GREMLIN Database
CobD_Cbib - CobD/Cbib protein
PFAM: PF03186 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 272 (269)
Sequences: 14467 (10594)
Seq/√Len: 645.9
META: 0.759

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_G154_G3.4591.00
161_V189_L3.4321.00
41_R180_W3.2421.00
198_A210_W2.8531.00
80_T155_A2.7851.00
100_D103_A2.5891.00
120_D123_G2.5321.00
171_R176_E2.5071.00
77_L147_F2.4871.00
56_A157_A2.4771.00
48_V185_L2.4621.00
176_E180_W2.4381.00
84_R88_D2.3991.00
240_P249_E2.3151.00
59_A156_L2.3071.00
242_V247_L2.2521.00
47_L168_I2.2231.00
48_V52_V2.2161.00
210_W224_W2.2151.00
90_V132_V2.2011.00
30_W34_R2.1971.00
236_R252_W2.1501.00
45_A181_A2.1111.00
41_R177_R1.9541.00
214_A224_W1.9271.00
107_A110_M1.9231.00
240_P247_L1.9111.00
258_R264_D1.8791.00
136_T197_T1.8521.00
3_L74_A1.8501.00
94_A266_R1.8401.00
147_F155_A1.8281.00
80_T156_L1.8131.00
45_A180_W1.8061.00
40_R177_R1.7841.00
201_I229_M1.7421.00
261_T264_D1.7401.00
26_R30_W1.7021.00
96_A103_A1.6971.00
103_A107_A1.6961.00
137_S225_P1.6781.00
264_D267_R1.6691.00
141_V197_T1.6491.00
161_V185_L1.6461.00
52_V157_A1.6351.00
75_L79_T1.6081.00
48_V181_A1.5591.00
87_A269_L1.5551.00
119_L123_G1.5491.00
32_E175_Y1.5311.00
92_A107_A1.5291.00
229_M271_L1.5181.00
129_I268_A1.5111.00
136_T201_I1.4981.00
48_V182_A1.4921.00
180_W184_R1.4881.00
87_A91_R1.4771.00
168_I182_A1.4751.00
63_L73_E1.4751.00
206_A231_G1.4711.00
55_A59_A1.4551.00
27_L51_L1.4481.00
172_N175_Y1.4481.00
66_L72_L1.4451.00
90_V128_A1.4251.00
36_N40_R1.4241.00
24_I160_A1.4211.00
103_A106_R1.4091.00
235_V260_A1.4081.00
158_Y162_N1.4021.00
96_A107_A1.4021.00
218_P248_V1.4011.00
158_Y190_N1.3791.00
51_L160_A1.3521.00
108_L124_V1.3511.00
85_S89_H1.3401.00
206_A232_A1.3331.00
31_L47_L1.3311.00
229_M268_A1.3281.00
177_R180_W1.3071.00
56_A60_W1.3071.00
133_A229_M1.3061.00
143_P158_Y1.2961.00
5_L83_Q1.2941.00
106_R110_M1.2911.00
24_I51_L1.2831.00
101_L124_V1.2731.00
18_P22_V1.2611.00
73_E152_L1.2561.00
60_W64_R1.2541.00
100_D104_A1.2461.00
22_V26_R1.2451.00
209_I231_G1.2411.00
28_I168_I1.2381.00
77_L155_A1.2341.00
164_L182_A1.2231.00
213_D216_K1.2171.00
202_A210_W1.2171.00
129_I229_M1.2141.00
28_I164_L1.2131.00
89_H110_M1.2131.00
91_R266_R1.2121.00
157_A189_L1.1971.00
121_E125_A1.1711.00
4_A77_L1.1691.00
39_G43_A1.1681.00
32_E174_R1.1661.00
55_A156_L1.1651.00
142_A158_Y1.1611.00
188_L191_W1.1581.00
113_G170_Y1.1481.00
89_H92_A1.1431.00
202_A206_A1.1391.00
181_A185_L1.1341.00
210_W214_A1.1271.00
118_A242_V1.1221.00
85_S88_D1.1201.00
136_T141_V1.1201.00
8_D13_D1.1191.00
90_V269_L1.1121.00
128_A265_I1.1031.00
30_W33_R1.1011.00
97_L125_A1.1001.00
240_P252_W1.0981.00
108_L127_A1.0961.00
202_A207_L1.0911.00
129_I237_L1.0821.00
91_R94_A1.0711.00
209_I212_R1.0691.00
212_R255_D1.0681.00
254_G257_R1.0641.00
202_A232_A1.0611.00
89_H107_A1.0611.00
209_I213_D1.0611.00
48_V164_L1.0561.00
92_A110_M1.0481.00
116_T119_L1.0481.00
35_L43_A1.0381.00
125_A262_A1.0351.00
109_S116_T1.0331.00
35_L47_L1.0311.00
56_A153_P1.0301.00
96_A100_D1.0301.00
76_L152_L1.0281.00
48_V161_V1.0191.00
9_L83_Q1.0171.00
122_A259_P1.0161.00
125_A265_I1.0151.00
40_R43_A1.0141.00
123_G126_R1.0131.00
91_R95_R1.0121.00
93_V128_A1.0111.00
112_V116_T1.0041.00
92_A96_A0.9981.00
145_F196_L0.9881.00
121_E262_A0.9861.00
234_G257_R0.9851.00
257_R260_A0.9841.00
198_A224_W0.9841.00
35_L178_F0.9791.00
159_K166_S0.9791.00
173_E176_E0.9761.00
4_A74_A0.9671.00
63_L66_L0.9661.00
125_A128_A0.9591.00
16_R22_V0.9541.00
185_L189_L0.9541.00
206_A210_W0.9481.00
106_R109_S0.9361.00
257_R264_D0.9301.00
83_Q140_V0.9241.00
24_I55_A0.9211.00
7_L78_Y0.9151.00
11_L78_Y0.9091.00
67_L70_L0.9061.00
139_G166_S0.9061.00
13_D22_V0.8991.00
111_I131_S0.8981.00
236_R256_G0.8951.00
137_S142_A0.8931.00
171_R218_P0.8921.00
18_P23_W0.8911.00
54_L58_L0.8871.00
207_L211_R0.8871.00
23_W26_R0.8841.00
157_A161_V0.8811.00
41_R181_A0.8731.00
205_R234_G0.8731.00
94_A125_A0.8721.00
141_V200_L0.8721.00
97_L104_A0.8711.00
39_G177_R0.8661.00
73_E147_F0.8661.00
137_S190_N0.8591.00
26_R29_A0.8581.00
59_A63_L0.8561.00
215_R224_W0.8561.00
147_F152_L0.8551.00
6_L10_L0.8491.00
93_V124_V0.8471.00
249_E252_W0.8391.00
96_A104_A0.8361.00
99_G103_A0.8361.00
15_R18_P0.8351.00
137_S197_T0.8351.00
197_T225_P0.8321.00
63_L152_L0.8301.00
55_A160_A0.8231.00
50_L54_L0.8221.00
47_L178_F0.8181.00
79_T156_L0.8181.00
101_L121_E0.8171.00
27_L54_L0.8121.00
201_I228_A0.8091.00
5_L9_L0.8051.00
125_A260_A0.8041.00
210_W228_A0.8011.00
23_W27_L0.8001.00
52_V185_L0.8001.00
201_I232_A0.7991.00
94_A265_I0.7941.00
102_E106_R0.7771.00
31_L51_L0.7751.00
91_R269_L0.7741.00
89_H131_S0.7741.00
198_A228_A0.7731.00
88_D92_A0.7701.00
205_R208_R0.7691.00
209_I255_D0.7681.00
214_A223_G0.7661.00
146_W150_G0.7631.00
7_L11_L0.7631.00
241_N250_R0.7591.00
238_G250_R0.7571.00
198_A202_A0.7571.00
38_A42_L0.7531.00
74_A78_Y0.7511.00
87_A90_V0.7471.00
96_A99_G0.7461.00
32_E36_N0.7451.00
41_R45_A0.7441.00
98_E266_R0.7441.00
93_V96_A0.7421.00
99_G121_E0.7371.00
162_N166_S0.7351.00
97_L121_E0.7351.00
76_L156_L0.7331.00
201_I271_L0.7321.00
54_L57_L0.7321.00
12_G84_R0.7301.00
31_L50_L0.7241.00
184_R187_D0.7221.00
122_A125_A0.7211.00
51_L54_L0.7201.00
113_G127_A0.7131.00
208_R211_R0.7061.00
27_L30_W0.7051.00
13_D18_P0.7051.00
94_A98_E0.7031.00
141_V225_P0.7021.00
238_G241_N0.6971.00
9_L87_A0.6971.00
146_W154_G0.6961.00
15_R110_M0.6841.00
217_H226_E0.6831.00
258_R261_T0.6821.00
61_L64_R0.6801.00
43_A47_L0.6801.00
115_D242_V0.6791.00
142_A190_N0.6771.00
123_G238_G0.6771.00
146_W189_L0.6761.00
25_G167_M0.6751.00
126_R241_N0.6741.00
59_A76_L0.6731.00
152_L155_A0.6731.00
213_D231_G0.6671.00
267_R270_R0.6661.00
80_T152_L0.6651.00
260_A264_D0.6631.00
238_G253_L0.6631.00
61_L65_L0.6601.00
35_L46_L0.6571.00
196_L200_L0.6571.00
261_T267_R0.6561.00
122_A126_R0.6551.00
84_R87_A0.6511.00
89_H111_I0.6491.00
199_L207_L0.6491.00
87_A132_V0.6451.00
4_A155_A0.6451.00
16_R23_W0.6431.00
232_A271_L0.6421.00
205_R209_I0.6411.00
90_V111_I0.6391.00
36_N175_Y0.6371.00
93_V108_L0.6371.00
123_G241_N0.6331.00
36_N39_G0.6321.00
13_D85_S0.6321.00
83_Q87_A0.6291.00
31_L34_R0.6281.00
15_R22_V0.6261.00
102_E117_A0.6261.00
28_I47_L0.6261.00
205_R257_R0.6251.00
7_L74_A0.6251.00
208_R212_R0.6201.00
95_R98_E0.6191.00
120_D124_V0.6181.00
108_L119_L0.6161.00
42_L46_L0.6131.00
115_D118_A0.6121.00
58_L61_L0.6111.00
77_L152_L0.6101.00
49_L53_L0.6081.00
73_E80_T0.6061.00
22_V85_S0.6051.00
80_T159_K0.6051.00
51_L55_A0.6031.00
132_V269_L0.6021.00
256_G259_P0.5961.00
216_K251_P0.5951.00
78_Y152_L0.5941.00
206_A209_I0.5911.00
81_L144_L0.5891.00
106_R117_A0.5881.00
151_G154_G0.5861.00
112_V127_A0.5851.00
187_D220_P0.5841.00
262_A265_I0.5831.00
60_W63_L0.5831.00
263_A266_R0.5831.00
27_L55_A0.5821.00
42_L45_A0.5811.00
93_V111_I0.5791.00
192_I196_L0.5721.00
139_G159_K0.5721.00
36_N178_F0.5721.00
27_L31_L0.5711.00
145_F149_L0.5671.00
218_P222_A0.5651.00
56_A154_G0.5651.00
60_W153_P0.5631.00
262_A266_R0.5621.00
146_W149_L0.5581.00
77_L81_L0.5581.00
113_G226_E0.5571.00
266_R270_R0.5571.00
235_V264_D0.5561.00
191_W194_A0.5491.00
29_A167_M0.5481.00
185_L188_L0.5481.00
172_N176_E0.5481.00
125_A129_I0.5471.00
202_A228_A0.5461.00
218_P250_R0.5451.00
89_H96_A0.5441.00
36_N43_A0.5441.00
82_A85_S0.5431.00
45_A49_L0.5411.00
36_N174_R0.5411.00
52_V161_V0.5401.00
73_E77_L0.5401.00
29_A33_R0.5371.00
175_Y178_F0.5371.00
158_Y189_L0.5371.00
168_I175_Y0.5360.99
150_G153_P0.5350.99
137_S141_V0.5350.99
59_A152_L0.5340.99
8_D12_G0.5340.99
199_L203_L0.5330.99
50_L53_L0.5310.99
123_G240_P0.5300.99
5_L144_L0.5300.99
211_R214_A0.5260.99
135_N166_S0.5260.99
209_I253_L0.5250.99
9_L84_R0.5250.99
152_L156_L0.5250.99
222_A227_A0.5240.99
18_P79_T0.5220.99
144_L148_A0.5220.99
157_A160_A0.5190.99
207_L210_W0.5180.99
63_L72_L0.5160.99
153_P157_A0.5150.99
172_N244_G0.5150.99
57_L60_W0.5150.99
131_S135_N0.5130.99
194_A224_W0.5130.99
81_L159_K0.5100.99
98_E262_A0.5080.99
250_R253_L0.5080.99
191_W195_R0.5060.99
39_G42_L0.5060.99
99_G104_A0.5040.99
82_A139_G0.5020.99
55_A58_L0.5020.99
244_G247_L0.5000.99
78_Y81_L0.5000.99
218_P241_N0.5000.99
76_L80_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tq3A 1 0.6838 27.2 0.951 Contact Map
4dmiA 5 0.2206 5.7 0.964 Contact Map
2ksdA 1 0.261 5.6 0.964 Contact Map
2l16A 1 0.1912 5.2 0.965 Contact Map
2lzrA 1 0.1801 2.9 0.969 Contact Map
3cuqB 1 0.2904 2.8 0.969 Contact Map
3fymA 1 0.0735 2.7 0.969 Contact Map
1n93X 3 0.1176 2.6 0.969 Contact Map
4od4A 1 0.6581 2.4 0.97 Contact Map
3v6zE 1 0.3603 2 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.