_E0.7380.25
93_E391_W0.7360.25
6_L20_K0.7350.25
89_A371_F0.7350.25
174_A336_L0.7340.25
113_N246_I0.7330.25
8_L18_G0.7320.25
101_H105_L0.7260.24
338_R352_R0.7230.24
177_Y284_L0.7220.24
53_T60_S0.7210.24
27_F42_P0.7200.24
56_L172_A0.7190.24
134_N137_N0.7160.24
344_E348_K0.7160.24
40_V116_F0.7130.24
186_R219_A0.7130.24
53_T353_Q0.7120.24
113_N117_S0.7110.24
367_I371_F0.7100.24
15_I207_S0.7060.23
160_Y168_Y0.7040.23
147_T263_L0.7020.23
30_W33_C0.7010.23
94_S172_A0.7010.23
13_S24_Y0.7000.23
48_F313_L0.6990.23
365_L402_A0.6980.23
280_D283_L0.6940.23
144_C164_F0.6920.23
157_G288_A0.6880.23
251_L256_S0.6860.23
291_Q366_W0.6860.23
381_V403_I0.6840.23
117_S121_L0.6840.23
333_I360_V0.6820.22
10_G52_Q0.6820.22
204_S221_I0.6810.22
159_P366_W0.6810.22
280_D404_F0.6800.22
51_V55_F0.6780.22
93_E225_I0.6780.22
48_F169_S0.6780.22
15_I18_G0.6760.22
58_V207_S0.6750.22
17_D22_G0.6740.22
110_S115_S0.6740.22
363_F389_W0.6720.22
20_K54_Y0.6710.22
171_I175_V0.6700.22
7_V171_I0.6660.22
221_I285_L0.6650.22
161_L366_W0.6640.22
9_F48_F0.6630.22
111_L114_L0.6630.22
354_I364_A0.6620.22
44_I257_L0.6620.22
76_M180_W0.6620.22
9_F328_Q0.6610.22
5_G15_I0.6600.22
47_V261_I0.6600.22
368_I377_E0.6590.21
320_L327_L0.6570.21
206_A356_T0.6550.21
54_Y59_H0.6540.21
17_D21_I0.6530.21
45_Q48_F0.6530.21
50_F57_W0.6520.21
221_I394_I0.6500.21
17_D33_C0.6490.21
261_I344_E0.6480.21
336_L395_T0.6470.21
55_F59_H0.6470.21
65_Q68_K0.6420.21
223_V271_Y0.6410.21
168_Y379_N0.6400.21
360_V375_R0.6400.21
71_T180_W0.6390.21
246_I322_I0.6360.21
18_G218_V0.6330.20
134_N260_L0.6330.20
217_L225_I0.6280.20
351_G357_F0.6260.20
147_T150_L0.6240.20
171_I404_F0.6230.20
301_A371_F0.6230.20
16_L23_Y0.6220.20
197_H205_G0.6220.20
21_I323_L0.6210.20
39_I92_N0.6140.20
338_R351_G0.6140.20
136_G139_T0.6140.20
161_L164_F0.6110.20
165_N289_L0.6100.20
7_V15_I0.6100.20
283_L286_G0.6100.20
391_W396_H0.6070.19
363_F375_R0.6060.19
196_H286_G0.6050.19
218_V297_F0.6050.19
184_G245_Y0.6050.19
41_F58_V0.6040.19
177_Y280_D0.6020.19
252_L255_M0.6020.19
362_N405_Y0.6010.19
162_Y175_V0.6000.19
108_T122_S0.5980.19
220_G227_Y0.5980.19
385_F391_W0.5980.19
276_T285_L0.5970.19
259_C263_L0.5960.19
19_F33_C0.5960.19
370_T404_F0.5940.19
365_L406_R0.5930.19
173_S255_M0.5930.19
285_L333_I0.5930.19
328_Q331_F0.5920.19
42_P279_L0.5910.19
32_E43_V0.5900.19
215_L237_K0.5870.19
16_L21_I0.5870.19
169_S324_Q0.5870.19
47_V138_S0.5860.19
164_F175_V0.5820.18
238_E323_L0.5810.18
42_P55_F0.5800.18
187_L261_I0.5800.18
17_D146_C0.5790.18
399_L405_Y0.5780.18
166_I337_H0.5770.18
293_L307_P0.5750.18
375_R395_T0.5730.18
13_S165_N0.5710.18
206_A246_I0.5710.18
80_A327_L0.5700.18
184_G374_Q0.5680.18
14_L41_F0.5670.18
81_T173_S0.5660.18
52_Q357_F0.5660.18
146_C155_Q0.5640.18
84_L321_M0.5630.18
355_V363_F0.5620.18
77_H81_T0.5610.18
203_C209_G0.5610.18
50_F53_T0.5600.18
6_L14_L0.5600.18
53_T57_W0.5590.18
221_I225_I0.5590.18
179_M183_V0.5580.18
16_L56_L0.5580.18
20_K25_F0.5580.18
290_G406_R0.5560.18
280_D329_N0.5560.18
40_V235_E0.5550.17
77_H213_G0.5550.17
113_N200_S0.5540.17
13_S70_L0.5510.17
221_I245_Y0.5500.17
162_Y304_A0.5500.17
210_L359_L0.5500.17
281_V330_L0.5490.17
245_Y354_I0.5490.17
295_S299_I0.5490.17
364_A376_A0.5480.17
231_V302_I0.5480.17
59_H62_D0.5470.17
47_V222_I0.5470.17
371_F391_W0.5460.17
223_V240_A0.5450.17
224_L228_F0.5450.17
328_Q400_P0.5450.17
25_F150_L0.5440.17
50_F203_C0.5430.17
169_S175_V0.5420.17
21_I26_E0.5410.17
75_L176_L0.5400.17
278_S285_L0.5400.17
17_D87_L0.5390.17
221_I303_V0.5390.17
372_E380_P0.5370.17
214_L243_L0.5360.17
111_L117_S0.5360.17
152_S321_M0.5360.17
158_S218_V0.5340.17
18_G183_V0.5330.17
17_D24_Y0.5300.17
174_A177_Y0.5300.17
12_G33_C0.5300.17
357_F401_L0.5280.17
139_T212_L0.5280.17
214_L397_I0.5260.16
372_E375_R0.5260.16
394_I400_P0.5260.16
138_S319_L0.5250.16
92_N244_Y0.5240.16
188_A348_K0.5230.16
34_K273_K0.5230.16
171_I314_N0.5230.16
216_V344_E0.5230.16
374_Q398_S0.5210.16
43_V316_A0.5200.16
199_L303_V0.5190.16
121_L138_S0.5190.16
15_I34_K0.5180.16
161_L297_F0.5180.16
106_N264_I0.5180.16
338_R394_I0.5170.16
45_Q59_H0.5170.16
57_W62_D0.5170.16
44_I320_L0.5160.16
168_Y214_L0.5150.16
40_V242_V0.5150.16
345_Q349_K0.5140.16
16_L22_G0.5130.16
45_Q63_C0.5100.16
357_F370_T0.5090.16
164_F288_A0.5080.16
17_D35_S0.5080.16
388_F398_S0.5070.16
38_E56_L0.5070.16
138_S257_L0.5040.16
173_S213_G0.5040.16
94_S188_A0.5040.16
191_H195_S0.5040.16
70_L323_L0.5020.16
150_L176_L0.5020.16
174_A339_R0.5010.16
112_T115_S0.5010.16
59_H67_H0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x5mA 2 0.2285 7.6 0.976 Contact Map
4g80S 1 0.3415 5.5 0.978 Contact Map
2llmA 1 0.1057 5.1 0.978 Contact Map
3wu2L 1 0.0909 3.9 0.979 Contact Map
4qncA 2 0.199 3.6 0.98 Contact Map
5a63D 1 0.113 3.4 0.98 Contact Map
4ryoA 1 0.3464 3.3 0.98 Contact Map
3j1zP 8 0.3219 3.2 0.98 Contact Map
2jwaA 2 0.0909 2.6 0.981 Contact Map
1amlA 1 0.0958 2.3 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0116 seconds.