OPT - PFAM28P - GREMLIN Contacts

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OPT - OPT oligopeptide transporter protein

PFAM:	PF03169	Sequences: ELTLRAVLLGLLLGVVFGAANAYLGLKAGLTVSASIPAAVISMALLRLLARVLPKFSLNPGPFTILENNIVQTIASAGGSLAYAAGVIFTLPALVILGLWPGFWQIFLIALLGGLLGVLFAIPLRRALVVDGKLPFPEGTATAEVLKAGHKGGGAAKSRAKFLLIAFGGGFVGGLLPLYLFPALSGFSWVTWIFPTNVVVAQLFGLGLAKLTFGWNLSPALLGVGYIVGLRVAASMLAGGVLAWGVLIPLLYFGGGWAPAYLPYNISAILAEAIWSNYVRYIGAGAMAVGGIITLSYGLSFAAITAKLLKTILSGFKSALAALRAASRRKEKDDAHAALMRTERDLPMWWVLIGLVLALVLAIALLPFLFFGLPLWAALLALVLGFLFAAVAGYIVGLTGSNPVSGMTILTLLIFGLLLPGGPAAALMVGAVVCIAAAIAGDLLQDLKTGYLLGATPRKQQIAQLIGVLVGALVIGPVLNLLNKAYGFGGAGDGSNALPAPQATLMAAVAEIGVGGGSNLPWGLLIGGALIGVVLILLDVFPKRRGKRFLPPPLAFALGMYLPLSLTLPIFVGGLIRWLVDRRRRPEWAERYGVLLASGLIAGEALMGVLIAFLV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	615 (582)
Sequences:	9459 (5667)
Seq/√Len:	234.9
META:	0.633

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
416_G	419_L	3.987	1.00
4_L	8_L	3.950	1.00
415_F	419_L	3.831	1.00
416_G	420_P	3.600	1.00
507_A	511_E	3.191	1.00
169_G	173_G	3.173	1.00
159_R	163_L	2.995	1.00
415_F	418_L	2.940	1.00
166_A	169_G	2.903	1.00
170_G	173_G	2.871	1.00
266_I	269_I	2.869	1.00
458_R	462_I	2.863	1.00
119_L	354_G	2.578	1.00
171_F	174_G	2.576	1.00
267_S	270_L	2.560	1.00
160_A	164_L	2.504	1.00
176_L	180_L	2.497	1.00
230_L	578_W	2.495	1.00
169_G	174_G	2.456	1.00
415_F	420_P	2.450	1.00
364_A	368_F	2.447	1.00
159_R	162_F	2.429	1.00
160_A	163_L	2.395	1.00
266_I	270_L	2.395	1.00
166_A	173_G	2.337	1.00
414_I	418_L	2.292	1.00
344_R	458_R	2.275	1.00
237_L	571_F	2.244	1.00
366_L	370_F	2.239	1.00
205_G	208_L	2.231	1.00
25_G	88_I	2.157	1.00
362_A	366_L	2.121	1.00
577_R	581_D	2.120	1.00
320_L	324_R	2.109	1.00
74_I	463_A	2.093	1.00
371_F	374_P	2.079	1.00
575_L	579_L	2.064	1.00
413_L	416_G	2.059	1.00
162_F	166_A	2.056	1.00
306_A	309_L	2.040	1.00
513_G	516_G	1.991	1.00
306_A	310_K	1.986	1.00
578_W	582_R	1.985	1.00
163_L	166_A	1.979	1.00
8_L	12_L	1.979	1.00
174_G	178_L	1.950	1.00
415_F	421_G	1.947	1.00
191_T	195_P	1.924	1.00
546_G	550_L	1.922	1.00
362_A	367_P	1.921	1.00
414_I	419_L	1.914	1.00
526_I	530_L	1.908	1.00
349_W	353_I	1.906	1.00
526_I	529_A	1.872	1.00
587_E	591_R	1.872	1.00
111_L	469_L	1.865	1.00
167_F	170_G	1.864	1.00
55_K	61_G	1.863	1.00
163_L	167_F	1.860	1.00
207_G	210_K	1.860	1.00
166_A	174_G	1.857	1.00
192_W	195_P	1.855	1.00
65_I	146_L	1.853	1.00
365_L	369_L	1.847	1.00
311_T	315_G	1.830	1.00
347_P	350_W	1.814	1.00
418_L	421_G	1.813	1.00
265_N	268_A	1.809	1.00
265_N	269_I	1.793	1.00
234_A	571_F	1.786	1.00
188_S	191_T	1.772	1.00
523_G	527_G	1.770	1.00
309_L	312_I	1.769	1.00
258_A	261_Y	1.723	1.00
234_A	238_A	1.699	1.00
170_G	174_G	1.686	1.00
242_L	246_V	1.686	1.00
267_S	271_A	1.676	1.00
162_F	165_I	1.669	1.00
314_S	318_S	1.662	1.00
352_L	356_V	1.662	1.00
314_S	317_K	1.662	1.00
177_P	180_L	1.649	1.00
529_A	533_V	1.647	1.00
158_S	162_F	1.646	1.00
7_V	466_I	1.633	1.00
257_W	262_L	1.628	1.00
439_I	468_V	1.627	1.00
162_F	596_L	1.626	1.00
310_K	314_S	1.621	1.00
24_L	220_A	1.617	1.00
115_L	465_L	1.616	1.00
340_M	343_E	1.616	1.00
222_L	576_I	1.609	1.00
11_L	470_V	1.602	1.00
362_A	370_F	1.600	1.00
259_P	263_P	1.594	1.00
315_G	318_S	1.589	1.00
70_I	463_A	1.589	1.00
173_G	178_L	1.579	1.00
528_G	532_G	1.571	1.00
273_A	277_N	1.563	1.00
532_G	535_L	1.559	1.00
307_K	319_A	1.559	1.00
318_S	321_A	1.557	1.00
243_A	560_M	1.546	1.00
174_G	177_P	1.545	1.00
319_A	322_A	1.545	1.00
531_I	535_L	1.540	1.00
318_S	322_A	1.538	1.00
173_G	176_L	1.534	1.00
253_F	256_G	1.531	1.00
164_L	168_G	1.525	1.00
243_A	279_V	1.524	1.00
54_P	62_P	1.522	1.00
188_S	192_W	1.522	1.00
545_R	549_F	1.515	1.00
364_A	367_P	1.514	1.00
182_P	186_G	1.512	1.00
258_A	262_L	1.510	1.00
358_A	362_A	1.507	1.00
530_L	534_V	1.494	1.00
587_E	590_E	1.486	1.00
366_L	369_L	1.479	1.00
527_G	531_I	1.479	1.00
367_P	370_F	1.474	1.00
157_K	160_A	1.473	1.00
165_I	169_G	1.468	1.00
5_R	67_E	1.458	1.00
257_W	261_Y	1.456	1.00
533_V	537_L	1.456	1.00
97_L	101_P	1.455	1.00
161_K	165_I	1.453	1.00
312_I	315_G	1.448	1.00
359_L	363_I	1.447	1.00
205_G	210_K	1.445	1.00
128_L	393_G	1.445	1.00
520_L	523_G	1.444	1.00
494_G	497_A	1.437	1.00
194_F	197_N	1.435	1.00
414_I	420_P	1.434	1.00
182_P	187_F	1.434	1.00
138_E	400_G	1.434	1.00
168_G	173_G	1.432	1.00
241_V	246_V	1.430	1.00
362_A	365_L	1.428	1.00
96_I	507_A	1.427	1.00
256_G	261_Y	1.419	1.00
143_A	452_L	1.412	1.00
546_G	549_F	1.410	1.00
2_L	462_I	1.409	1.00
537_L	541_F	1.407	1.00
477_P	481_L	1.404	1.00
417_L	420_P	1.402	1.00
542_P	545_R	1.398	1.00
353_I	357_L	1.389	1.00
307_K	311_T	1.387	1.00
42_S	46_L	1.386	1.00
186_G	189_W	1.386	1.00
514_V	517_G	1.381	1.00
161_K	164_L	1.376	1.00
363_I	367_P	1.375	1.00
184_L	187_F	1.374	1.00
206_L	209_A	1.373	1.00
241_V	245_G	1.370	1.00
186_G	190_V	1.368	1.00
278_Y	282_I	1.366	1.00
308_L	311_T	1.365	1.00
313_L	316_F	1.364	1.00
230_L	575_L	1.363	1.00
306_A	312_I	1.349	1.00
547_K	550_L	1.343	1.00
309_L	315_G	1.337	1.00
160_A	166_A	1.335	1.00
310_K	317_K	1.334	1.00
159_R	165_I	1.330	1.00
144_E	147_K	1.329	1.00
289_V	529_A	1.328	1.00
362_A	369_L	1.327	1.00
392_A	402_N	1.326	1.00
266_I	271_A	1.326	1.00
187_F	190_V	1.323	1.00
244_W	275_W	1.313	1.00
363_I	366_L	1.312	1.00
190_V	194_F	1.310	1.00
167_F	171_F	1.304	1.00
521_P	524_L	1.302	1.00
320_L	323_L	1.297	1.00
11_L	466_I	1.297	1.00
171_F	175_L	1.296	1.00
252_Y	257_W	1.292	1.00
490_G	495_S	1.291	1.00
308_L	312_I	1.288	1.00
583_R	586_P	1.288	1.00
312_I	319_A	1.288	1.00
182_P	189_W	1.285	1.00
182_P	185_S	1.284	1.00
253_F	257_W	1.283	1.00
413_L	420_P	1.280	1.00
114_G	468_V	1.278	1.00
118_V	468_V	1.277	1.00
107_F	473_L	1.269	1.00
306_A	311_T	1.265	1.00
532_G	536_I	1.261	1.00
158_S	161_K	1.253	1.00
360_V	364_A	1.251	1.00
310_K	313_L	1.246	1.00
181_F	185_S	1.237	1.00
316_F	319_A	1.235	1.00
311_T	314_S	1.231	1.00
361_L	366_L	1.229	1.00
205_G	209_A	1.227	1.00
97_L	100_W	1.227	1.00
188_S	193_I	1.227	1.00
361_L	365_L	1.224	1.00
185_S	192_W	1.211	1.00
186_G	192_W	1.208	1.00
167_F	173_G	1.201	1.00
570_I	573_G	1.200	1.00
15_V	470_V	1.199	1.00
289_V	533_V	1.199	1.00
363_I	368_F	1.197	1.00
486_Y	489_G	1.196	1.00
164_L	167_F	1.194	1.00
264_Y	273_A	1.194	1.00
108_L	112_L	1.193	1.00
606_L	610_L	1.191	1.00
103_F	107_F	1.188	1.00
358_A	363_I	1.187	1.00
307_K	310_K	1.186	1.00
309_L	313_L	1.179	1.00
226_Y	593_G	1.168	1.00
264_Y	268_A	1.168	1.00
315_G	319_A	1.167	1.00
255_G	261_Y	1.166	1.00
545_R	550_L	1.165	1.00
228_V	232_V	1.165	1.00
361_L	367_P	1.164	1.00
279_V	283_G	1.162	1.00
359_L	382_L	1.160	1.00
316_F	320_L	1.159	1.00
308_L	319_A	1.159	1.00
259_P	262_L	1.156	1.00
413_L	418_L	1.156	1.00
265_N	270_L	1.156	1.00
215_W	568_L	1.155	1.00
257_W	263_P	1.154	1.00
268_A	271_A	1.152	1.00
380_L	418_L	1.151	1.00
450_G	460_Q	1.151	1.00
359_L	362_A	1.150	1.00
528_G	531_I	1.139	1.00
38_A	75_A	1.139	1.00
469_L	473_L	1.137	1.00
413_L	419_L	1.133	1.00
372_G	376_W	1.131	1.00
157_K	161_K	1.130	1.00
11_L	15_V	1.127	1.00
373_L	376_W	1.124	1.00
350_W	354_G	1.117	1.00
389_A	440_A	1.114	1.00
183_A	186_G	1.109	1.00
293_I	533_V	1.109	1.00
14_G	471_G	1.108	1.00
183_A	187_F	1.106	1.00
247_L	279_V	1.106	1.00
260_A	263_P	1.106	1.00
346_L	350_W	1.105	1.00
473_L	477_P	1.103	1.00
363_I	369_L	1.103	1.00
240_G	567_T	1.102	1.00
4_L	7_V	1.101	1.00
474_V	478_V	1.099	1.00
319_A	323_L	1.093	1.00
312_I	316_F	1.091	1.00
310_K	315_G	1.090	1.00
49_L	61_G	1.090	1.00
73_T	460_Q	1.083	1.00
189_W	195_P	1.082	1.00
310_K	316_F	1.078	1.00
188_S	195_P	1.077	1.00
43_M	47_R	1.076	1.00
308_L	316_F	1.072	1.00
308_L	318_S	1.072	1.00
254_G	257_W	1.070	1.00
317_K	321_A	1.069	1.00
492_G	495_S	1.068	1.00
163_L	170_G	1.067	1.00
181_F	187_F	1.066	1.00
189_W	193_I	1.065	1.00
309_L	316_F	1.062	1.00
223_G	600_L	1.062	1.00
185_S	189_W	1.060	1.00
524_L	527_G	1.060	1.00
414_I	417_L	1.054	1.00
191_T	194_F	1.053	1.00
257_W	260_A	1.050	1.00
311_T	316_F	1.049	1.00
168_G	172_V	1.047	1.00
13_L	41_I	1.046	1.00
184_L	190_V	1.046	1.00
317_K	320_L	1.044	1.00
443_L	447_L	1.043	1.00
255_G	260_A	1.043	1.00
230_L	234_A	1.041	1.00
365_L	370_F	1.039	1.00
252_Y	255_G	1.036	1.00
323_L	326_A	1.032	1.00
179_Y	182_P	1.028	1.00
42_S	68_N	1.026	1.00
181_F	186_G	1.025	1.00
237_L	241_V	1.025	1.00
15_V	474_V	1.023	1.00
255_G	259_P	1.020	1.00
278_Y	281_Y	1.020	1.00
485_A	488_F	1.019	1.00
313_L	317_K	1.019	1.00
402_N	441_G	1.019	1.00
535_L	556_F	1.013	1.00
252_Y	256_G	1.010	1.00
362_A	378_A	1.010	1.00
174_G	179_Y	1.009	1.00
19_A	478_V	1.005	1.00
187_F	191_T	1.004	1.00
542_P	547_K	1.003	1.00
465_L	469_L	1.003	1.00
187_F	192_W	1.000	1.00
308_L	314_S	1.000	1.00
264_Y	267_S	0.999	1.00
348_M	352_L	0.999	1.00
159_R	166_A	0.995	1.00
180_L	184_L	0.994	1.00
375_L	379_L	0.989	1.00
311_T	318_S	0.986	1.00
255_G	258_A	0.984	1.00
192_W	196_T	0.978	1.00
191_T	196_T	0.978	1.00
2_L	459_K	0.977	1.00
361_L	370_F	0.976	1.00
256_G	262_L	0.975	1.00
9_L	45_L	0.974	1.00
185_S	188_S	0.971	1.00
189_W	192_W	0.971	1.00
607_M	610_L	0.969	1.00
143_A	449_T	0.968	1.00
190_V	193_I	0.960	1.00
404_V	438_A	0.959	1.00
166_A	596_L	0.959	1.00
237_L	568_L	0.955	1.00
545_R	548_R	0.953	1.00
264_Y	269_I	0.949	1.00
168_G	174_G	0.948	1.00
586_P	589_A	0.943	1.00
242_L	247_L	0.941	1.00
244_W	248_I	0.937	1.00
459_K	462_I	0.932	1.00
176_L	179_Y	0.930	1.00
35_S	72_Q	0.928	1.00
568_L	572_V	0.927	1.00
280_R	283_G	0.925	1.00
120_F	386_F	0.924	1.00
184_L	192_W	0.924	1.00
6_A	70_I	0.924	1.00
256_G	259_P	0.923	1.00
173_G	177_P	0.922	1.00
167_F	174_G	0.918	1.00
254_G	259_P	0.917	1.00
371_F	376_W	0.915	1.00
159_R	164_L	0.915	1.00
306_A	319_A	0.915	1.00
63_F	71_V	0.913	1.00
201_A	204_F	0.913	1.00
175_L	178_L	0.912	1.00
142_T	449_T	0.907	1.00
314_S	319_A	0.907	1.00
322_A	325_A	0.906	1.00
166_A	171_F	0.905	1.00
542_P	546_G	0.905	1.00
316_F	326_A	0.904	1.00
519_N	522_W	0.902	1.00
134_L	397_G	0.900	1.00
495_S	499_P	0.898	1.00
103_F	477_P	0.897	0.99
233_A	574_G	0.896	0.99
417_L	421_G	0.896	0.99
111_L	472_A	0.895	0.99
34_A	79_G	0.893	0.99
522_W	525_L	0.892	0.99
272_E	276_S	0.891	0.99
2_L	7_V	0.889	0.99
3_T	6_A	0.888	0.99
308_L	315_G	0.886	0.99
306_A	315_G	0.881	0.99
163_L	174_G	0.880	0.99
341_R	344_R	0.880	0.99
41_I	45_L	0.880	0.99
372_G	375_L	0.880	0.99
173_G	180_L	0.879	0.99
594_V	598_S	0.879	0.99
504_T	507_A	0.879	0.99
544_R	548_R	0.878	0.99
309_L	314_S	0.876	0.99
307_K	313_L	0.870	0.99
206_L	210_K	0.870	0.99
178_L	181_F	0.868	0.99
389_A	436_A	0.866	0.99
68_N	71_V	0.863	0.99
188_S	194_F	0.863	0.99
228_V	400_G	0.862	0.99
265_N	271_A	0.862	0.99
313_L	319_A	0.862	0.99
564_L	568_L	0.861	0.99
17_F	38_A	0.860	0.99
126_R	131_D	0.858	0.99
269_I	273_A	0.857	0.99
2_L	6_A	0.857	0.99
190_V	195_P	0.853	0.99
488_F	491_A	0.851	0.99
181_F	184_L	0.850	0.99
275_W	280_R	0.848	0.99
531_I	536_I	0.846	0.99
578_W	581_D	0.845	0.99
182_P	188_S	0.844	0.99
322_A	326_A	0.843	0.99
254_G	261_Y	0.842	0.99
255_G	263_P	0.842	0.99
165_I	168_G	0.841	0.99
5_R	49_L	0.841	0.99
254_G	258_A	0.840	0.99
481_L	613_F	0.840	0.99
568_L	571_F	0.839	0.99
256_G	260_A	0.834	0.99
68_N	150_H	0.833	0.99
87_V	110_A	0.831	0.99
318_S	323_L	0.831	0.99
569_P	572_V	0.829	0.99
66_L	455_A	0.827	0.99
151_K	154_G	0.827	0.99
74_I	467_G	0.826	0.99
254_G	260_A	0.825	0.99
586_P	590_E	0.825	0.99
513_G	517_G	0.823	0.99
360_V	368_F	0.822	0.99
55_K	62_P	0.822	0.99
315_G	320_L	0.821	0.99
306_A	316_F	0.820	0.99
544_R	549_F	0.820	0.99
307_K	315_G	0.818	0.99
489_G	504_T	0.817	0.99
306_A	313_L	0.816	0.99
361_L	364_A	0.814	0.99
487_G	495_S	0.812	0.99
160_A	167_F	0.812	0.99
610_L	613_F	0.811	0.99
308_L	322_A	0.811	0.99
112_L	362_A	0.811	0.99
264_Y	270_L	0.809	0.99
42_S	71_V	0.808	0.99
525_L	528_G	0.808	0.99
309_L	319_A	0.806	0.99
98_G	102_G	0.804	0.99
341_R	345_D	0.803	0.99
480_N	484_K	0.800	0.99
536_I	539_D	0.798	0.99
307_K	320_L	0.798	0.99
408_T	434_C	0.796	0.99
519_N	523_G	0.794	0.99
178_L	184_L	0.793	0.99
230_L	571_F	0.792	0.99
64_T	67_E	0.791	0.99
252_Y	259_P	0.790	0.99
314_S	323_L	0.789	0.99
180_L	186_G	0.789	0.99
43_M	46_L	0.788	0.99
426_A	430_G	0.787	0.99
99_L	102_G	0.787	0.99
21_N	25_G	0.785	0.99
312_I	318_S	0.782	0.99
179_Y	190_V	0.781	0.99
49_L	54_P	0.778	0.99
416_G	426_A	0.775	0.99
361_L	368_F	0.773	0.98
607_M	611_I	0.773	0.98
488_F	495_S	0.772	0.98
184_L	189_W	0.770	0.98
187_F	194_F	0.769	0.98
5_R	62_P	0.768	0.98
107_F	111_L	0.768	0.98
271_A	275_W	0.768	0.98
69_N	72_Q	0.768	0.98
185_S	190_V	0.766	0.98
414_I	421_G	0.766	0.98
522_W	527_G	0.765	0.98
90_T	427_L	0.763	0.98
534_V	538_L	0.763	0.98
258_A	263_P	0.762	0.98
585_R	589_A	0.762	0.98
484_K	487_G	0.760	0.98
185_S	191_T	0.760	0.98
311_T	319_A	0.760	0.98
487_G	496_N	0.759	0.98
365_L	368_F	0.758	0.98
290_G	553_P	0.756	0.98
187_F	213_F	0.752	0.98
572_V	576_I	0.752	0.98
193_I	196_T	0.750	0.98
534_V	537_L	0.748	0.98
339_L	343_E	0.748	0.98
293_I	536_I	0.747	0.98
609_V	613_F	0.747	0.98
89_F	92_P	0.746	0.98
552_P	555_A	0.742	0.98
174_G	607_M	0.742	0.98
307_K	314_S	0.742	0.98
180_L	187_F	0.741	0.98
542_P	550_L	0.741	0.98
234_A	575_L	0.740	0.98
270_L	273_A	0.740	0.98
575_L	578_W	0.737	0.98
520_L	524_L	0.736	0.98
532_G	539_D	0.735	0.98
285_G	289_V	0.735	0.98
115_L	358_A	0.734	0.98
359_L	365_L	0.734	0.98
256_G	263_P	0.733	0.98
574_G	577_R	0.732	0.98
172_V	176_L	0.731	0.98
85_A	89_F	0.728	0.98
181_F	188_S	0.728	0.98
139_G	449_T	0.727	0.98
245_G	249_P	0.726	0.98
10_G	74_I	0.726	0.98
579_L	584_R	0.726	0.98
416_G	421_G	0.725	0.98
213_F	245_G	0.724	0.98
584_R	588_W	0.723	0.98
292_I	306_A	0.723	0.98
542_P	548_R	0.723	0.98
364_A	370_F	0.722	0.98
551_P	557_A	0.722	0.98
581_D	586_P	0.719	0.98
139_G	445_Q	0.718	0.98
169_G	178_L	0.716	0.98
520_L	525_L	0.716	0.98
528_G	535_L	0.716	0.98
183_A	188_S	0.715	0.98
585_R	588_W	0.715	0.98
184_L	188_S	0.714	0.97
359_L	370_F	0.714	0.97
98_G	101_P	0.712	0.97
160_A	165_I	0.712	0.97
367_P	375_L	0.711	0.97
174_G	180_L	0.711	0.97
281_Y	286_A	0.711	0.97
496_N	499_P	0.710	0.97
162_F	592_Y	0.710	0.97
193_I	197_N	0.710	0.97
535_L	539_D	0.709	0.97
342_T	345_D	0.709	0.97
13_L	45_L	0.709	0.97
596_L	600_L	0.706	0.97
286_A	557_A	0.706	0.97
158_S	163_L	0.706	0.97
544_R	550_L	0.705	0.97
307_K	322_A	0.705	0.97
351_V	354_G	0.704	0.97
412_L	426_A	0.704	0.97
358_A	361_L	0.704	0.97
18_G	22_A	0.703	0.97
252_Y	258_A	0.702	0.97
307_K	312_I	0.702	0.97
477_P	480_N	0.702	0.97
411_T	433_V	0.702	0.97
359_L	367_P	0.702	0.97
455_A	459_K	0.702	0.97
567_T	570_I	0.702	0.97
179_Y	184_L	0.701	0.97
482_L	498_L	0.701	0.97
186_G	191_T	0.701	0.97
182_P	190_V	0.700	0.97
235_S	556_F	0.700	0.97
289_V	293_I	0.699	0.97
422_G	425_A	0.696	0.97
86_G	92_P	0.696	0.97
396_V	441_G	0.696	0.97
520_L	527_G	0.695	0.97
581_D	590_E	0.694	0.97
599_G	603_G	0.691	0.97
108_L	111_L	0.691	0.97
44_A	160_A	0.689	0.97
306_A	314_S	0.688	0.97
252_Y	263_P	0.686	0.97
307_K	318_S	0.686	0.97
536_I	553_P	0.685	0.97
486_Y	490_G	0.685	0.97
253_F	258_A	0.683	0.97
470_V	474_V	0.683	0.97
247_L	282_I	0.683	0.97
544_R	547_K	0.683	0.97
584_R	587_E	0.681	0.97
344_R	347_P	0.681	0.97
166_A	170_G	0.681	0.97
66_L	454_G	0.681	0.97
468_V	472_A	0.680	0.97
523_G	526_I	0.678	0.97
489_G	494_G	0.678	0.97
340_M	344_R	0.678	0.97
9_L	46_L	0.677	0.97
310_K	318_S	0.677	0.97
175_L	179_Y	0.677	0.97
478_V	482_L	0.676	0.97
576_I	580_V	0.676	0.97
38_A	42_S	0.674	0.96
240_G	564_L	0.674	0.96
338_A	344_R	0.673	0.96
5_R	64_T	0.670	0.96
154_G	161_K	0.668	0.96
275_W	278_Y	0.667	0.96
125_R	345_D	0.667	0.96
306_A	318_S	0.665	0.96
551_P	556_F	0.663	0.96
352_L	355_L	0.663	0.96
536_I	540_V	0.663	0.96
601_I	604_E	0.661	0.96
314_S	322_A	0.661	0.96
494_G	499_P	0.661	0.96
388_F	411_T	0.660	0.96
490_G	494_G	0.660	0.96
311_T	317_K	0.659	0.96
321_A	324_R	0.659	0.96
140_T	452_L	0.658	0.96
97_L	102_G	0.658	0.96
157_K	162_F	0.657	0.96
339_L	344_R	0.657	0.96
171_F	607_M	0.656	0.96
339_L	342_T	0.655	0.96
194_F	198_V	0.654	0.96
106_I	476_G	0.654	0.96
110_A	472_A	0.653	0.96
552_P	559_G	0.653	0.96
35_S	142_T	0.653	0.96
25_G	28_A	0.652	0.96
35_S	449_T	0.652	0.96
226_Y	580_V	0.651	0.96
353_I	356_V	0.650	0.96
396_V	404_V	0.650	0.96
179_Y	186_G	0.650	0.96
73_T	450_G	0.649	0.96
314_S	321_A	0.648	0.96
76_S	80_S	0.648	0.96
66_L	69_N	0.648	0.96
63_F	68_N	0.645	0.95
279_V	282_I	0.645	0.95
87_V	91_L	0.645	0.95
130_V	345_D	0.643	0.95
335_A	338_A	0.642	0.95
415_F	429_V	0.641	0.95
121_A	444_L	0.639	0.95
521_P	527_G	0.638	0.95
112_L	358_A	0.637	0.95
214_G	565_S	0.636	0.95
563_P	566_L	0.636	0.95
583_R	587_E	0.635	0.95
175_L	180_L	0.635	0.95
527_G	530_L	0.635	0.95
393_G	444_L	0.634	0.95
86_G	89_F	0.634	0.95
189_W	194_F	0.634	0.95
182_P	192_W	0.633	0.95
168_G	171_F	0.633	0.95
487_G	490_G	0.633	0.95
442_D	446_D	0.632	0.95
13_L	42_S	0.631	0.95
24_L	31_T	0.630	0.95
241_V	571_F	0.629	0.95
115_L	469_L	0.629	0.95
6_A	10_G	0.627	0.95
562_L	566_L	0.627	0.95
527_G	532_G	0.626	0.95
571_F	575_L	0.626	0.95
361_L	369_L	0.625	0.95
69_N	73_T	0.625	0.95
594_V	601_I	0.624	0.95
316_F	323_L	0.624	0.95
348_M	351_V	0.624	0.95
394_Y	398_L	0.621	0.94
309_L	323_L	0.618	0.94
232_V	399_T	0.618	0.94
351_V	355_L	0.618	0.94
608_G	612_A	0.617	0.94
235_S	238_A	0.616	0.94
240_G	243_A	0.614	0.94
250_L	527_G	0.613	0.94
180_L	185_S	0.612	0.94
280_R	284_A	0.611	0.94
162_F	173_G	0.611	0.94
360_V	363_I	0.611	0.94
184_L	195_P	0.610	0.94
179_Y	183_A	0.610	0.94
611_I	614_L	0.610	0.94
360_V	365_L	0.610	0.94
214_G	218_S	0.610	0.94
187_F	193_I	0.609	0.94
231_R	539_D	0.609	0.94
505_L	508_A	0.608	0.94
80_S	442_D	0.608	0.94
309_L	325_A	0.606	0.94
363_I	370_F	0.603	0.94
466_I	470_V	0.602	0.93
135_P	140_T	0.602	0.93
446_D	464_Q	0.601	0.93
159_R	167_F	0.599	0.93
208_L	213_F	0.599	0.93
366_L	432_V	0.599	0.93
502_Q	513_G	0.598	0.93
177_P	181_F	0.597	0.93
125_R	447_L	0.597	0.93
195_P	198_V	0.596	0.93
313_L	320_L	0.596	0.93
272_E	275_W	0.595	0.93
163_L	173_G	0.592	0.93
341_R	456_T	0.592	0.93
80_S	439_I	0.591	0.93
362_A	368_F	0.590	0.93
309_L	320_L	0.590	0.93
479_L	483_N	0.589	0.93
379_L	383_V	0.589	0.93
315_G	322_A	0.588	0.93
337_A	340_M	0.588	0.93
488_F	494_G	0.587	0.93
5_R	63_F	0.586	0.93
493_D	496_N	0.586	0.93
358_A	364_A	0.582	0.92
516_G	519_N	0.581	0.92
502_Q	505_L	0.581	0.92
527_G	536_I	0.578	0.92
360_V	369_L	0.577	0.92
228_V	570_I	0.575	0.92
283_G	291_G	0.573	0.92
219_P	222_L	0.573	0.92
373_L	377_A	0.573	0.92
190_V	196_T	0.572	0.92
360_V	366_L	0.571	0.92
46_L	71_V	0.570	0.92
173_G	179_Y	0.569	0.91
346_L	462_I	0.568	0.91
443_L	464_Q	0.568	0.91
498_L	501_P	0.568	0.91
610_L	614_L	0.567	0.91
309_L	318_S	0.566	0.91
313_L	318_S	0.565	0.91
358_A	370_F	0.565	0.91
184_L	191_T	0.565	0.91
405_S	502_Q	0.565	0.91
384_L	411_T	0.565	0.91
419_L	422_G	0.564	0.91
378_A	382_L	0.564	0.91
311_T	322_A	0.564	0.91
129_V	451_Y	0.563	0.91
360_V	367_P	0.563	0.91
588_W	592_Y	0.563	0.91
187_F	195_P	0.563	0.91
370_F	373_L	0.561	0.91
541_F	545_R	0.561	0.91
91_L	106_I	0.560	0.91
170_G	176_L	0.560	0.91
176_L	182_P	0.559	0.91
357_L	361_L	0.559	0.91
508_A	511_E	0.558	0.91
533_V	536_I	0.558	0.91
120_F	382_L	0.558	0.91
94_L	424_A	0.556	0.90
175_L	181_F	0.555	0.90
541_F	544_R	0.555	0.90
283_G	560_M	0.554	0.90
478_V	481_L	0.553	0.90
86_G	90_T	0.552	0.90
224_V	597_A	0.552	0.90
521_P	525_L	0.552	0.90
138_E	445_Q	0.551	0.90
539_D	552_P	0.550	0.90
334_D	337_A	0.550	0.90
538_L	551_P	0.550	0.90
491_A	494_G	0.550	0.90
88_I	92_P	0.550	0.90
116_L	382_L	0.549	0.90
580_V	588_W	0.549	0.90
535_L	538_L	0.549	0.90
477_P	482_L	0.548	0.90
282_I	527_G	0.547	0.90
318_S	325_A	0.546	0.90
500_A	503_A	0.546	0.90
141_A	227_I	0.545	0.90
336_H	339_L	0.545	0.90
502_Q	561_Y	0.545	0.90
25_G	31_T	0.542	0.89
242_L	531_I	0.541	0.89
511_E	519_N	0.539	0.89
371_F	375_L	0.538	0.89
488_F	493_D	0.538	0.89
358_A	365_L	0.537	0.89
334_D	340_M	0.537	0.89
240_G	558_L	0.536	0.89
243_A	247_L	0.536	0.89
111_L	473_L	0.536	0.89
126_R	345_D	0.534	0.89
215_W	569_P	0.532	0.88
284_A	291_G	0.531	0.88
263_P	269_I	0.531	0.88
275_W	279_V	0.531	0.88
54_P	61_G	0.530	0.88
102_G	105_Q	0.530	0.88
34_A	37_P	0.530	0.88
364_A	369_L	0.530	0.88
246_V	250_L	0.530	0.88
192_W	197_N	0.528	0.88
283_G	295_L	0.526	0.88
171_F	178_L	0.526	0.88
17_F	20_A	0.525	0.88
65_I	147_K	0.525	0.88
359_L	366_L	0.525	0.88
140_T	451_Y	0.523	0.88
347_P	354_G	0.523	0.88
45_L	48_L	0.522	0.88
139_G	455_A	0.520	0.87
28_A	570_I	0.520	0.87
349_W	352_L	0.520	0.87
233_A	237_L	0.519	0.87
103_F	476_G	0.519	0.87
254_G	263_P	0.518	0.87
308_L	313_L	0.518	0.87
115_L	119_L	0.518	0.87
409_I	509_V	0.517	0.87
21_N	32_V	0.517	0.87
107_F	476_G	0.517	0.87
106_I	480_N	0.516	0.87
315_G	321_A	0.516	0.87
23_Y	29_G	0.516	0.87
348_M	353_I	0.516	0.87
33_S	37_P	0.516	0.87
42_S	45_L	0.516	0.87
24_L	28_A	0.514	0.87
183_A	190_V	0.513	0.87
471_G	475_I	0.512	0.87
204_F	207_G	0.512	0.87
291_G	294_T	0.511	0.86
133_K	451_Y	0.511	0.86
86_G	91_L	0.510	0.86
178_L	182_P	0.509	0.86
157_K	165_I	0.509	0.86
15_V	18_G	0.508	0.86
485_A	495_S	0.507	0.86
527_G	535_L	0.507	0.86
442_D	464_Q	0.507	0.86
265_N	273_A	0.507	0.86
540_V	552_P	0.506	0.86
8_L	49_L	0.506	0.86
109_I	428_M	0.506	0.86
75_A	81_L	0.505	0.86
158_S	165_I	0.505	0.86
161_K	166_A	0.504	0.86
69_N	146_L	0.503	0.86
73_T	76_S	0.503	0.86
198_V	202_Q	0.503	0.86
246_V	249_P	0.503	0.86
49_L	55_K	0.503	0.86
507_A	510_A	0.502	0.85
6_A	67_E	0.502	0.85
355_L	382_L	0.501	0.85
316_F	322_A	0.501	0.85
31_T	40_V	0.501	0.85
504_T	508_A	0.501	0.85
189_W	196_T	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3nd0A	2	0.2146	13	0.977	Contact Map
4eneA	2	0.2163	11.4	0.978	Contact Map
3rlbA	1	0.2764	9.2	0.979	Contact Map
4tkrA	2	0.2829	7.4	0.98	Contact Map
1kf6D	2	0.1935	2.9	0.983	Contact Map
2l35A	2	0.0439	2.4	0.984	Contact Map
2l34A	2	0.0439	2.3	0.984	Contact Map
1v54K	1	0.0455	2	0.985	Contact Map
4p6vB	1	0.0943	2	0.985	Contact Map
4w6vA	1	0.2065	1.8	0.985	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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