DUF247 - PFAM28P - GREMLIN Contacts

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DUF247 - Plant protein of unknown function

PFAM:	PF03140	Sequences: IYRVPKSLREVNPKAYTPQVVSIGPYHHGKPHLKAMEEHKLRYLKRFLKRSLEDLVEAIKELEERARACYSEDIDLSDEFVEMMLLDGCFILELLLKYSEGEERDIFSKPWMLPAIRRDLLLLENQLPFFVLEKLFELTKGSSVNLEALRFFKPLLPEPKHLLDLLRKSLLPKLIPSATELREAGVKFKPAKKSKTKSLLDIKFDKNGVLEIPPLTIDDSTESLLRNLIAFEQCHPGPGSSYVTSYVVFMDSLIDTAEDVELLREKGIIENWLGSDEEVADLFNKLCKGVVLDPDDSYYSDVCEDVNKYYRSWNRWRATLKHTYFSNPWAIISLVAAVILLLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	343 (337)
Sequences:	2093 (1594)
Seq/√Len:	86.8
META:	0.023

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
50_R	93_E	4.883	1.00
63_E	67_R	4.879	1.00
66_A	80_F	4.309	1.00
251_D	284_N	3.366	1.00
251_D	255_D	3.230	1.00
164_D	167_R	3.122	1.00
301_D	305_D	3.053	1.00
309_Y	314_N	2.884	1.00
317_R	321_K	2.695	1.00
250_M	283_F	2.676	1.00
264_R	276_D	2.578	1.00
316_W	328_P	2.525	1.00
125_N	128_P	2.497	1.00
129_F	159_P	2.461	1.00
74_I	77_S	2.452	1.00
178_A	188_F	2.416	1.00
229_I	247_V	2.381	1.00
257_A	277_E	2.356	1.00
167_R	171_L	2.296	1.00
22_S	29_G	2.280	1.00
88_G	135_L	2.267	1.00
39_H	42_R	2.230	1.00
203_K	211_E	2.205	1.00
255_D	284_N	2.153	1.00
222_E	226_R	2.133	1.00
280_A	284_N	2.122	1.00
23_I	91_I	2.109	1.00
337_A	343_L	2.105	1.00
119_D	125_N	2.102	1.00
336_A	340_L	2.095	1.00
189_K	211_E	2.093	1.00
62_L	66_A	2.087	1.00
258_E	261_E	2.082	1.00
12_N	15_A	2.074	1.00
22_S	33_L	2.034	1.00
210_L	306_V	1.997	1.00
65_R	130_F	1.954	1.00
91_I	120_L	1.953	1.00
161_H	164_D	1.950	1.00
336_A	341_L	1.945	1.00
2_Y	235_H	1.929	1.00
251_D	280_A	1.917	1.00
249_F	302_V	1.907	1.00
183_E	322_H	1.907	1.00
340_L	343_L	1.906	1.00
119_D	124_E	1.894	1.00
254_I	283_F	1.892	1.00
324_Y	328_P	1.849	1.00
324_Y	329_W	1.837	1.00
23_I	131_V	1.835	1.00
325_F	329_W	1.832	1.00
31_P	34_K	1.824	1.00
44_L	86_L	1.824	1.00
338_V	342_L	1.808	1.00
161_H	165_L	1.773	1.00
119_D	126_Q	1.750	1.00
255_D	280_A	1.714	1.00
178_A	262_L	1.708	1.00
143_S	146_L	1.707	1.00
329_W	336_A	1.698	1.00
151_F	155_L	1.698	1.00
160_K	164_D	1.696	1.00
325_F	330_A	1.690	1.00
10_E	14_K	1.688	1.00
12_N	222_E	1.681	1.00
231_F	235_H	1.677	1.00
80_F	83_M	1.666	1.00
30_K	33_L	1.663	1.00
66_A	84_M	1.650	1.00
164_D	168_K	1.647	1.00
63_E	80_F	1.646	1.00
23_I	120_L	1.636	1.00
9_R	17_T	1.628	1.00
64_E	68_A	1.623	1.00
28_H	37_E	1.621	1.00
162_L	167_R	1.613	1.00
59_I	85_L	1.577	1.00
123_L	126_Q	1.562	1.00
330_A	333_S	1.555	1.00
333_S	340_L	1.550	1.00
186_V	306_V	1.543	1.00
328_P	333_S	1.542	1.00
161_H	167_R	1.539	1.00
3_R	72_E	1.536	1.00
335_V	339_I	1.515	1.00
59_I	81_V	1.515	1.00
331_I	334_L	1.510	1.00
326_S	330_A	1.506	1.00
44_L	48_L	1.501	1.00
129_F	136_F	1.477	0.99
318_A	328_P	1.464	0.99
121_L	166_L	1.456	0.99
210_L	249_F	1.446	0.99
74_I	80_F	1.443	0.99
163_L	167_R	1.409	0.99
331_I	335_V	1.395	0.99
62_L	134_K	1.373	0.99
60_K	78_D	1.373	0.99
229_I	244_T	1.363	0.99
278_E	288_K	1.358	0.99
53_E	57_E	1.348	0.99
122_L	125_N	1.345	0.99
320_L	325_F	1.343	0.99
124_E	128_P	1.341	0.99
148_A	152_F	1.337	0.99
323_T	330_A	1.335	0.99
123_L	230_A	1.326	0.99
46_R	97_K	1.316	0.99
59_I	131_V	1.303	0.99
134_K	137_E	1.297	0.99
325_F	328_P	1.293	0.99
122_L	299_Y	1.286	0.98
41_L	86_L	1.286	0.98
318_A	324_Y	1.281	0.98
116_I	120_L	1.273	0.98
17_T	30_K	1.272	0.98
106_I	112_M	1.260	0.98
29_G	36_M	1.239	0.98
254_I	284_N	1.234	0.98
242_Y	245_S	1.226	0.98
96_L	139_T	1.195	0.98
175_I	181_L	1.194	0.98
62_L	65_R	1.185	0.97
226_R	265_E	1.183	0.97
179_T	262_L	1.181	0.97
241_S	250_M	1.179	0.97
328_P	331_I	1.153	0.97
241_S	245_S	1.152	0.97
202_I	213_P	1.150	0.97
2_Y	26_Y	1.149	0.97
152_F	155_L	1.143	0.97
224_L	228_L	1.139	0.97
58_A	134_K	1.138	0.97
133_E	158_E	1.137	0.97
188_F	210_L	1.115	0.96
122_L	126_Q	1.114	0.96
320_L	336_A	1.109	0.96
44_L	85_L	1.104	0.96
332_I	337_A	1.102	0.96
163_L	170_L	1.100	0.96
151_F	157_P	1.097	0.96
260_V	279_V	1.094	0.96
333_S	337_A	1.089	0.96
217_I	221_T	1.084	0.96
181_L	185_G	1.083	0.96
5_P	234_C	1.075	0.95
251_D	274_G	1.065	0.95
304_E	308_K	1.058	0.95
320_L	324_Y	1.057	0.95
313_W	330_A	1.053	0.95
159_P	168_K	1.047	0.95
328_P	334_L	1.022	0.94
119_D	122_L	1.015	0.94
316_W	334_L	1.007	0.94
180_E	264_R	1.001	0.93
163_L	169_S	1.001	0.93
177_S	181_L	0.999	0.93
119_D	128_P	0.995	0.93
84_M	89_C	0.994	0.93
212_I	250_M	0.994	0.93
43_Y	97_K	0.991	0.93
324_Y	333_S	0.990	0.93
43_Y	47_F	0.990	0.93
44_L	63_E	0.979	0.93
20_V	36_M	0.972	0.92
93_E	97_K	0.971	0.92
22_S	27_H	0.967	0.92
47_F	135_L	0.961	0.92
167_R	170_L	0.957	0.92
207_N	269_I	0.954	0.92
202_I	249_F	0.954	0.92
73_D	245_S	0.953	0.92
133_E	137_E	0.952	0.91
248_V	252_S	0.951	0.91
317_R	327_N	0.951	0.91
16_Y	36_M	0.949	0.91
36_M	39_H	0.936	0.91
324_Y	330_A	0.935	0.91
277_E	281_D	0.933	0.91
189_K	209_V	0.931	0.91
153_K	157_P	0.929	0.90
58_A	61_E	0.925	0.90
29_G	34_K	0.915	0.90
287_C	337_A	0.908	0.89
162_L	166_L	0.905	0.89
327_N	330_A	0.903	0.89
122_L	128_P	0.903	0.89
43_Y	105_D	0.903	0.89
252_S	303_C	0.902	0.89
29_G	37_E	0.898	0.89
167_R	240_S	0.897	0.89
47_F	97_K	0.896	0.89
44_L	80_F	0.896	0.89
229_I	290_V	0.896	0.89
314_N	318_A	0.895	0.89
318_A	330_A	0.893	0.89
70_Y	84_M	0.887	0.88
188_F	250_M	0.886	0.88
329_W	341_L	0.879	0.88
180_E	310_Y	0.878	0.88
130_F	134_K	0.874	0.88
316_W	325_F	0.873	0.88
21_V	38_E	0.872	0.87
63_E	66_A	0.871	0.87
208_G	314_N	0.868	0.87
227_N	230_A	0.866	0.87
332_I	338_V	0.864	0.87
217_I	282_L	0.860	0.87
148_A	162_L	0.860	0.87
193_K	196_T	0.853	0.86
175_I	306_V	0.853	0.86
257_A	280_A	0.852	0.86
255_D	287_C	0.850	0.86
27_H	124_E	0.847	0.86
114_P	117_R	0.846	0.86
318_A	323_T	0.843	0.86
84_M	88_G	0.843	0.86
251_D	260_V	0.838	0.85
44_L	81_V	0.838	0.85
319_T	340_L	0.838	0.85
29_G	33_L	0.837	0.85
198_S	201_D	0.836	0.85
274_G	290_V	0.834	0.85
316_W	319_T	0.832	0.85
203_K	305_D	0.832	0.85
63_E	130_F	0.829	0.85
323_T	334_L	0.827	0.85
329_W	333_S	0.826	0.84
149_L	152_F	0.823	0.84
148_A	157_P	0.822	0.84
176_P	307_N	0.818	0.84
34_K	37_E	0.816	0.84
171_L	306_V	0.810	0.83
314_N	317_R	0.809	0.83
174_L	181_L	0.804	0.83
330_A	334_L	0.804	0.83
178_A	318_A	0.802	0.83
88_G	131_V	0.800	0.83
6_K	21_V	0.799	0.82
275_S	278_E	0.799	0.82
274_G	287_C	0.792	0.82
11_V	15_A	0.789	0.82
214_P	270_E	0.785	0.81
328_P	336_A	0.781	0.81
73_D	76_L	0.780	0.81
10_E	13_P	0.774	0.80
4_V	9_R	0.772	0.80
268_I	282_L	0.771	0.80
179_T	258_E	0.770	0.80
325_F	337_A	0.768	0.80
251_D	254_I	0.768	0.80
315_R	326_S	0.767	0.80
150_R	154_P	0.764	0.80
59_I	62_L	0.764	0.80
80_F	286_L	0.764	0.80
125_N	129_F	0.762	0.79
18_P	24_G	0.762	0.79
323_T	328_P	0.759	0.79
322_H	326_S	0.759	0.79
318_A	325_F	0.758	0.79
319_T	323_T	0.757	0.79
82_E	86_L	0.755	0.79
166_L	199_L	0.755	0.79
132_L	135_L	0.748	0.78
299_Y	303_C	0.748	0.78
248_V	275_S	0.748	0.78
186_V	210_L	0.747	0.78
332_I	339_I	0.744	0.78
245_S	253_L	0.743	0.78
217_I	279_V	0.742	0.78
120_L	126_Q	0.736	0.77
333_S	341_L	0.735	0.77
201_D	283_F	0.734	0.77
115_A	132_L	0.734	0.77
247_V	282_L	0.733	0.77
229_I	233_Q	0.733	0.77
254_I	286_L	0.732	0.77
2_Y	264_R	0.727	0.76
5_P	15_A	0.726	0.76
43_Y	224_L	0.726	0.76
81_V	85_L	0.726	0.76
16_Y	278_E	0.721	0.76
122_L	127_L	0.718	0.75
148_A	156_L	0.715	0.75
316_W	323_T	0.712	0.75
116_I	199_L	0.711	0.75
22_S	44_L	0.710	0.74
154_P	157_P	0.708	0.74
49_K	64_E	0.707	0.74
60_K	63_E	0.707	0.74
67_R	78_D	0.706	0.74
285_K	288_K	0.701	0.73
159_P	165_L	0.701	0.73
265_E	308_K	0.697	0.73
146_L	152_F	0.696	0.73
62_L	131_V	0.696	0.73
140_K	342_L	0.692	0.73
92_L	132_L	0.692	0.73
89_C	163_L	0.689	0.72
269_I	279_V	0.688	0.72
262_L	312_S	0.688	0.72
95_L	248_V	0.688	0.72
258_E	340_L	0.687	0.72
161_H	166_L	0.686	0.72
321_K	324_Y	0.685	0.72
100_E	103_E	0.684	0.72
120_L	136_F	0.683	0.72
21_V	42_R	0.681	0.71
196_T	201_D	0.681	0.71
127_L	131_V	0.679	0.71
330_A	337_A	0.676	0.71
4_V	256_T	0.675	0.71
11_V	198_S	0.675	0.71
47_F	54_D	0.674	0.71
333_S	336_A	0.674	0.71
328_P	337_A	0.673	0.70
285_K	309_Y	0.673	0.70
102_E	202_I	0.673	0.70
319_T	330_A	0.672	0.70
148_A	153_K	0.671	0.70
327_N	333_S	0.666	0.70
84_M	283_F	0.666	0.70
47_F	139_T	0.666	0.70
253_L	299_Y	0.665	0.70
277_E	335_V	0.665	0.70
18_P	27_H	0.664	0.69
28_H	76_L	0.664	0.69
324_Y	337_A	0.663	0.69
197_K	201_D	0.662	0.69
128_P	132_L	0.661	0.69
320_L	329_W	0.659	0.69
233_Q	244_T	0.659	0.69
330_A	343_L	0.658	0.69
127_L	295_D	0.658	0.69
260_V	264_R	0.657	0.69
162_L	172_P	0.657	0.69
234_C	298_Y	0.656	0.68
215_L	272_W	0.654	0.68
149_L	154_P	0.654	0.68
126_Q	131_V	0.651	0.68
123_L	128_P	0.651	0.68
59_I	66_A	0.651	0.68
84_M	90_F	0.648	0.68
126_Q	132_L	0.647	0.67
202_I	255_D	0.645	0.67
92_L	117_R	0.644	0.67
16_Y	117_R	0.644	0.67
261_E	276_D	0.641	0.67
57_E	60_K	0.641	0.67
337_A	340_L	0.640	0.67
182_R	189_K	0.639	0.66
55_L	59_I	0.639	0.66
185_G	204_F	0.638	0.66
28_H	84_M	0.635	0.66
143_S	313_W	0.631	0.65
169_S	249_F	0.631	0.65
208_G	219_D	0.629	0.65
60_K	230_A	0.628	0.65
61_E	103_E	0.627	0.65
28_H	33_L	0.627	0.65
53_E	281_D	0.626	0.65
11_V	199_L	0.625	0.65
123_L	161_H	0.625	0.65
307_N	311_R	0.623	0.64
93_E	96_L	0.623	0.64
68_A	306_V	0.622	0.64
22_S	25_P	0.622	0.64
336_A	343_L	0.622	0.64
48_L	250_M	0.622	0.64
318_A	322_H	0.621	0.64
16_Y	67_R	0.621	0.64
114_P	122_L	0.619	0.64
321_K	326_S	0.618	0.64
174_L	178_A	0.618	0.64
9_R	13_P	0.618	0.64
66_A	74_I	0.618	0.64
117_R	154_P	0.617	0.64
327_N	336_A	0.615	0.64
324_Y	334_L	0.615	0.64
327_N	341_L	0.615	0.64
80_F	92_L	0.613	0.63
219_D	244_T	0.612	0.63
204_F	208_G	0.612	0.63
81_V	92_L	0.612	0.63
178_A	181_L	0.611	0.63
267_G	311_R	0.609	0.63
322_H	330_A	0.609	0.63
90_F	93_E	0.608	0.63
94_L	98_Y	0.608	0.63
229_I	278_E	0.607	0.62
203_K	298_Y	0.605	0.62
134_K	138_L	0.604	0.62
268_I	342_L	0.604	0.62
325_F	334_L	0.603	0.62
34_K	127_L	0.602	0.62
65_R	277_E	0.601	0.62
15_A	222_E	0.601	0.62
261_E	264_R	0.598	0.61
1_I	208_G	0.596	0.61
260_V	276_D	0.595	0.61
69_C	95_L	0.593	0.61
3_R	63_E	0.593	0.61
156_L	166_L	0.588	0.60
271_N	279_V	0.587	0.60
220_S	224_L	0.587	0.60
12_N	226_R	0.586	0.60
267_G	308_K	0.586	0.60
50_R	137_E	0.585	0.60
299_Y	302_V	0.584	0.60
325_F	333_S	0.584	0.60
14_K	49_K	0.583	0.59
79_E	247_V	0.582	0.59
7_S	115_A	0.579	0.59
2_Y	162_L	0.579	0.59
215_L	221_T	0.577	0.59
327_N	332_I	0.576	0.58
129_F	215_L	0.575	0.58
124_E	230_A	0.574	0.58
83_M	91_I	0.573	0.58
97_K	105_D	0.573	0.58
216_T	270_E	0.573	0.58
117_R	151_F	0.571	0.58
164_D	186_V	0.570	0.58
245_S	299_Y	0.569	0.58
249_F	303_C	0.569	0.58
149_L	153_K	0.569	0.58
315_R	327_N	0.567	0.57
107_F	110_P	0.566	0.57
117_R	220_S	0.564	0.57
173_K	176_P	0.563	0.57
287_C	290_V	0.562	0.57
2_Y	319_T	0.560	0.56
151_F	161_H	0.560	0.56
95_L	253_L	0.559	0.56
106_I	110_P	0.558	0.56
93_E	132_L	0.557	0.56
244_T	249_F	0.557	0.56
162_L	250_M	0.557	0.56
92_L	286_L	0.556	0.56
332_I	336_A	0.556	0.56
315_R	319_T	0.555	0.56
251_D	283_F	0.554	0.56
121_L	125_N	0.551	0.55
111_W	114_P	0.551	0.55
162_L	278_E	0.551	0.55
57_E	61_E	0.551	0.55
162_L	165_L	0.550	0.55
335_V	338_V	0.549	0.55
225_L	247_V	0.549	0.55
43_Y	93_E	0.548	0.55
325_F	340_L	0.548	0.55
175_I	252_S	0.546	0.55
166_L	169_S	0.546	0.55
180_E	261_E	0.545	0.54
149_L	169_S	0.543	0.54
248_V	291_V	0.543	0.54
47_F	93_E	0.542	0.54
199_L	202_I	0.538	0.53
320_L	334_L	0.538	0.53
123_L	234_C	0.537	0.53
14_K	32_H	0.537	0.53
19_Q	115_A	0.536	0.53
275_S	332_I	0.535	0.53
60_K	131_V	0.533	0.53
200_L	212_I	0.532	0.53
274_G	302_V	0.532	0.53
63_E	81_V	0.531	0.52
116_I	119_D	0.531	0.52
17_T	32_H	0.531	0.52
317_R	320_L	0.530	0.52
152_F	224_L	0.530	0.52
100_E	104_R	0.527	0.52
6_K	342_L	0.527	0.52
133_E	140_K	0.526	0.52
18_P	28_H	0.525	0.52
143_S	154_P	0.524	0.52
48_L	51_S	0.523	0.51
103_E	147_E	0.523	0.51
228_L	306_V	0.521	0.51
181_L	186_V	0.521	0.51
94_L	120_L	0.520	0.51
22_S	28_H	0.520	0.51
118_R	218_D	0.520	0.51
91_I	244_T	0.520	0.51
57_E	78_D	0.517	0.51
221_T	228_L	0.517	0.51
96_L	101_G	0.517	0.51
42_R	93_E	0.516	0.50
305_D	319_T	0.515	0.50
86_L	258_E	0.514	0.50
136_F	146_L	0.514	0.50
158_E	265_E	0.513	0.50
222_E	282_L	0.512	0.50
337_A	341_L	0.512	0.50
60_K	81_V	0.511	0.50
249_F	299_Y	0.509	0.50
222_E	285_K	0.509	0.50
219_D	290_V	0.509	0.50
231_F	271_N	0.507	0.49
197_K	273_L	0.507	0.49
20_V	71_S	0.506	0.49
121_L	128_P	0.505	0.49
121_L	126_Q	0.503	0.49
152_F	157_P	0.503	0.49
224_L	287_C	0.501	0.48
244_T	291_V	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4lxdA	1	0.2624	11.9	0.974	Contact Map
3b8cA	1	0.2099	11.6	0.974	Contact Map
4ercA	1	0.3061	8	0.976	Contact Map
1neiA	2	0.1749	7.7	0.976	Contact Map
4p4hI	3	0.2653	7.5	0.976	Contact Map
3ar4A	1	0.2128	7.3	0.977	Contact Map
1fafA	1	0.2303	6.1	0.977	Contact Map
2iqtA	2	0.4052	5.9	0.978	Contact Map
1sbxA	1	0.2886	5.8	0.978	Contact Map
4k6jA	1	0.2886	5.6	0.978	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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