GREMLIN Database
DUF247 - Plant protein of unknown function
PFAM: PF03140 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 343 (337)
Sequences: 2093 (1594)
Seq/√Len: 86.8
META: 0.023

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_R93_E4.8831.00
63_E67_R4.8791.00
66_A80_F4.3091.00
251_D284_N3.3661.00
251_D255_D3.2301.00
164_D167_R3.1221.00
301_D305_D3.0531.00
309_Y314_N2.8841.00
317_R321_K2.6951.00
250_M283_F2.6761.00
264_R276_D2.5781.00
316_W328_P2.5251.00
125_N128_P2.4971.00
129_F159_P2.4611.00
74_I77_S2.4521.00
178_A188_F2.4161.00
229_I247_V2.3811.00
257_A277_E2.3561.00
167_R171_L2.2961.00
22_S29_G2.2801.00
88_G135_L2.2671.00
39_H42_R2.2301.00
203_K211_E2.2051.00
255_D284_N2.1531.00
222_E226_R2.1331.00
280_A284_N2.1221.00
23_I91_I2.1091.00
337_A343_L2.1051.00
119_D125_N2.1021.00
336_A340_L2.0951.00
189_K211_E2.0931.00
62_L66_A2.0871.00
258_E261_E2.0821.00
12_N15_A2.0741.00
22_S33_L2.0341.00
210_L306_V1.9971.00
65_R130_F1.9541.00
91_I120_L1.9531.00
161_H164_D1.9501.00
336_A341_L1.9451.00
2_Y235_H1.9291.00
251_D280_A1.9171.00
249_F302_V1.9071.00
183_E322_H1.9071.00
340_L343_L1.9061.00
119_D124_E1.8941.00
254_I283_F1.8921.00
324_Y328_P1.8491.00
324_Y329_W1.8371.00
23_I131_V1.8351.00
325_F329_W1.8321.00
31_P34_K1.8241.00
44_L86_L1.8241.00
338_V342_L1.8081.00
161_H165_L1.7731.00
119_D126_Q1.7501.00
255_D280_A1.7141.00
178_A262_L1.7081.00
143_S146_L1.7071.00
329_W336_A1.6981.00
151_F155_L1.6981.00
160_K164_D1.6961.00
325_F330_A1.6901.00
10_E14_K1.6881.00
12_N222_E1.6811.00
231_F235_H1.6771.00
80_F83_M1.6661.00
30_K33_L1.6631.00
66_A84_M1.6501.00
164_D168_K1.6471.00
63_E80_F1.6461.00
23_I120_L1.6361.00
9_R17_T1.6281.00
64_E68_A1.6231.00
28_H37_E1.6211.00
162_L167_R1.6131.00
59_I85_L1.5771.00
123_L126_Q1.5621.00
330_A333_S1.5551.00
333_S340_L1.5501.00
186_V306_V1.5431.00
328_P333_S1.5421.00
161_H167_R1.5391.00
3_R72_E1.5361.00
335_V339_I1.5151.00
59_I81_V1.5151.00
331_I334_L1.5101.00
326_S330_A1.5061.00
44_L48_L1.5011.00
129_F136_F1.4770.99
318_A328_P1.4640.99
121_L166_L1.4560.99
210_L249_F1.4460.99
74_I80_F1.4430.99
163_L167_R1.4090.99
331_I335_V1.3950.99
62_L134_K1.3730.99
60_K78_D1.3730.99
229_I244_T1.3630.99
278_E288_K1.3580.99
53_E57_E1.3480.99
122_L125_N1.3450.99
320_L325_F1.3430.99
124_E128_P1.3410.99
148_A152_F1.3370.99
323_T330_A1.3350.99
123_L230_A1.3260.99
46_R97_K1.3160.99
59_I131_V1.3030.99
134_K137_E1.2970.99
325_F328_P1.2930.99
122_L299_Y1.2860.98
41_L86_L1.2860.98
318_A324_Y1.2810.98
116_I120_L1.2730.98
17_T30_K1.2720.98
106_I112_M1.2600.98
29_G36_M1.2390.98
254_I284_N1.2340.98
242_Y245_S1.2260.98
96_L139_T1.1950.98
175_I181_L1.1940.98
62_L65_R1.1850.97
226_R265_E1.1830.97
179_T262_L1.1810.97
241_S250_M1.1790.97
328_P331_I1.1530.97
241_S245_S1.1520.97
202_I213_P1.1500.97
2_Y26_Y1.1490.97
152_F155_L1.1430.97
224_L228_L1.1390.97
58_A134_K1.1380.97
133_E158_E1.1370.97
188_F210_L1.1150.96
122_L126_Q1.1140.96
320_L336_A1.1090.96
44_L85_L1.1040.96
332_I337_A1.1020.96
163_L170_L1.1000.96
151_F157_P1.0970.96
260_V279_V1.0940.96
333_S337_A1.0890.96
217_I221_T1.0840.96
181_L185_G1.0830.96
5_P234_C1.0750.95
251_D274_G1.0650.95
304_E308_K1.0580.95
320_L324_Y1.0570.95
313_W330_A1.0530.95
159_P168_K1.0470.95
328_P334_L1.0220.94
119_D122_L1.0150.94
316_W334_L1.0070.94
180_E264_R1.0010.93
163_L169_S1.0010.93
177_S181_L0.9990.93
119_D128_P0.9950.93
84_M89_C0.9940.93
212_I250_M0.9940.93
43_Y97_K0.9910.93
324_Y333_S0.9900.93
43_Y47_F0.9900.93
44_L63_E0.9790.93
20_V36_M0.9720.92
93_E97_K0.9710.92
22_S27_H0.9670.92
47_F135_L0.9610.92
167_R170_L0.9570.92
207_N269_I0.9540.92
202_I249_F0.9540.92
73_D245_S0.9530.92
133_E137_E0.9520.91
248_V252_S0.9510.91
317_R327_N0.9510.91
16_Y36_M0.9490.91
36_M39_H0.9360.91
324_Y330_A0.9350.91
277_E281_D0.9330.91
189_K209_V0.9310.91
153_K157_P0.9290.90
58_A61_E0.9250.90
29_G34_K0.9150.90
287_C337_A0.9080.89
162_L166_L0.9050.89
327_N330_A0.9030.89
122_L128_P0.9030.89
43_Y105_D0.9030.89
252_S303_C0.9020.89
29_G37_E0.8980.89
167_R240_S0.8970.89
47_F97_K0.8960.89
44_L80_F0.8960.89
229_I290_V0.8960.89
314_N318_A0.8950.89
318_A330_A0.8930.89
70_Y84_M0.8870.88
188_F250_M0.8860.88
329_W341_L0.8790.88
180_E310_Y0.8780.88
130_F134_K0.8740.88
316_W325_F0.8730.88
21_V38_E0.8720.87
63_E66_A0.8710.87
208_G314_N0.8680.87
227_N230_A0.8660.87
332_I338_V0.8640.87
217_I282_L0.8600.87
148_A162_L0.8600.87
193_K196_T0.8530.86
175_I306_V0.8530.86
257_A280_A0.8520.86
255_D287_C0.8500.86
27_H124_E0.8470.86
114_P117_R0.8460.86
318_A323_T0.8430.86
84_M88_G0.8430.86
251_D260_V0.8380.85
44_L81_V0.8380.85
319_T340_L0.8380.85
29_G33_L0.8370.85
198_S201_D0.8360.85
274_G290_V0.8340.85
316_W319_T0.8320.85
203_K305_D0.8320.85
63_E130_F0.8290.85
323_T334_L0.8270.85
329_W333_S0.8260.84
149_L152_F0.8230.84
148_A157_P0.8220.84
176_P307_N0.8180.84
34_K37_E0.8160.84
171_L306_V0.8100.83
314_N317_R0.8090.83
174_L181_L0.8040.83
330_A334_L0.8040.83
178_A318_A0.8020.83
88_G131_V0.8000.83
6_K21_V0.7990.82
275_S278_E0.7990.82
274_G287_C0.7920.82
11_V15_A0.7890.82
214_P270_E0.7850.81
328_P336_A0.7810.81
73_D76_L0.7800.81
10_E13_P0.7740.80
4_V9_R0.7720.80
268_I282_L0.7710.80
179_T258_E0.7700.80
325_F337_A0.7680.80
251_D254_I0.7680.80
315_R326_S0.7670.80
150_R154_P0.7640.80
59_I62_L0.7640.80
80_F286_L0.7640.80
125_N129_F0.7620.79
18_P24_G0.7620.79
323_T328_P0.7590.79
322_H326_S0.7590.79
318_A325_F0.7580.79
319_T323_T0.7570.79
82_E86_L0.7550.79
166_L199_L0.7550.79
132_L135_L0.7480.78
299_Y303_C0.7480.78
248_V275_S0.7480.78
186_V210_L0.7470.78
332_I339_I0.7440.78
245_S253_L0.7430.78
217_I279_V0.7420.78
120_L126_Q0.7360.77
333_S341_L0.7350.77
201_D283_F0.7340.77
115_A132_L0.7340.77
247_V282_L0.7330.77
229_I233_Q0.7330.77
254_I286_L0.7320.77
2_Y264_R0.7270.76
5_P15_A0.7260.76
43_Y224_L0.7260.76
81_V85_L0.7260.76
16_Y278_E0.7210.76
122_L127_L0.7180.75
148_A156_L0.7150.75
316_W323_T0.7120.75
116_I199_L0.7110.75
22_S44_L0.7100.74
154_P157_P0.7080.74
49_K64_E0.7070.74
60_K63_E0.7070.74
67_R78_D0.7060.74
285_K288_K0.7010.73
159_P165_L0.7010.73
265_E308_K0.6970.73
146_L152_F0.6960.73
62_L131_V0.6960.73
140_K342_L0.6920.73
92_L132_L0.6920.73
89_C163_L0.6890.72
269_I279_V0.6880.72
262_L312_S0.6880.72
95_L248_V0.6880.72
258_E340_L0.6870.72
161_H166_L0.6860.72
321_K324_Y0.6850.72
100_E103_E0.6840.72
120_L136_F0.6830.72
21_V42_R0.6810.71
196_T201_D0.6810.71
127_L131_V0.6790.71
330_A337_A0.6760.71
4_V256_T0.6750.71
11_V198_S0.6750.71
47_F54_D0.6740.71
333_S336_A0.6740.71
328_P337_A0.6730.70
285_K309_Y0.6730.70
102_E202_I0.6730.70
319_T330_A0.6720.70
148_A153_K0.6710.70
327_N333_S0.6660.70
84_M283_F0.6660.70
47_F139_T0.6660.70
253_L299_Y0.6650.70
277_E335_V0.6650.70
18_P27_H0.6640.69
28_H76_L0.6640.69
324_Y337_A0.6630.69
197_K201_D0.6620.69
128_P132_L0.6610.69
320_L329_W0.6590.69
233_Q244_T0.6590.69
330_A343_L0.6580.69
127_L295_D0.6580.69
260_V264_R0.6570.69
162_L172_P0.6570.69
234_C298_Y0.6560.68
215_L272_W0.6540.68
149_L154_P0.6540.68
126_Q131_V0.6510.68
123_L128_P0.6510.68
59_I66_A0.6510.68
84_M90_F0.6480.68
126_Q132_L0.6470.67
202_I255_D0.6450.67
92_L117_R0.6440.67
16_Y117_R0.6440.67
261_E276_D0.6410.67
57_E60_K0.6410.67
337_A340_L0.6400.67
182_R189_K0.6390.66
55_L59_I0.6390.66
185_G204_F0.6380.66
28_H84_M0.6350.66
143_S313_W0.6310.65
169_S249_F0.6310.65
208_G219_D0.6290.65
60_K230_A0.6280.65
61_E103_E0.6270.65
28_H33_L0.6270.65
53_E281_D0.6260.65
11_V199_L0.6250.65
123_L161_H0.6250.65
307_N311_R0.6230.64
93_E96_L0.6230.64
68_A306_V0.6220.64
22_S25_P0.6220.64
336_A343_L0.6220.64
48_L250_M0.6220.64
318_A322_H0.6210.64
16_Y67_R0.6210.64
114_P122_L0.6190.64
321_K326_S0.6180.64
174_L178_A0.6180.64
9_R13_P0.6180.64
66_A74_I0.6180.64
117_R154_P0.6170.64
327_N336_A0.6150.64
324_Y334_L0.6150.64
327_N341_L0.6150.64
80_F92_L0.6130.63
219_D244_T0.6120.63
204_F208_G0.6120.63
81_V92_L0.6120.63
178_A181_L0.6110.63
267_G311_R0.6090.63
322_H330_A0.6090.63
90_F93_E0.6080.63
94_L98_Y0.6080.63
229_I278_E0.6070.62
203_K298_Y0.6050.62
134_K138_L0.6040.62
268_I342_L0.6040.62
325_F334_L0.6030.62
34_K127_L0.6020.62
65_R277_E0.6010.62
15_A222_E0.6010.62
261_E264_R0.5980.61
1_I208_G0.5960.61
260_V276_D0.5950.61
69_C95_L0.5930.61
3_R63_E0.5930.61
156_L166_L0.5880.60
271_N279_V0.5870.60
220_S224_L0.5870.60
12_N226_R0.5860.60
267_G308_K0.5860.60
50_R137_E0.5850.60
299_Y302_V0.5840.60
325_F333_S0.5840.60
14_K49_K0.5830.59
79_E247_V0.5820.59
7_S115_A0.5790.59
2_Y162_L0.5790.59
215_L221_T0.5770.59
327_N332_I0.5760.58
129_F215_L0.5750.58
124_E230_A0.5740.58
83_M91_I0.5730.58
97_K105_D0.5730.58
216_T270_E0.5730.58
117_R151_F0.5710.58
164_D186_V0.5700.58
245_S299_Y0.5690.58
249_F303_C0.5690.58
149_L153_K0.5690.58
315_R327_N0.5670.57
107_F110_P0.5660.57
117_R220_S0.5640.57
173_K176_P0.5630.57
287_C290_V0.5620.57
2_Y319_T0.5600.56
151_F161_H0.5600.56
95_L253_L0.5590.56
106_I110_P0.5580.56
93_E132_L0.5570.56
244_T249_F0.5570.56
162_L250_M0.5570.56
92_L286_L0.5560.56
332_I336_A0.5560.56
315_R319_T0.5550.56
251_D283_F0.5540.56
121_L125_N0.5510.55
111_W114_P0.5510.55
162_L278_E0.5510.55
57_E61_E0.5510.55
162_L165_L0.5500.55
335_V338_V0.5490.55
225_L247_V0.5490.55
43_Y93_E0.5480.55
325_F340_L0.5480.55
175_I252_S0.5460.55
166_L169_S0.5460.55
180_E261_E0.5450.54
149_L169_S0.5430.54
248_V291_V0.5430.54
47_F93_E0.5420.54
199_L202_I0.5380.53
320_L334_L0.5380.53
123_L234_C0.5370.53
14_K32_H0.5370.53
19_Q115_A0.5360.53
275_S332_I0.5350.53
60_K131_V0.5330.53
200_L212_I0.5320.53
274_G302_V0.5320.53
63_E81_V0.5310.52
116_I119_D0.5310.52
17_T32_H0.5310.52
317_R320_L0.5300.52
152_F224_L0.5300.52
100_E104_R0.5270.52
6_K342_L0.5270.52
133_E140_K0.5260.52
18_P28_H0.5250.52
143_S154_P0.5240.52
48_L51_S0.5230.51
103_E147_E0.5230.51
228_L306_V0.5210.51
181_L186_V0.5210.51
94_L120_L0.5200.51
22_S28_H0.5200.51
118_R218_D0.5200.51
91_I244_T0.5200.51
57_E78_D0.5170.51
221_T228_L0.5170.51
96_L101_G0.5170.51
42_R93_E0.5160.50
305_D319_T0.5150.50
86_L258_E0.5140.50
136_F146_L0.5140.50
158_E265_E0.5130.50
222_E282_L0.5120.50
337_A341_L0.5120.50
60_K81_V0.5110.50
249_F299_Y0.5090.50
222_E285_K0.5090.50
219_D290_V0.5090.50
231_F271_N0.5070.49
197_K273_L0.5070.49
20_V71_S0.5060.49
121_L128_P0.5050.49
121_L126_Q0.5030.49
152_F157_P0.5030.49
224_L287_C0.5010.48
244_T291_V0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lxdA 1 0.2624 11.9 0.974 Contact Map
3b8cA 1 0.2099 11.6 0.974 Contact Map
4ercA 1 0.3061 8 0.976 Contact Map
1neiA 2 0.1749 7.7 0.976 Contact Map
4p4hI 3 0.2653 7.5 0.976 Contact Map
3ar4A 1 0.2128 7.3 0.977 Contact Map
1fafA 1 0.2303 6.1 0.977 Contact Map
2iqtA 2 0.4052 5.9 0.978 Contact Map
1sbxA 1 0.2886 5.8 0.978 Contact Map
4k6jA 1 0.2886 5.6 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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