GREMLIN Database
Alg6_Alg8 - ALG6, ALG8 glycosyltransferase family
PFAM: PF03155 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 453 (441)
Sequences: 830 (589)
Seq/√Len: 28.1
META: 0.108

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
283_A310_A4.6031.00
160_F205_V4.5821.00
65_A74_V4.4531.00
244_F314_F4.3621.00
145_S179_Y4.3081.00
167_N213_S3.6271.00
214_F225_V3.5981.00
248_Y254_V3.5301.00
415_H419_H3.5131.00
90_F94_T3.4851.00
149_L158_G3.4191.00
183_L202_L3.3161.00
146_I304_L3.3091.00
354_S443_A3.2971.00
308_S326_V3.1291.00
137_F168_F3.0731.00
148_A161_L2.9521.00
59_W63_Q2.9521.00
244_F444_F2.9101.00
154_D186_K2.9061.00
155_L205_V2.9001.00
167_N214_F2.8811.00
249_N265_F2.8621.00
323_I326_V2.7801.00
368_K415_H2.7771.00
17_F87_T2.7441.00
70_D73_M2.7391.00
172_Y175_Y2.7321.00
141_L168_F2.6881.00
105_P144_L2.6861.00
167_N210_F2.6030.99
73_M87_T2.5690.99
138_L172_Y2.5660.99
42_D80_R2.5140.99
166_L210_F2.5050.99
237_F249_N2.3650.99
8_L125_L2.3440.99
180_F206_V2.3370.99
284_Q310_A2.2740.98
41_E76_L2.2140.98
57_F98_S2.1930.98
410_G441_Y2.1390.98
107_V143_L2.0250.97
149_L182_Y2.0070.96
326_V329_P1.9960.96
43_L47_T1.9740.96
327_L351_G1.9470.96
199_L203_G1.9350.96
125_L371_L1.9280.96
171_M174_Y1.9260.95
166_L176_A1.9170.95
425_P434_P1.8850.95
154_D158_G1.8810.95
214_F229_L1.8630.95
283_A286_P1.8540.94
29_S76_L1.8540.94
224_Q227_S1.8150.94
284_Q307_C1.7960.93
273_P316_W1.7800.93
298_R336_E1.7760.93
432_F436_M1.7690.93
349_V376_L1.7280.92
159_A206_V1.7180.92
60_L64_V1.6990.91
115_A119_L1.6970.91
171_M325_L1.6960.91
72_E75_A1.6950.91
181_V288_L1.6870.91
111_S429_R1.6680.91
103_Y119_L1.6660.90
15_T19_V1.6450.90
178_A202_L1.6270.89
26_I32_I1.6270.89
308_S325_L1.6130.89
138_L168_F1.6120.89
123_G327_L1.5900.88
232_F316_W1.5880.88
47_T54_F1.5870.88
65_A73_M1.5810.88
240_Y432_F1.5750.88
325_L329_P1.5720.88
28_H63_Q1.5530.87
165_L172_Y1.5450.87
129_H136_G1.5450.87
16_D23_W1.5330.86
198_R201_K1.5300.86
26_I123_G1.5250.86
28_H62_G1.5190.86
232_F273_P1.5190.86
252_D266_A1.5160.86
123_G351_G1.5150.86
15_T20_H1.5100.85
73_M82_Y1.4960.85
18_E21_R1.4930.85
149_L179_Y1.4910.85
4_L333_L1.4880.85
177_P284_Q1.4850.85
65_A90_F1.4840.84
159_A163_A1.4800.84
19_V22_H1.4750.84
54_F58_E1.4570.83
253_K314_F1.4470.83
206_V210_F1.4320.82
121_S177_P1.4150.81
180_F184_L1.4080.81
310_A313_L1.4010.81
303_A313_L1.3850.80
227_S233_S1.3830.80
361_T364_L1.3760.80
254_V279_L1.3750.80
139_L172_Y1.3740.80
76_L79_S1.3680.79
189_L194_F1.3510.78
180_F203_G1.3490.78
75_A78_T1.3370.78
199_L202_L1.3360.78
95_V134_Y1.3320.77
231_P234_R1.3310.77
241_W246_C1.3290.77
20_H54_F1.3280.77
214_F222_L1.3200.77
248_Y439_S1.3190.77
54_F57_F1.3130.76
228_R231_P1.3120.76
58_E91_M1.3110.76
163_A202_L1.3100.76
129_H307_C1.3000.76
61_L90_F1.2950.75
19_V54_F1.2920.75
306_L310_A1.2870.75
217_F225_V1.2860.75
347_L446_V1.2830.75
22_H26_I1.2690.74
283_A314_F1.2690.74
6_L93_L1.2640.73
206_V209_T1.2630.73
407_G446_V1.2630.73
309_L326_V1.2610.73
435_L439_S1.2610.73
19_V25_A1.2420.72
228_R234_R1.2370.72
160_F209_T1.2290.71
121_S351_G1.2250.71
164_L209_T1.2250.71
20_H25_A1.2250.71
364_L416_C1.2240.71
208_A428_A1.2100.70
238_H241_W1.2090.70
269_P273_P1.2050.70
158_G203_G1.2040.70
175_Y311_F1.1940.69
143_L430_Y1.1910.69
174_Y178_A1.1880.69
94_T134_Y1.1800.68
178_A291_L1.1800.68
228_R235_G1.1770.68
221_Q224_Q1.1750.68
204_L207_I1.1750.68
18_E82_Y1.1740.68
19_V47_T1.1660.67
124_L136_G1.1640.67
39_Y44_S1.1570.67
133_Q169_K1.1530.66
181_V185_R1.1530.66
6_L9_P1.1520.66
214_F355_L1.1490.66
231_P235_G1.1470.66
15_T22_H1.1330.65
15_T25_A1.1290.65
236_L272_L1.1280.65
144_L148_A1.1240.64
18_E79_S1.1180.64
59_W62_G1.1100.63
176_A202_L1.1020.63
288_L307_C1.0880.62
47_T55_A1.0860.62
161_L203_G1.0850.61
146_I300_F1.0720.61
72_E82_Y1.0690.60
432_F435_L1.0650.60
121_S168_F1.0610.60
11_M54_F1.0600.60
25_A79_S1.0580.60
20_H58_E1.0510.59
138_L408_L1.0480.59
438_T442_C1.0450.59
9_P93_L1.0440.58
96_I125_L1.0400.58
126_L364_L1.0380.58
109_L148_A1.0380.58
309_L323_I1.0340.58
72_E141_L1.0320.58
74_V87_T1.0310.58
20_H43_L1.0300.57
285_L373_L1.0290.57
174_Y280_T1.0290.57
39_Y43_L1.0250.57
59_W68_F1.0130.56
210_F214_F1.0100.56
18_E324_L1.0050.56
130_G362_D0.9990.55
57_F87_T0.9930.55
200_I203_G0.9900.54
244_F254_V0.9870.54
45_Y237_F0.9850.54
98_S444_F0.9790.54
408_L442_C0.9790.54
308_S311_F0.9790.54
22_H25_A0.9780.53
23_W27_T0.9780.53
54_F316_W0.9760.53
128_D132_F0.9730.53
33_S227_S0.9710.53
279_L322_A0.9660.53
211_A373_L0.9660.53
131_H228_R0.9660.53
76_L80_R0.9640.52
57_F61_L0.9630.52
112_S153_R0.9570.52
89_L93_L0.9560.52
16_D27_T0.9510.51
129_H140_G0.9490.51
415_H420_L0.9490.51
152_G297_P0.9480.51
135_N321_K0.9410.51
238_H246_C0.9390.50
17_F84_S0.9380.50
58_E322_A0.9370.50
254_V444_F0.9370.50
163_A210_F0.9340.50
4_L143_L0.9330.50
121_S348_S0.9320.50
81_G137_F0.9290.50
97_V227_S0.9230.49
116_L332_L0.9220.49
71_P74_V0.9190.49
136_G232_F0.9180.49
182_Y291_L0.9170.49
228_R238_H0.9170.49
25_A47_T0.9130.48
182_Y242_A0.9100.48
182_Y303_A0.9100.48
150_R297_P0.9070.48
154_D195_G0.9060.48
247_L251_L0.9060.48
143_L328_L0.9050.48
277_F290_K0.9000.47
166_L180_F0.9000.47
149_L436_M0.8950.47
64_V75_A0.8950.47
397_L421_L0.8950.47
5_K8_L0.8950.47
172_Y177_P0.8930.47
291_L296_T0.8920.47
22_H47_T0.8920.47
154_D182_Y0.8850.46
94_T100_L0.8840.46
172_Y326_V0.8820.46
22_H91_M0.8810.46
120_L296_T0.8800.46
272_L275_L0.8730.45
159_A205_V0.8710.45
20_H47_T0.8710.45
29_S75_A0.8710.45
45_Y81_G0.8680.45
43_L62_G0.8660.45
244_F248_Y0.8650.45
56_Y216_P0.8610.45
94_T277_F0.8600.44
239_A361_T0.8560.44
110_F143_L0.8530.44
273_P276_T0.8520.44
370_V412_L0.8500.44
15_T47_T0.8480.44
436_M440_V0.8430.43
174_Y354_S0.8420.43
258_A431_P0.8410.43
120_L126_L0.8400.43
88_K91_M0.8400.43
73_M84_S0.8390.43
2_T101_L0.8360.43
43_L54_F0.8350.43
248_Y444_F0.8340.42
70_D136_G0.8300.42
323_I340_D0.8280.42
168_F229_L0.8260.42
131_H358_L0.8240.42
48_L55_A0.8200.41
131_H231_P0.8190.41
354_S442_C0.8180.41
268_L271_I0.8170.41
57_F168_F0.8150.41
344_F375_W0.8140.41
15_T54_F0.8100.41
376_L380_L0.8010.40
5_K129_H0.7980.40
173_L230_F0.7980.40
322_A328_L0.7970.40
70_D86_S0.7970.40
203_G206_V0.7950.40
185_R292_W0.7950.40
123_G312_F0.7940.40
105_P416_C0.7930.39
131_H135_N0.7920.39
278_L289_I0.7910.39
14_S19_V0.7900.39
90_F281_L0.7900.39
263_T447_F0.7890.39
26_I436_M0.7880.39
281_L352_H0.7870.39
62_G166_L0.7860.39
18_E71_P0.7850.39
210_F225_V0.7830.39
19_V58_E0.7820.39
47_T238_H0.7800.38
126_L258_A0.7800.38
132_F135_N0.7800.38
432_F439_S0.7780.38
331_S351_G0.7770.38
141_L428_A0.7750.38
138_L175_Y0.7750.38
273_P277_F0.7730.38
32_I418_L0.7720.38
144_L147_A0.7710.38
61_L436_M0.7680.38
131_H235_G0.7670.38
8_L316_W0.7670.38
112_S296_T0.7660.37
372_T375_W0.7660.37
414_L437_L0.7640.37
87_T178_A0.7590.37
32_I417_L0.7590.37
33_S40_Y0.7570.37
14_S20_H0.7560.37
159_A309_L0.7550.37
73_M76_L0.7540.37
140_G178_A0.7530.37
412_L416_C0.7530.37
102_L118_I0.7530.37
436_M439_S0.7510.36
111_S205_V0.7480.36
90_F196_F0.7480.36
257_F264_S0.7470.36
106_A109_L0.7470.36
53_L213_S0.7460.36
70_D221_Q0.7460.36
71_P403_L0.7460.36
391_E406_L0.7450.36
127_I152_G0.7430.36
56_Y87_T0.7420.36
404_Y441_Y0.7420.36
162_F312_F0.7410.36
146_I271_I0.7410.36
374_L378_L0.7410.36
100_L143_L0.7400.36
285_L417_L0.7400.36
128_D131_H0.7400.36
34_Q278_L0.7360.35
240_Y435_L0.7350.35
168_F240_Y0.7340.35
387_A407_G0.7330.35
284_Q308_S0.7290.35
300_F451_L0.7280.35
163_A209_T0.7220.34
95_V166_L0.7210.34
321_K358_L0.7210.34
235_G238_H0.7180.34
345_L375_W0.7140.34
132_F140_G0.7120.34
31_P35_W0.7110.34
199_L430_Y0.7100.34
110_F118_I0.7100.34
97_V108_L0.7090.33
81_G313_L0.7090.33
282_L337_D0.7070.33
6_L208_A0.7070.33
34_Q40_Y0.7060.33
313_L447_F0.7060.33
224_Q434_P0.7050.33
177_P288_L0.7040.33
26_I300_F0.7040.33
232_F333_L0.7030.33
249_N263_T0.7020.33
165_L175_Y0.7020.33
348_S351_G0.6990.33
131_H318_V0.6990.33
49_D55_A0.6980.33
31_P310_A0.6970.33
153_R157_L0.6970.33
307_C311_F0.6950.33
404_Y445_G0.6940.32
65_A87_T0.6940.32
347_L351_G0.6940.32
183_L243_N0.6940.32
444_F448_Y0.6930.32
71_P82_Y0.6890.32
185_R295_P0.6890.32
401_E448_Y0.6890.32
207_I421_L0.6880.32
21_R30_L0.6880.32
110_F281_L0.6880.32
152_G203_G0.6880.32
137_F283_A0.6880.32
185_R432_F0.6870.32
224_Q281_L0.6860.32
250_V440_V0.6850.32
318_V321_K0.6850.32
203_G359_L0.6850.32
79_S82_Y0.6850.32
185_R288_L0.6830.32
196_F212_L0.6830.32
346_W350_V0.6820.32
246_C311_F0.6810.32
207_I418_L0.6790.31
308_S328_L0.6780.31
47_T58_E0.6780.31
11_M43_L0.6770.31
105_P140_G0.6750.31
73_M79_S0.6740.31
45_Y80_R0.6740.31
242_A312_F0.6730.31
236_L242_A0.6720.31
236_L276_T0.6720.31
64_V369_V0.6700.31
183_L187_Y0.6690.31
99_D341_A0.6610.30
199_L207_I0.6600.30
81_G340_D0.6570.30
53_L262_D0.6560.30
64_V90_F0.6560.30
132_F358_L0.6540.30
144_L182_Y0.6540.30
115_A450_W0.6520.30
237_F354_S0.6520.30
27_T318_V0.6510.30
142_L165_L0.6510.30
110_F295_P0.6510.30
34_Q205_V0.6500.30
110_F195_G0.6490.29
69_V116_L0.6460.29
312_F374_L0.6440.29
97_V278_L0.6430.29
176_A205_V0.6420.29
214_F253_K0.6420.29
92_R135_N0.6420.29
23_W49_D0.6410.29
116_L199_L0.6410.29
23_W51_P0.6410.29
290_K306_L0.6400.29
167_N300_F0.6390.29
131_H321_K0.6370.29
93_L97_V0.6370.29
53_L212_L0.6370.29
214_F226_L0.6350.29
207_I452_L0.6340.29
385_R400_L0.6330.28
212_L332_L0.6330.28
412_L443_A0.6330.28
57_F240_Y0.6320.28
288_L292_W0.6310.28
311_F315_G0.6310.28
286_P371_L0.6310.28
111_S412_L0.6310.28
18_E46_W0.6300.28
54_F238_H0.6290.28
187_Y439_S0.6280.28
133_Q320_E0.6270.28
131_H234_R0.6270.28
168_F264_S0.6260.28
99_D263_T0.6250.28
400_L406_L0.6240.28
39_Y47_T0.6240.28
29_S70_D0.6220.28
151_Q443_A0.6220.28
32_I127_I0.6210.28
293_R451_L0.6190.28
110_F302_L0.6190.28
149_L300_F0.6190.28
313_L449_S0.6180.28
241_W315_G0.6180.28
442_C447_F0.6180.28
16_D50_Y0.6180.28
20_H317_H0.6180.28
327_L348_S0.6170.27
312_F319_H0.6170.27
95_V183_L0.6150.27
312_F320_E0.6140.27
248_Y252_D0.6140.27
409_I412_L0.6140.27
198_R326_V0.6120.27
125_L429_R0.6120.27
288_L309_L0.6090.27
244_F253_K0.6090.27
386_L389_K0.6080.27
11_M44_S0.6080.27
253_K263_T0.6070.27
303_A369_V0.6050.27
374_L428_A0.6050.27
20_H57_F0.6050.27
220_G225_V0.6040.27
364_L368_K0.6040.27
135_N169_K0.6040.27
173_L323_I0.6030.27
181_V417_L0.6030.27
250_V436_M0.6030.27
143_L392_S0.6030.27
98_S168_F0.6020.27
247_L440_V0.6010.27
95_V136_G0.5990.26
142_L172_Y0.5980.26
68_F164_L0.5940.26
439_S445_G0.5930.26
132_F228_R0.5930.26
168_F175_Y0.5930.26
96_I421_L0.5930.26
80_R83_E0.5910.26
103_Y176_A0.5910.26
112_S184_L0.5900.26
436_M444_F0.5900.26
323_I351_G0.5870.26
132_F321_K0.5870.26
343_A348_S0.5860.26
87_T90_F0.5850.26
305_T326_V0.5850.26
353_F443_A0.5840.26
362_D444_F0.5840.26
177_P243_N0.5840.26
306_L325_L0.5830.25
121_S352_H0.5820.25
4_L96_I0.5820.25
204_L418_L0.5800.25
110_F332_L0.5800.25
312_F446_V0.5790.25
94_T98_S0.5790.25
18_E80_R0.5780.25
2_T5_K0.5760.25
174_Y311_F0.5750.25
83_E309_L0.5750.25
403_L406_L0.5740.25
34_Q211_A0.5730.25
210_F295_P0.5730.25
171_M246_C0.5720.25
47_T240_Y0.5710.25
78_T81_G0.5710.25
49_D52_P0.5700.25
120_L186_K0.5700.25
19_V43_L0.5680.25
25_A54_F0.5680.25
313_L374_L0.5680.25
77_H269_P0.5670.25
25_A80_R0.5670.25
94_T110_F0.5670.25
48_L51_P0.5670.25
177_P307_C0.5660.24
222_L322_A0.5660.24
199_L363_G0.5650.24
195_G198_R0.5620.24
249_N314_F0.5620.24
50_Y55_A0.5610.24
167_N291_L0.5610.24
51_P55_A0.5590.24
252_D268_L0.5590.24
282_L289_I0.5580.24
238_H315_G0.5570.24
193_R208_A0.5570.24
160_F279_L0.5570.24
114_A285_L0.5540.24
79_S83_E0.5540.24
15_T238_H0.5510.24
230_F236_L0.5500.24
135_N231_P0.5490.24
148_A253_K0.5490.24
197_L211_A0.5480.23
241_W322_A0.5480.23
142_L175_Y0.5480.23
135_N234_R0.5470.23
99_D435_L0.5460.23
35_W55_A0.5450.23
60_L106_A0.5440.23
4_L276_T0.5440.23
17_F248_Y0.5430.23
202_L278_L0.5430.23
65_A434_P0.5420.23
111_S155_L0.5410.23
212_L366_L0.5410.23
168_F182_Y0.5400.23
135_N235_G0.5400.23
58_E88_K0.5400.23
185_R401_E0.5390.23
359_L364_L0.5390.23
346_W404_Y0.5390.23
181_V292_W0.5380.23
47_T239_A0.5380.23
270_S379_S0.5380.23
366_L377_I0.5370.23
350_V411_M0.5360.23
253_K257_F0.5360.23
167_N225_V0.5350.23
341_A379_S0.5320.23
20_H41_E0.5320.23
110_F374_L0.5320.23
194_F418_L0.5310.23
46_W174_Y0.5310.23
97_V289_I0.5310.23
46_W50_Y0.5300.22
114_A155_L0.5290.22
188_C209_T0.5280.22
139_L175_Y0.5280.22
92_R321_K0.5270.22
62_G81_G0.5270.22
44_S47_T0.5270.22
178_A303_A0.5260.22
121_S327_L0.5250.22
437_L440_V0.5250.22
122_P265_F0.5250.22
54_F170_H0.5240.22
146_I149_L0.5240.22
20_H23_W0.5230.22
303_A361_T0.5230.22
146_I333_L0.5230.22
4_L183_L0.5220.22
42_D76_L0.5210.22
182_Y210_F0.5210.22
439_S443_A0.5210.22
215_G334_A0.5200.22
110_F147_A0.5200.22
124_L165_L0.5200.22
18_E65_A0.5180.22
82_Y100_L0.5180.22
174_Y325_L0.5180.22
330_L350_V0.5180.22
172_Y178_A0.5160.22
357_P439_S0.5160.22
287_S362_D0.5160.22
351_G415_H0.5150.22
254_V277_F0.5150.22
143_L276_T0.5140.22
86_S373_L0.5130.22
57_F450_W0.5130.22
32_I450_W0.5110.21
305_T309_L0.5100.21
18_E73_M0.5100.21
22_H43_L0.5090.21
107_V119_L0.5090.21
171_M280_T0.5080.21
119_L127_I0.5080.21
94_T114_A0.5080.21
407_G441_Y0.5070.21
167_N206_V0.5060.21
178_A325_L0.5050.21
135_N318_V0.5050.21
171_M322_A0.5040.21
361_T366_L0.5040.21
104_Y108_L0.5030.21
221_Q378_L0.5030.21
159_A262_D0.5030.21
159_A203_G0.5030.21
59_W125_L0.5030.21
230_F234_R0.5030.21
47_T62_G0.5000.21
240_Y322_A0.5000.21
100_L104_Y0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wajA 1 0.7373 43.9 0.977 Contact Map
2ki9A 1 0.0728 41.5 0.977 Contact Map
4qncA 2 0.1722 3 0.987 Contact Map
1rh5B 1 0.117 2.5 0.987 Contact Map
2ljbA 3 0.0662 2.3 0.988 Contact Map
3rjaA 1 0.1678 2.2 0.988 Contact Map
3ahqA 1 0.1258 1.5 0.989 Contact Map
2dawA 1 0.1634 1.4 0.989 Contact Map
1tc1A 2 0.1038 1.4 0.989 Contact Map
1spfA 1 0.0773 1.2 0.989 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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