GREMLIN Database
BURP - BURP domain
PFAM: PF03181 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 215 (212)
Sequences: 575 (372)
Seq/√Len: 25.5
META: 0.052

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
207_P210_D4.8481.00
119_Q164_G4.3261.00
33_R93_D3.5241.00
183_W190_F3.4601.00
180_T183_W3.3841.00
50_L62_A2.8721.00
183_W187_H2.8601.00
86_T146_V2.6040.99
49_I65_M2.4170.99
187_H190_F2.4130.99
186_K191_Q2.3770.98
42_S73_E2.3220.98
161_S171_E2.3160.98
195_V200_V2.2700.98
58_G63_K2.2230.97
106_A211_I2.1760.97
94_F135_V2.1700.97
99_L135_V2.1350.97
45_K93_D2.0970.96
180_T190_F2.0880.96
108_S147_F2.0550.96
68_T146_V2.0520.96
33_R37_D1.9980.95
78_K182_A1.9720.95
10_P85_A1.8940.94
81_T98_V1.8370.92
110_E171_E1.8200.92
123_I127_K1.8090.92
36_A86_T1.7790.91
94_F211_I1.7420.90
179_D183_W1.7160.90
42_S144_Y1.6870.89
59_S62_A1.6730.88
13_K120_N1.6520.88
49_I142_Y1.6470.88
44_S78_K1.6290.87
45_K142_Y1.6280.87
178_L184_N1.6280.87
59_S164_G1.6140.86
136_A155_T1.6050.86
32_P35_I1.5990.86
136_A170_V1.5840.85
95_A154_K1.5720.85
143_P147_F1.5660.85
157_V178_L1.5330.83
148_Y175_V1.5040.82
180_T185_P1.4660.81
5_E156_R1.4540.80
162_L181_S1.4510.80
71_E82_K1.4470.80
13_K17_P1.4420.79
8_L14_M1.4010.77
41_F144_Y1.3890.77
159_E171_E1.3710.76
100_G108_S1.3690.76
50_L54_S1.3650.76
71_E140_M1.3590.75
56_P65_M1.3560.75
41_F142_Y1.3560.75
147_F174_A1.3370.74
3_F8_L1.3370.74
50_L59_S1.3140.73
102_R158_Y1.2970.72
33_R40_P1.2660.70
43_S73_E1.2650.70
180_T187_H1.2480.69
146_V166_D1.2420.68
181_S190_F1.2310.68
18_F170_V1.2220.67
6_K43_S1.2170.67
34_E142_Y1.2170.67
118_K121_Y1.2030.66
196_K210_D1.1690.63
194_G214_V1.1550.63
68_T102_R1.1330.61
113_K116_T1.1120.60
106_A123_I1.1060.59
192_V212_V1.1000.59
109_T172_A1.0970.58
31_L187_H1.0860.58
135_V173_V1.0840.58
152_V192_V1.0790.57
16_L170_V1.0760.57
92_V156_R1.0730.57
71_E94_F1.0690.56
39_I42_S1.0680.56
37_D69_L1.0670.56
85_A198_G1.0520.55
60_P64_A1.0480.55
34_E173_V1.0460.55
53_F164_G1.0430.55
53_F175_V1.0380.54
7_D12_K1.0300.54
25_S44_S1.0260.53
109_T173_V1.0240.53
88_L145_A1.0160.53
198_G204_H1.0160.53
1_V16_L1.0140.52
190_F193_L0.9960.51
97_S213_W0.9930.51
63_K169_K0.9900.51
57_P86_T0.9870.50
109_T208_E0.9850.50
138_H150_H0.9800.50
90_S186_K0.9790.50
66_K70_R0.9780.50
147_F191_Q0.9770.50
95_A126_V0.9710.49
50_L55_V0.9690.49
134_S152_V0.9680.49
56_P64_A0.9660.49
195_V199_T0.9640.49
77_I157_V0.9580.48
18_F32_P0.9560.48
180_T193_L0.9550.48
67_D135_V0.9540.48
188_V202_V0.9530.48
49_I73_E0.9480.48
64_A70_R0.9370.47
13_K36_A0.9360.47
91_M94_F0.9350.47
162_L214_V0.9340.47
97_S156_R0.9310.46
73_E209_D0.9300.46
122_T167_G0.9250.46
55_V159_E0.9190.46
56_P67_D0.9150.45
181_S187_H0.9140.45
91_M109_T0.9140.45
2_F104_V0.9130.45
63_K106_A0.9110.45
30_F33_R0.9110.45
7_D164_G0.9070.45
85_A164_G0.9060.45
55_V213_W0.9030.44
200_V206_L0.8980.44
38_S47_P0.8920.44
206_L214_V0.8910.43
45_K48_E0.8890.43
10_P83_Y0.8800.43
59_S119_Q0.8790.43
98_V157_V0.8720.42
46_L70_R0.8660.42
121_Y129_I0.8650.42
62_A205_F0.8640.42
41_F53_F0.8620.41
55_V65_M0.8620.41
121_Y205_F0.8530.41
100_G180_T0.8530.41
116_T174_A0.8480.40
18_F121_Y0.8390.40
121_Y171_E0.8330.39
54_S142_Y0.8280.39
185_P196_K0.8260.39
92_V152_V0.8230.39
126_V129_I0.8210.39
163_V175_V0.8190.38
111_V114_G0.8170.38
141_P199_T0.8170.38
43_S59_S0.8040.37
28_A99_L0.7960.37
109_T193_L0.7940.37
65_M142_Y0.7920.37
1_V151_S0.7900.36
177_H204_H0.7890.36
104_V158_Y0.7890.36
65_M70_R0.7880.36
93_D186_K0.7880.36
49_I56_P0.7870.36
47_P143_P0.7860.36
50_L61_E0.7860.36
58_G65_M0.7850.36
160_V205_F0.7830.36
81_T108_S0.7810.36
17_P25_S0.7790.36
13_K163_V0.7780.36
96_T123_I0.7760.35
49_I53_F0.7750.35
86_T209_D0.7710.35
136_A194_G0.7660.35
121_Y127_K0.7620.35
70_R78_K0.7510.34
9_K157_V0.7450.33
80_E187_H0.7400.33
132_T153_P0.7370.33
65_M143_P0.7360.33
159_E168_T0.7330.33
93_D172_A0.7320.33
81_T170_V0.7080.31
201_P207_P0.7060.31
29_S32_P0.7060.31
65_M184_N0.7060.31
125_G186_K0.7040.31
59_S142_Y0.7020.31
158_Y197_P0.7000.31
29_S135_V0.7000.31
39_I46_L0.7000.31
39_I73_E0.6990.30
1_V192_V0.6960.30
41_F86_T0.6950.30
20_K23_D0.6950.30
85_A195_V0.6940.30
69_L98_V0.6930.30
55_V120_N0.6870.30
126_V131_G0.6820.29
102_R214_V0.6810.29
4_L19_I0.6800.29
46_L65_M0.6780.29
42_S142_Y0.6770.29
66_K77_I0.6740.29
18_F77_I0.6730.29
56_P161_S0.6710.29
49_I54_S0.6700.29
103_N110_E0.6690.29
147_F184_N0.6680.29
180_T184_N0.6680.29
82_K198_G0.6670.29
4_L104_V0.6660.28
47_P62_A0.6650.28
66_K123_I0.6610.28
30_F213_W0.6600.28
66_K104_V0.6600.28
6_K19_I0.6550.28
10_P46_L0.6550.28
15_P152_V0.6480.27
26_P77_I0.6450.27
12_K20_K0.6420.27
193_L198_G0.6400.27
100_G198_G0.6390.27
105_R129_I0.6340.27
126_V174_A0.6340.27
52_R55_V0.6340.27
13_K116_T0.6290.26
132_T194_G0.6270.26
169_K174_A0.6250.26
65_M192_V0.6220.26
33_R41_F0.6220.26
15_P81_T0.6220.26
41_F59_S0.6170.26
78_K94_F0.6150.26
15_P64_A0.6140.25
24_K76_P0.6040.25
82_K94_F0.6040.25
163_V169_K0.6040.25
9_K12_K0.6030.25
85_A196_K0.6020.25
3_F179_D0.6020.25
20_K130_K0.6000.25
38_S65_M0.5990.25
90_S170_V0.5980.25
41_F146_V0.5980.25
13_K106_A0.5950.24
46_L143_P0.5930.24
129_I214_V0.5930.24
175_V212_V0.5880.24
124_G163_V0.5870.24
188_V210_D0.5850.24
35_I165_E0.5840.24
129_I168_T0.5830.24
134_S192_V0.5790.24
10_P102_R0.5790.24
72_C100_G0.5780.24
204_H213_W0.5770.23
86_T164_G0.5760.23
28_A205_F0.5750.23
18_F207_P0.5750.23
154_K160_V0.5730.23
82_K193_L0.5730.23
59_S193_L0.5710.23
9_K133_K0.5710.23
6_K13_K0.5710.23
188_V192_V0.5690.23
92_V174_A0.5680.23
73_E123_I0.5650.23
95_A128_K0.5580.22
108_S142_Y0.5570.22
76_P139_K0.5510.22
121_Y124_G0.5500.22
133_K161_S0.5500.22
119_Q142_Y0.5490.22
152_V174_A0.5480.22
81_T191_Q0.5460.22
147_F158_Y0.5460.22
142_Y167_G0.5450.22
27_K120_N0.5450.22
99_L197_P0.5440.22
48_E166_D0.5430.22
83_Y108_S0.5410.22
18_F205_F0.5400.22
20_K112_V0.5390.22
29_S129_I0.5390.22
174_A207_P0.5380.21
51_N136_A0.5370.21
83_Y95_A0.5350.21
63_K67_D0.5320.21
181_S185_P0.5310.21
8_L190_F0.5290.21
170_V210_D0.5270.21
18_F206_L0.5270.21
46_L69_L0.5260.21
48_E118_K0.5250.21
184_N212_V0.5240.21
55_V64_A0.5210.21
36_A42_S0.5180.21
114_G162_L0.5160.20
125_G129_I0.5150.20
53_F141_P0.5150.20
50_L68_T0.5120.20
94_F173_V0.5110.20
2_F175_V0.5110.20
82_K170_V0.5080.20
69_L111_V0.5080.20
10_P34_E0.5070.20
12_K161_S0.5070.20
6_K173_V0.5050.20
15_P120_N0.5050.20
83_Y188_V0.5020.20
131_G208_E0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n08A 2 0.3535 14.6 0.967 Contact Map
2afdA 1 0.4093 7.1 0.972 Contact Map
3pqhA 4 0.1581 6.3 0.972 Contact Map
1g0dA 1 0.2465 6.2 0.972 Contact Map
1hjrA 2 0.6279 5.1 0.973 Contact Map
4ep4A 2 0.6419 5 0.974 Contact Map
2m5rA 1 0.3674 3.9 0.975 Contact Map
3nbiA 1 0.2372 3.7 0.975 Contact Map
2xzzA 9 0.2372 3.5 0.976 Contact Map
1l0iA 1 0.3535 3.4 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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